Polyhydroxy benzoic acid derivatives and their use as neuraminidase inhibitors

ABSTRACT

The present invention is directed to compositions of the formula: ##STR1## wherein: R 2  is H, or an alkyl group having 1 to 3 carbon atoms and 0 to 2 hydroxyls; 
     R 3  is H, or hydroxyl; 
     R 4  is H, or forms a hydrolyzable ester or amide with --CO 2  --; 
     R 5  are H, or are taken together to form ═NH; and 
     R 6  comprises an amine, or a group having 1 to 12 carbon atoms and 1 to 3 amine groups. The invention is also directed to methods of inhibiting the activity of neuraminidase using the compounds of the invention.

CROSS-REFERENCE TO RELATED APPLICATION

This application is a continuation-in-part of U.S. patent applicationSer. No. 08/300,819, filed Sep. 2, 1994, which was acontinuation-in-part of U.S. patent application Ser. No. 08/116,417,filed Sep. 3, 1993, now abandoned, which are incorporated by reference.This application is also related to U.S. patent application Ser. No.08/300,607, filed Sep. 2, 1994, and to U.S. patent application havingAttorney Docket Number 197.1, filed Jun. 7, 1995, which are incorporatedby reference.

BACKGROUND OF THE INVENTION

1. Field of the Invention

Neuraminidase (also known as sialidase, acylneuraminyl hydrolase, and EC3.2.1.18) is an enzyme common among animals and a number ofmicroorganisms. It is a glycohydrolase that cleaves terminalalpha-ketosidically linked sialic acids from glycoproteins, glycolipidsand oligiosaccharides. Many of the microorganisms containingneuraminidase are pathogenic to man and other animals including fowl,horses, swine and seals. These pathogenic organisms include influenzavirus.

Neuraminidase has been implicated in the pathogenicity of influenzavirus. It is thought to help the elution of newly synthesized vironsfrom infected cells and assist in the movement of the virus (through itshydrolase activity) through the mucus of the respiratory tract.

Inhibition of glycolytic enzymes such as one of the neuraminidases areobjects of the invention. Compositions capable of such inhibition areuseful to limit the establishment and progression of infection byinfluenza virus and other neuraminidase utilizing organisms. Becauseneuraminidase cleaves sialic acid residues from a variety ofbiomolecules, compositions capable of such inhibition are also usefulfor inhibiting the cleavage of sialic acid residues from biomolecules.Accordingly, preparation of compositions capable of inhibitingneuraminidase is also an object of the invention.

An additional object is to provide compositions useful in preparingpolymers and surfactant and for use in other industrial processes andarticles.

Inhibition of glycolytic enzymes such as neuraminidase is an object ofthe invention.

An additional object of the invention is to provide neuraminidaseinhibitors that exhibit lengthy biological half-lives compared to knowncompounds.

Another object is to provide improved and less costly methods forsynthesis of neuraminidase inhibitors.

A further object is to provide such inhibitors having elevated potency,substantial oral bioavailability (>15%) and pharmaceutically acceptableor absent toxicity.

An additional object is to provide compositions useful in preparingpolymers, surfactants, immunogens and for use in other industrialprocesses and articles as will be readily apparent to the ordinaryartisan or as is further described herein.

2. Brief Description of Related Art

Itzstein, M. von; et al.; Nature 1993, 363(6428), 418-423, discloses therational design of sialidase-based inhibitors of influenza virusreplication.

Colman, P. M.; et al.; International Patent Publication No. WO 92/06691(Int. App. No. PCT/AU90/00501, publication date Apr. 30, 1992),Itzstein, L. M. von; et al.; European Patent Publication No. 0 539 204A1 (EP App. No. 92309684.6, publication date Apr. 28, 1993), andItzstein, L. M. von; et al.; International Publication No. WO 91/16320(Int. App. No. PCT/AU91/00161, publication date Oct. 31, 1991) discloseanti-viral compounds that bind neuraminidase.

SUMMARY OF THE INVENTION

One aspect of the present invention is directed to compositionscomprising compounds of the formula: ##STR2## wherein: A isindependently ═N--, ═C(H)--, ═C(R₅₀)-- or ═C(Z)--;

E is ═N-- or ═C(R₁)--, wherein R₁ is H, OH, CN, F, Cl, Br, or I;

X is --X₁ W₆ ;

Y is H, or W₁ ;

Z is H, or W₂ ;

W₁ is a group comprising an acidic hydrogen or a protected acidic group;

W₂ is a group comprising a basic heteroatom or a protected basicheteroatom;

W₃ is W₄ or heterocycle;

W₄ is R₅₁ or --C(O)R₅₅, --C(O)W₅, --SO₂ R₅₅, or --SO₂ W₅ ;

W₅ is carbocycle or heterocycle wherein each W₅ is independentlysubstituted with 0 to 3 R₅₂ groups;

W₆ is W₇, --C(O)OW₇, --C(O)N(W₇)(W₇), --C(N(W₇))N(W₇)(W₇),--C(S)N(W₇)(W₇), --C(O)W₇, --C(N(W₇))W₇, --C(S)W₇, or --CHR₅₂ W₇ ;

W₇ is W₅, R₅₂, or R₅₆ ;

X₁ is a bond, --CR₅₁ R₅₁ --, --(CR₅₁ R₅₁)₂ --, --O--, --NR₅₆ --,--N(OR₅₆)--, --N(NR₅₆ R₅₆)--, --S--, --SO--, or --SO₂ --;

R₅₀ is --W₃, --OW₃, --SW₃, --S(O)W₃, --S(O)₂ W₃, or --N(W₃)(W₃);

R₅₁ is H or R₅₂ ;

R₅₂ is R₅₃ or R₅₅ ;

R₅₃ is --O--(antigenic polypeptide), --N(R₅₆)-(antigenic polypeptide),--C(O)--O-- (antigenic polypeptide), --C(O)--N(R₅₆)-(antigenicpolypeptide), F, Cl, Br, I, --CN, N₃, --NO₂, --OR₅₆, --N(R₅₆)₂, --SR₅₆,--C(O)OR₅₆, --OC(O)R₅₁, --NR₅₆ C(O)R₅₁, --C(O)N(R₅₆)₂,--C(NR₅₆)(N(R₅₆)₂), --C(S)--OR₅₆, --C(S)--N(R₅₆)₂, --OC(S)R₅₁,--OC(NR₅₆)R₅₁, --N(R₅₆)(C(NR₅₆)(N(R₅₆)₂)), ═O, ═S, or ═N(R₅₆);

R₅₄ is alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, oralkynyl of 2 to 6 carbon atoms;

R₅₅ is R₅₄ wherein each R₅₄ is substituted with 0 to 3 R₅₃ groups;

R₅₆ is H, an alkyl of 1 to 6 carbon atoms, or a protecting group; and

with the proviso that one A is CZ and the others are N, CH, or CR₅₀ ; orone A is N, CH, or CR₅₀ and the remaining two are adjacent to oneanother and are taken together to form a 5 to 7 membered heterocyclicring comprising Z;

with the further proviso that when X₁ is a bond or --O--, then W₆ is notH;

with the further proviso that no more than one of Y and Z are H, andwhen Y or Z are H then W₆ comprises an alkyl of 3 to 6 carbon atomshaving 2 to 4 hydroxyls; and the salts, solvates, resolved enantiomersand purified diastereomers thereof.

Another aspect of the invention is directed to compositions comprisingcompounds of the formula: ##STR3## wherein: E is ═N-- or ═C(R₁)--,wherein R₁ is H, OH, CN, F, Cl, Br, or I;

E₂ is --O--, --N(R₅₆)--, or --S--;

A₁ is ═C(Z)--;

A₂ is independently ═N--, ═C(H)--, ═C(R₅₀)--, or ═C(Z)--

X is --X₁ W₆ ;

Y is H, or W₁ ;

Z is H, or W₂ ;

W₁ is a group comprising an acidic hydrogen or a protected acidic group;

W₂ is a group comprising a basic heteroatom or a protected basicheteroatom;

W₃ is W₄ or heterocycle;

W₄ is R₅₁ or --C(O)R₅₅, --C(O)W₅, --SO₂ R₅₅, or --SO₂ W₅ ;

W₅ is carbocycle or heterocycle wherein each W₅ is independentlysubstituted with 0 to 3 R₅₂ groups;

W₆ is W₇, --C(O)OW₇, --C(O)N(W₇)(W₇), --C(N(W₇))N(W₇)(W₇),--C(S)N(W₇)(W₇), --C(O)W₇, --C(N(W₇))W₇, --C(S)W₇, or --CHR₅₂ W₇ ;

W₇ is W₅, R₅₂, or R₅₆ ;

X₁ is a bond, --CR₅₁ R₅₁ --, --(CR₅₁ R₅₁)₂ --, --O--, --NR₅₆ --,--N(OR₅₆)--, --N(NR₅₆ R₅₆)--, --S--, --SO--, or --SO₂ --;

R₅₀ is --W₃, --OW₃, --SW₃, --S(O)W₃, --S(O)₂ W₃, or --N(W₃)(W₃);

R₅₁ is H or R₅₂ ;

R₅₂ is R₅₃ or R₅₅ ;

R₅₃ is F, Cl, Br, I, --CN, N₃, --OR₅₆, --N(R₅₆)₂, --SR₅₆, --C(O)OR₅₆,--OC(O)R₅₁, --NR₅₆ C(O)R₅₁, --C(O)N(R₅₆)₂, --C(NR₅₆)(N(R₅₆)₂), ═O, ═S,or ═N(R₅₆);

R₅₄ is alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, oralkynyl of 2 to 6 carbon atoms;

R₅₅ is R₅₄ wherein each R₅₄ is substituted with 0 to 3 R₅₃ groups;

R₅₆ is H, an alkyl of 1 to 6 carbon atoms, a protecting group, or anester-, thioester-, thioamide- or amide-forming group; and

with the proviso that one A₂ is CZ and the other is N, CH, or CR₅₀ ; orboth are taken together to form a 5 to 7 membered heterocyclic ringcomprising Z;

with the further proviso that when X₁ is a bond or --O--, then W₆ is notH;

with the further proviso that no more than one of Y and Z are H, andwhen Y or Z are H then W₆ comprises an alkyl of 3 to 6 carbon atomshaving 2 to 4 hydroxyls; and the salts, solvates, resolved enantiomersand purified diastereomers thereof.

Another aspect of the invention is directed to the salts, solvates,resolved enantiomers and purified diastereomers of the foregoingcompositions.

Another aspect of the invention relates to the foregoing compositionscomprising one or more pharmaceutically-acceptable carriers.

Another aspect of the invention relates to methods of inhibiting theactivity of neuraminidase comprising the step of treating a samplesuspected of containing neuraminidase with one or more of the foregoingcompositions.

In other embodiments, novel methods for synthesis of the compounds ofthis invention are provided.

BRIEF DESCRIPTION OF THE DRAWINGS

FIGS. 1a and 1b depict exemplary aromatic carbocycles and heterocyclesfalling within structures (1) and (3), wherein Q₁, Q₂ and Q₃ representthe substitution sites for X, Y, and Z respectively, and Q₄, whenpresent, represents the substitution site of R₄₀ or R₅₀.

FIGS. 2a-2d depict exemplary X groups, wherein Q₁ designates the FIGS.1a and 1b carbocycle or heterocycle substitution sites.

FIGS. 3a-3b depicts exemplary Y groups, wherein Q₂ designates the FIGS.1a and 1b carbocycle or heterocycle substitution sites.

FIGS. 4a-4d depict exemplary Z groups, wherein Q₃ designates the FIGS.1a and 1b carbocycle or heterocycle substitution sites.

FIGS. 5a-c depict exemplary R₄₀ and R₅₀ groups, wherein Q₄ designatesthe FIGS. 1a and 1b carbocycle or heterocycle substitution sites.

DETAILED DESCRIPTION Compositions of the Invention

Typically, the compositions of the invention comprise compounds of theformulas: ##STR4## Y is H, or W₁, typically W₁. W₁ is a group comprisingan acidic hydrogen or a protected acidic group, which, within thecontext of the invention, means a group having a hydrogen atom that canbe removed by a base yielding an anion or its corresponding salt orsolvate. The general principles of acidity and basicity of organicmaterials are well understood and are to be understood as defining W₁.They will not be detailed here. However, a description appears inStreitwieser, A.; and Heathcock, C. H.; "Introduction to OrganicChemistry, Second Edition" (Macmillan, New York, 1981), pages 60-64.Generally, acidic groups of the invention have pK values less than thatof water, usually less than pK=10, typically less than pK=8, andfrequently less than pK=6. Such groups include the common organic acids.

By way of example and not limitation, typical W₁ groups include acids ofcarbon, sulfur, phosphorous, and nitrogen, such groups includingcarboxylic (--CO₂ H), alkyl sulfuric (alk--O--SO₃ H), sulfonic (alk--SO₃H), sulfinic (alk--SO₂ H), alkyl phosphoric (alk--O--PO₃ H₂), phosphoric(--O--PO₃ H₂), alkyl phosphonic (alk--PO₃ H₂), phosphonic (--PO₃ H₂),monoalkyl alkyl phosphonic (alk--P(O--alk)O₂ H) and tetrazoles.Ordinarily W₁ is carboxy (--CO₂ H), methylene carboxy (--CH₂ CO₂ H),phosphonate, methylene phosphonate (--CH₂ PO₃ H₂), sulfonate (--SO₃ H),methylene sulfonate (--CH₂ SO₃ H), or tetrazole. Exemplary W₁ groups areshown in FIGS. 3a-3b. The nomenclature of phosphorous compounds followsthat of Corbridge, D.E.C. "Phosphorus. An outline of its chemistry,Biochemistry and technology." (Elsevier, New York, 1985), Appendix II,pages 731-733, and sections cited therein.

W₁ may also be a protected acidic group, which, within the context ofthe invention means an acidic group as described above that has beenprotected by one of the groups commonly used in the art for such groups.Exemplary carboxylic acid, phosphonic acid, phosphonate, sulfonic acidand other protecting groups for W₁ acids are described in detail inGreene, T. W., "Protective Groups in Organic Synthesis" (John Wiley &sons, New York, 1981) as set forth below. Such groups include by way ofexample and not limitation, esters, amides, hydrizides, and the like. Insome embodiments, the protecting group will be cleavable underphysiological conditions, more typically it will be cleavable in vivo,where the protecting group forms an ester or amide with an acidhydroxyl, including hydrolyzable esters or amides withnaturally-occurring alcohols or amino acids respectively, suitable onesof which are set forth below as R₆ groups. Typical W₁ groups that arehydrolyzable under physiological conditions include esters and/or amidesof the foregoing acid phosphorus, sulfur and carboxyl groups, inparticular esters with groups selected from aryl (especially phenyl),lower alkoxy-substituted aryl (especially O-ethoxyphenyl) or thealkylacyloxyalkyl groups of U.S. Pat. No. 4,968,788, or amides formedwith a naturally-occurring amines such as one of the naturally occurringamino acids or a polypeptide. One or more of the acid hydroxyls areesterified or amidated. The substituent esters or amines optionally arethe same, or they may be different. W₁ protecting groups also containgroups of the the structure --CH₂ O(CO)R₃₇ or --CH₂ (CO)OR₃₈ (linked tooxygen of the acidic group) wherein R₃₇ and R₃₈ are alkyl, aryl, oralkylaryl groups. Frequently R₃₇ and R₃₈ are bulky groups such asbranched alkyl, ortho-substituted aryl, meta-substituted aryl, orcombinations thereof, including normal, secondary, iso- and tertiaryalkyls of 1-6 carbon atoms. Further examples of protecting groups arefound below.

More typically, W₁ is --CO₂ R₅₆, --SO₃ R₅₆, --S(O)OR₅₆, --P(O)(OR₅₆)₂,--C(O)NHSO₂ R₅₅, --SO₂ NHC(O)--R₅₅ or tetrazolyl. R₅₆ and R₅₅ aredescribed above and in detail below.

Most typically, Y is selected from the group consisting of: ##STR5##

Exemplary Y groups are listed in FIGS. 3a-3b.

X is --X₁ W₆.

X₁ is a bond, --CR₅₁ R₅₁ --, --(CR₅₁ R₅₁)₂ --, --O--, --NR₅₆ --,--N(OR₅₆)--, --N(NR₅₆ R₅₆)--, --S--, --SO--, or --SO₂ --. Typically, X₁is a bond, --CR₅₅ R₅₅ --, or --O--, more typically, a bond or --O--. R₅₁and R₅₆ are described above and in detail below.

W₆ is W₇, --C(O)OW₇, --C(O)N(W₇)(W₇), --C(N(W₇))N(W₇)(W₇),--C(S)N(W₇)(W₇), --C(O)W₇, --C(N(W₇))W₇, --C(S)W₇, or --CHR₅₂ W₇.Typically W₆ is W₇, --C(O)OW₇, --C(O)W₇, or --CHR₅₅ W₇, more typically,W₇, or --CH₂ W₇.

W₇ is W₅, R₅₂, or R₅₆. R₅₂ and R₅₆ are described above and in detailbelow. Typically W₇ is W₅ or R₅₂, more typically, a heterocycle, H, orR₅₅.

W₅ is carbocycle or heterocycle wherein each W₅ is independentlysubstituted with 0 to 3 R₅₂ groups. Carbocycles and heterocycles aredescribed in detail below. R₅₂ is described above and in detail below.

In one embodiment of the invention, X₁ is ordinarily --O--, --NH--,--S--, --SO--, or --SO₂ --, and W₆ is --CHR₅₅ W₇ or --C(O)W₇. Moretypically in this embodiment, W₆ is --CH₂ W₇ and W₇ is --OR₅₅ or analkyl of 1 to 3 carbon atoms and is substituted with 0 to 2 hydroxygroups.

It is provided in all embodiments of the invention that when X₁ is abond or --O--, then W₆ is not H.

In general, X is selected from the group consisting of: ##STR6##Exemplary X groups are listed in FIGS. 2a-2d. Z is H, or W₂, typicallyW₂.

W₂ is a group comprising a basic heteroatom or a protected basicheteroatom. W₂ generally comprises a basic heteroatom, which, within thecontext of the invention means a heteroatom capable of protonation,typically by an acidic hydrogen having an acidity in the range describedabove for W₁. The basic principles of basicity are described inStreitwieser and Heathcock (op. cit.) and provide meaning for the termbasic heteroatom as will be understood by those ordinarily skilled inthe art. Generally, the basic heteroatoms employed in the compounds ofthe invention have pK values for the corresponding protonated form thatare in the range of values described above for W₁. Basic heteroatomsinclude the heteroatoms common in organic compounds which have anun-shared, non-bonding, n-type, or the like, electron pair. By way ofexample and not limitation, typical basic heteroatoms include theoxygen, nitrogen, and sulfur atoms of groups such as alcohols, amines,amidines, guanidines, sulfides, and the like, frequently, amines,amidines and guanidines. Ordinarily, W₂ is an amino alkyl (generallylower alkyl) group such as aminomethyl, aminoethyl or aminopropyl; anamidinoalkyl group such as amidinomethyl, amidinoethyl, oramidinopropyl; or a guanidinoalkyl group such as guanidinomethyl,guanidinoethyl, or guanidinopropyl (in each instance wherein the alkylgroup serves to bridge the basic substitutent to the carbocyclic ring).

W₂ optionally is a protected basic heteroatom which within the contextof the invention means a basic heteroatom as described above that hasbeen protected by one of the groups common in the art. Such groups aredescribed in detail in Greene (op. cit.) as set forth below. Such groupsinclude by way of example and not limitation, amides, carbamates, aminoacetals, imines, enamines, N-alkyl or N-aryl phosphinyls, N-alkyl orN-aryl sulfenyls or sulfonyls, N-alkyl or N-aryl silyls, thioethers,thioesters, disulfides, sulfenyls, and the like as are described in moredetail below as amino protecting groups. In some embodiments, theprotecting group will be cleavable under physiological conditions,typically it will be cleavable in vivo where, for example, the basicheteroatom that forms an amide with an organic acid or an amino acidsuch as a naturally occurring amino acid or a polypeptide.

More typically, W₂ is amino, amidino, guanidino, heterocycle or an alkylof 2 to 3 carbon atoms substituted with guanidino, or with an amino anda second group selected from the group consisting of hydroxy and amino.

Still more typically, W₂ is --NHR₅₅, --C(NH)(NH₂), --NR₅₅ -- C(NR₅₅)(NR₅₅ R₅₃), --NH--C(NH)(NHR₅₃), --NH--C(NH)(NHR₅₅), --NH-- C(NH)NH₂),--CH(CH₂ NHR₅₅)(CH₂ OH), --CH(CH₂ NHR₅₅)(CH₂ NHR₅₅), --CH(NHR₅₅)--(CR₅₅R₅₅)_(m20) --CH(NHR₅₅)R₅₅, --CH(OH)--(CR₅₅ R₅₅)_(m20) --S--CH(NHR₅₅)R₅₅, or --CH(NHR₅₅)--(CR₅₅ R₅₅)_(m20) --CH(OH)R₅₅, --(CR₅₅R₅₅)_(m20) --S-- C(NH)NH₂, --N═C(NHR₅₅)(R₅₃) or --N═C(NHR₅₅)(R₅₅);wherein each m20 is independently an integer from 0 to 1; and R₅₃ andR₅₅ are described above and in detail below.

Typically Z is selected from the group consisting of: ##STR7##

Exemplary Z groups are listed in 4a-4c.

It is provided in all aspects of the invention that no more than one ofY and Z are H, and when Y or Z are H then W₆ comprises an alkyl of 3 to6 carbon atoms having 2 to 4 hydroxyls.

E is ═N-- or ═C(R₁)--. R₁ is H, OH, CN, F, Cl, Br, or I, typically H,OH, or F, more typically, H or F.

E₂ is --O--, --N(R₅₆)--, or --S--, typically, --O--, --N(H)--, or --S--.

Each A is independently ═N--, ═C(H)--, ═C(R₅₀)-- or ═C(Z)--. However, itis provided that one A is CZ and the others are N, CH, or CR₅₀ ; or oneA is N, CH, or CR₅₀ and the remaining two are adjacent to one anotherand are taken together to form a 5 to 7 membered heterocyclic ringcomprising Z. Typically one A is CZ, a second A is CR₅₀ and the third Ais CH. More typically, one A is CZ, a second A is CR₅₀ and the third Ais CH; and CZ and CR₅₀ are adjacent. R₅₀ is described above and indetail below.

A₁ is ═C(Z)-- and each A₂ is independently ═N--, ═C(H)--, ═C(R₅₀)--, or═C(Z)--.

R₅₀ is --W₃, --OW₃, --SW₃, --S(O)W₃, --S(O)₂ W₃, or --N(W₃)(W₃),typically, --W₃, or --N(W₃)(W₃), more typically a heterocycle or--N(W₄)(W₄). Even more typically R₅₀ is an nitrogen containingheterocycle bonded through a nitrogen atom thereof or --N(R₅₁)(C(O)R₅₅),still more typically, --N(H)(C(O)R₅₅). R₅₁, R₅₄ and R₅₅ are describedabove and in detail below.

W₃ is W₄ or heterocycle.

W₄ is R₅₁ or --C(O)R₅₅, --C(O)W₅, --SO₂ R₅₅, or --SO₂ W₅. Typically W₄is R₅₁ or --C(O)R₅₅, more typically, R₅₅ or --C(O)R₅₅, still moretypically, --C(O)CH₃, --C(O)CH₂ F, --C(O)CHF₂, or --C(O)CF₃.

Generally R₅₀ is selected from the group consisting of: ##STR8##Exemplary R₅₀ groups are listed in Tables 5a-5b. R₅₁ is H or R₅₂.

R₅₂ is R₅₃ or R₅₅.

R₅₃ is --O--(antigenic polypeptide), --N(R₅₆)-(antigenic polypeptide),--C(O)--O-- (antigenic polypeptide), --C(O)--N(R₅₆)-(antigenicpolypeptide), F, Cl, Br, I, --CN, N₃, --NO₂, --OR₅₆, --N(R₅₆)₂, --SR₅₆,--C(O)OR₅₆, --OC(O)R₅₁, --NR₅₆ C(O)R₅₁, --C(O)N(R₅₆)₂,--C(NR₅₆)(N(R₅₆)₂), --C(S)--OR₅₆, --C(S)--N(R₅₆)₂, --OC(S)R₅₁,--OC(NR₅₆)R₅₁, --N(R₅₆)(C(NR₅₆)(N(R₅₆)₂)), ═O, ═S, or ═N(R₅₆). TypicallyR₅₃ is F, Cl, --CN, N₃, --OR₅₆, --N(R₅₆)₂, --SR₅₆, --C(O)OR₅₆,--OC(O)R₅₁, or ═O. More typically, R₅₃ is F, --OR₅₆, --N(R₅₆)₂, or ═O.In the context of the present application, "═O" denotes a double bonedoxygen atom (oxo), and "═S" and "═N(R₅₆)" denote the sulfur and nitrogenanalogs.

R₅₄ is alkyl of 1 to 6 carbon atoms, alkenyl of 2 to 6 carbon atoms, oralkynyl of 2 to 6 carbon atoms.

R₅₅ is R₅₄ wherein each R₅₄ is substituted with 0 to 3 R₅₃ groups.

R₅₆ is H, an alkyl of 1 to 6 carbon atoms, or a protecting group.

Group R₅₆ is not a critical functionality and may vary widely. In oneembodiment, R₅₆ is bound to any acidic group such as, by way of exampleand not limitation, a --CO₂ H, --C(O)NH₂, --C(O)N(H)(R₁), --C(S)OH,--C(S)NH₂, or --C(S)N(H)(R₁) group, thereby functioning as an ester-,thioester, thioamide-, or amide-forming group as in a --CO₂ R₅₆,--C(O)N(R₅₆)₂, --C(O)N(R₅₆)(R₅₁), --C(S)OR₅₆, --C(S)N(R₅₆)₂, or--C(S)N(R₅₆)(R₅₁) group. Such R₅₆ groups for example include C₃ -C₆ aryl(including phenyl, 2- and 3-pyrrolyl, 2- and 3-thienyl, 2- and4-imidazolyl, 2-, 4- and 5-oxazolyl, 3- and 4-isoxazolyl, 2-, 4- and5-thiazolyl, 3-, 4- and 5-isothiazolyl, 3- and 4-pyrazolyl, 1-, 2-, 3-and 4-pyridinyl, and 1-, 2-, 4- and 5-pyrimidinyl), C₃ -C₆ arylsubstituted with halo, alkyl C₁ -C₁₂ alkoxy, CN, NO₂, OH, carboxy,carboxyester, thiol, thiolester, C₁ -C₁₂ haloalkyl (1-6 halogen atoms),C₂ -C₁₂ alkenyl or C₂ -C₁₂ alkynyl including 2-, 3- and 4-alkoxyphenyl(C₁ -C₁₂ alkyl), 2-, 3- and 4-methoxyphenyl, 2-, 3- and 4-ethoxyphenyl,2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-diethoxyphenyl, 2- and3-carboethoxy-4-hydroxyphenyl, 2- and 3-ethoxy-4-hydroxyphenyl, 2- and3-ethoxy-5-hydroxyphenyl, 2- and 3-ethoxy-6-hydroxyphenyl, 2-, 3- and4-O-acetylphenyl, 2-, 3- and 4-dimethylaminophenyl, 2-, 3- and4-methylmercaptophenyl, 2-, 3- and 4-halophenyl (including 2-, 3- and4-fluorophenyl and 2-, 3- and 4-chlorophenyl!, 2,3-, 2,4-, 2,5-, 2,6-,3,4- and 3,5-dimethylphenyl, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and3,5-biscarboxyethylphenyl, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and3,5-dimethoxyphenyl, 2,3-, 2,4-, 2,5-, 2,6-, 3,4- and 3,5-dihalophenyl(including 2,4-difluorophenyl and 3,5-difluorophenyl), 2-, 3- and4-haloalkylphenyl (1 to 5 halogen atoms, C₁ -C₁₂ alkyl including4-trifluoromethylphenyl), 2-, 3- and 4-cyanophenyl, 2-, 3- and4-nitrophenyl, 2-, 3- and 4-haloalkylbenzyl (1 to 5 halogen atoms, C₁-C₁₂ alkyl including 4-trifluoromethylbenzyl and 2-, 3- and4-trichloromethylphenyl and 2-, 3- and 4-trichloromethylphenyl),4-N-methylpiperidinyl, 3-N-methylpiperidinyl, 1-ethylpiperazinyl,benzyl, alkylsalicylphenyl (C₁ -C₄ alkyl, including 2-, 3- and4-ethylsalicylphenyl), 2-,3- and 4-acetylphenyl, 1,8-dihydroxynaphthyl(--O--C₁₀ H₆ --OH) and aryloxy ethyl C₆ -C₉ aryl (including phenoxyethyl)!, 2,2'-dihydroxybiphenyl, alkoxy ethyl C₁ -C₆ alkyl including--CH₂ --CH₂ --O--CH₃ (methoxy ethyl)!, alkyl substituted by OH or by 1to 3 halo atoms (including --CH₃, --CH(CH₃)₂, --C(CH₃)₃, --CH₂ CH₃,--(CH₂)₂ CH₃, --(CH₂)₃ CH₃, --(CH₂)₄ CH₃, --(CH₂)₅ CH₃, --CH₂ CH₂ F,--CH₂ CH₂ Cl, --CH₂ CF₃, and --CH₂ CCl₃), 2-, 3- and4-N,N-dialkylaminophenol, --C₆ H₄ CH₂ --N(CH₃)₂, ##STR9##--N-2-propylmorpholino, 2,3-dihydro-6-hydroxyindene, sesamol, catecholmonoester, --CH₂ --C(O)--N(R⁸)₂ wherein each R⁸ is the same or differentH or C₁ -C₄ alkyl, --CH₂ --S(O)(R⁸), --CH₂ -S(O)₂ (R⁸), --CH₂--CH(OC(O)CH₂ R⁸)--CH₂ (OC(O)CH₂ R⁸), cholesteryl, a 5 or 6 carbonmonosaccharide, disaccharide or oligosaccharide (3 to 9 monosaccharideresidues), enolpyruvate (HOOC--C(═CH₂)O), glycerol, α-D-β-diglycerides(wherein the fatty acids composing glyceride lipids generally arenaturally occurring saturated or unsaturated C₆₋₂₆, C₆₋₁₈ or C₆₋₁₀ fattyacids such as linoleic, lauric, myristic, palmitic, stearic, oleic,palmitoleic, linolenic and the like fatty acids), trimethoxybenzyl,triethoxybenzyl, 2-alkyl pyridinyl (C₁₋₄ alkyl), ##STR10## C₁ -C₄alkylene-C₃ -C₆ aryl (including benzyl, --CH₂ -pyrrolyl, --CH₂ -thienyl,--CH₂ -imidazolyl, --CH₂ -oxazolyl, --CH₂ -isoxazolyl, --CH₂ -thiazolyl,--CH₂ -isothiazolyl, --CH₂ -pyrazolyl, --CH₂ -pyridinyl and --CH₂-pyrimidinyl) substituted in the aryl moiety by 3 to 5 halogen atoms or1 to 2 atoms or groups selected from halogen, C₁ -C₁₂ alkoxy (includingmethoxy and ethoxy), cyano, nitro, OH, C₁ -C₁₂ haloalkyl (1 to 6 halogenatoms; including --CH₂ --CCl₃), C₁ -C₁₂ alkyl (including methyl andethyl), C₂ -C₁₂ alkenyl or C₂ -C₁₂ alkynyl, and other compounds setforth in Table B below. The hydroxyl groups of the compounds of thisinvention optionally are substituted with one of groups III, IV or Vdisclosed in WO94/21604, or with isopropyl.

Particularly useful R₅₆ groups are alkylacyloxymethyl groups and theirderivatives, including --CH(CH₂ CH₂ OCH₃)OC(O)C(CH₃)₃, ##STR11## --CH₂OC(O)C₁₀ H₁₅, --CH₂ OC(O)C(CH₃)₃, --CH(CH₂ OCH₃)OC(O)C(CH₃)₃,--CH(CH(CH₃)₂)OC(O)C(CH₃)₃, --CH₂ OC(O)CH₂ CH(CH₃)₂, --CH₂ OC(O)C₆ H₁₁,--CH₂ OC(O)C₆ H₅, --CH₂ OC(O)C₁₀ H₁₅, --CH₂ OC(O)CH₂ CH₃, --CH₂OC(O)CH(CH₃)₂, --CH₂ OC(O)C(CH₃)₃ and --CH₂ OC(O)CH₂ C₆ H₅.

Protecting groups (PRT) are used to prevent side reactions with theprotected group during synthetic procedures. For the most part thedecision as to which groups to protect, when to do so, and the nature ofthe PRT will be dependent upon the chemistry of the reaction to beprotected against (e.g., acidic, basic, oxidative, reductive or otherconditions) and the intended direction of the synthesis. The PRT groupsdo not need to be, and generally are not, the same if the compound issubstituted with multiple PRT. In general, PRT will be used to protectcarboxyl, hydroxyl or amino groups. The order of deprotection to yieldfree groups is dependent upon the intended direction of the synthesisand the reaction conditions to be encountered, and may occur in anyorder.

Protecting groups are described in detail together with general conceptsand specific strategies for their use in Kocienski, Philip J.;"Protecting Groups" (Georg Thieme Verlag Stuttgart, New York, 1994)(Philip), which is incorporated by reference in its entirety herein. Inparticular Chapter 1, Protecting Groups: An Overview, pages 1-20,Chapter 2, Hydroxyl Protecting Groups, pages 21-94, Chapter 3, DiolProtecting Groups, pages 95-117, Chapter 4, Carboxyl Protecting Groups,pages 118-154, Chapter 5, Carbonyl Protecting Groups, pages 155-184,Chapter 6, Amino Protecting Groups, pages 185-243, Chapter 7, Epilogue,pages 244-252, and Index, pages 253-260, are incorporated withspecificity in the context of their contents. More particularly,Sections 2.3 Silyl Ethers, 2.4 Alkyl Ethers, 2.5 Alkoxyalkyl Ethers(Acetals), 2.6 Reviews (hydroxy and thiol protecting groups), 3.2Acetals, 3.3 Silylene Derivatives, 3.41,1,3,3-Tetraisopropyldisiloxanylidene Derivatives, 3.5 Reviews (diolprotecting groups), 4.2 Esters, 4.3 2,6,7-Trioxabicyclo 2.2.2!octanesOBO! and Other Ortho Esters, 4.4 Oxazolines, 4.5 Reviews (carboxylprotecting groups), 5.2 O,O-Acetals, 5.3 S,S-Acetals, 5.4 O,S-Acetals,5.5 Reviews (carbonyl protecting groups), 6.2 N-Acyl Derivatives, 6.3N-Sulfonyl Derivatives, 6.4 N-Sulfenyl Derivatives, 6.5 N-AlkylDerivatives, 6.6 N-Silyl Derivatives, 6.7 Imine Derivatives, and 6.8Reviews (amino protecting groups), are each incorporated withspecificity where protection/deprotection of the requisitefunctionalities is discussed. Further still, the tables "Index to thePrincipal Protecting Groups" appearing on the inside front cover andfacing page, "Abbreviations" at page xiv, and "reagents and Solvents" atpage xv are each incorporated in their entirety herein at this location.

A very large number of hydroxy protecting groups and correspondingchemical cleavage reactions are described in "Protective Groups inOrganic Chemistry", Theodora W. Greene (John Wiley & Sons, Inc., NewYork, 1991, ISBN 0-471-62301-6), ("Greene"). As will be seen from thediscussion below, some R₅₆ groups described above also are capable ofacting as PRT.

Typical hydroxy protecting groups are described in Greene at pages14-118 and include Ethers (Methyl); Substituted Methyl Ethers(Methoxymethyl, Methylthiomethyl, t-Butylthiomethyl,(Phenyldimethylsilyl)methoxymethyl, Benzyloxymethyl,p-Methoxybenzyloxymethyl, (4-Methoxyphenoxy)methyl, Guaiacolmethyl,t-Butoxymethyl, 4-Pentenyloxymethyl, Siloxymethyl,2-Methoxyethoxymethyl, 2,2,2-Trichloroethoxymethyl,Bis(2-chloroethoxy)methyl, 2-(Trimethylsilyl)ethoxymethyl,Tetrahydropyranyl, 3-Bromotetrahydropyranyl, Tetrahydropthiopyranyl,1-Methoxycyclohexyl, 4-Methoxytetrahydropyranyl,4-Methoxytetrahydrothiopyranyl, 4-MethoxytetrahydropthiopyranylS,S-Dioxido, 1- (2-Chloro-4-methyl)phenyl!-4-methoxypiperidin-4-yl, 35,1,4-Dioxan-2-yl, Tetrahydrofuranyl, Tetrahydrothiofuranyl,2,3,3a,4,5,6,7,7a-Octahydro-7,8,8-trimethyl-4,7-methanobenzofuran-2-yl));Substituted Ethyl Ethers (1-Ethoxyethyl, 1-(2-Chloroethoxy)ethyl,1-Methyl-1-methoxyethyl, 1-Methyl-1-benzyloxyethyl,1-Methyl-1-benzyloxy-2-fluoroethyl, 2,2,2-Trichloroethyl,2-Trimethylsilylethyl, 2-(Phenylselenyl)ethyl, t-Butyl, Allyl,,p-Chlorophenyl, p-Methoxyphenyl, 2,4-Dinitrophenyl, Benzyl); SubstitutedBenzyl Ethers (p-Methoxybenzyl, 3,4-Dimethoxybenzyl, o-Nitrobenzyl,p-Nitrobenzyl, p-Halobenzyl, 2,6-Dichlorobenzyl, p-Cyanobenzyl,p-Phenylbenzyl, 2- and 4-Picolyl, 3-Methyl-2-picolyl N-Oxido,Diphenylmethyl, p,p'-Dinitrobenzhydryl, 5-Dibenzosuberyl,Triphenylmethyl, α-Naphthyldiphenylmethyl,p-methoxyphenyldiphenylmethyl, Di(p-methoxyphenyl)phenylmethyl,Tri(p-methoxyphenyl)methyl, 4-(4'-Bromophenacyloxy)phenyldiphenylmethyl,4,4',4"-Tris(4,5-dichlorophthalimidophenyl)methyl,4,4',4"-Tris(levulinoyloxyphenyl)methyl,4,4',4"-Tris(benxoyloxyphenyl)methyl,3-(Imidazol-1-ylmethyl)bis(4',4"-dimethoxyphenyl)methyl,1,1-Bis(4-methoxyphenyl)-1'-pyrenylmethyl, 9-Anthryl,9-(9-Phenyl)xanthenyl, 9-(9-Phenyl-10-oxo)anthryl,1,3-Benzodithiolan-2-yl, Benzisothiazolyl S,S-Dioxido); Silyl Ethers(Trimethylsilyl, Triethylsilyl, Triisopropylsilyl,Dimethylisopropylsilyl, Diethylisopropylsily, Dimethylthexylsilyl,t-Butyldimethylsilyl, t-Butyldiphenylsilyl, Tribenzylsilyl,Tri-p-xylylsilyl, Triphenylsilyl, Diphenylmethylsilyl,t-Butylmethoxyphenylsilyl); Esters (Formate, Benzoylformate, Acetate,Choroacetate, Dichloroacetate, Trichloroacetate, Trifluoroacetate,Methoxyacetate, Triphenylmethoxyacetate, Phenoxyacetate,p-Chlorophenoxyacetate, p-poly-Phenylacetate, 3-Phenylpropionate,4-Oxopentanoate (Levulinate), 4,4-(Ethylenedithio)pentanoate, Pivaloate,Adamantoate, Crotonate, 4-Methoxycrotonate, Benzoate, p-Phenylbenzoate,2,4,6-Trimethylbenzoate (Mesitoate)); Carbonates (Methyl,9-Fluorenylmethyl, Ethyl, 2,2,2-Trichloroethyl, 2-(Trimethylsilyl)ethyl,2-(Phenylsulfonyl)ethyl, 2-(Triphenylphosphonio)ethyl, Isobutyl, Vinyl,Allyl, p-Nitrophenyl, Benzyl, p-Methoxybenzyl, 3,4-Dimethoxybenzyl,o-Nitrobenzyl, p-Nitrobenzyl, S-Benzyl Thiocarbonate,4-Ethoxy-1-naphthyl, Methyl Dithiocarbonate); Groups With AssistedCleavage (2-Iodobenzoate, 4-Azidobutyrate, 4-Niotro-4-methylpentanoate,o-(Dibromomethyl)benzoate, 2-Formylbenzenesulfonate,2-(Methylthiomethoxy)ethyl Carbonate, 4-(Methylthiomethoxy)butyrate,2-(Methylthiomethoxymethyl)benzoate); Miscellaneous Esters(2,6-Dichloro-4-methylphenoxyacetate,2,6-Dichloro-4-(1,1,3,3-tetramethylbutyl)phenoxyacetate,2,4-Bis(1,1-dimethylpropyl)phenoxyacetate, Chorodiphenylacetate,Isobutyrate, Monosuccinoate, (E)-2-Methyl-2-butenoate (Tigloate),o-(Methoxycarbonyl)benzoate, p-poly-Benzoate, α-Naphthoate, Nitrate,Alkyl N,N,N',N'-Tetramethylphosphorodiamidate, N-Phenylcarbamate,Borate, Dimethylphosphinothioyl, 2,4-Dinitrophenylsulfonate); andSulfonates (Sulfate, Methanesulfonate (Mesylate), Benzylsulfonate,Tosylate).

More typically, hydroxy protecting groups include substituted methylethers, substituted benzyl ethers, silyl ethers, and esters includingsulfonic acid esters, still more typically, trialkylsilyl ethers,tosylates and acetates.

Typical 1,2-diol protecting groups (thus, generally where two OH groupsare taken together with a protecting functionality) are described inGreene at pages 118-142 and include Cyclic Acetals and Ketals(Methylene, Ethylidene, 1-t-Butylethylidene, 1-Phenylethylidene,(4-Methoxyphenyl)ethylidene, 2,2,2-Trichloroethylidene, Acetonide(Isopropylidene), Cyclopentylidene, Cyclohexylidene, Cycloheptylidene,Benzylidene, p-Methoxybenzylidene, 2,4-Dimethoxybenzylidene,3,4-Dimethoxybenzylidene, 2-Nitrobenzylidene); Cyclic Ortho Esters(Methoxymethylene, Ethoxymethylene, Dimethoxymethylene,1-Methoxyethylidene, 1-Ethoxyethylidine, 1,2-Dimethoxyethylidene,α-Methoxybenzylidene, 1-(N,N-Dimethylamino)ethylidene Derivative,α-(N,N-Dimethylamino)benzylidene Derivative, 2-Oxacyclopentylidene);Silyl Derivatives (Di-t-butylsilylene Group,1,3-(1,1,3,3-Tetraisopropyldisiloxanylidene), andTetra-t-butoxydisiloxane-1,3-diylidene), Cyclic Carbonates, CyclicBoronates, Ethyl Boronate and Phenyl Boronate.

More typically, 1,2-diol protecting groups include those shown in TableA, still more typically, epoxides, acetonides, cyclic ketals and arylacetals.

                  TABLE A    ______________________________________    1 #STR12##    2 #STR13##    3 #STR14##    ______________________________________

wherein R⁹ is H or C₁ -C₆ alkyl.

Another embodiment of R₅₆ is directed to carboxyl or phosphonic acidderivatives. Carboxyl or phosphonic acids also are reacted withamino-containing compounds to form amides, as in --C(O)Y¹, --P(O)(Y¹)₂or --P(O)(OH)(Y¹). Y¹ may be an amino acid residue. In general, theamino acid residue has the structure R¹¹ OC(O)CH(R¹⁰)NH--, where R¹¹ isanother R₅₆, one or more additional amino acid residues linked viapeptide bonds, or H and R¹⁰ is lower alkyl or lower alkyl (C₁ -C₆)substituted with amino, carboxyl, amide, carboxyl ester, hydroxyl, C₆-C₇ aryl, guanidinyl, imidazolyl, indolyl, sulfhydryl, sulfoxide, and/oralkylphosphate. Ordinarily R¹¹ is R₅₆ and R¹⁰ is a side chain of anaturally occurring amino acid. With respect to the carboxyl-containingside chains it will be understood that if the C atom of the subjectcarboxyl is linked by 5 or less atoms to the phosphoamide N then thecarboxyl optionally will be blocked, e.g. by esterification with R₅₆ oramidation wherein the ester or amide bonds are hydrolyzable in vivo. R¹⁰also is taken together with the amino acid α N to form a proline residue(R¹⁰ ═--CH₂)₃ --). However, R¹⁰ is generally a side group such as H,--CH₃, --CH(CH₃)₂, --CH₂ --CH(CH₃)₂, --CHCH₃ --CH₂ --CH₃, --CH₂ --C₆ H₅,--CH₂ CH₂ --S--CH₃, --CH₂ OH, --CH(OH)--CH₃, --CH₂ --SH, --CH₂ --C₆ H₄OH, --CH₂ --CO--NH₂, --CH₂ --CH₂ --CO--NH₂, --CH₂ --COOH, --CH₂ --CH₂--COOH, --(CH₂)₄ --NH₂ and --(CH₂)₃ --NH--C(NH₂)--NH₂. R¹⁰ also includes1-guanidinoprop-3-yl, benzyl, 4-hydroxybenzyl, imidazol-4-yl,indol-3-yl, methoxyphenyl and ethoxyphenyl.

When the amino acid residue contains one or more chiral centers, any ofthe D, L, meso, threo or erythro (as appropriate) racemates, scalematesor mixtures thereof may be used as group Y¹. In general, if theintermediates are to be hydrolyzed non-enzymatically (as would be thecase where the compounds are used as chemical intermediates for the freeacids), D isomers are useful. On the other hand, L isomers are moreversatile since they can be susceptible to both non-enzymatic andenzymatic hydrolysis, and are more efficiently transported by amino acidor dipeptidyl transport systems in the gastrointestinal tract.

Examples of suitable amino acid residues include the following:

Glycyl;

Aminopolycarboxylic acids, e.g., aspartic acid, β-hydroxyaspartic acid,glutamic acid, β-hydroxyglutamic acid, β-methylaspartic acid,β-methylglutamic acid, β,β-dimethylaspartic acid, γ-hydroxyglutamicacid, β,γ-dihydroxyglutamic acid, β-phenylglutamic acid,γ-methyleneglutamic acid, 3-aminoadipic acid, 2-aminopimelic acid,2-aminosuberic acid and 2-aminosebacic acid residues;

Amino acid amides such as glutaminyl and asparaginyl;

Polyamino- or polybasic-monocarboxylic acids such as arginine, lysine,β-aminoalanine, γ-aminobutyrine, ornithine, citruline, homoarginine,homocitrulline, 5-hydroxy-2,6-diaminohexanoic acid (commonly,hydroxylysine, including allohydroxylysine), diaminobutyric andhistidine residues;

Diaminodicarboxylic acids such as α,α'-diaminosuccinic acid,(α,α'-diaminoglutaric acid, α,α'-diaminoadipic acid, α,α'-diaminopimelicacid, α,α'-diamino-β-hydroxypimelic acid, α,α'-diaminosuberic acid,α,α'-diaminoazelaic acid, and α,α'-diaminosebacic acid residues;

Imino acids such as proline, 4- or 3-hydroxy-2-pyrrolidinecarboxylicacid (commonly, hydroxyproline, including allohydroxyproline),γ-methylproline, pipecolic acid, 5-hydroxypipecolic acid, --N( CH₂!_(ml) COOR₅₆)₂, wherein ml and R₅₆ are as defined above, andazetidine-2-carboxylic acid residues;

A mono- or di-alkyl (typically C₁ -C₈ branched or normal) amino acidsuch as alanine, valine, leucine, allylglycine, butyrine, norvaline,norleucine, heptyline, α-methylserine, α-amino-α-methyl-γ-hydroxyvalericacid, α-amino-α-methyl-δ-hydroxyvaleric acid,α-amino-α-methyl-ε-hydroxycaproic acid, isovaline, α-methylglutamicacid, α-aminoisobutyric acid, α-aminodiethylacetic acid,α-aminodiisopropylacetic acid, α-aminodi-n-propylacetic acid,α-aminodiisobutylacetic acid, α-aminodi-n-butylacetic acid,α-aminoethylisopropylacetic acid, α-amino-n-propylacetic acid,α-aminodiisoamyacetic acid, α-methylaspartic acid, α-methylglutamicacid, 1-aminocyclopropane-1-carboxylic acid; isoleucine, alloisoleucine,tert-leucine, β-methyltryptophan and α-amino-β-ethyl-β-phenylpropionicacid residues; β-phenylserinyl;

Aliphatic α-amino-β-hydroxy acids such as serine, β-hydroxyleucine,β-hydroxynorleucine, β-hydroxynorvaline, and α-amino-β-hydroxystearicacid residues;

α-Amino, α-, γ-, δ- or ε-hydroxy acids such as homoserine,γ-hydroxynorvaline, δ-hydroxynorvaline and epsilon-hydroxynorleucineresidues; canavinyl and canalinyl; γ-hydroxyornithinyl;

2-hexosaminic acids such as D-glucosaminic acid or D-galactosaminic acidresidues;

α-Amino-β-thiols such as penicillamine, β-thiolnorvaline orβ-thiolbutyrine residues;

Other sulfur containing amino acid residues including cysteine;homocystine; β-phenylmethionine; methionine; S-allyl-L-cysteinesulfoxide; 2-thiolhistidine; cystathionine; and thiol ethers of cysteineor homocysteine;

Phenylalanine, tryptophan and ring-substituted α amino acids such as thephenyl- or cyclohexylamino acids α-aminophenylacetic acid,α-aminocyclohexylacetic acid and α-amino-β-cyclohexylpropionic acid;phenylalanine analogues and derivatives comprising aryl, lower alkyl,hydroxy, guanidino, oxyalkylether, nitro, sulfur or halo-substitutedphenyl (e.g., tyrosine, methyltyrosine and o-chloro-, p-chloro-,3,4-dicloro, o-, m- or p-methyl-, 2,4,6-trimethyl-, 2-ethoxy-5-nitro,2-hydroxy-5-nitro and p-nitro-phenylalanine); furyl-, thienyl-,pyridyl-, pyrimidinyl-, purine or naphthylalanines; and tryptophananalogues and derivatives including kynurenine, 3-hydroxykynurenine,2-hydroxytryptophan and 4-carboxytryptophan residues;

α-Amino substituted amino acid residues including sarcosine(N-methylglycine), N-benzylglycine, N-methylalanine, N-benzylalanine,N-methylphenylalanine, N-benzylphenylalanine, N-methylvaline andN-benzylvaline; and

α-Hydroxy and substituted α-hydroxy amino acid residues includingserine, threonine, allothreonine, phosphoserine and phosphothreonineresidues.

Any one of the foregoing or other known amino acids are suitablyemployed in this invention particularly if they are capable ofautocatalytically hydrolyzing a P-amidate bond. Thus, in this case theyshould contain a free carboxyl group, or should do so upon hydrolysis invivo.

Of particular interest are hydrophobic residues such as mono-or di-alkylor aryl amino acids, cycloalkylamino acids and the like. These residuescontribute to cell permeability by increasing the partition coefficientof the nucleotide analogue amidate. Typically, the residue does notcontain a sulfhydryl or guanidino substituent.

Y¹ optionally is a polypeptide radical. Polypeptides comprise dipeptides(2 residues), or polypeptides of 3, 5, 10 and up to 100 or moreresidues. They include enzymes (e.g., hydrogen peroxidase) as well asantibodies or proteins of any type against which one wishes to raise animmune response. The nature and identity of the polypeptide may varywidely. The polypeptide optionally contains a peptidolytic enzymecleavage site at the peptide bond between the first and second residuesadjacent to the phosphorus atom. Such cleavage sites are flanked byenzymatic recognition structures, e.g. a particular sequence of residuesrecognized by a peptidolytic enzyme.

Peptidolytic enzymes for cleaving the polypeptide conjugates of thisinvention are well known, and in particular include carboxypeptidases.Carboxypeptidases digest polypeptides by removing C-terminal residues,and are specific in many instances for particular C-terminal sequences.Such enzymes and their substrate requirements in general are well known.For example, a dipeptide (having a given pair of residues and a freecarboxyl terminus) is covalently bonded through its (x-amino group tothe phosphorus or carbon atoms of the compounds herein. It is expectedthat this peptide will be cleaved by the appropriate peptidolyticenzyme, leaving the carboxyl of the proximal amino acid residue toautocatalytically cleave a phosphonoamidate bond.

Suitable dipeptidyl groups (designated by their single letter code) areAA, AR, AN, AD, AC, AE, AQ, AG, AH, AI, AL, AK, AM, AF, AP, AS, AT, AW,AY, AV, RA, RR, RN, RD, RC, RE, RQ, RG, RH, RI, RL, RK, RM, RF, RP, RS,RT, RW, RY, RV, NA, NR, NN, ND, NC, NE, NQ, NG, NH, NI, NL, NK, NM, NF,NP, NS, NT, NW, NY, NV, DA, DR, DN, DD, DC, DE, DQ, DG, DH, DI, DL, DK,DM, DF, DP, DS, DT, DW, DY, DV, CA, CR, CN, CD, CC, CE, CQ, CG, CH, CI,CL, CK, CM, CF, CP, CS, CT, CW, CY, CV, EA, ER, EN, ED, EC, EE, EQ, EG,EH, EI, EL, EK, EM, EF, EP, ES, ET, EW, EY, EV, QA, QR, QN, QD, QC, QE,QQ, QG, QH, QI, QL, QK, QM, QF, QP, QS, QT, QW, QY, QV, GA, GR, GN, GD,GC, GE, GQ, GG, GH, GI, GL, GK, GM, GF, GP, GS, GT, GW, GY, GV, HA, HR,HN, HD, HC, HE, HQ, HG, HH, HI, HL, HK, HM, HF, HP, HS, HT, HW, HY, HV,IA, IR, IN, ID, IC, IE, IQ, IG, IH, II, IL, IK, IM, IF, IP, IS, IT, IW,IY, IV, LA, LR, LN, LD, LC, LE, LQ, LG, LH, LI, LL, LK, LM, LF, LP, LS,LT, LW, LY, LV, KA, KR, KN, KD, KC, KE, KQ, KG, KH, KI, KL, KK, KM, KF,KP, KS, KT, KW, KY, KV, MA, MR, MN, MD, MC, ME, MQ, MG, MH, MI, ML, MK,MM, MF, MP, MS, MT, MW, MY, MV, FA, FR, FN, FD, FC, FE, FQ, FG, FH, Fl,FL, FK, FM, FF, FP, FS, FT, FW, FY, FV, PA, PR, PN, PD, PC, PE, PQ, PG,PH, PI, PL, PK, PM, PF, PP, PS, PT, PW, PY, PV, SA, SR, SN, SD, SC, SE,SQ, SG, SH, SI, SL, SK, SM, SF, SP, SS, ST, SW, SY, SV, TA, TR, TN, TD,TC, TE, TQ, TG, TH, TI, TL, TK, TM, TF, TP, TS, TT, TW, TY, TV, WA, WR,WN, WD, WC, WE, WQ, WG, WH, WI, WL, WK, WM, WF, WP, WS, WT, WW, WY, WV,YA, YR, YN, YD, YC, YE, YQ, YG, YH, YI, YL, YK, YM, YF, YP, YS, YT, YW,YY, YV, VA, VR, VN, VD, VC, VE, VQ, VG, VH, VI, VL, VK, VM, VF, VP, VS,VT, VW, VY and VV.

Tripeptides are also useful as Y¹. The sequence -X4-pro-X5- (where X4 isany amino acid residue and X5 is an amino acid residue, a carboxyl esterof proline, or hydrogen) will be cleaved by luminal carboxypeptidase toyield X4 with a free carboxyl, which in turn autocatalytically cleavesthe phosphono amidate bond or the monoamino acid amidate is hydrolyzeditself by peptidases capable of yielding the free carboxyl. X5 usuallywill be a benzyl ester of the carboxy group of X5.

Dipeptide or tripeptide species can be selected on the basis of knowntransport properties and/or susceptibility to peptidases that can affecttransport to intestinal mucosal or other cell types. Dipeptides andtripeptides lacking an α-amino group are transport substrates for thepeptide transporter found in brush border membrane of intestinal mucosalcells (Bai, J. P. F., "Pharm Res." 9:969-978 (1992). Transport competentpeptides can thus be used to enhance bioavailability of Y¹ amidatecompounds. Di- or tripeptides having one or more amino acids in the Dconfiguration are also compatible with peptide transport and can beutilized in Y¹ amidate compounds. Amino acids in the D configuration canbe used to reduce the susceptibility of a di- or tripeptide tohydrolysis by proteases common to the brush border such asaminopeptidase N (EC 3.4.11.2). In addition, di- or tripeptides withamino acid residues can be selected on the basis of their relativeresistance to hydrolysis by proteases found in the lumen of theintestine. For example, tripeptides or oligopeptides lacking asp and/orglu are poor substrates for aminopeptidase A (EC 3.4.11.7), di- ortripeptides lacking amino acid residues on the N-terminal side ofhydrophobic amino acids (leu, tyr, phe, val, trp) are poor substratesfor endopeptidase 24.11 (EC 3.4.24.11), and peptides lacking a proresidue at the penultimate position at a free carboxyl terminus are poorsubstrates for carboxypeptidase P (EC 3.4.17). Similar considerationscan also be applied to the selection of peptides that are eitherrelatively resistant or relatively susceptible to hydrolysis bycytosolic, renal, hepatic, serum or other peptidases. Such poorlycleaved polypeptide amidates are immunogens or are useful for bonding toproteins in order to prepare immunogens.

Typical amino protecting group embodiments of R₅₆ are described inGreene at pages 315-385 and include Carbamates (methyl and ethyl,9-fluorenylmethyl, 9(2-sulfo)fluoroenylmethyl, 9-(2,7-dibromo)fluorenylmethyl, 2,7-di-t-buthyl-9-(10,10-dioxo-10,10,10,10-tetrahydrothioxanthyl)!methyl,4-methoxyphenacyl); Substituted Ethyl (2,2,2-trichoroethyl,2-trimethylsilylethyl, 2-phenylethyl, 1-(1-adamantyl)-1-methylethyl,1,1-dimethyl-2-haloethyl, 1,1-dimethyl-2,2-dibromoethyl,1,1-dimethyl-2,2,2-trichloroethyl, 1-methyl-1-(4-biphenylyl)ethyl,1-(3,5-di-t-butylphenyl)-1-methylethyl, 2-(2'- and 4'-pyridyl)ethyl,2-(N,N-dicyclohexylcarboxamido)ethyl, t-butyl, 1-adamantyl, vinyl,allyl, 1-isopropylallyl, cinnamyl, 4-nitrocinnamyl, 8-quinolyl,N-hydroxypiperidinyl, alkyldithio, benzyl, p-methoxybenzyl,p-nitrobenzyl, p-bromobenzyl, p-chorobenzyl, 2,4-dichlorobenzyl,4-methylsulfinylbenzyl, 9-anthrylmethyl, diphenylmethyl); Groups WithAssisted Cleavage (2-methylthioethyl, 2-methylsulfonylethyl,2-(p-toluenesulfonyl)ethyl, 2-(1,3-dithianyl)!methyl,4-methylthiophenyl, 2,4-dimethylthiophenyl, 2-phosphonioethyl,2-triphenylphosphonioisopropyl, 1,1-dimethyl-2-cyanoethyl,m-choro-p-acyloxybenzyl, p-(dihydroxyboryl)benzyl,5-benzisoxazolylmethyl, 2-(trifluoromethyl)-6-chromonylmethyl); GroupsCapable of Photolytic Cleavage (m-nitrophenyl, 3,5-dimethoxybenzyl,o-nitrobenzyl, 3,4-dimethoxy-6-nitrobenzyl,phenyl(o-nitrophenyl)methyl); Urea-Type Derivatives(phenothiazinyl-(10)-carbonyl, N'-p-toluenesulfonylaminocarbonyl,N'-phenylaminothiocarbonyl); Miscellaneous Carbamates (t-amyl, S-benzylthiocarbamate, p-cyanobenzyl, cyclobutyl, cyclohexyl, cyclopentyl,cyclopropylmethyl, p-decyloxybenzyl, diisopropylmethyl,2,2-dimethoxycarbonylvinyl, o-(N,N-dimethylcarboxamido)benzyl,1,1-dimethyl-3-(N,N-dimethylcarboxamido)propyl, 1,1-dimethylpropynyl,di(2-pyridyl)methyl, 2-furanylmethyl, 2-Iodoethyl, Isobornyl, Isobutyl,Isonicotinyl, p-(p'-Methoxyphenylazo)benzyl, 1-methylcyclobutyl,1-methylcyclohexyl, 1-methyl-1-cyclopropylmethyl, 1-methyl-1-(3,5-dimethoxyphenyl)ethyl, 1-methyl-1-(p-phenylazophenyl)ethyl,1-methyl-1-phenylethyl, 1-methyl-1-(4-pyridyl)ethyl, phenyl,p-(phenylazo)benzyl, 2,4,6-tri-t-butylphenyl,4-(trimethylammonium)benzyl, 2,4,6-trimethylbenzyl); Amides (N-formyl,N-acetyl, N-choroacetyl, N-trichoroacetyl, N-trifluoroacetyl,N-phenylacetyl, N-3-phenylpropionyl, N-picolinoyl,N-3-pyridylcarboxamide, N-benzoylphenylalanyl, N-benzoyl,N-p-phenylbenzoyl); Amides With Assisted Cleavage(N-o-nitrophenylacetyl, N-o-nitrophenoxyacetyl, N-acetoacetyl,(N'-dithiobenzyloxycarbonylamino)acetyl, N-3-(p-hydroxyphenyl)propionyl,N-3-(o-nitrophenyl)propionyl, N-2-methyl-2-(o-nitrophenoxy)propionyl,N-2-methyl-2-(o-phenylazophenoxy)propionyl, N-4-chlorobutyryl,N-3-methyl-3-nitrobutyryl, N-o-nitrocinnamoyl, N-acetylmethionine,N-o-nitrobenzoyl, N-o-(benzoyloxymethyl)benzoyl,4,5-diphenyl-3-oxazolin-2-one); Cyclic Imide Derivatives (N-phthalimide,N-dithiasuccinoyl, N-2,3-diphenylmaleoyl, N-2,5-dimethylpyrrolyl,N-1,1,4,4-tetramethyldisilylazacyclopentane adduct, 5-substituted1,3-dimethyl-1,3,5-triazacyclohexan-2-one, 5-substituted1,3-dibenzyl-1,3-5-triazacyclohexan-2-one, 1-substituted3,5-dinitro-4-pyridonyl); N-Alkyl and N-Aryl Amines (N-methyl, N-allyl,N- 2-(trimethylsilyl)ethoxy!methyl, N-3-acetoxypropyl,N-(1-isopropyl-4-nitro-2-oxo-3-pyrrolin-3-yl), Quaternary AmmoniumSalts, N-benzyl, N-di(4-methoxyphenyl)methyl, N-5-dibenzosuberyl,N-triphenylmethyl, N-(4-methoxyphenyl)diphenylmethyl,N-9-phenylfluorenyl, N-2,7-dichloro-9-fluorenylmethylene,N-ferrocenylmethyl, N-2-picolylamine N'-oxide), Imine Derivatives(N-1,1-dimethylthiomethylene, N-benzylidene, N-p-methoxybenylidene,N-diphenylmethylene, N- (2-pyridyl)mesityl!methylene,N,(N',N'-dimethylaminomethylene, N,N'-isopropylidene,N-p-nitrobenzylidene, N-salicylidene, N-5-chlorosalicylidene,N-(5-chloro-2-hydroxyphenyl)phenylmethylene, N-cyclohexylidene); EnamineDerivatives (N-(5,5-dimethyl-3-oxo-1-cyclohexenyl)); N-Metal Derivatives(N-borane derivatives, N-diphenylborinic acid derivatives, N-phenyl(pentacarbonylchromium- or -tungsten)!carbenyl, N-copper or N-zincchelate); N--N Derivatives (N-nitro, N-nitroso, N-oxide); N-PDerivatives (N-diphenylphosphinyl, N-dimethylthiophosphinyl,N-diphenylthiophosphinyl, N-dialkyl phosphoryl, N-dibenzyl phosphoryl,N-diphenyl phosphoryl); N-Si Derivatives; N-S Derivatives; N-SulfonylDerivatives (N-benzenesulfenyl, N-o-nitrobenzenesulfenyl,N-2,4-dinitrobenzenesulfenyl, N-pentachlorobenzenesulfenyl,N-2-nitro-4-methoxybenzenesulfenyl, N-triphenylmethylsulfenyl,N-3-nitropyridinesulfenyl); and N-sulfonyl Derivatives(N-p-toluenesulfonyl, N-benzenesulfonyl,N-2,3,6-trimethyl-4-methoxybenzenesulfonyl,N-2,4,6-trimethoxybenzenesulfonyl,N-2,6-dimethyl-4-methoxybenzenesulfonyl, N-pentamethylbenzenesulfonyl,N-2,3,5,6,-tetramethyl-4-methoxybenzenesulfonyl,N-4-methoxybenzenesulfonyl, N-2,4,6-trimethylbenzenesulfonyl,N-2,6-dimethoxy-4-methylbenzenesulfonyl,N-2,2,5,7,8-pentamethylchroman-6-sulfonyl, N-methanesulfonyl,N-β-trimethylsilyethanesulfonyl, N-9-anthracenesulfonyl,N-4-(4',8'-dimethoxynaphthylmethyl)benzenesulfonyl, N-benzylsulfonyl,N-trifluoromethylsulfonyl, N-phenacylsulfonyl).

More typically, protected amino groups include carbamates and amides,still more typically, --NHC(O)R₅₆ or --N═CR¹¹ N(R₅₆)₂.

Table B lists R₅₆ ester and Y¹ amidate moieties that can be bonded viaoxygen or directly, respectively, to --C(O)O-- and --P(O)(O--)₂ groups.Esters of structures 1-5, 8-10 and 16, 17, 19-22 are synthesized byreacting a compound having a free hydroxyl with the corresponding halide(chloride or acyl chloride and the like) and N,N-dicylohexyl-N-morpholine carboxamidine (or another base such as DBU,triethylamine, CsCO₃, N,N-dimethylaniline and the like) in DMF (or othersolvent such as acetonitrile or N-methylpyrrolidone). Esters ofstructures 5-7, 11, 12, 21, and 23-26 are synthesized by reaction of thealcohol or alkoxide salt (or the corresponding amines in the case ofcompounds such as 13, 14 and 15) with the monochlorophosphonate ordichlorophosphonate or another activated phosphonate.

                  TABLE B    ______________________________________    1.        --CH.sub.2 --C(O)--N(R.sup.8).sub.2 *    2.        --CH.sub.2 --S(O)(R.sup.8)    3.        --CH.sub.2 --S(O).sub.2 (R.sup.8)    4.        --CH.sub.2 --O--C(O)--CH.sub.2 --C.sub.6 H.sub.5    5.        3-cholesteryl    6.        3-pyridyl    7.        N-ethylmorpholino    8.        --CH.sub.2 O--C(O)--C.sub.6 H.sub.5    9.        --CH.sub.2 --O--C(O)--CH.sub.2 CH.sub.3    10.       --CH.sub.2 --O--C(O)--C(CH.sub.3).sub.3    11.       --CH.sub.2 --CCl.sub.3    12.       --C.sub.6 H.sub.5    13.       --NH--CH.sub.2 --C(O)O--CH.sub.2 CH.sub.3    14.       --N(CH.sub.3)--CH.sub.2 --C(O)O--CH.sub.2 CH.sub.3    15.       --NHR.sub.5.sbsb.6    16.       --CH.sub.2 --O--C(O)--C.sub.10 H.sub.15    17.       --CH.sub.2 --O--C(O)--CH(CH.sub.3).sub.2    18.       --CH.sub.2 --C#H(OC)(O)CH.sub.2 R.sup.8)--CH.sub.2 --              (OC(O)CH.sub.2 R.sup.8)*              1 #STR15##    20.              2 #STR16##              3 #STR17##              4 #STR18##              5 #STR19##              6 #STR20##              7 #STR21##              8 #STR22##    ______________________________________     *Each R.sup.8 is the same or different (includes methyl, ethyl, propyl,     isopropyl and tbutyl).     #chiral center is (R), (S) or racemate.

Other esters that are suitable for use herein are described in EP632,048.

Alkyl as used herein (for instance in respect to the various R's)typically is lower alkyl containing 1 to 6 normal, secondary, tertiaryor cyclic carbon atoms such as methyl (Me, --CH₃), ethyl (Et, --CH₂CH₃), 1-propyl (n-Pr, n-propyl, --CH₂ CH₂ CH₃), 2-propyl (i-Pr,i-propyl, --CH(CH₃)₂), 1-butyl (n-Bu, n-butyl, --CH₂ CH₂ CH₂ CH₃),2-methyl-1-propyl (i-Bu, i-butyl, --CH₂ CH(CH₃)₂), 2-butyl (s-Bu,s-butyl, --CH(CH₃)CH₂ CH₃), 2-methyl-2-propyl (t-Bu, t-butyl,--C(CH₃)₃), 1-pentyl (n-pentyl, --CH₂ CH₂ CH₂ CH₂ CH₃), 2-pentyl(--CH(CH₃)CH₂ CH₂ CH₃), 3-pentyl (--CH(CH₂ CH₃)₂), 2-methyl-2-butyl(--C(CH₃)₂ CH₂ CH₃), 3-methyl-2-butyl (--CH(CH₃)CH(CH₃)₂),3-methyl-1-butyl (--CH₂ CH₂ CH(CH₃)₂), 2-methyl-1-butyl (--CH₂CH(CH₃)CH₂ CH₃), 1-hexyl (--CH₂ CH₂ CH₂ CH₂ CH₂ CH₃), 2-hexyl(--CH(CH₃)CH₂ CH₂ CH₂ CH₃), 3-hexyl (--CH(CH₂ CH₃)(CH₂ CH₂ CH₃)),2-methyl-2-pentyl (--C(CH₃)₂ CH₂ CH₂ CH₃), 3-methyl-2-pentyl(--CH(CH₃)CH(CH₃)CH₂ CH₃), 4-methyl-2-pentyl (--CH(CH₃)CH₂ CH(CH₃)₂),3-methyl-3-pentyl (--C(CH₃)(CH₂ CH₃)₂), 2-methyl-3-pentyl (--CH(CH₂CH₃)CH(CH₃)₂), 2,3-dimethyl-2-butyl (--C(CH₃)₂ CH(CH₃)₂),3,3-dimethyl-2-butyl (--CH(CH₃)C(CH₃)₃), or the like. Typically, alkylis of 1, 2, 3 or 4 carbon atoms, more typically, 1, 2 or 3 carbon atoms.

Alkenyl as used herein (for instance in respect to the various R's) istypically lower alkenyl containing 2 to 6 normal, secondary, tertiary orcyclic carbon atoms such as ethenyl (--CH═CH₂), 1-prop-1-enyl(--CH═CHCH₃), 1-prop-2-enyl (--CH₂ CH═CH₂), 2-prop-1-enyl(--C(═CH₂)(CH₃)), 1-but-1-enyl (--CH═CHCH₂ CH₃), 1-but-2-enyl (--CH₂CH═CHCH₃), 1-but-3-enyl (--CH₂ CH₂ CH═CH₂), 2-methyl-1-prop-1-enyl(--CH═C(CH₃)₂), 2-methyl-1-prop-2-enyl (--CH₂ C(═CH₂)(CH₃)),2-but-1-enyl (--C(═CH₂)CH₂ CH₃), 2-but-2-enyl (--C(CH₃)═CHCH₃),2-but-3-enyl (--CH(CH₃)CH═CH₂), 1-pent-1-enyl (--C═CHCH₂ CH₂ CH₃),1-pent-2-enyl (--CHCH═CHCH₂ CH₃), 1-pent-3-enyl (--CHCH₂ CH═CHCH₃),1-pent-4-enyl (--CHCH₂ CH₂ CH═CH₂), 2-pent-1-enyl (--C(═CH₂)CH₂ CH₂CH₃), 2-pent-2-enyl (--C(CH₃)═CH₂ CH₂ CH₃), 2-pent-3-enyl(--CH(CH₃)CH═CHCH₃), 2-pent-4-enyl (--CH(CH₃)CH₂ CH═CH₂) or3-methyl-1-but-2-enyl (--CH₂ CH═C(CH₃)₂). More typically, alkenyl groupsare of 2, 3 or 4 carbon atoms. Still more typically 2 or 3 carbon atoms.

Alkynyl as used herein (for instance in respect to the various R's) istypically lower alkynyl containing 2 to 6 normal, secondary, tertiary orcyclic carbon atoms such as alkynyl ethynyl (--CCH), 1-prop-1-ynyl(--CCCH₃), 1-prop-2-ynyl (--CH₂ CCH), 1-but-1-ynyl (--CCCH₂ CH₃),1-but-2-ynyl (--CH₂ CCCH₃), 1-but-3-ynyl (--CH₂ CH₂ CCH), 2-but-3-ynyl(CH(CH₃)CCH), 1-pent-1-ynyl (--CCCH₂ CH₂ CH₃), 1-pent-2-ynyl (--CH₂CCCH₂ CH₃), 1-pent-3-ynyl (--CH₂ CH₂ CCCH₃) or 1-pent-4-ynyl (--CH₂ CH₂CH₂ CCH). More typically, alkynyl groups are of 2, 3 or 4 carbon atoms.Still more typically 2 or 3 carbon atoms.

Carbocycles of W₅ and heterocycles of W₃ and W₅ are stable chemicalstructures. Such structures are isolatable in measurable yield, withmeasurable purity, from reaction mixtures at temperatures from -78° C.to 200° C. Each W₃ and W₅, including carbocycles and heterocycles, areindependently substituted with 0 to 3 R₂ groups. Typically, W₃ and W₅are a saturated, unsaturated or aromatic ring comprising a mono- orbicyclic carbocycle or heterocycle. More typically, W₃ or W₅ has 3 to 10ring atoms, still more typically, 3 to 7 ring atoms, and ordinarily 3 to6 ring atoms. The W₃ and W₅ rings are saturated when containing 3 ringatoms, saturated or monounsaturated when containing 4 ring atoms,saturated, or mono- or diunsaturated when containing 5 ring atoms, andsaturated, mono- or diunsaturated, or aromatic when containing 6 ringatoms.

When W₅ is carbocyclic, it is typically a 3 to 7 carbon monocycle or a 7to 10 carbon atom bicycle. More typically, W₅ monocyclic carbocycleshave 3 to 6 ring atoms, still more typically 5 or 6 ring atoms. W₅bicyclic carbocycles have 7 to 10 ring atoms arranged as a bicyclo 4,5!,5,5!, 5,6! or 6,6! system, still more typically, 9 or 10 ring atomsarranged as a bicyclo 5,6! or 6,6! system Examples include cyclopropyl,cyclobutyl, cyclopentyl, 1-cyclopent-1-enyl, 1-cyclopent-2-enyl,1-cyclopent-3-enyl, cyclohexyl, 1-cyclohex-1-enyl, 1-cyclohex-2-enyl,1-cyclohex-3-enyl, phenyl, and naphthyl.

A W₃ or W₅ heterocycle is typically a monocycle having 3 to 7 ringmembers (2 to 6 carbon atoms and 1 to 3 heteroatoms selected from N, O,P, and S) or a bicycle having 7 to 10 ring members (4 to 9 carbon atomsand 1 to 3 heteroatoms selected from N, O, P, and S). More typically, W₃and W₅ heterocyclic monocycles have 3 to 6 ring atoms (2 to 5 carbonatoms and 1 to 2 heteroatoms selected from N, O, and S), still moretypically, 5 or 6 ring atoms (3 to 5 carbon atoms and 1 to 2 heteroatomsselected from N and S). W₃ and W₅ heterocyclic bicycles have 7 to 10ring atoms (6 to 9 carbon atoms and 1 to 2 heteroatoms selected from N,O, and S) arranged as a bicyclo 4,5!, 5,5!, 5,6!, or 6,6! system, stillmore typically, 9 to 10 ring atoms (8 to 9 carbon atoms and 1 to 2hetero atoms selected from N and S) arranged as a bicyclo 5,6! or 6,6!system.

Heterocycles include by way of example and not limitation thosedescribed in Paquette, Leo A.; "Principles of Modern HeterocyclicChemistry" (W. A. Benjamin, New York, 1968), particularly Chapters 1, 3,4, 6, 7, and 9; "The Chemistry of Heterocyclic Compounds, A series ofMonographs" (John Wiley & Sons, New York, 1950 to present), inparticular Volumes 13, 14, 16, 19, and 28; and J. Am. Chem. Soc. 1960,82, 5566; each of which is incorporated herein by reference.

Examples of heterocycles include by way of example and not limitationpyridyl, thiazolyl, tetrahydrothiophenyl, sulfur oxidizedtetrahydrothiophenyl, pyrimidinyl, furanyl, thienyl, pyrrolyl,pyrazolyl, imidazolyl, tetrazolyl, benzofuranyl, thianaphthalenyl,indolyl, indolenyl, quinolinyl, isoquinolinyl, benzimidazolyl,piperidinyl, 4-piperidonyl, pyrrolidinyl, 2-pyrrolidonyl, pyrrolinyl,tetrahydrofuranyl, tetrahydroquinolinyl, tetrahydroisoquinolinyl,decahydroquinolinyl, octahydroisoquinolinyl, azocinyl, triazinyl,6H-1,2,5-thiadiazinyl, 2H,6H-1,5,2-dithiazinyl, thienyl, thianthrenyl,pyranyl, isobenzofuranyl, chromenyl, xanthenyl, phenoxathiinyl,2H-pyrrolyl, isothiazolyl, isoxazolyl, pyrazinyl, pyridazinyl,indolizinyl, isoindolyl, 3H-indolyl, 1H-indazoly, purinyl,4H-quinolizinyl, phthalazinyl, naphthyridinyl, quinoxalinyl,quinazolinyl, cinnolinyl, pteridinyl, 4aH-carbazolyl, carbazolyl,β-carbolinyl, phenanthridinyl, acridinyl, pyrimidinyl, phenanthrolinyl,phenazinyl, phenothiazinyl, furazanyl, phenoxazinyl, isochromanyl,chromanyl, imidazolidinyl, imidazolinyl, pyrazolidinyl, pyrazolinyl,piperazinyl, indolinyl, isoindolinyl, quinuclidinyl, morpholinyl,oxazolidinyl, benzotriazolyl, benzisoxazolyl, oxindolyl, benzoxazolinyl,and isatinoyl.

Typically W₃ and W₅ heterocycles are selected from pyridyl, pyridazinyl,pyrimidinyl, pyrazinyl, s-triazinyl, oxazolyl, imidazolyl, thiazolyl,isoxazolyl, pyrazolyl, isothiazolyl, furanyl, thiofuranyl, thienyl, orpyrrolyl.

More typically, the heterocycle of W₃ and W₅ is bonded through a carbonatom or nitrogen atom thereof. Still more typically W₃ heterocycles arebonded by a stable covalent bond through a nitrogen atom thereof to thecyclohexene ring of the compositions of the invention and W₅heterocycles are bonded by a stable covalent bond through a carbon ornitrogen atom thereof to the cyclohexene ring of the compositions of theinvention. Stable covalent bonds are chemically stable structures asdescribed above.

By way of example and not limitation, carbon bonded heterocycles includeposition 2, 3, 4, 5, or 6 of a pyridine, position 3, 4, 5, or 6 of apyridazine, position 2, 4, 5, or 6 of a pyrimidine, position 2, 3, 5, or6 of a pyrazine, position 2, 3, 4, or 5 of a furan, tetrahydrofuran,thiofuran, thiophene, pyrrole or tetrahydropyrrole, position 2, 4, or 5of an oxazole, imidazole or thiazole, position 3, 4, or 5 of anisoxazole, pyrazole, or isothiazole, position 2 or 3 of an aziridine,position 2, 3, or 4 of an azetidine, position 2, 3, 4, 5, 6, 7, or 8 ofa quinoline or position 1, 3, 4, 5, 6, 7, or 8 of an isoquinoline. Stillmore typically, carbon bonded heterocycles include 2-pyridyl, 3-pyridyl,4-pyridyl, 5-pyridyl, 6-pyridyl, 3-pyridazinyl, 4-pyridazinyl,5-pyridazinyl, 6-pyridazinyl, 2-pyrimidinyl, 4-pyrimidinyl,5-pyrimidinyl, 6-pyrimidinyl, 2-pyrazinyl, 3-pyrazinyl, 5-pyrazinyl,6-pyrazinyl, 2-thiazolyl, 4-thiazolyl, or 5-thiazolyl.

By way of example and not limitation, nitrogen bonded heterocyclesinclude position 1 of an aziridine, azetedine, pyrrole, pyrrolidine,2-pyrroline, 3-pyrroline, imidazole, imidazolidine, 2-imidazoline,3-imidazoline, pyrazole, pyrazoline, 2-pyrazoline, 3-pyrazoline,piperidine, piperazine, indole, indoline, 1H-indazole, position 2 of aisoindole, or isoindoline, position 4 of a morpholine, and position 9 ofa carbazole, or β-carboline. Still more typically, nitrogen bondedheterocycles include 1-aziridyl, 1-azetedyl, 1-pyrrolyl, 1-imidazolyl,1-pyrazolyl, and 1-piperidinyl.

Another aspect of the invention relates to composition of as describedabove comprising compounds of the formula: ##STR23##

X is R₄₁, OR₄₁, SR₄₁, S(O)R₄₁, S(O)₂ R₄₁, or NR₄₁ R₄₂ wherein R₄₁ is analkyl group comprising 1 to 6 carbon atoms and 1 to 4 hydroxyl groups.The alkyl group is normal, branched, cyclic or a combination thereof.The hydroxyl groups are primary, secondary or tertiary. Typically X is anormal alkyl containing 3 to 5 carbon atoms and 2 to 3 hydroxyl groups.Ordinary X groups include, by way of example and not limitation,ethanol, propanol, butanol, ethylene glycol, propylene glycol, andglycerol moieties having various configurations and stereochemistries. Xordinarily is a residue or radical of a naturally occurring carbohydratesuch as glycerol, erythritol, threitol, adonitol, arabitol, and xylitol.R₄₂ is H, OH, alkyl of 1 to 3 carbon atoms, or comprises an amine.Exemplary X groups are listed in FIGS. 2a-2d.

Y comprises a group capable of hydrogen bonding to an amino, guanidinoor imidazole function group. Ordinarily Y is capable of hydrogen bondingto the side chain of an arginine, lysine, or histidine amino acidresidue within a polypeptide. Exemplary Y groups of this type includecarboxylic acid and nitro functions, such as --CO₂ R₄ as defined below.Y may also comprise an acidic hydrogen atom or a protected acidic groupas described above

In some embodiments Y is taken together with Z to form anintramolecularly protected Y group. For example, when Y is a carboxylicacid function (e.g. a --CO₂ H group) and Z comprises an amine function(e.g. a --(CH₂)_(m) --NH₂ group, wherein m is 1 to 4), theintramolecular cyclic amide is a intramolecularly protected Y and Zgroup.

E is N or CR₁, wherein R₁ is H, OH, CN, F, Cl, Br, or I.

E₂ is O, NH, or S.

A is independently N, CH, CR₄₀ or CZ, provided that one A is CZ and theothers are N, CH, or CR₄₀ ; or one A is N, CH, or CR₄₀ and the remainingtwo are adjacent to one another and one is CH or CR₄₀ and the other isCZ, and CH or CR₄₀ is taken together with CZ to form a 5 to 7 memberedheterocyclic ring comprising Z;

A₁ is CZ.

A₂ is independently N, CH, CR₄₀, or CZ, provided that one A₂ is CZ andthe other is N, CH, or CR₄₀ ; or one A₂ is CZ and the other is CH orCR₄₀, and CH or CR₄₀ is taken together with CZ to form a 5 to 7 memberedheterocyclic ring comprising Z;

R₄₀ is R₄₃, OR₄₃, SR₄₃, S(O)R₄₃, S(O)₂ R₄₃, or NR₄₃ R₄₄ wherein R₄₃comprises an alkyl of 1 to 3 carbon atoms, an acyl of 2 to 3 carbonatoms, or an alkyl of 1 to 3 carbon atoms substituted with an acyl of 2to 3 carbon atoms, and R₄₄ is H or an alkyl of 1 to 2 carbon atoms.

Exemplary R₄₃ groups include by way of example and not limitation,methyl (CH₃, group 0.1 in FIG. 5a), ethyl (CH₃ CH₂, group 0.2 in FIG.5a), n-propyl (CH₃ CH₂ CH₂, group 0.3 in FIG. 5a), i-propyl ((CH₃)₂ CH,group 0.4 in FIG. 5a), 2 carbon acyl (CH₃ C(O), group 0.5 in FIG. 5a), 3carbon acyl (CH₃ CH₂ C(O), group 0.6 in FIG. 5a), 1 carbon alkyl havinga 2 carbon acyl (2-propanone-1-yl, CH₃ C(O)CH₂, group 0.7 in FIG. 5a), 1carbon alkyl having a 3 carbon acyl (2-butanone-1-yl, CH₃ CH₂ C(O)CH₂),2 carbon alkyl having a 2 carbon acyl (e.g. 2-butanone-3-yl, CH₃C(O)CHCH₃ or 2-butanone-4-yl, CH₃ C(O)CH₂ CH₂), and the like. OrdinarilyR₄₃ is a 2 or 3 carbon acyl.

R₄₃ is optionally substituted with one or more non-polar electronwithdrawing groups. When R₄₃ is an Acyl of 2 to 3 carbon atoms, thesubstitution by the non-polar electron withdrawing group is typically onthe carbon atom alpha to the acyl carbonyl carbon atom. Such groups arewell known in the art and, by way of example and not limitation, theyinclude halides (e.g. F, Cl, Br, or I), pseudo halides (e.g. CN), andatoms having electronegativities greater than hydrogen and being capableof forming covalent bonds to carbon wherein the bonds are stable underphysiological conditions. Ordinary non-polar electron withdrawing groupsare halides and in particular F. Exemplary R₄₃ groups having non-polarelectron withdrawing groups include mono-, di-, and trihalo- acyl groupsof 2 to 3 carbon atom such as mono-, di-, and trifluoro- 2 carbon acyl.

Z comprises a group capable of hydrogen bonding to a carboxyl group.Ordinarily Z is capable of hydrogen bonding to the side chain of anaspartate or glutamate amino acid residue within a polypeptide. Zgenerally comprises a basic heteroatom or a protected basic heteroatomas described above.

In this embodiment of the invention one of Y and Z may alternatively beH. When Y or Z is H, X comprises an alkyl of 3 to 6 carbon atoms having2 to 4 hydroxyls

One embodiment of the invention is a compound of the formula: ##STR24##

Wherein R₂ is H or an alkyl group having 1 to 3 carbon atoms and 0 to 2hydroxyls; R₃ is H, or hydroxyl; R₄ is H, or forms a hydrolyzable esteror amide with --CO₂ --; R₅ are H, or are taken together to form ═NH; R₆is --NH₂, or comprises a group having 1 to 12 carbon atoms and 1 to 3amine groups.

Ordinarily, R₂ is H; R₃ is H or OH; R₄ is H; and R₅ are taken togetherto form ═NH and R₆ is NH₂ ; or R₅ are H and R₆ is amino substituted C₁--C₁₂ (ordinarily C₁ -C₆) alkyl such as aminomethyl, aminoethyl oraminopropyl.

Another embodiment of the invention is a compound of the formula:##STR25## wherein R₂, R₃, R₄, R₅ and R₆ are defined above A₃ isindependently N, CH or CR₄₀ and R₄₀ is defined above.

Another embodiment of the invention is a compound of the formula:##STR26## wherein R₄ and R₆ are defined above, and m is 1 to 4.Ordinarily, m is 1 or 2.

Another embodiment of the invention is a compound of the formula:##STR27## wherein R₄, R₆, and m are defined above.

Another embodiment of the invention is a compound of the formula:##STR28## wherein R₄, R₆, and m are defined above.

Another embodiment of the invention is a compound of the formula:##STR29## wherein E, R₂, R₃, R₄, R₅, R₆, R₄₃, and R₄₄ are defined above.

Another embodiment of the invention is a compound of the formula:##STR30## wherein X, Y, A₁, A₂, E, and E₂ are defined above.

Another embodiment of the invention is a compound of the formula:##STR31## wherein E₂, R₂, R₃, R₄, R₅, R₆, and A₂ are defined above.

Another embodiment of the invention is a compound of the formula:##STR32## wherein E₂, R₄, R₆, R₄₃, R₄₄, and m are defined above.

Another embodiment of the invention is a compound of the formula:##STR33## wherein E₂, R₂, R₃, R₄, R₅, R₆, and A₂ are defined above.

Another embodiment of the invention is a compound of the formula:##STR34## wherein E₂, R₄, R₆, R₄₃, R₄₄ and m are defined above.

The compounds of the invention are enriched or resolved optical isomersat any or all asymmetric atom. For example, the chiral centersdesignated by "*" in the depictions are provided as the chiral isomersor racemic mixtures. Both racemic and diasteromeric mixtures of theseisomers which may exist for certain compounds, as well as the individualoptical isomers isolated or synthesized, being substantially free oftheir enantiomeric or diastereomeric partners, are all within the scopeof the invention. The racemic mixtures are separated into theirindividual, substantially optically pure isomers through well-knowntechniques such as, for example, the separation of diastereomeric saltsformed with optically active adjuncts, e.g., acids or bases followed byconversion back to the optically active substances. In most instances,the desired optical isomer is synthesized by means of stereospecificreactions, beginning with the appropriate stereoisomer of the desiredstarting material.

The compounds of the invention can also exist as tautomeric isomers incertain cases. For example, ene-amine tautomers can exist for imidazole,guanine, amidine, and tetrazole systems and all the possible tautomericforms of either are within the scope of the invention.

The compositions of this invention optionally comprise pharmaceuticallyacceptable non-toxic salts of the compounds herein, containing, forexample, Na⁺, Li⁺, K⁺, Ca⁺⁺ and Mg⁺⁺. Such salts may include thosederived by combination of appropriate cations such as alkali andalkaline earth metal ions or ammonium and quaternary amino ions with anacid anion moiety, typically the Y group carboxylic acid.

Metal salts typically are prepared by reacting the metal hydroxide witha compound of this invention. Examples of metal salts which are preparedin this way are salts containing Li⁺, Na⁺, and K⁺. A less soluble metalsalt can be precipitated from the solution of a more soluble salt byaddition of the suitable metal compound.

In addition, salts may be formed from acid addition of certain organicand inorganic acids, e.g., HCl, HBr, H₂ SO₄ or organic sulfonic acids,with basic centers, typically group Z amines. Finally, it is to beunderstood that the compositions herein comprise compounds of theinvention in their un-ionized, as well as zwitterionic form.

The compounds of the invention may be optimized to exhibit desiredpharmaco-properties (as used herein pharmaco-dynamic, pharmaco-kinetic,bioavailability, or the like). One method of optimization is themodification of functional groups in particular amino and carboxylgroups to form materials having improve pharmaco-properties. Suchmodifications generally lead to compounds having hydrolyzable bonds atformer acidic or basic sites.

Exemplary Enumerated Compounds

By way of example and not limitation, a number of exemplary enumeratedcompounds of the invention are listed below. Generally, the compositionsof the invention are depicted by the structures of formulas (1), (3),(15) or (16).

The compounds of the invention included in these exemplary compounds aredesignated by numerical format in which the first digit is the structure(1), (3), (15) or (16) carbocycle or heterocycle as numbered in FIGS.1a-1b, the second digit represents X of FIGS. 2a-d, the third digitrepresents Y of FIGS. 3a-3b, the fourth digit represents Z of FIGS.4a-4d, and the fifth digit when present represents R₄₀ or R₅₀ of FIGS.5a-5c.

The carbocyclic or heterocyclic fragments from FIGS. 1a or 1b havegroups Q₁, Q₂, Q₃, and optionally, Q₄ as shown. These are the attachmentpoints for the groups X, Y, Z, and, optionally, R₄₀ or R₅₀ respectively.Each of the group fragments from FIGS. 2-5 have groups Q₁, Q₂, Q₃, and,optionally, Q₄ shown. These are the points of attachment to thecorresponding Q₁, Q₂, Q₃, or Q₄ groups shown on the carbocyclic orheterocyclic fragment. By attachment it is intended that the two groupsQ₁, the two groups Q₂, the two groups Q₃ and, when present, the twogroups Q₄ are combined to form a chemical bond. In this manner thegroups (one each from FIGS. 1-4, and when present, one from FIG. 5) arecombined to produce a single chemical formula (or structure)representing the compound named according to the above description.

By way of example, four compounds having the designation 2.19.1.1,7.5.5.36, 12.5.5.36 and 17.34.10.1.22 are shown below. Note inparticular that 7.5.5.36 and 12.5.5.36 have the same X, Y, and Z groupsand differ only in the aromatic core. The stereochemistry of the methylsubstituent is preserved in the two compounds.

                                      TABLE 1    __________________________________________________________________________    Table 1 is a list of exemplary enumerated compounds of the    __________________________________________________________________________    invention.    9 #STR35##    2.19.1.1    0 #STR36##    7.5.5.36    1 #STR37##    12.5.5.36    2 #STR38##    17.34.10.46.22    Exemplary Enumerated Compounds    __________________________________________________________________________    1.17.1.1           1.17.1.2                   1.17.1.5                          1.17.1.7                                  1.17.1.14    1.17.1.17           1.17.1.34                   1.17.1.35                          1.17.1.46                                  1.17.1.47    1.17.2.1           1.17.2.2                   1.17.2.5                          1.17.2.7                                  1.17.2.14    1.17.2.17           1.17.2.34                   1.17.2.35                          1.17.2.46                                  1.17.2.47    1.17.6.1           1.17.6.2                   1.17.6.5                          1.17.6.7                                  1.17.6.14    1.17.6.17           1.17.6.34                   1.17.6.35                          1.17.6.46                                  1.17.6.47    1.17.7.1           1.17.7.2                   1.17.7.5                          1.17.7.7                                  1.17.7.14    1.17.7.17           1.17.7.34                   1.17.7.35                          1.17.7.46                                  1.17.7.47    1.17.8.1           1.17.8.2                   1.17.8.5                          1.17.8.7                                  1.17.8.14    1.17.8.17           1.17.8.34                   1.17.8.35                          1.17.8.46                                  1.17.8.47    1.17.9.1           1.17.9.2                   1.17.9.5                          1.17.9.7                                  1.17.9.14    1.17.9.17           1.17.9.34                   1.17.9.35                          1.17.9.46                                  1.17.9.47    1.17.10.1           1.17.10.2                   1.17.10.5                          1.17.10.7                                  1.17.10.14    1.17.10.17           1.17.10.34                   1.17.10.35                          1.17.10.46                                  1.17.10.47    1.18.1.1           1.18.1.2                   1.18.1.5                          1.18.1.7                                  1.18.1.14    1.18.1.17           1.18.1.34                   1.18.1.35                          1.18.1.46                                  1.18.1.47    1.18.2.1           1.18.2.2                   1.18.2.5                          1.18.2.7                                  1.18.2.14    1.18.2.17           1.18.2.34                   1.18.2.35                          1.18.2.46                                  1.18.2.47    1.18.6.1           1.18.6.2                   1.18.6.5                          1.18.6.7                                  1.18.6.14    1.18.6.17           1.18.6.34                   1.18.6.35                          1.18.6.46                                  1.18.6.47    1.18.7.1           1.18.7.2                   1.18.7.5                          1.18.7.7                                  1.18.7.14    1.18.7.17           1.18.7.34                   1.18.7.35                          1.18.7.46                                  1.18.7.47    1.18.8.1           1.18.8.2                   1.18.8.5                          1.18.8.7                                  1.18.8.14    1.18.8.17           1.18.8.34                   1.18.8.35                          1.18.8.46                                  1.18.8.47    1.18.9.1           1.18.9.2                   1.18.9.5                          1.18.9.7                                  1.18.9.14    1.18.9.17           1.18.9.34                   1.18.9.35                          1.18.9.46                                  1.18.9.47    1.18.10.1           1.18.10.2                   1.18.10.5                          1.18.10.7                                  1.18.10.14    1.18.10.17           1.18.10.34                   1.18.10.35                          1.18.10.46                                  1.18.10.47    1.19.1.1           1.19.1.2                   1.19.1.5                          1.19.1.7                                  1.19.1.14    1.19.1.17           1.19.1.34                   1.19.1.35                          1.19.1.46                                  1.19.1.47    1.19.2.1           1.19.2.2                   1.19.2.5                          1.19.2.7                                  1.19.2.14    1.19.2.17           1.19.2.34                   1.19.2.35                          1.19.2.46                                  1.19.2.47    1.19.6.1           1.19.6.2                   1.19.6.5                          1.19.6.7                                  1.19.6.14    1.19.6.17           1.19.6.34                   1.19.6.35                          1.19.6.46                                  1.19.6.47    1.19.7.1           1.19.7.2                   1.19.7.5                          1.19.7.7                                  1.19.7.14    1.19.7.17           1.19.7.34                   1.19.7.35                          1.19.7.46                                  1.19.7.47    1.19.8.1           1.19.8.2                   1.19.8.5                          1.19.8.7                                  1.19.8.14    1.19.8.17           1.19.8.34                   1.19.8.35                          1.19.8.46                                  1.19.8.47    1.19.9.1           1.19.9.2                   1.19.9.5                          1.19.9.7                                  1.19.9.14    1.19.9.17           1.19.9.34                   1.19.9.35                          1.19.9.46                                  1.19.9.47    1.19.10.1           1.19.10.2                   1.19.10.5                          1.19.10.7                                  1.19.10.14    1.19.10.17           1.19.10.34                   1.19.10.35                          1.19.10.46                                  1.19.10.47    1.20.1.1           1.20.1.2                   1.20.1.5                          1.20.1.7                                  1.20.1.14    1.20.1.17           1.20.1.34                   1.20.1.35                          1.20.1.46                                  1.20.1.47    1.20.2.1           1.20.2.2                   1.20.2.5                          1.20.2.7                                  1.20.2.14    1.20.2.17           1.20.2.34                   1.20.2.35                          1.20.2.46                                  1.20.2.47    1.20.6.1           1.20.6.2                   1.20.6.5                          1.20.6.7                                  1.20.6.14    1.20.6.17           1.20.6.34                   1.20.6.35                          1.20.6.46                                  1.20.6.47    1.20.7.1           1.20.7.2                   1.20.7.5                          1.20.7.7                                  1.20.7.14    1.20.7.17           1.20.7.34                   1.20.7.35                          1.20.7.46                                  1.20.7.47    1.20.8.1           1.20.8.2                   1.20.8.5                          1.20.8.7                                  1.20.8.14    1.20.8.17           1.20.8.34                   1.20.8.35                          1.20.8.46                                  1.20.8.47    1.20.9.1           1.20.9.2                   1.20.9.5                          1.20.9.7                                  1.20.9.14    1.20.9.17           1.20.9.34                   1.20.9.35                          1.20.9.46                                  1.20.9.47    1.20.10.1           1.20.10.2                   1.20.10.5                          1.20.10.7                                  1.20.10.14    1.20.10.17           1.20.10.34                   1.20.10.35                          1.20.10.46                                  1.20.10.47    1.21.1.1           1.21.1.2                   1.21.1.5                          1.21.1.7                                  1.21.1.14    1.21.1.17           1.21.1.34                   1.21.1.35                          1.21.1.46                                  1.21.1.47    1.21.2.1           1.21.2.2                   1.21.2.5                          1.21.2.7                                  1.21.2.14    1.21.2.17           1.21.2.34                   1.21.2.35                          1.21.2.46                                  1.21.2.47    1.21.6.1           1.21.6.2                   1.21.6.5                          1.21.6.7                                  1.21.6.14    1.21.6.17           1.21.6.34                   1.21.6.35                          1.21.6.46                                  1.21.6.47    1.21.7.1           1.21.7.2                   1.21.7.5                          1.21.7.7                                  1.21.7.14    1.21.7.17           1.21.7.34                   1.21.7.35                          1.21.7.46                                  1.21.7.47    1.21.8.1           1.21.8.2                   1.21.8.5                          1.21.8.7                                  1.21.8.14    1.21.8.17           1.21.8.34                   1.21.8.35                          1.21.8.46                                  1.21.8.47    1.21.9.1           1.21.9.2                   1.21.9.5                          1.21.9.7                                  1.21.9.14    1.21.9.17           1.21.9.34                   1.21.9.35                          1.21.9.46                                  1.21.9.47    1.21.10.1           1.21.10.2                   1.21.10.5                          1.21.10.7                                  1.21.10.14    1.21.10.17           1.21.10.34                   1.21.10.35                          1.21.10.46                                  1.21.10.47    1.22.1.1           1.22.1.2                   1.22.1.5                          1.22.1.7                                  1.22.1.14    1.22.1.17           1.22.1.34                   1.22.1.35                          1.22.1.46                                  1.22.1.47    1.22.2.1           1.22.2.2                   1.22.2.5                          1.22.2.7                                  1.22.2.14    1.22.2.17           1.22.2.34                   1.22.2.35                          1.22.2.46                                  1.22.2.47    1.22.6.1           1.22.6.2                   1.22.6.5                          1.22.6.7                                  1.22.6.14    1.22.6.17           1.22.6.34                   1.22.6.35                          1.22.6.46                                  1.22.6.47    1.22.7.1           1.22.7.2                   1.22.7.5                          1.22.7.7                                  1.22.7.14    1.22.7.17           1.22.7.34                   1.22.7.35                          1.22.7.46                                  1.22.7.47    1.22.8.1           1.22.8.2                   1.22.8.5                          1.22.8.7                                  1.22.8.14    1.22.8.17           1.22.8.34                   1.22.8.35                          1.22.8.46                                  1.22.8.47    1.22.9.1           1.22.9.2                   1.22.9.5                          1.22.9.7                                  1.22.9.14    1.22.9.17           1.22.9.34                   1.22.9.35                          1.22.9.46                                  1.22.9.47    1.22.10.1           1.22.10.2                   1.22.10.5                          1.22.10.7                                  1.22.10.14    1.22.10.17           1.22.10.34                   1.22.10.35                          1.22.10.46                                  1.22.10.47    1.33.1.1           1.33.1.2                   1.33.1.5                          1.33.1.7                                  1.33.1.14    1.33.1.17           1.33.1.34                   1.33.1.35                          1.33.1.46                                  1.33.1.47    1.33.2.1           1.33.2.2                   1.33.2.5                          1.33.2.7                                  1.33.2.14    1.33.2.17           1.33.2.34                   1.33.2.35                          1.33.2.46                                  1.33.2.47    1.33.6.1           1.33.6.2                   1.33.6.5                          1.33.6.7                                  1.33.6.14    1.33.6.17           1.33.6.34                   1.33.6.35                          1.33.6.46                                  1.33.6.47    1.33.7.1           1.33.7.2                   1.33.7.5                          1.33.7.7                                  1.33.7.14    1.33.7.17           1.33.7.34                   1.33.7.35                          1.33.7.46                                  1.33.7.47    1.33.8.1           1.33.8.2                   1.33.8.5                          1.33.8.7                                  1.33.8.14    1.33.8.17           1.33.8.34                   1.33.8.35                          1.33.8.46                                  1.33.8.47    1.33.9.1           1.33.9.2                   1.33.9.5                          1.33.9.7                                  1.33.9.14    1.33.9.17           1.33.9.34                   1.33.9.35                          1.33.9.46                                  1.33.9.47    1.33.10.1           1.33.10.2                   1.33.10.5                          1.33.10.7                                  1.33.10.14    1.33.10.17           1.33.10.34                   1.33.10.35                          1.33.10.46                                  1.33.10.47    1.34.1.1           1.34.1.2                   1.34.1.5                          1.34.1.7                                  1.34.1.14    1.34.1.17           1.34.1.34                   1.34.1.35                          1.34.1.46                                  1.34.1.47    1.34.2.1           1.34.2.2                   1.34.2.5                          1.34.2.7                                  1.34.2.14    1.34.2.17           1.34.2.34                   1.34.2.35                          1.34.2.46                                  1.34.2.47    1.34.6.1           1.34.6.2                   1.34.6.5                          1.34.6.7                                  1.34.6.14    1.34.6.17           1.34.6.34                   1.34.6.35                          1.34.6.46                                  1.34.6.47    1.34.7.1           1.34.7.2                   1.34.7.5                          1.34.7.7                                  1.34.7.14    1.34.7.17           1.34.7.34                   1.34.7.35                          1.34.7.46                                  1.34.7.47    1.34.8.1           1.34.8.2                   1.34.8.5                          1.34.8.7                                  1.34.8.14    1.34.8.17           1.34.8.34                   1.34.8.35                          1.34.8.46                                  1.34.8.47    1.34.9.1           1.34.9.2                   1.34.9.5                          1.34.9.7                                  1.34.9.14    1.34.9.17           1.34.9.34                   1.34.9.35                          1.34.9.46                                  1.34.9.47    1.34.10.1           1.34.10.2                   1.34.10.5                          1.34.10.7                                  1.34.10.14    1.34.10.17           1.34.10.34                   1.34.10.35                          1.34.10.46                                  1.34.10.47    1.37.1.1           1.37.1.2                   1.37.1.5                          1.37.1.7                                  1.37.1.14    1.37.1.17           1.37.1.34                   1.37.1.35                          1.37.1.46                                  1.37.1.47    1.37.2.1           1.37.2.2                   1.37.2.5                          1.37.2.7                                  1.37.2.14    1.37.2.17           1.37.2.34                   1.37.2.35                          1.37.2.46                                  1.37.2.47    1.37.6.1           1.37.6.2                   1.37.6.5                          1.37.6.7                                  1.37.6.14    1.37.6.17           1.37.6.34                   1.37.6.35                          1.37.6.46                                  1.37.6.47    1.37.7.1           1.37.7.2                   1.37.7.5                          1.37.7.7                                  1.37.7.14    1.37.7.17           1.37.7.34                   1.37.7.35                          1.37.7.46                                  1.37.7.47    1.37.8.1           1.37.8.2                   1.37.8.5                          1.37.8.7                                  1.37.8.14    1.37.8.17           1.37.8.34                   1.37.8.35                          1.37.8.46                                  1.37.8.47    1.37.9.1           1.37.9.2                   1.37.9.5                          1.37.9.7                                  1.37.9.14    1.37.9.17           1.37.9.34                   1.37.9.35                          1.37.9.46                                  1.37.9.47    1.37.10.1           1.37.10.2                   1.37.10.5                          1.37.10.7                                  1.37.10.14    1.37.10.17           1.37.10.34                   1.37.10.35                          1.37.10.46                                  1.37.10.47    2.17.1.1           2.17.1.2                   2.17.1.5                          2.17.1.7                                  2.17.1.14    2.17.1.17           2.17.1.34                   2.17.1.35                          2.17.1.46                                  2.17.1.47    2.17.2.1           2.17.2.2                   2.17.2.5                          2.17.2.7                                  2.17.2.14    2.17.2.17           2.17.2.34                   2.17.2.35                          2.17.2.46                                  2.17.2.47    2.17.6.1           2.17.6.2                   2.17.6.5                          2.17.6.7                                  2.17.6.14    2.17.6.17           2.17.6.34                   2.17.6.35                          2.17.6.46                                  2.17.6.47    2.17.7.1           2.17.7.2                   2.17.7.5                          2.17.7.7                                  2.17.7.14    2.17.7.17           2.17.7.34                   2.17.7.35                          2.17.7.46                                  2.17.7.47    2.17.8.1           2.17.8.2                   2.17.8.5                          2.17.8.7                                  2.17.8.14    2.17.8.17           2.17.8.34                   2.17.8.35                          2.17.8.46                                  2.17.8.47    2.17.9.1           2.17.9.2                   2.17.9.5                          2.17.9.7                                  2.17.9.14    2.17.9.17           2.17.9.34                   2.17.9.35                          2.17.9.46                                  2.17.9.47    2.17.10.1           2.17.10.2                   2.17.10.5                          2.17.10.7                                  2.17.10.47    2.17.10.17           2.17.10.34                   2.17.10.35                          2.17.10.46                                  2.17.10.47    2.18.1.1           2.18.1.2                   2.18.1.5                          2.18.1.7                                  2.18.1.14    2.18.1.17           2.18.1.34                   2.18.1.35                          2.18.1.46                                  2.18.1.47    2.18.2.1           2.18.2.2                   2.18.2.5                          2.18.2.7                                  2.18.2.14    2.18.2.17           2.18.2.34                   2.18.2.35                          2.18.2.46                                  2.18.2.47    2.18.6.1           2.18.6.2                   2.18.6.5                          2.18.6.7                                  2.18.6.14    2.18.6.17           2.18.6.34                   2.18.6.35                          2.18.6.46                                  2.18.6.47    2.18.7.1           2.18.7.2                   2.18.7.5                          2.18.7.7                                  2.18.7.14    2.18.7.17           2.18.7.34                   2.18.7.35                          2.18.7.46                                  2.18.7.47    2.18.8.1           2.18.8.2                   2.18.8.5                          2.18.8.7                                  2.18.8.14    2.18.8.17           2.18.8.34                   2.18.8.35                          2.18.8.46                                  2.18.8.47    2.18.9.1           2.18.9.2                   2.18.9.5                          2.18.9.7                                  2.18.9.14    2.18.9.17           2.18.9.34                   2.18.9.35                          2.18.9.46                                  2.18.9.47    2.18.10.1           2.18.10.2                   2.18.10.5                          2.18.10.7                                  2.18.10.14    2.18.10.17           2.18.10.34                   2.18.10.35                          2.18.10.46                                  2.18.10.47    2.19.1.1           2.19.1.2                   2.19.1.5                          2.19.1.7                                  2.19.1.14    2.19.1.17           2.19.1.34                   2.19.1.35                          2.19.1.46                                  2.19.1.47    2.19.2.1           2.19.2.2                   2.19.2.5                          2.19.2.7                                  2.19.2.14    2.19.2.17           2.19.2.34                   2.19.2.35                          2.19.2.46                                  2.19.2.47    2.19.6.1           2.19.6.2                   2.19.6.5                          2.19.6.7                                  2.19.6.14    2.19.6.17           2.19.6.34                   2.19.6.35                          2.19.6.46                                  2.19.6.47    2.19.7.1           2.19.7.2                   2.19.7.5                          2.19.7.7                                  2.19.7.14    2.19.7.17           2.19.7.34                   2.19.7.35                          2.19.7.46                                  2.19.7.47    2.19.8.1           2.19.8.2                   2.19.8.5                          2.19.8.7                                  2.19.8.14    2.19.8.17           2.19.8.34                   2.19.8.35                          2.19.8.46                                  2.19.8.47    2.19.9.1           2.19.9.2                   2.19.9.5                          2.19.9.7                                  2.19.9.14    2.19.9.17           2.19.9.34                   2.19.9.35                          2.19.9.46                                  2.19.9.47    2.19.10.1           2.19.10.2                   2.19.10.5                          2.19.10.7                                  2.19.10.14    2.19.10.17           2.19.10.34                   2.19.10.35                          2.19.10.46                                  2.19.10.47    2.20.1.1           2.20.10.2                   2.20.1.5                          2.20.1.7                                  2.20.1.14    2.20.1.17           2.20.1.34                   2.20.1.35                          2.20.1.46                                  2.20.1.47    2.20.2.1           2.20.2.2                   2.20.2.5                          2.20.2.7                                  2.20.2.14    2.20.2.17           2.20.2.34                   2.20.2.35                          2.20.2.46                                  2.20.2.47    2.20.6.1           2.20.6.2                   2.20.6.5                          2.20.6.7                                  2.20.6.14    2.20.6.17           2.20.6.34                   2.20.6.35                          2.20.6.46                                  2.20.6.47    2.20.7.1           2.20.7.2                   2.20.7.5                          2.20.7.7                                  2.20.7.14    2.20.7.17           2.20.7.34                   2.20.7.35                          2.20.7.46                                  2.20.7.47    2.20.8.1           2.20.8.2                   2.20.8.5                          2.20.8.7                                  2.20.8.14    2.20.8.17           2.20.8.34                   2.20.8.35                          2.20.8.46                                  2.20.8.47    2.20.9.1           2.20.9.2                   2.20.9.5                          2.20.9.7                                  2.20.9.14    2.20.9.17           2.20.9.34                   2.20.9.35                          2.20.9.46                                  2.20.9.47    2.20.10.1           2.20.10.2                   2.20.10.5                          2.20.10.7                                  2.20.10.14    2.20.10.17           2.20.10.34                   2.20.10.35                          2.20.10.46                                  2.20.10.47    2.21.1.1           2.21.1.2                   2.21.1.5                          2.21.1.7                                  2.21.1.14    2.21.1.17           2.21.1.34                   2.21.1.35                          2.21.1.46                                  2.21.1.47    2.21.2.1           2.21.2.2                   2.21.2.5                          2.21.2.7                                  2.21.2.14    2.21.2.17           2.21.2.34                   2.21.2.35                          2.21.2.46                                  2.21.2.47    2.21.6.1           2.21.6.2                   2.21.6.5                          2.21.6.7                                  2.21.6.14    2.21.6.17           2.21.6.34                   2.21.6.35                          2.21.6.46                                  2.21.6.47    2.21.7.1           2.21.7.2                   2.21.7.5                          2.21.7.7                                  2.21.7.14    2.21.7.17           2.21.7.34                   2.21.7.35                          2.21.7.46                                  2.21.7.47    2.21.8.1           2.21.8.2                   2.21.8.5                          2.21.8.7                                  2.21.8.14    2.21.8.17           2.21.8.34                   2.21.8.35                          2.21.8.46                                  2.21.8.47    2.21.9.1           2.21.9.2                   2.21.9.5                          2.21.9.7                                  2.21.9.14    2.21.9.17           2.21.9.34                   2.21.9.35                          2.21.9.46                                  2.21.9.47    2.21.10.1           2.21.10.2                   2.21.10.5                          2.21.10.7                                  2.21.10.14    2.21.10.17           2.21.10.34                   2.21.10.35                          2.21.10.46                                  2.21.10.47    2.22.1.1           2.22.1.2                   2.22.1.5                          2.22.1.7                                  2.22.1.14    2.22.1.17           2.22.1.34                   2.22.1.35                          2.22.1.46                                  2.22.1.47    2.22.2.1           2.22.2.2                   2.22.2.5                          2.22.2.7                                  2.22.2.14    2.22.2.17           2.22.2.34                   2.22.2.35                          2.22.2.46                                  2.22.2.47    2.22.6.1           2.22.6.2                   2.22.6.5                          2.22.6.7                                  2.22.6.14    2.22.6.17           2.22.6.34                   2.22.6.35                          2.22.6.46                                  2.22.6.47    2.22.7.1           2.22.7.2                   2.22.7.5                          2.22.7.7                                  2.22.7.14    2.22.7.17           2.22.7.34                   2.22.7.35                          2.22.7.46                                  2.22.7.47    2.22.8.1           2.22.8.2                   2.22.8.5                          2.22.8.7                                  2.22.8.14    2.22.8.17           2.22.8.34                   2.22.8.35                          2.22.8.46                                  2.22.8.47    2.22.9.1           2.22.9.2                   2.22.9.5                          2.22.9.7                                  2.22.9.14    2.22.9.17           2.22.9.34                   2.22.9.35                          2.22.9.46                                  2.22.9.47    2.22.10.1           2.22.10.2                   2.22.10.5                          2.22.10.7                                  2.22.10.14    2.22.10.17           2.22.10.34                   2.22.10.35                          2.22.10.46                                  2.22.10.47    2.33.1.1           2.33.1.2                   2.33.1.5                          2.33.1.7                                  2.33.1.14    2.33.1.17           2.33.1.34                   2.33.1.35                          2.33.1.46                                  2.33.1.47    2.33.2.1           2.33.2.2                   2.33.2.5                          2.33.2.7                                  2.33.2.14    2.33.2.17           2.33.2.34                   2.33.2.35                          2.33.2.46                                  2.33.2.47    2.33.6.1           2.33.6.2                   2.33.6.5                          2.33.6.7                                  2.33.6.14    2.33.6.17           2.33.6.34                   2.33.6.35                          2.33.6.46                                  2.33.6.47    2.33.7.1           2.33.7.2                   2.33.7.5                          2.33.7.7                                  2.33.7.14    2.33.7.17           2.33.7.34                   2.33.7.35                          2.33.7.46                                  2.33.7.47    2.33.8.1           2.33.8.2                   2.33.8.5                          2.33.8.7                                  2.33.8.14    2.33.8.17           2.33.8.34                   2.33.8.35                          2.33.8.46                                  2.33.8.47    2.33.9.1           2.33.9.2                   2.33.9.5                          2.33.9.7                                  2.33.9.14    2.33.9.17           2.33.9.34                   2.33.9.35                          2.33.9.46                                  2.33.9.47    2.33.10.1           2.33.10.2                   2.33.10.5                          2.33.10.7                                  2.33.10.14    2.33.10.17           2.33.10.34                   2.33.10.35                          2.33.10.46                                  2.33.10.47    2.34.1.1           2.34.1.2                   2.34.1.5                          2.34.1.7                                  2.34.1.14    2.34.1.17           2.34.1.34                   2.34.1.35                          2.34.1.46                                  2.34.1.47    2.34.2.1           2.34.2.2                   2.34.2.5                          2.34.2.7                                  2.34.2.14    2.34.2.17           2.34.2.34                   2.34.2.35                          2.34.2.46                                  2.34.2.47    2.34.6.1           2.34.6.2                   2.34.6.5                          2.34.6.7                                  2.34.6.14    2.34.6.17           2.34.6.34                   2.34.6.35                          2.34.6.46                                  2.34.6.47    2.34.7.1           2.34.7.2                   2.34.7.5                          2.34.7.7                                  2.34.7.14    2.34.7.17           2.34.7.34                   2.34.7.35                          2.34.7.46                                  2.34.7.47    2.34.8.1           2.34.8.2                   2.34.8.5                          2.34.8.7                                  2.34.8.14    2.34.8.17           2.34.8.34                   2.34.8.35                          2.34.8.46                                  2.34.8.47    2.34.9.1           2.34.9.2                   2.34.9.5                          2.34.9.7                                  2.34.9.14    2.34.9.17           2.34.9.34                   2.34.9.35                          2.34.9.46                                  2.34.9.47    2.34.10.1           2.34.10.2                   2.34.10.5                          2.34.10.7                                  2.34.10.14    2.34.10.17           2.34.10.34                   2.34.10.35                          2.34.10.46                                  2.34.10.47    2.37.1.1           2.37.1.2                   2.37.1.5                          2.37.1.7                                  2.37.1.14    2.37.1.17           2.37.1.34                   2.37.1.35                          2.37.1.46                                  2.37.1.47    2.37.2.1           2.37.2.2                   2.37.2.5                          2.37.2.7                                  2.37.2.14    2.37.2.17           2.37.2.34                   2.37.2.35                          2.37.2.46                                  2.37.2.47    2.37.6.1           2.37.6.2                   2.37.6.5                          2.37.6.7                                  2.37.6.14    2.37.6.17           2.37.6.34                   2.37.6.35                          2.37.6.46                                  2.37.6.47    2.37.7.1           2.37.7.2                   2.37.7.5                          2.37.7.7                                  2.37.7.14    2.37.7.17           2.37.7.34                   2.37.7.35                          2.37.7.46                                  2.37.7.47    2.37.8.1           2.37.8.2                   2.37.8.5                          2.37.8.7                                  2.37.8.14    2.37.8.17           2.37.8.34                   2.37.8.35                          2.37.8.46                                  2.37.8.47    2.37.9.1           2.37.9.2                   2.37.9.5                          2.37.9.7                                  2.37.9.14    2.37.9.17           2.37.9.34                   2.37.9.35                          2.37.9.46                                  2.37.9.47    2.37.10.1           2.37.10.2                   2.37.10.5                          2.37.10.7                                  2.37.10.14    2.37.10.17           2.37.10.34                   2.37.10.35                          2.37.10.46                                  2.37.10.47    3.17.1.1           3.17.1.2                   3.17.1.5                          3.17.1.7                                  3.17.1.14    3.17.1.17           3.17.1.34                   3.17.1.35                          3.17.1.46                                  3.17.1.47    3.17.2.1           3.17.2.2                   3.17.2.5                          3.17.2.7                                  3.17.2.14    3.17.2.17           3.17.2.34                   3.17.2.35                          3.17.2.46                                  3.17.2.47    3.17.6.1           3.17.6.2                   3.17.6.5                          3.17.6.7                                  3.17.6.14    3.17.6.17           3.17.6.34                   3.17.6.35                          3.17.6.46                                  3.17.6.47    3.17.7.1           3.17.7.2                   3.17.7.5                          3.17.7.7                                  3.17.7.14    3.17.7.17           3.17.7.34                   3.17.7.35                          3.17.7.46                                  3.17.7.47    3.17.8.1           3.17.8.2                   3.17.8.5                          3.17.8.7                                  3.17.8.14    3.17.8.17           3.17.8.34                   3.17.8.35                          3.17.8.46                                  3.17.8.47    3.17.9.1           3.17.9.2                   3.17.9.5                          3.17.9.7                                  3.17.9.14    3.17.9.17           3.17.9.34                   3.17.9.35                          3.17.9.46                                  3.17.9.47    3.17.10.1           3.17.10.2                   3.17.10.5                          3.17.10.7                                  3.17.10.14    3.17.10.17           3.17.10.34                   3.17.10.35                          3.17.10.46                                  3.17.10.47    3.18.1.1           3.18.1.2                   3.18.1.5                          3.18.1.7                                  3.18.1.14    3.18.1.17           3.18.1.34                   3.18.1.35                          3.18.1.46                                  3.18.1.47    3.18.2.1           3.18.2.2                   3.18.2.5                          3.18.2.7                                  3.18.2.14    3.18.2.17           3.18.2.34                   3.18.2.35                          3.18.2.46                                  3.18.2.47    3.18.6.1           3.18.6.2                   3.18.6.5                          3.18.6.7                                  3.18.6.14    3.18.6.17           3.18.6.34                   3.18.6.35                          3.18.6.46                                  3.18.6.47    3.18.7.1           3.18.7.2                   3.18.7.5                          3.18.7.7                                  3.18.7.14    3.18.7.17           3.18.7.34                   3.18.7.35                          3.18.7.46                                  3.18.7.47    3.18.8.1           3.18.8.2                   3.18.8.5                          3.18.8.7                                  3.18.8.14    3.18.8.17           3.18.8.34                   3.18.8.35                          3.18.8.46                                  3.18.8.47    3.18.9.1           3.18.9.2                   3.18.9.5                          3.18.9.7                                  3.18.9.14    3.18.9.17           3.18.9.34                   3.18.9.35                          3.18.9.46                                  3.18.9.47    3.18.10.1           3.18.10.2                   3.18.10.5                          3.18.10.7                                  3.18.10.14    3.18.10.17           3.18.10.34                   3.18.10.35                          3.18.10.46                                  3.18.10.47    3.19.1.1           3.19.1.2                   3.19.1.5                          3.19.1.7                                  3.19.1.14    3.19.1.17           3.19.1.34                   3.19.1.35                          3.19.1.46                                  3.19.1.47    3.19.2.1           3.19.2.2                   3.19.2.5                          3.19.2.7                                  3.19.2.14    3.19.2.17           3.19.2.34                   3.19.2.35                          3.19.2.46                                  3.19.2.47    3.19.6.1           3.19.6.2                   3.19.6.5                          3.19.6.7                                  3.19.6.14    3.19.6.17           3.19.6.34                   3.19.6.35                          3.19.6.46                                  3.19.6.47    3.19.7.1           3.19.7.2                   3.19.7.5                          3.19.7.7                                  3.19.7.14    3.19.7.17           3.19.7.34                   3.19.7.35                          3.19.7.46                                  3.19.7.47    3.19.8.1           3.19.8.2                   3.19.8.5                          3.19.8.7                                  3.19.8.14    3.19.8.17           3.19.8.34                   3.19.8.35                          3.19.8.46                                  3.19.8.47    3.19.9.1           3.19.9.2                   3.19.9.5                          3.19.9.7                                  3.19.9.14    3.19.9.17           3.19.9.34                   3.19.9.35                          3.19.9.46                                  3.19.9.47    3.19.10.1           3.19.10.2                   3.19.10.5                          3.19.10.7                                  3.19.10.14    3.19.10.17           3.19.10.34                   3.19.10.35                          3.19.10.46                                  3.19.10.47    3.20.1.1           3.20.1.2                   3.20.1.5                          3.20.1.7                                  3.20.1.14    3.20.1.17           3.20.1.34                   3.20.1.35                          3.20.1.46                                  3.20.1.47    3.20.2.1           3.20.2.2                   3.20.2.5                          3.20.2.7                                  3.20.2.14    3.20.2.17           3.20.2.34                   3.20.2.35                          3.20.2.46                                  3.20.2.47    3.20.6.1           3.20.6.2                   3.20.6.5                          3.20.6.7                                  3.20.6.14    3.20.6.17           3.20.6.34                   3.20.6.35                          3.20.6.46                                  3.20.6.47    3.20.7.1           3.20.7.2                   3.20.7.5                          3.20.7.7                                  3.20.7.14    3.20.7.17           3.20.7.34                   3.20.7.35                          3.20.7.46                                  3.20.7.47    3.20.8.1           3.20.8.2                   3.20.8.5                          3.20.8.7                                  3.20.8.14    3.20.8.17           3.20.8.34                   3.20.8.35                          3.20.8.46                                  3.20.8.47    3.20.9.1           3.20.9.2                   3.20.9.5                          3.20.9.7                                  3.20.9.14    3.20.9.17           3.20.9.34                   3.20.9.35                          3.20.9.46                                  3.20.9.47    3.20.10.1           3.20.10.2                   3.20.10.5                          3.20.10.7                                  3.20.10.14    3.20.10.17           3.20.10.34                   3.20.10.35                          3.20.10.46                                  3.20.10.47    3.21.1.1           3.21.1.2                   3.21.1.5                          3.21.1.7                                  3.21.1.14    3.21.1.17           3.21.1.34                   3.21.1.35                          3.21.1.46                                  3.21.1.47    3.21.2.1           3.21.2.2                   3.21.2.5                          3.21.2.7                                  3.21.2.14    3.21.2.17           3.21.2.34                   3.21.2.35                          3.21.2.46                                  3.21.2.47    3.21.6.1           3.21.6.2                   3.21.6.5                          3.21.6.7                                  3.21.6.14    3.21.6.17           3.21.6.34                   3.21.6.35                          3.21.6.46                                  3.21.6.47    3.21.7.1           3.21.7.2                   3.21.7.5                          3.21.7.7                                  3.21.7.14    3.21.7.17           3.21.7.34                   3.21.7.35                          3.21.7.46                                  3.21.7.47    3.21.8.1           3.21.8.2                   3.21.8.5                          3.21.8.7                                  3.21.8.14    3.21.8.17           3.21.8.34                   3.21.8.35                          3.21.8.46                                  3.21.8.47    3.21.9.1           3.21.9.2                   3.21.9.5                          3.21.9.7                                  3.21.9.14    3.21.9.17           3.21.9.34                   3.21.9.35                          3.21.9.46                                  3.21.9.47    3.21.10.1           3.21.10.2                   3.21.10.5                          3.21.10.7                                  3.21.10.14    3.21.10.17           3.21.10.34                   3.21.10.35                          3.21.10.46                                  3.21.10.47    3.22.1.1           3.22.1.2                   3.22.1.5                          3.22.1.7                                  3.22.1.14    3.22.1.17           3.22.1.34                   3.22.1.35                          3.22.1.46                                  3.22.1.47    3.22.2.1           3.22.2.2                   3.22.2.5                          3.22.2.7                                  3.22.2.14    3.22.2.17           3.22.2.34                   3.22.2.35                          3.22.2.46                                  3.22.2.47    3.22.6.1           3.22.6.2                   3.22.6.5                          3.22.6.7                                  3.22.6.14    3.22.6.17           3.22.6.34                   3.22.6.35                          3.22.6.46                                  3.22.6.47    3.22.7.1           3.22.7.2                   3.22.7.5                          3.22.7.7                                  3.22.7.14    3.22.7.17           3.22.7.34                   3.22.7.35                          3.22.7.46                                  3.22.7.47    3.22.8.1           3.22.8.2                   3.22.8.5                          3.22.8.7                                  3.22.8.14    3.22.8.17           3.22.8.34                   3.22.8.35                          3.22.8.46                                  3.22.8.47    3.22.9.1           3.22.9.2                   3.22.9.5                          3.22.9.7                                  3.22.9.14    3.22.9.17           3.22.9.34                   3.22.9.35                          3.22.9.46                                  3.22.9.47    3.22.10.1           3.22.10.2                   3.22.10.5                          3.22.10.7                                  3.22.10.14    3.22.10.17           3.22.10.34                   3.22.10.35                          3.22.10.46                                  3.22.10.47    3.33.1.1           3.33.1.2                   3.33.1.5                          3.33.1.7                                  3.33.1.14    3.33.1.17           3.33.1.34                   3.33.1.35                          3.33.1.46                                  3.33.1.47    3.33.2.1           3.33.2.2                   3.33.2.5                          3.33.2.7                                  3.33.2.14    3.33.2.17           3.33.2.34                   3.33.2.35                          3.33.2.46                                  3.33.2.47    3.33.6.1           3.33.6.2                   3.33.6.5                          3.33.6.7                                  3.33.6.14    3.33.6.17           3.33.6.34                   3.33.6.35                          3.33.6.46                                  3.33.6.47    3.33.7.1           3.33.7.2                   3.33.7.5                          3.33.7.7                                  3.33.7.14    3.33.7.17           3.33.7.34                   3.33.7.35                          3.33.7.46                                  3.33.7.47    3.33.8.1           3.33.8.2                   3.33.8.5                          3.33.8.7                                  3.33.8.14    3.33.8.17           3.33.8.34                   3.33.8.35                          3.33.8.46                                  3.33.8.47    3.33.9.1           3.33.9.2                   3.33.9.5                          3.33.9.7                                  3.33.9.14    3.33.9.17           3.33.9.34                   3.33.9.35                          3.33.9.46                                  3.33.9.47    3.33.10.1           3.33.10.2                   3.33.10.5                          3.33.10.7                                  3.33.10.14    3.33.10.17           3.33.10.34                   3.33.10.35                          3.33.10.46                                  3.33.10.47    3.34.1.1           3.34.1.2                   3.34.1.5                          3.34.1.7                                  3.34.1.14    3.34.1.17           3.34.1.34                   3.34.1.35                          3.34.1.46                                  3.34.1.47    3.34.2.1           3.34.2.2                   3.34.2.5                          3.34.2.7                                  3.34.2.14    3.34.2.17           3.34.2.34                   3.34.2.35                          3.34.2.46                                  3.34.2.47    3.34.6.1           3.34.6.2                   3.34.6.5                          3.34.6.7                                  3.34.6.14    3.34.6.17           3.34.6.34                   3.34.6.35                          3.34.6.46                                  3.34.6.47    3.34.7.1           3.34.7.2                   3.34.7.5                          3.34.7.7                                  3.34.7.14    3.34.7.17           3.34.7.34                   3.34.7.35                          3.34.7.46                                  3.34.7.47    3.34.8.1           3.34.8.2                   3.34.8.5                          3.34.8.7                                  3.34.8.14    3.34.8.17           3.34.8.34                   3.34.8.35                          3.34.8.46                                  3.34.8.47    3.34.9.1           3.34.9.2                   3.34.9.5                          3.34.9.7                                  3.34.9.14    3.34.9.17           3.34.9.34                   3.34.9.35                          3.34.9.46                                  3.34.9.47    3.34.10.1           3.34.10.2                   3.34.10.5                          3.34.10.7                                  3.34.10.14    3.34.10.17           3.34.10.34                   3.34.10.35                          3.34.10.46                                  3.34.10.47    3.37.1.1           3.37.1.2                   3.37.1.5                          3.37.1.7                                  3.37.1.14    3.37.1.17           3.37.1.34                   3.37.1.35                          3.37.1.46                                  3.37.1.47    3.37.2.1           3.37.2.2                   3.37.2.5                          3.37.2.7                                  3.37.2.14    3.37.2.17           3.37.2.34                   3.37.2.35                          3.37.2.46                                  3.37.2.47    3.37.6.1           3.37.6.2                   3.37.6.5                          3.37.6.7                                  3.37.6.14    3.37.6.17           3.37.6.34                   3.37.6.35                          3.37.6.46                                  3.37.6.47    3.37.7.1           3.37.7.2                   3.37.7.5                          3.37.7.7                                  3.37.7.14    3.37.7.17           3.37.7.34                   3.37.7.35                          3.37.7.46                                  3.37.7.47    3.37.8.1           3.37.8.2                   3.37.8.5                          3.37.8.7                                  3.37.8.14    3.37.8.17           3.37.8.34                   3.37.8.35                          3.37.8.46                                  3.37.8.47    3.37.9.1           3.37.9.2                   3.37.9.5                          3.37.9.7                                  3.37.9.14    3.37.9.17           3.37.9.34                   3.37.9.35                          3.37.9.46                                  3.37.9.47    3.37.10.1           3.37.10.2                   3.37.10.5                          3.37.10.7                                  3.37.10.14    3.37.10.17           3.37.10.34                   3.37.10.35                          3.37.10.46                                  3.37.10.47    4.17.1.1           4.17.1.2                   4.17.1.5                          4.17.1.7                                  4.17.1.14    4.17.1.17           4.17.1.34                   4.17.1.35                          4.17.1.46                                  4.17.1.47    4.17.2.1           4.17.2.2                   4.17.2.5                          4.17.2.7                                  4.17.2.14    4.17.2.17           4.17.2.34                   4.17.2.35                          4.17.2.46                                  4.17.2.47    4.17.6.1           4.17.6.2                   4.17.6.5                          4.17.6.7                                  4.17.6.14    4.17.6.17           4.17.6.34                   4.17.6.35                          4.17.6.46                                  4.17.6.47    4.17.7.1           4.17.7.2                   4.17.7.5                          4.17.7.7                                  4.17.7.14    4.17.7.17           4.17.7.34                   4.17.7.35                          4.17.7.46                                  4.17.7.47    4.17.8.1           4.17.8.2                   4.17.8.5                          4.17.8.7                                  4.17.8.14    4.17.8.17           4.17.8.34                   4.17.8.35                          4.17.8.46                                  4.17.8.47    4.17.9.1           4.17.9.2                   4.17.9.5                          4.17.9.7                                  4.17.9.14    4.17.9.17           4.17.9.34                   4.17.9.35                          4.17.9.46                                  4.17.9.47    4.17.10.1           4.17.10.2                   4.17.10.5                          4.17.10.7                                  4.17.10.14    4.17.10.17           4.17.10.34                   4.17.10.35                          4.17.10.46                                  4.17.10.47    4.18.1.1           4.18.1.2                   4.18.1.5                          4.18.1.7                                  4.18.1.14    4.18.1.17           4.18.1.34                   4.18.1.35                          4.18.1.46                                  4.18.1.47    4.18.2.1           4.18.2.2                   4.18.2.5                          4.18.2.7                                  4.18.2.14    4.18.2.17           4.18.2.34                   4.18.2.35                          4.18.2.46                                  4.18.2.47    4.18.6.1           4.18.6.2                   4.18.6.5                          4.18.6.7                                  4.18.6.14    4.18.6.17           4.18.6.34                   4.18.6.35                          4.18.6.46                                  4.18.6.47    4.18.7.1           4.18.7.2                   4.18.7.5                          4.18.7.7                                  4.18.7.14    4.18.7.17           4.18.7.34                   4.18.7.35                          4.18.7.46                                  4.18.7.47    4.18.8.1           4.18.8.2                   4.18.8.5                          4.18.8.7                                  4.18.8.14    4.18.8.17           4.18.8.34                   4.18.8.35                          4.18.8.46                                  4.18.8.47    4.18.9.1           4.18.9.2                   4.18.9.5                          4.18.9.7                                  4.18.9.14    4.18.9.17           4.18.9.34                   4.18.9.35                          4.18.9.46                                  4.18.9.47    4.18.10.1           4.18.10.2                   4.18.10.5                          4.18.10.7                                  4.18.10.14    4.18.10.17           4.18.10.34                   4.18.10.35                          4.18.10.46                                  4.18.10.47    4.19.1.1           4.19.1.2                   4.19.1.5                          4.19.1.7                                  4.19.1.14    4.19.1.17           4.19.1.34                   4.19.1.35                          4.19.1.46                                  4.19.1.47    4.19.2.1           4.19.2.2                   4.19.2.5                          4.19.2.7                                  4.19.2.14    4.19.2.17           4.19.2.34                   4.19.2.35                          4.19.2.46                                  4.19.2.47    4.19.6.1           4.19.6.2                   4.19.6.5                          4.19.6.7                                  4.19.6.14    4.19.6.17           4.19.6.34                   4.19.6.35                          4.19.6.46                                  4.19.6.47    4.19.7.1           4.19.7.2                   4.19.7.5                          4.19.7.7                                  4.19.7.14    4.19.7.17           4.19.7.34                   4.19.7.35                          4.19.7.46                                  4.19.7.47    4.19.8.1           4.19.8.2                   4.19.8.5                          4.19.8.7                                  4.19.8.14    4.19.8.17           4.19.8.34                   4.19.8.35                          4.19.8.46                                  4.19.8.47    4.19.9.1           4.19.9.2                   4.19.9.5                          4.19.9.7                                  4.19.9.14    4.19.9.17           4.19.9.34                   4.19.9.35                          4.19.9.46                                  4.19.9.47    4.19.10.1           4.19.10.2                   4.19.10.5                          4.19.10.7                                  4.19.10.14    4.19.10.17           4.19.10.34                   4.19.10.35                          4.19.10.46                                  4.19.10.47    4.20.1.1           4.20.1.2                   4.20.1.5                          4.20.1.7                                  4.20.1.14    4.20.1.17           4.20.1.34                   4.20.1.35                          4.20.1.46                                  4.20.1.47    4.20.2.1           4.20.2.2                   4.20.2.5                          4.20.2.7                                  4.20.2.14    4.20.2.17           4.20.2.34                   4.20.2.35                          4.20.2.46                                  4.20.2.47    4.20.6.1           4.20.6.2                   4.20.6.5                          4.20.6.7                                  4.20.6.14    4.20.6.17           4.20.6.34                   4.20.6.35                          4.20.6.46                                  4.20.6.47    4.20.7.1           4.20.7.2                   4.20.7.5                          4.20.7.7                                  4.20.7.14    4.20.7.17           4.20.7.34                   4.20.7.35                          4.20.7.46                                  4.20.7.47    4.20.8.1           4.20.8.2                   4.20.8.5                          4.20.8.7                                  4.20.8.14    4.20.8.17           4.20.8.34                   4.20.8.35                          4.20.8.46                                  4.20.8.47    4.20.9.1           4.20.9.2                   4.20.9.5                          4.20.9.7                                  4.20.9.14    4.20.9.17           4.20.9.34                   4.20.9.35                          4.20.9.46                                  4.20.9.47    4.20.10.1           4.20.10.2                   4.20.10.5                          4.20.10.7                                  4.20.10.14    4.20.10.17           4.20.10.34                   4.20.10.35                          4.20.10.46                                  4.20.10.47    4.21.1.1           4.21.1.2                   4.21.1.5                          4.21.1.7                                  4.21.1.14    4.21.1.17           4.21.1.34                   4.21.1.35                          4.21.1.46                                  4.21.1.47    4.21.2.1           4.21.2.2                   4.21.2.5                          4.21.2.7                                  4.21.2.14    4.21.2.17           4.21.2.34                   4.21.2.35                          4.21.2.46                                  4.21.2.47    4.21.6.1           4.21.6.2                   4.21.6.5                          4.21.6.7                                  4.21.6.14    4.21.6.17           4.21.6.34                   4.21.6.35                          4.21.6.46                                  4.21.6.47    4.21.7.1           4.21.7.2                   4.21.7.5                          4.21.7.7                                  4.21.7.14    4.21.7.17           4.21.7.34                   4.21.7.35                          4.21.7.46                                  4.21.7.47    4.21.8.1           4.21.8.2                   4.21.8.5                          4.21.8.7                                  4.21.8.14    4.21.8.17           4.21.8.34                   4.21.8.35                          4.21.8.46                                  4.21.8.47    4.21.9.1           4.21.9.2                   4.21.9.5                          4.21.9.7                                  4.21.9.14    4.21.9.17           4.21.9.34                   4.21.9.35                          4.21.9.46                                  4.21.9.47    4.21.10.1           4.21.10.2                   4.21.10.5                          4.21.10.7                                  4.21.10.14    4.21.10.17           4.21.10.34                   4.21.10.35                          4.21.10.46                                  4.21.19.47    4.22.1.1           4.22.1.2                   4.22.1.5                          4.22.1.7                                  4.22.1.14    4.22.1.17           4.22.1.34                   4.22.1.35                          4.22.1.46                                  4.22.1.47    4.22.2.1           4.22.2.2                   4.22.2.5                          4.22.2.7                                  4.22.2.14    4.22.2.17           4.22.2.34                   4.22.2.35                          4.22.2.46                                  4.22.2.47    4.22.6.1           4.22.6.2                   4.22.6.5                          4.22.6.7                                  4.22.6.14    4.22.6.17           4.22.6.34                   4.22.6.35                          4.22.6.46                                  4.22.6.47    4.22.7.1           4.22.7.2                   4.22.7.5                          4.22.7.7                                  4.22.7.14    4.22.7.17           4.22.7.34                   4.22.7.35                          4.22.7.46                                  4.22.7.47    4.22.8.1           4.22.8.2                   4.22.8.5                          4.22.8.7                                  4.22.8.14    4.22.8.17           4.22.8.34                   4.22.8.35                          4.22.8.46                                  4.22.8.47    4.22.9.1           4.22.9.2                   4.22.9.5                          4.22.9.7                                  4.22.9.14    4.22.9.17           4.22.9.34                   4.22.9.35                          4.22.9.46                                  4.22.9.47    4.22.10.1           4.22.10.2                   4.22.10.5                          4.22.10.7                                  4.22.10.14    4.22.10.17           4.22.10.34                   4.22.10.35                          4.22.10.46                                  4.22.10.47    4.33.1.1           4.33.1.2                   4.33.1.5                          4.33.1.7                                  4.33.1.14    4.33.1.17           4.33.1.34                   4.33.1.35                          4.33.1.46                                  4.33.1.47    4.33.2.1           4.33.2.2                   4.33.2.5                          4.33.2.7                                  4.33.2.14    4.33.2.17           4.33.2.34                   4.33.2.35                          4.33.2.46                                  4.33.2.47    4.33.6.1           4.33.6.2                   4.33.6.5                          4.33.6.7                                  4.33.6.14    4.33.6.17           4.33.6.34                   4.33.6.35                          4.33.6.46                                  4.33.6.47    4.33.7.1           4.33.7.2                   4.33.7.5                          4.33.7.7                                  4.33.7.14    4.33.7.17           4.33.7.34                   4.33.7.35                          4.33.7.46                                  4.33.7.47    4.33.8.1           4.33.8.2                   4.33.8.5                          4.33.8.7                                  4.33.8.14    4.33.8.17           4.33.8.34                   4.33.8.35                          4.33.8.46                                  4.33.8.47    4.33.9.1           4.33.9.2                   4.33.9.5                          4.33.9.7                                  4.33.9.14    4.33.9.17           4.33.9.34                   4.33.9.35                          4.33.9.46                                  4.33.9.47    4.33.10.1           4.33.10.2                   4.33.10.5                          4.33.10.7                                  4.33.10.14    4.33.10.17           4.33.10.34                   4.33.10.35                          4.33.10.46                                  4.33.10.47    4.34.1.1           4.34.1.2                   4.34.1.5                          4.34.1.7                                  4.34.1.14    4.34.1.17           4.34.1.34                   4.34.1.35                          4.34.1.46                                  4.34.1.47    4.34.2.1           4.34.2.2                   4.34.2.5                          4.34.2.7                                  4.34.2.14    4.34.2.17           4.34.2.34                   4.34.2.35                          4.34.2.46                                  4.34.2.47    4.34.6.1           4.34.6.2                   4.34.6.5                          4.34.6.7                                  4.34.6.14    4.34.6.17           4.34.6.34                   4.34.6.35                          4.34.6.46                                  4.34.6.47    4.34.7.1           4.34.7.2                   4.34.7.5                          4.34.7.7                                  4.34.7.14    4.34.7.17           4.34.7.34                   4.34.7.35                          4.34.7.46                                  4.34.7.47    4.34.8.1           4.34.8.2                   4.34.8.5                          4.34.8.7                                  4.34.8.14    4.34.8.17           4.34.8.34                   4.34.8.35                          4.34.8.46                                  4.34.8.47    4.34.9.1           4.34.9.2                   4.34.9.5                          4.34.9.7                                  4.34.9.14    4.34.9.17           4.34.9.34                   4.34.9.35                          4.34.9.46                                  4.34.9.47    4.34.10.1           4.34.10.2                   4.34.10.5                          4.34.10.7                                  4.34.10.14    4.34.10.17           4.34.10.34                   4.34.10.35                          4.34.10.46                                  4.34.10.47    4.37.1.1           4.37.1.2                   4.37.1.5                          4.37.1.7                                  4.37.1.14    4.37.1.17           4.37.1.34                   4.37.1.35                          4.37.1.46                                  4.37.1.47    4.37.2.1           4.37.2.2                   4.37.2.5                          4.37.2.7                                  4.37.2.14    4.37.2.17           4.37.2.34                   4.37.2.35                          4.37.2.46                                  4.37.2.47    4.37.6.1           4.37.6.2                   4.37.6.5                          4.37.6.7                                  4.37.6.14    4.37.6.17           4.37.6.34                   4.37.6.35                          4.37.6.46                                  4.37.6.47    4.37.7.1           4.37.7.2                   4.37.7.5                          4.37.7.7                                  4.37.7.14    4.37.7.17           4.37.7.34                   4.37.7.35                          4.37.7.46                                  4.37.7.47    4.37.8.1           4.37.8.2                   4.37.8.5                          4.37.8.7                                  4.37.8.14    4.37.8.17           4.37.8.34                   4.37.8.35                          4.37.8.46                                  4.37.8.47    4.37.9.1           4.37.9.2                   4.37.9.5                          4.37.9.7                                  4.37.9.14    4.37.9.17           4.37.9.34                   4.37.9.35                          4.37.9.46                                  4.37.9.47    4.37.10.1           4.37.10.2                   4.37.10.5                          4.37.10.7                                  4.37.10.14    4.37.10.17           4.37.10.34                   4.37.10.35                          4.37.10.46                                  4.37.10.47    17.17.1.1.5           17.17.1.1.13                   17.17.1.1.18                          17.17.1.1.22                                  17.17.1.1.25    17.17.1.2.5           17.17.1.2.13                   17.17.1.2.18                          17.17.1.2.22                                  17.17.1.2.25    17.17.1.5.5           17.17.1.5.13                   17.17.1.5.18                          17.17.1.5.22                                  17.17.1.5.25    17.17.1.7.5           17.17.1.7.13                   17.17.1.7.18                          17.17.1.7.22                                  17.17.1.7.25    17.17.1.46.5           17.17.1.46.13                   17.17.1.46.18                          17.17.1.46.22                                  17.17.1.46.25    17.17.1.47.5           17.17.1.47.13                   17.17.1.47.18                          17.17.1.47.22                                  17.17.1.47.25    17.17.2.1.5           17.17.2.1.13                   17.17.2.1.18                          17.17.2.1.22                                  17.17.2.1.25    17.17.2.2.5           17.17.2.2.13                   17.17.2.2.18                          17.17.2.2.22                                  17.17.2.2.25    17.17.2.5.5           17.17.2.5.13                   17.17.2.5.18                          17.17.2.5.22                                  17.17.2.5.25    17.17.2.7.5           17.17.2.7.13                   17.17.2.7.18                          17.17.2.7.22                                  17.17.2.7.25    17.17.2.46.5           17.17.2.46.13                   17.17.2.46.18                          17.17.2.46.22                                  17.17.2.46.25    17.17.2.47.5           17.17.2.47.13                   17.17.2.47.18                          17.17.2.47.22                                  17.17.2.47.25    17.17.6.1.5           17.17.6.1.13                   17.17.6.1.18                          17.17.6.1.22                                  17.17.6.1.25    17.17.6.2.5           17.17.6.2.13                   17.17.6.2.18                          17.17.6.2.22                                  17.17.6.2.25    17.17.6.5.5           17.17.6.5.13                   17.17.6.5.18                          17.17.6.5.22                                  17.17.6.5.25    17.17.6.7.5           17.17.6.7.13                   17.17.6.7.18                          17.17.6.7.22                                  17.17.6.7.25    17.17.6.46.5           17.17.6.46.13                   17.17.6.46.18                          17.17.6.46.22                                  17.17.6.46.25    17.17.6.47.5           17.17.6.47.13                   17.17.6.47.18                          17.17.6.47.22                                  17.17.6.47.25    17.17.7.1.5           17.17.7.1.13                   17.17.7.1.18                          17.17.7.1.22                                  17.17.7.1.25    17.17.7.2.5.           17.17.7.2.13                   17.17.7.2.18                          17.17.7.2.22                                  17.17.7.2.25    17.17.7.5.5           17.17.7.5.13                   17.17.7.5.18                          17.17.7.5.22                                  17.17.7.5.25    17.17.7.7.5           17.17.7.7.13                   17.17.7.7.18                          17.17.7.7.22                                  17.17.7.7.25    17.17.7.46.5           17.17.7.46.13                   17.17.7.46.18                          17.17.7.46.22                                  17.17.7.46.25    17.17.7.47.5           17.17.7.47.13                   17.17.7.47.18                          17.17.7.47.22                                  17.17.7.47.25    17.17.8.1.5           17.17.8.1.13                   17.17.8.1.18                          17.17.8.1.22                                  17.17.8.1.25    17.17.8.2.5           17.17.8.2.13                   17.17.8.2.18                          17.17.8.2.22                                  17.17.8.2.25    17.17.8.5.5           17.17.8.5.13                   17.17.8.5.18                          17.17.8.5.22                                  17.17.8.5.25    17.17.8.7.5           17.17.8.7.13                   17.17.8.7.18                          17.17.8.7.22                                  17.17.8.7.25    17.17 8.46.5           17.17.8.46.13                   17.17.8.46.18                          17.17.8.46.22                                  17.17.8.46.25    17.17.8.47.5           17.17.8.47.13                   17.17.8.47.18                          17.17.8.47.22                                  17.17.8.47.25    17.17.9.1.5           17.17.9.1.13                   17.17.9.1.18                          17.17.9.1.22                                  17.17.9.1.25    17.17.9.2.5           17.17.9.2.13                   17.17.9.2.18                          17.17.9.2.22                                  17.17.9.2.25    17.17.9.5.5           17.17.9.5.13                   17.17.9.5.18                          17.17.9.5.22                                  17.17.9.5.25    17.17.9.7.5           17.17.9.7.13                   17.17.9.7.18                          17.17.9.7.22                                  17.17.9.7.25    17.17.9.46.5           17.17.9.46.13                   17.17.9.46.18                          17.17.9.46.22                                  17.17.9.46.25    17.17.9.47.5           17.17.9.47.13                   17.17.9.47.18                          17.17.9.47.22                                  17.17.9.47.25    17.17.10.1.5           17.17.10.1.13                   17.17.10.1.18                          17.17.10.1.22                                  17.17.10.1.25    17.17.10.2.5           17.17.10.2.13                   17.17.10.2.18                          17.17.10.2.22                                  17.17.10.2.25    17.17.10.5.5           17.17.10.5.13                   17.17.10.5.18                          17.17.10.5.22                                  17.17.10.5.25    17.17.10.7.5           17.17.10.7.13                   17.17.10.7.18                          17.17.10.7.22                                  17.17.10.7.25    17.17.10.46.5           17.17.10.46.13                   17.17.10.46.18                          17.17.10.46.22                                  17.17.10.46.25    17.17.10.47.5           17.17.10.47.13                   17.17.10.47.18                          17.17.10.47.22                                  17.17.10.47.25    17.18.1.1.5           17.18.1.1.13                   17.18.1.1.18                          17.18.1.1.22                                  17.18.1.1.25    17.18.1.2.5           17.18.1.2.13                   17.18.1.2.18                          17.18.1.2.22                                  17.18.1.2.25    17.18.1.5.5           17.18.1.5.13                   17.18.1.548                          17.18.1.5.22                                  17.18.1.5.25    17.18.1.7.5           17.18.1.7.13                   17.18.1.7.18                          17.18.1.7.22                                  17.18.1.7.25    17.18.1.46.5           17.18.1.46.13                   17.18.1.46.18                          17.18.1.46.22                                  17.18.1.46.25    17.18.1.47.5           17.18.1.47.13                   17.18.1.47.18                          17.18.1.47.22                                  17.18.1.47.25    17.18.2.1.5           17.18.2.1.13                   17.18.2.1.18                          17.18.2.1.22                                  17.18.2.1.25    17.18.2.2.5           17.18.2.2.13                   17.18.2.2.18                          17.18.2.2.22                                  17.18.2.2.25    17.18.2.5.5           17.18.2.5.13                   17.18.2.5.18                          17.18.2.5.22                                  17.18.2.5.25    17.18.2.7.5           17.18.2.7.13                   17.18.2.7.18                          17.18.2.7.22                                  17.18.2.7.25    17.18.2.46.5           17.18.2.46.13                   17.18.2.46.18                          17.18.2.46.22                                  17.18.2.46.25    17.18.2.47.5           17.18.2.47.13                   17.18.2.47.18                          17.18.2.47.22                                  17.18.2.47.25    17.18.6.1.5           17.18.6.1.13                   17.18.6.1.18                          17.18.6.1.22                                  17.18.6.1.25    17.18.6.2.5           17.18.6.2.13                   17.18.6.2.18                          17.18.6.2.22                                  17.18.6.2.25    17.18.6.5.5           17.18.6.5.13                   17.18.6.5.18                          17.18.6.5.22                                  17.18.6.5.25    17.18.6.7.5           17.18.6.7.13                   17.18.6.7.18                          17.18.6.7.22                                  17.18.6.7.25    17.18.6.46.5           17.18.6.46.13                   17.18.6.46.18                          17.18.6.46.22                                  17.18.6.46.25    17.18.6.47.5           17.18.6.47.13                   17.18.6.47.18                          17.18.6.47.22                                  17.18.6.47.25    17.18.7.1.5           17.18.7.1.13                   17.18.7.1.18                          17.18.7.1.22                                  17.18.7.1.25    17.18.7.2.5           17.18.7.2.13                   17.18.7.2.18                          17.18.7.2.22                                  17.18.7.2.25    17.18.7.5.5           17.18.7.5.13                   17.18.7.5.18                          17.18.7.5.22                                  17.18.7.5.25    17.18.7.7.5           17.18.7.7.13                   17.18.7.7.18                          17.18.7.7.22                                  17.18.7.7.25    17.18.7.46.5           17.18.7.46.13                   17.18.7.46.18                          17.18.7.46.22                                  17.18.7.46.25    17.18.7.47.5           17.18.7.47.13                   17.18.7.47.18                          17.18.7.47.22                                  17.18.7.47.25    17.18.8.1.5           17.18.8.1.13                   17.18.8.1.18                          17.18.8.1.22                                  17.18.8.1.25    17.18.8.2.5           17.18.8.2.13                   17.18.8.2.18                          17.18.8.2.22                                  17.18.8.2.25    17.18.8.5.5           17.18.8.5.13                   17.18.8.5.18                          17.18.8.5.22                                  17.18.8.5.25    17.18.8.7.5           17.18.8.7.13                   17.18.8.7.18                          17.18.8.7.22                                  17.18.8.7.25    17.18.8.46.5           17.18.8.46.13                   17.18.8.46.18                          17.18.8.46.22                                  17.18.8.46.25    17.18.8.47.5           17.18.8.47.13                   17.18.8.47.18                          17.18.8.47.22                                  17.18.8.47.25    17.18.9.1.5           17.18.9.1.13                   17.18.9.1.18                          17.18.9.1.22                                  17.18.9.1.25    17.18.9.2.5           17.18.9.2.13                   17.18.9.2.18                          17.18.9.2.22                                  17.18.9.2.25    17.18.9.5.5           17.18.9.5.13                   17.18.9.5.18                          17.18.9.5.22                                  17.18.9.5.25    17.18.9.7.5           17.18.9.7.13                   17.18.9.7.18                          17.18.9.7.22                                  17.18.9.7.25    17.18.9.46.5           17.18.9.46.13                   17.18.9.46.18                          17.18.9.46.22                                  17.18.9.46.25    17.18.9.47.5           17.18.9.47.13                   17.18.9.47.18                          17.18.9.47.22                                  17.18.9.47.25    17.18.10.1.5           17.18.10.1.13                   17.18.10.1.18                          17.18.10.1.22                                  17.18.10.1.25    17.18.10.2.5           17.18.10.2.13                   17.18.10.2.18                          17.18.10.2.22                                  17.18.10.2.25    17.18.10.5.5           17.18.10.5.13                   17.18.10.5.18                          17.18.10.5.22                                  17.18.10.5.25    17.18.10.7.5           17.18.10.7.13                   17.18.10.7.18                          17.18.10.7.22                                  17.18.10.7.25    17.18.10.46.5           17.18.10.46.13                   17.18.10.46.18                          17.18.10.46.22                                  17.18.10.46.25    17.18.10.47.5           17.18.10.47.13                   17.18.10.47.18                          17.18.10.47.22                                  17.18.10.47.25    17.19.1.1.5           17.19.1.1.13                   17.19.1.1.18                          17.19.1.1.22                                  17.19.1.1.25    17.19.1.2.5           17.19.1.2.13                   17.19.1.2.18                          17.19.1.2.22                                  17.19.1.2.25    17.19.1.5.5           17.19.1.5.13                   17.19.1.5.18                          17.19.1.5.22                                  17.19.1.5.25    17.19.1.7.5           17.19.1.7.13                   17.19.1.7.18                          17.19.1.7.22                                  17.19.1.7.25    17.19.1.46.5           17.19.1.46.13                   17.19.1.46.18                          17.19.1.46.22                                  17.19.1.46.25    17.19.1.47.5           17.19.1.47.13                   17.19.1.47.18                          17.19.1.47.22                                  17.19.1.47.25    17.19.2.1.5           17.19.2.1.13                   17.19.2.1.18                          17.19.2.1.22                                  17.19.2.1.25    17.19.2.2.5           17.19.2.2.13                   17.19.2.2.18                          17.19.2.2.22                                  17.19.2.2.25    17.19.2.5.5           17.19.2.5.13                   17.19.2.5.18                          17.19.2.5.22                                  17.19.2.5.25    17.19.2.7.5           17.19.2.7.13                   17.19.2.7.18                          17.19.2.7.22                                  17.19.2.7.25    17.19.2.46.5           17.19.2.46.13                   17.19.2.46.18                          17.19.2.46.22                                  17.19.2.46.25    17.19.2.47.5           17.19.2.47.13                   17.19.2.47.18                          17.19.2.47.22                                  17.19.2.47.25    17.19.6.1.5           17.19.6.1.13                   17.19.6.1.18                          17.19.6.1.22                                  17.19.6.1.25    17.19.6.2.5           17.19.6.2.13                   17.19.6.2.18                          17.19.6.2.22                                  17.19.6.2.25    17.19.6.5.5           17.19.6.5.13                   17.19.6.5.18                          17.19.6.5.22                                  17.19.6.5.25    17.19.6.7.5           17.19.6.7.13                   17.19.6.7.18                          17.19.6.7.22                                  17.19.6.7.25    17.19.6.46.5           17.19.6.46.13                   17.19.6.46.18                          17.19.6.46.22                                  17.19.6.46.25    17.19.6.47.5           17.19.6.47.13                   17.19.6.47.18                          17.19.6.47.22                                  17.19.6.47.25    17.19.7.1.5           17.19.7.1.13                   17.19.7.1.18                          17.19.7.1.22                                  17.19.7.1.25    17.19.7.2.5           17.19.7.2.13                   17.19.7.2.18                          17.19.7.2.22                                  17.19.7.2.25    17.19.7.5.5           17.19.7.5.13                   17.19.7.5.18                          17.19.7.5.22                                  17.19.7.5.25    17.19.7.7.5           17.19.7.7.13                   17.19.7.7.18                          17.19.7.7.22                                  17.19.7.7.25    17.19.7.46.5           17.19.7.46.13                   17.19.7.46.18                          17.19.7.46.22                                  17.19.7.46.25    17.19.7.47.5           17.19.7.47.13                   17.19.7.47.18                          17.19.7.47.22                                  17.19.7.47.25    17.19.8.1.5           17.19.8.1.13                   17.19.8.1.18                          17.19.8.1.22                                  17.19.8.1.25    17.19.8.2.5           17.19.8.2.13                   17.19.8.2.18                          17.19.8.2.22                                  17.19.8.2.25    17.19.8.5.5           17.19.8.5.13                   17.19.8.5.18                          17.19.8.5.22                                  17.19.8.5.25    17.19.8.7.5           17.19.8.7.13                   17.19.8.7.18                          17.19.8.7.22                                  17.19.8.7.25    17.19.8.46.5           17.19.8.46.13                   17.19.8.46.18                          17.19.8.46.22                                  17.19.8.46.25    17.19.8.47.5           17.19.8.47.13                   17.19.8.47.18                          17.19.8.47.22                                  17.19.8.47.25    17.19.9.1.5           17.19.9.1.13                   17.19.9.1.18                          17.19.9.1.22                                  17.19.9.1.25    17.19.9.2.5           17.19.9.2.13                   17.19.9.2.18                          17.19.9.2.22                                  17.19.9.2.25    17.19.9.5.5           17.19.9.5.13                   17.19.9.5.18                          17.19.9.5.22                                  17.19.9.5.25    17.19.9.7.5           17.19.9.7.13                   17.19.9.7.18                          17.19.9.7.22                                  17.19.9.7.25    17.19.9.46.5           17.19.9.46.13                   17.19.9.46.18                          17.19.9.46.22                                  17.19.9.46.25    17.19.9.47.5           17.19.9.47.13                   17.19.9.47.18                          17.19.9.47.22                                  17.19.9.47.25    17.19.10.1.5           17.19.10.1.13                   17.19.10.1.18                          17.19.10.1.22                                  17.19.10.1.25    17.19.10.2.5           17.19.10.2.13                   17.19.10.2.18                          17.19.10.2.22                                  17.19.10.2.25    17.19.10.5.5           17.19.10.5.13                   17.19.10.5.18                          17.19.10.5.22                                  17.19.10.5.25    17.19.10.7.5           17.19.10.7.13                   17.19.10.7.18                          17.19.10.7.22                                  17.19.10.7.25    17.19.10.46.5           17.19.10.46.13                   17.19.10.46.18                          17.19.10.46.22                                  17.19.10.46.25    17.19.10.47.5           17.19.10.47.13                   17.19.10.47.18                          17.19.10.47.22                                  17.19.10.47.25    17.20.1.1.5           17.20.1.1.13                   17.20.1.1.18                          17.20.1.1.22                                  17.20.1.1.25    17.20.1.2.5           17.20.1.2.13                   17.20.1.2.18                          17.20.1.2.22                                  17.20.1.2.25    17.20.1.5.5           17.20.1.5.13                   17.20.1.5.18                          17.20.1.5.22                                  17.20.1.5.25    17.20.1.7.5           17.20.1.7.13                   17.20.1.7.18                          17.20.1.7.22                                  17.20.1.7.25    17.20.1.46.5           17.20.1.46.13                   17.20.1.46.18                          17.20.1.46.22                                  17.20.1.46.25    17.20.1.47.5           17.20.1.47.13                   17.20.1.47.18                          17.20.1.47.22                                  17.20.1.47.25    17.20.2.1.5           17.20.2.1.13                   17.20.2.1.18                          17.20.2.1.22                                  17.20.2.1.25    17.20.2.2.5           17.20.2.2.13                   17.20.2.2.18                          17.20.2.2.22                                  17.20.2.2.25    17.20.2.5.5           17.20.2.5.13                   17.20.2.5.18                          17.20.2.5.22                                  17.20.2.5.25    17.20.2.7.5           17.20.2.7.13                   17.20.2.7.18                          17.20.2.7.22                                  17.20.2.7.25    17.20.2.46.5           17.20.2.46.13                   17.20.2.46.18                          17.20.2.46.22                                  17.20.2.46.25    17.20.2.47.5           17.20.2.47.13                   17.20.2.47.18                          17.20.2.47.22                                  17.20.2.47.25    17.20.6.1.5           17.20.6.1.13                   17.20.6.1.18                          17.20.6.1.22                                  17.20.6.1.25    17.20.6.2.5           17.20.6.2.13                   17.20.6.2.18                          17.20.6.2.22                                  17.20.6.2.25    17.20.6.5.5           17.20.6.5.13                   17.20.6.5.18                          17.20.6.5.22                                  17.20.6.5.25    17.20.6.7.5           17.20.6.7.13                   17.20.6.7.18                          17.20.6.7.22                                  17.20.6.7.25    17.20.6.46.5           17.20.6.46.13                   17.20.6.46.18                          17.20.6.46.22                                  17.20.6.46.25    17.20.6.47.5           17.20.6.47.13                   17.20.6.47.18                          17.20.6.47.22                                  17.20.6.47.25    17.20.7.1.5           17.20.7.1.13                   17.20.7.1.18                          17.20.7.1.22                                  17.20.7.1.25    17.20.7.2.5           17.20.7.2.13                   17.20.7.2.18                          17.20.7.2.22                                  17.20.7.2.25    17.20.7.5.5           17.20.7.5.13                   17.20.7.5.18                          17.20.7.5.22                                  17.20.7.5.25    17.20.7.7.5           17.20.7.7.13                   17.20.7.7.18                          17.20.7.7.22                                  17.20.7.7.25    17.20.7.46.5           17.20.7.46.13                   17.20.7.46.18                          17.20.7.46.22                                  17.20.7.46.25    17.20.7.47.5           17.20.7.47.13                   17.20.7.47.18                          17.20.7.47.22                                  17.20.7.47.25    17.20.8.1.5           17.20.8.1.13                   17.20.8.1.18                          17.20.8.1.22                                  17.20.8.1.25    17.20.8.2.5           17.20.8.2.13                   17.20.8.2.18                          17.20.8.2.22                                  17.20.8.2.25    17.20.8.5.5           17.20.8.5.13                   17.20.8.5.18                          17.20.8.5.22                                  17.20.8.5.25    17.20.8.7.5           17.20.8.7.13                   17.20.8.7.18                          17.20.8.7.22                                  17.20.8.7.25    17.20.8.46.5           17.20.8.46.13                   17.20.8.46.18                          17.20.8.46.22                                  17.20.8.46.25    17.20.8.47.5           17.20.8.47.13                   17.20.8.47.18                          17.20.8.47.22                                  17.20.8.47.25    17.20.9.1.5           17.20.9.1.13                   17.20.9.1.18                          17.20.9.1.22                                  17.20.9.1.25    17.20.9.2.5           17.20.9.2.13                   17.20.9.2.18                          17.20.9.2.22                                  17.20.9.2.25    17.20.9.5.5           17.20.9.5.13                   17.20.9.5.18                          17.20.9.5.22                                  17.20.9.5.25    17.20.9.7.5           17.20.9.7.13                   17.20.9.7.18                          17.20.9.7.22                                  17.20.9.7.25    17.20.9.46.5           17.20.9.46.13                   17.20.9.46.18                          17.20.9.46.22                                  17.20.9.46.25    17.20.9.47.5           17.20.9.47.13                   17.20.9.47.18                          17.20.9.47.22                                  17.20.9.47.25    17.20.10.1.5           17.20.10.1.13                   17.20.10.1.18                          17.20.10.1.22                                  17.20.10.1.25    17.20.10.2.5           17.20.10.2.13                   17.20.40.2.18                          17.20.10.2.22                                  17.20.10.2.25    17.20.10.5.5           17.20.10.5.13                   17.20.10.5.18                          17.20.10.5.22                                  17.20.10.5.25    17.20.10.7.5           17.20.10.7.13                   17.20.10.7.18                          17.20.10.7.22                                  17.20.10.7.25    17.20.10.46.5           17.20.10.46.13                   17.20.10.46.18                          17.20.10.46.22                                  17.20.10.46.25    17.20.10.47.5           17.20.10.47.13                   17.20.10.47.18                          17.20.10.47.22                                  17.20.10.47.25    17.21.1.1.5           17.21.1.1.13                   17.21.1.1.18                          17.21.1.1.22                                  17.21.1.1.25    17.21.1.2.5           17.21.1.2.13                   17.21.1.2.18                          17.21.1.2.22                                  17.21.1.2.25    17.21.1.5.5           17.21.1.5.13                   17.21.1.5.18                          17.21.1.5.22                                  17.21.1.5.25    17.21.1.7.5           17.21.1.7.13                   17.21.7.18                          17.21.1.7.22                                  17.21.1.7.25    17.21.1.46.5           17.21.1.46.13                   17.21.1.46.18                          17.21.1.46.22                                  17.21.1.46.25    17.21.1.47.5           17.21.1.47.13                   17.21.1.47.18                          17.21.1.47.22                                  17.21.1.47.25    17.21.2.1.5           17.21.2.1.13                   17.21.2.1.18                          17.21.2.1.22                                  17.21.2.1.25    17.21.2.2.5           17.21.2.2.13                   17.21.2.2.18                          17.21.2.2.22                                  17.21.2.2.25    17.21.2.5.5           17.21.2.5.13                   17.21.2.5.18                          17.21.2.5.22                                  17.21.2.5.25    17.21.2.7.5           17.21.2.7.13                   17.21.2.7.18                          17.21.2.7.22                                  17.21.2.7.25    17.21.2.46.5           17.21.2.46.13                   17.21.2.46.18                          17.21.2.46.22                                  17.21.2.46.25    17.21.2.47.5           17.21.2.47.13                   17.21.2.47.18                          17.21.2.47.22                                  17.21.2.47.25    17.21.6.1.5           17.21.6.1.13                   17.21.6.1.18                          17.21.6.1.22                                  17.21.6.1.25    17.21.6.2.5           17.21.6.2.13                   17.21.6.2.18                          17.21.6.2.22                                  17.21.6.2.25    17.21.6.5.5           17.21.6.5.13                   17.21.6.5.18                          17.21.6.5.22                                  17.21.6.5.25    17.21.6.7.5           17.21.6.7.13                   17.21.6.7.18                          17.21.6.7.22                                  17.21.6.7.25    17.21.6.46.5           17.21.6.46.13                   17.21.6.46.18                          17.21.6.46.22                                  17.21.6.46.25    17.21.6.47.5           17.21.6.47.13                   17.21.6.47.18                          17.21.6.47.22                                  17.21.6.47.25    17.21.7.1.5           17.21.7.1.13                   17.21.7.1.18                          17.21.7.1.22                                  17.21.7.1.25    17.21.7.2.5           17.21.7.2.13                   17.21.7.2.18                          17.21.7.2.22                                  17.21.7.2.25    17.21.7.5.5           17.21.7.5.13                   17.21.7.5.18                          17.21.7.5.22                                  17.21.7.5.25    17.21.7.7.5           17.21.7.7.13                   17.21.7.7.18                          17.21.7.7.22                                  17.21.7.7.25    17.21.7.46.5           17.21.7.46.13                   17.21.7.46.18                          17.21.7.46.22                                  17.21.7.46.25    17.21.7.47.5           17.21.7.47.13                   17.21.7.47.18                          17.21.7.47.22                                  17.21.7.47.25    17.21.8.1.5           17.21.8.1.13                   17.21.8.1.18                          17.21.8.1.22                                  17.21.8.1.25    17.21.8.2.5           17.21.8.2.13                   17.21.8.2.18                          17.21.8.2.22                                  17.21.8.2.25    17.21.8.5.5           17.21.8.5.13                   17.21.8.5.18                          17.21.8.5.22                                  17.21.8.5.25    17.21.8.7.5           17.21.8.7.13                   17.21.8.7.18                          17.21.8.7.22                                  17.21.8.7.25    17.21.8.46.5           17.21.8.46.13                   17.21.8.46.18                          17.21.8.46.22                                  17.21.8.46.25    17.21.8 47.5           17.21.8.47.13                   17.21.8.47.18                          17.21.8.47.22                                  17.21.8.47.25    17.21.9.1.5           17.21.9.1.13                   17.21.9.1.18                          17.21.9.1.22                                  17.21.9.1.25    17.21.9.2.5           17.21.9.2.13                   17.21.9.2.18                          17.21.9.2.22                                  17.21.9.2.25    17.21.9.5.5           17.21.9.5.13                   17.21.9.5.18                          17.21.9.5.22                                  17.21.9.5.25    17.21.9.7.5           17.21.9.7.13                   17.21.9.7.18                          17.21.9.7.22                                  17.21.9.7.25    17.21.9.46.5           17.21.9.46.13                   17.21.9.46.18                          17.21.9.46.22                                  17.21.9.46.25    17.21.9.47.5           17.21.9.47.13                   17.21.9.47.18                          17.21.9.47.22                                  17.21.9.47.25    17.21.10.1.5           17.21.10.1.13                   17.21.10.1.18                          17.21.10.1.22                                  17.21.10.1.25    17.21.10.2.5           17.21.10.2.13                   17.21.10.2.18                          17.21.10.2.22                                  17.21.10.2.25    17.21.10.5.5           17.21.10.5.13                   17.21.10.5.18                          17.21.10.5.22                                  17.21.10.5.25    17.21.10.7.5           17.21.10.7.13                   17.21.10.7.18                          17.21.10.7.22                                  17.21.10.7.25    17.21.10.46.5           17.21.10.46.13                   17.21.10.46.18                          17.21.10.46.22                                  17.21.10.46.25    17.21.10.47.5           17.21.10.47.13                   17.21.10.47.18                          17.21.10.47.22                                  17.21.10.47.25    17.22.1.1.5           17.22.1.1.13                   17.22.1.1.18                          17.22.1.1.22                                  17.22.1.1.25    17.22.1.2.5           17.22.1.2.13                   17.22.1.2.18                          17.22.1.2.22                                  17.22.1.2.25    17.22.1.5.5           17.22.1.5.13                   17.22.1.5.18                          17.22.1.5.22                                  17.22.1.5.25    17.22.1.7.5           17.22.1.7.13                   17.22.1.7.18                          17.22.1.7.22                                  17.22.1.7.25    17.22.1.46.5           17.22.1.46.13                   17.22.1.46.18                          17.22.1.46.22                                  17.22.1.46.25    17.22.1.47.5           17.22.1.47.13                   17.22.1.47.18                          17.22.1.47.22                                  17.22.1.47.25    17.22.2.1.5           17.22.2.1.13                   17.22.2.1.18                          17.22.2.1.22                                  17.22.2.1.25    17.22.2.2.5           17.22.2.2.13                   17.22.2.2.18                          17.22.2.2.22                                  17.22.2.2.25    17.22.2.5.5           17.22.2.5.13                   17.22.2.5.18                          17.22.2.5.22                                  17.22.2.5.25    17.22.2.7.5           17.22.2.7.13                   17.22.2.7.18                          17.22.2.7.22                                  17.22.2.7.25    17.22.2.46.5           17.22.2.46.13                   17.22.2.46.18                          17.22.2.46.22                                  17.22.2.46.25    17.22.2.47.5           17.22.2.47.13                   17.22.2.47.18                          17.22.2.47.22                                  17.22.2.47.25    17.22.6.1.5           17.22.6.1.13                   17.22.6.1.18                          17.22.6.1.22                                  17.22.6.1.25    17.22.6.2.5           17.22.6.2.13                   17.22.6.2.18                          17.22.6.2.22                                  17.22.6.2.25    17.22.6.5.5           17.22.6.5.13                   17.22.6.5.18                          17.22.6.5.22                                  17.22.6.5.25    17.22.6.7.5           17.22.6.7.13                   17.22.6.7.18                          17.22.6.7.22                                  17.22.6.7.25    17.22.6.46.5           17.22.6.46.13                   17.22.6.46.18                          17.22.6.46.22                                  17.22.6.46.25    17.22.6.47.5           17.22.6.47.13                   17.22.6.47.18                          17.22.6.47.22                                  17.22.6.47.25    17.22.7.1.5           17.22.7.1.13                   17.22.7.1.18                          17.22.7.1.22                                  17.22.7.1.25    17.22.7.2.5           17.22.7.2.13                   17.22.7.2.18                          17.22.7.2.22                                  17.22.7.2.25    17.22.7.5.5           17.22.7.5.13                   17.22.7.5.18                          17.22.7.5.22                                  17.22.7.5.25    17.22.7.7.5           17.22.7.7.13                   17.22.7.7.18                          17.22.7.7.22                                  17.22.7.7.25    17.22.7.46.5           17.22.7.46.13                   17.22.7.46.18                          17.22.7.46.22                                  17.22.7.46.25    17.22.7.47.5           17.22.7.47.13                   17.22.7.47.18                          17.22.7.47.22                                  17.22.7.47.25    17.22.8.1.5           17.22.8.1.13                   17.22.8.1.18                          17.22.8.1.22                                  17.22.8.1.25    17.22.8.2.5           17.22.8.2.13                   17.22.8.2.18                          17.22.8.2.22                                  17.22.8.2.25    17.22.8.5.5           17.22.8.5.13                   17.22.8.5.18                          17.22.8.5.22                                  17.22.8.5.25    17.22.8.7.5           17.22.8.7.13                   17.22.8.7.18                          17.22.8.7.22                                  17.22.8.7.25    17.22.8.46.5           17.22.8.46.13                   17.22.8.46.18                          17.22.8.46.22                                  17.22.8.46.25    17.22.8.47.5           17.22.8.47.13                   17.22.8.47.18                          17.22.8.47.22                                  17.22.8.47.25    17.22.9.1.5           17.22.9.1.13                   17.22.9.1.18                          17.22.9.1.22                                  17.22.9.1.25    17.22.9.2.5           17.22.9.2.13                   17.22.9.2.18                          17.22.9.2.22                                  17.22.9.2.25    17.22.9.5.5           17.22.9.5.13                   17.22.9.5.18                          17.22.9.5.22                                  17.22.9.5.25    17.22.9.7.5           17.22.9.7.13                   17.22.9.7.18                          17.22.9.7.22                                  17.22.9.7.25    17.22.9.46.5           17.22.9.46.13                   17.22.9.46.18                          17.22.9.46.22                                  17.22.9.46.25    17.22.9.47.5           17.22.9.47.13                   17.22.9.47.18                          17.22.9.47.22                                  17.22.9.47.25    17.22.10.1.5           17.22.10.1.13                   17.22.10.1.18                          17.22.10.1.22                                  17.22.10.1.25    17.22.10.2.5           17.22.10.2.13                   17.22.10.2.18                          17.22.10.2.22                                  17.22.10.2.25    17.22.10.5.5           17.22.10.5.13                   17.22.10.5.18                          17.22.10.5.22                                  17.22.10.5.25    17.22.10.7.5           17.22.10.7.13                   17.22.10.7.18                          17.22.10.7.22                                  17.22.10.7.25    17.22.10.46.5           17.22.10.46.13                   17.22.10.46.18                          17.22.10.46.22                                  17.22.10.46.25    17.22.10.47.5           17.22.10.47.13                   17.22.10.47.18                          17.22.10.47.22                                  17.22.10.47.25    17.33.1.1.5           17.33.1.1.13                   17.33.1.1.18                          17.33.1.1.22                                  17.33.1.1.25    17.33.1.2.5           17.33.1.2.13                   17.33.1.2.18                          17.33.1.2.22                                  17.33.1.2.25    17.33.1.5.5           17.33.1.5.13                   17.33.1.5.18                          17.33.1.5.22                                  17.33.1.5.25    17.33.1.7.5           17.33.1.7.13                   17.33.1.7.18                          17.33.1.7.22                                  17.33.1.7.25    17.33.1.46.5           17.33.1.46.13                   17.33.1.46.18                          17.33.1.46.22                                  17.33.1.46.25    17.33.1.47.5           17.33.1.47.13                   17.33.1.47.18                          17.33.1.47.22                                  17.33.1.47.25    17.33.2.1.5           17.33.2.1.13                   17.33.2.1.18                          17.33.2.1.22                                  17.33.2.1.25    17.33.2.2.5           17.33.2.2.13                   17.33.2.2.18                          17.33.2.2.22                                  17.33.2.2.25    17.33.2.5.5           17.33.2.5.13                   17.33.2.5.18                          17.33.2.5.22                                  17.33.2.5.25    17.33.2.7.5           17.33.2.7.13                   17.33.2.7.18                          17.33.2.7.22                                  17.33.2.7.25    17.33.2.46.5           17.33.2.46.13                   17.33.2.46.18                          17.33.2.46.22                                  17.33.2.46.25    17.33.2.47.5           17.33.2.47.13                   17.33.2.47.18                          17.33.2.47.22                                  17.33.2.47.25    17.33.6.1.5           17.33.6.1.13                   17.33.6.1.18                          17.33.6.1.22                                  17.33.6.1.25    17.33.6.2.5           17.33.6.2.13                   17.33.6.2.18                          17.33.6.2.22                                  17.33.6.2.25    17.33.6.5.5           17.33.6.5.13                   17.33.6.5.18                          17.33.6.5.22                                  17.33.6.5.25    17.33.6.7.5           17.33.6.7.13                   17.33.6.7.18                          17.33.6.7.22                                  17.33.6.7.25    17.33.6.46.5           17.33.6.46.13                   17.33.6.46.18                          17.33.6.46.22                                  17.33.6.46.25    17.33.6.47.5           17.33.6.47.13                   17.33.6.47.18                          17.33.6.47.22                                  17.33.6.47.25    17.33.7.1.5           17.33.7.1.13                   17.33.7.1.18                          17.33.7.1.22                                  17.33.7.1.25    17.33.7.2.5           17.33.7.2.13                   17.33.7.2.18                          17.33.7.2.22                                  17.33.7.2.25    17.33.7.5.5           17.33.7.5.13                   17.33.7.5.18                          17.33.7.5.22                                  17.33.7.5.25    17.33.7.7.5           17.33.7.7.13                   17.33.7.7.18                          17.33.7.7.22                                  17.33.7.7.25    17.33.7.46.5           17.33.7.46.13                   17.33.7.46.18                          17.33.7.46.22                                  17.33.7.46.25    17.33.7.47.5           17.33.7.47.13                   17.33.7.47.18                          17.33.7.47.22                                  17.33.7.47.25    17.33.8.1.5           17.33.8.1.13                   17.33.8.1.18                          17.33.8.1.22                                  17.33.8.1.25    17.33.8.2.5           17.33.8.2.13                   17.33.8.2.18                          17.33.8.2.22                                  17.33.8.2.25    17.33.8.5.5           17.33.8.5.13                   17.33.8.5.18                          17.33.8.5.22                                  17.33.8.5.25    17.33.8.7.5           17.33.8.7.13                   17.33.8.7.18                          17.33.8.7.22                                  17.33.8.7.25    17.33.8.46.5           17.33.8.46.13                   17.33.8.46.18                          17.33.8.46.22                                  17.33.8.46.25    17.33.8.47.5           17.33.8.47.13                   17.33.8.47.18                          17.33.8.47.22                                  17.33.8.47.25    17.33.9.1.5           17.33.9.1.13                   17.33.9.1.18                          17.33.9.1.22                                  17.33.9.1.25    17.33.9.2.5           17.33.9.2.13                   17.33.9.2.18                          17.33.9.2.22                                  17.33.9.2.25    17.33.9.5.5           17.33.9.5.13                   17.33.9.5.18                          17.33.9.5.22                                  17.33.9.5.25    17.33.9.7.5           17.33.9.7.13                   17.33.9.7.18                          17.33.9.7.22                                  17.33.9.7.25    17.33.9.46.5           17.33.9.46.13                   17.33.9.46.18                          17.33.9.46.22                                  17.33.9.46.25    17.33.9.47.5           17.33.9.47.13                   17.33.9.47.18                          17.33.9.47.22                                  17.33.9.47.25    17.33.10.1.5           17.33.10.1.13                   17.33.10.1.18                          17.33.10.1.22                                  17.33.10.1.25    17.33.10.2.5           17.33.10.2.13                   17.33.10.2.18                          17.33.10.2.22                                  17.33.10.2.25    17.33.10.5.5           17.33.10.5.13                   17.33.10.5.18                          17.33.10.5.22                                  17.33.10.5.25    17.33.10.7.5           17.33.10.7.13                   17.33.10.7.18                          17.33.10.7.22                                  17.33.10.7.25    17.33.10.46.5           17.33.10.46.13                   17.33.10.46.18                          17.33.10.46.22                                  17.33.10.46.25    17.33.10.47.5           17.33.10.47.13                   17.33.10.47.18                          17.33.10.47.22                                  17.33.10.47.25    17.34.1.1.5           17.34.1.1.13                   17.34.1.1.18                          17.34.1.1.22                                  17.34.1.1.25    17.34.1.2.5           17.34.1.2.13                   17.34.1.2.18                          17.34.1.2.22                                  17.34.1.2.25    17.34.1.5.5           17.34.1.5.13                   17.34.1.5.18                          17.34.1.5.22                                  17.34.1.5.25    17.34.1.7.5           17.34.1.7.13                   17.34.1.7.18                          17.34.1.7.22                                  17.34.1.7.25    17.34.1.46.5           17.34.1.46.13                   17.34.1.46.18                          17.34.1.46.22                                  17.34.1.46.25    17.34.1.47.5           17.34.1.47.13                   17.34.1.47.18                          17.34.1.47.22                                  17.34.1.47.25    17.34.2.1.5           17.34.2.1.13                   17.34.2.1.18                          17.34.2.1.22                                  17.34.2.1.25    17.34.2.2.5           17.34.2.2.13                   17.34.2.2.18                          17.34.2.2.22                                  17.34.2.2.25    17.34.2.5.5           17.34.2.5.13                   17.34.2.5.18                          17.34.2.5.22                                  17.34.2.5.25    17.34.2.7.5           17.34.2.7.13                   17.34.2.7.18                          17.34.2.7.22                                  17.34.2.7.25    17.34.2.46.5           17.34.2.46.13                   17.34.2.46.18                          17.34.2.46.22                                  17.34.2.46.25    17.34.2.47.5           17.34.2.47.13                   17.34.2.47.18                          17.34.2.47.22                                  17.34.2.47.25    17.34.6.1.5           17.34.6.1.13                   17.34.6.1.18                          17.34.6.1.22                                  17.34.6.1.25    17.34.6.2.5           17.34.6.2.13                   17.34.6.2.18                          17.34.6.2.22                                  17.34.6.2.25    17.34.6.5.5           17.34.6.5.13                   17.34.6.5.18                          17.34.6.5.22                                  17.34.6.5.25    17.34.6.7.5           17.34.6.7.13                   17.34.6.7.18                          17.34.6.7.22                                  17.34.6.7.25    17.34.6.46.5           17.34.6.46.13                   17.34.6.46.18                          17.34.6.46.22                                  17.34.6.46.25    17.34.6.47.5           17.34.6.47.13                   17.34.6.47.18                          17.34.6.47.22                                  17.34.6.47.25    17.34.7.1.5           17.34.7.1.13                   17.34.7.1.18                          17.34.7.1.22                                  17.34.7.1.25    17.34.7.2.5           17.34.7.2.13                   17.34.7.2.18                          17.34.7.2.22                                  17.34.7.2.25    17.34.7.5.5           17.34.7.5.13                   17.34.7.5.18                          17.34.7.5.22                                  17.34.7.5.25    17.34.7.7.5           17.34.7.7.13                   17.34.7.7.18                          17.34.7.7.22                                  17.34.7.7.25    17.34.7.46.5           17.34.7.46.13                   17.34.7.46.18                          17.34.7.46.22                                  17.34.7.46.25    17.34.7.47.5           17.34.7.47.13                   17.34.7.47.18                          17.34.7.47.22                                  17.34.7.47.25    17.34.8.1.5           17.34.8.1.13                   17.34.8.1.18                          17.34.8.1.22                                  17.34.8.1.25    17.34.8.2.5           17.34.8.2.13                   17.34.8.2.18                          17.34.8.2.22                                  17.34.8.2.25    17.34.8.5.5           17.34.8.5.13                   17.34.8.5.18                          17.34.8.5.22                                  17.34.8.5.25    17.34.8.7.5           17.34.8.7.13                   17.34.8.7.18                          17.34.8.7.22                                  17.34.8.7.25    17.34.8.46.5           17.34.8.46.13                   17.34.8.46.18                          17.34.8.46.22                                  17.34.8.46.25    17.34.8.47.5           17.34.8.47.13                   17.34.8.47.18                          17.34.8.47.22                                  17.34.8.47.25    17.34.9.1.5           17.34.9.1.13                   17.34.9.1.18                          17.34.9.1.22                                  17.34.9.1.25    17.34.9.2.5           17.34.9.2.13                   17.34.9.2.18                          17.34.9.2.22                                  17.34.9.2.25    17.34.9.5.5           17.34.9.5.13                   17.34.9.5.18                          17.34.9.5.22                                  17.34.9.5.25    17.34.9.7.5           17.34.9.7.13                   17.34.9.7.18                          17.34.9.7.22                                  17.34.9.7.25    17.34.9.46.5           17.34.9.46.13                   17.34.9.46.18                          17.34.9.46.22                                  17.34.9.46.25    17.34.9.47.5           17.34.9.47.13                   17.34.9.47.18                          17.34.9.47.22                                  17.34.9.47.25    17.34.10.1.5           17.34.10.1.13                   17.34.10.1.18                          17.34.10.1.22                                  17.34.10.1.25    17.34.10.2.5           17.34.10.2.13                   17.34.10.2.18                          17.34.10.2.22                                  17.34.10.2.25    17.34.10.5.5           17.34.10.5.13                   17.34.10.5.18                          17.34.10.5.22                                  17.34.10.5.25    17.34.10.7.5           17.34.10.7.13                   17.34.10.7.18                          17.34.10.7.22                                  17.34.10.7.25    17.34.10.46.5           17.34.10.46.13                   17.34.10.46.18                          17.34.10.46.22                                  17.34.10.46.25    17.34.10.47.5           17.34.10.47.13                   17.34.10.47.18                          17.34.10.47.22                                  17.34.10.47.25    17.37.1.1.5           17.37.1.1.13                   17.37.1.1.18                          17.37.1.1.22                                  17.37.1.1.25    17.37.1.2.5           17.37.1.2.13                   17.37.1.2.18                          17.37.1.2.22                                  17.37.1.2.25    17.37.1.5.5           17.37.1.5.13                   17.37.1.5.18                          17.37.1.5.22                                  17.37.1.5.25    17.37.1.7.5           17.37.1.7.13                   17.37.1.7.18                          17.37.1.7.22                                  17.37.1.7.25    17.37.1.46.5           17.37.1.46.13                   17.37.1.46.18                          17.37.1.46.22                                  17.37.1.46.25    17.37.1.47.5           17.37.1.47.13                   17.37.1.47.18                          17.37.1.47.22                                  17.37.1.47.25    17.37.2.1.5           17.37.2.1.13                   17.37.2.1.18                          17.37.2.1.22                                  17.37.2.1.25    17.37.2.2.5           17.37.2.2.13                   17.37.2.2.18                          17.37.2.2.22                                  17.37.2.2.25    17.37.2.5.5           17.37.2.5.13                   17.37.2.5.18                          17.37.2.5.22                                  17.37.2.5.25    17.37.2.7.5           17.37.2.7.13                   17.37.2.7.18                          17.37.2.7.22                                  17.37.2.7.25    17.37.2.46.5           17.37.2.46.13                   17.37.2.46.18                          17.37.2.46.22                                  17.37.2.46.25    17.37.2.47.5           17.37.2.47.13                   17.37.2.47.18                          17.37.2.47.22                                  17.37.2.47.25    17.37.6.1.5           17.37.6.1.13                   17.37.6.1.18                          17.37.6.1.22                                  17.37.6.1.25    17.37.6.2.5           17.37.6.2.13                   17.37.6.2.18                          17.37.6.2.22                                  17.37.6.2.25    17.37.6.5.5           17.37.6.5.13                   17.37.6.5.18                          17.37.6.5.22                                  17.37.6.5.25    17.37.6.7.5           17.37.6.7.13                   17.37.6.7.18                          17.37.6.7.22                                  17.37.6.7.25    17.37.6.46.5           17.37.6.46.13                   17.37.6.46.18                          17.37.6.46.22                                  17.37.6.46.25    17.37.6.47.5           17.37.6.47.13                   17.37.6.47.18                          17.37.6.47.22                                  17.37.6.47.25    17.37.7.1.5           17.37.7.1.13                   17.37.7.1.18                          17.37.7.1.22                                  17.37.7.1.25    17.37.7.2.5           17.37.7.2.13                   17.37.7.2.18                          17.37.7.2.22                                  17.37.7.2.25    17.37.7.5.5           17.37.7.5.13                   17.37.7.5.18                          17.37.7.5.22                                  17.37.7.5.25    17.37.7.7.5           17.37.7.7.13                   17.37.7.7.18                          17.37.7.7.22                                  17.37.7.7.25    17.37.7.46.5           17.37.7.46.13                   17.37.7.46.18                          17.37.7.46.22                                  17.37.7.46.25    17.37.7.47.5           17.37.7.47.13                   17.37.7.47.18                          17.37.7.47.22                                  17.37.7.47.25    17.37.8.1.5           17.37.8.1.13                   17.37.8.1.18                          17.37.8.1.22                                  17.37.8.1.25    17.37.8.2.5           17.37.8.2.13                   17.37.8.2.18                          17.37.8.2.22                                  17.37.8.2.25    17.37.8.5.5           17.37.8.5.13                   17.37.8.5.18                          17.37.8.5.22                                  17.37.8.5.25    17.37.8.7.5           17.37.8.7.13                   17.37.8.7.18                          17.37.8.7.22                                  17.37.8.7.25    17.37.8.46.5           17.37.8.46.13                   17.37.8.46.18                          17.37.8.46.22                                  17.37.8.46.25    17.37.8.47.5           17.37.8.47.13                   17.37.8.47.18                          17.37.8.47.22                                  17.37.8.47.25    17.37.9.1.5           17.37.9.1.13                   17.37.9.1.18                          17.37.9.1.22                                  17.37.9.1.25    17.37.9.2.5           17.37.9.2.13                   17.37.9.2.18                          17.37.9.2.22                                  17.37.9.2.25    17.37.9.5.5           17.37.9.5.13                   17.37.9.5.18                          17.37.9.5.22                                  17.37.9.5.25    17.37.9.7.5           17.37.9.7.13                   17.37.9.7.18                          17.37.9.7.22                                  17.37.9.7.25    17.37.9.46.5           17.37.9.46.13                   17.37.9.46.18                          17.37.9.46.22                                  17.37.9.46.25    17.37.9.47.5           17.37.9.47.13                   17.37.9.47.18                          17.37.9.47.22                                  17.37.9.47.25    17.37.10.1.5           17.37.10.1.13                   17.37.10.1.18                          17.37.10.1.22                                  17.37.10.1.25    17.37.10.2.5           17.37.10.2.13                   17.37.10.2.18                          17.37.10.2.22                                  17.37.10.2.25    17.37.10.5.5           17.37.10.5.13                   17.37.10.5.18                          17.37.10.5.22                                  17.37.10.5.25    17.37.10.7.5           17.37.10.7.13                   17.37.10.7.18                          17.37.10.7.22                                  17.37.10.7.25    17.37.10.46.5           17.37.10.46.13                   17.37.10.46.18                          17.37.10.46.22                                  17.37.10.46.25    17.37.10.47.5           17.37.10.47.13                   17.37.10.47.18                          17.37.10.47.22                                  17.37.10.47.25    18.17.1.1.5           18.17.1.1.13                   18.17.1.1.18                          18.17.1.1.22                                  18.17.1.1.25    18.17.1.2.5           18.17.1.2.13                   18.17.1.2.18                          18.17.1.2.22                                  18.17.1.2.25    18.17.1.5.5           18.17.1.5.13                   18.17.1.5.18                          18.17.1.5.22                                  18.17.1.5.25    18.17.1.7.5           18.17.1.7.13                   18.17.1.7.18                          18.17.1.7.22                                  18.17.1.7.25    18.17.1.46.5           18.17.1.46.13                   18.17.1.46.18                          18.17.1.46.22                                  18.17.1.46.25    18.17.1.47.5           18.17.1.47.13                   18.17.1.47.18                          18.17.1.47.22                                  18.17.1.47.25    18.17.2.1.5           18.17.2.1.13                   18.17.2.1.18                          18.17.2.1.22                                  18.17.2.1.25    18.17.2.2.5           18.17.2.2.13                   18.17.2.2.18                          18.17.2.2.22                                  18.17.2.2.25    18.17.2.5.5           18.17.2.5.13                   18.17.2.5.18                          18.17.2.5.22                                  18.17.2.5.25    18.17.2.7.5           18.17.2.7.13                   18.17.2.7.18                          18.17.2.7.22                                  18.17.2.7.25    18.17.2.46.5           18.17.2.46.13                   18.17.2.46.18                          18.17.2.46.22                                  18.17.2.46.25    18.17.2.47.5           18.17.2.47.13                   18.17.2.47.18                          18.17.2.47.22                                  18.17.2.47.25    18.17.6.1.5           18.17.6.1.13                   18.17.6.1.18                          18.17.6.1.22                                  18.17.6.1.25    18.17.6.2.5           18.17.6.2.13                   18.17.6.2.18                          18.17.6.2.22                                  18.17.6.2.25    18.17.6.5.5           18.17.6.5.13                   18.17.6.5.18                          18.17.6.5.22                                  18.17.6.5.25    18.17.6.7.5           18.17.6.7.13                   18.17.6.7.18                          18.17.6.7.22                                  18.17.6.7.25    18.17.6.46.5           18.17.6.46.13                   18.17.6.46.18                          18.17.6.46.22                                  18.17.6.46.25    18.17.6.47.5           18.17.6.47.13                   18.17.6.47.18                          18.17.6.47.22                                  18.17.6.47.25    18.17.7.1.5           18.17.7.1.13                   18.17.7.1.18                          18.17.7.1.22                                  18.17.7.1.25    18.17.7.2.5           18.17.7.2.13                   18.17.7.2.18                          18.17.7.2.22                                  18.17.7.2.25    18.17.7.5.5           18.17.7.5.13                   18.17.7.5.18                          18.17.7.5.22                                  18.17.7.5.25    18.17.7.7.5           18.17.7.7.13                   18.17.7.7.18                          18.17.7.5.22                                  18.17.7.5.25    18.17.7.46.5           18.17.7.46.13                   18.17.7.46.18                          18.17.7.46.22                                  18.17.7.46.25    18.17.7.47.5           18.17.7.47.13                   18.17.7.47.18                          18.17.7.47.22                                  18.17.7.47.25    18.17.8.1.5           18.17.8.1.13                   18.17.8.1.18                          18.17.8.1.22                                  18.17.8.1.25    18.17.8.2.5           18.17.8.2.13                   18.17.8.2.18                          18.17.8.2.22                                  18.17.8.2.25    18.17.8.5.5           18.17.8.5.13                   18.17.8.5.18                          18.17.8.5.22                                  18.17.8.5.25    18.17.8.7.5           18.17.8.7.13                   18.17.8.7.18                          18.17.8.7.22                                  18.17.8.7.25    18.17.8.46.5           18.17.8.46.13                   18.17.8.46.18                          18.17.8.46.22                                  18.17.8.46.25    18.17.8.47.5           18.17.8.47.13                   18.17.8.47.18                          18.17.8.47.22                                  18.17.8.47.25    18.17.9.1.5           18.17.9.1.13                   18.17.9.1.18                          18.17.9.1.22                                  18.17.9.1.25    18.17.9.2.5           18.17.9.2.13                   18.17.9.2.18                          18.17.9.2.22                                  18.17.9.2.25    18.17.9.5.5           18.17.9.5.13                   18.17.9.5.18                          18.17.9.5.22                                  18.17.9.5.25    18.17.9.7.5           18.17.9.7.13                   18.17.9.7.18                          18.17.9.7.22                                  18.17.9.7.25    18.17.9.46.5           18.17.9.46.13                   18.17.9.46.18                          18.17.9.46.22                                  18.17.9.46.25    18.17.9.47.5           18.17.9.47.13                   18.17.9.47.18                          18.17.9.47.22                                  18.17.9.47.25    18.17.10.1.5           18.17.10.1.13                   18.17.10.1.18                          18.17.10.1.22                                  18.17.10.1.25    18.17.10.2.5           18.17.10.2.13                   18.17.10.2.18                          18.17.10.2.22                                  18.17.10.2.25    18.17.10.5.5           18.17.10.5.13                   18.17.10.5.18                          18.17.10.5.22                                  18.17.10.5.25    18.17.10.7.5           18.17.10.7.13                   18.17.10.7.18                          18.17.10.7.22                                  18.17.10.7.25    18.17.10.46.5           18.17.10.46.13                   18.17.10.46.18                          18.17.10.46.22                                  18.17.10.46.25    18.17.10.47.5           18.17.10.47.13                   18.17.10.47.18                          18.17.10.47.22                                  18.17.10.47.25    18.18.1.1.5           18.18.1.1.13                   18.18.1.1.18                          18.18.1.1.22                                  18.18.1.1.25    18.18.1.2.5           18.18.1.2.13                   18.18.1.2.18                          18.18.1.2.22                                  18.18.1.2.25    18.18.1.5.5           18.18.1.5.13                   18.18.1.5.18                          18.18.1.5.22                                  18.18.1.5.25    18.18.1.7.5           18.18.1.7.13                   18.18.1.7.18                          18.18.1.7.22                                  18.18.1.7.25    18.18.1.46.5           18.18.1.46.13                   18.18.1.46.18                          18.18.1.46.22                                  18.18.1.46.25    18.18.1.47.5           18.18.1.47.13                   18.18.1.47.18                          18.18.1.47.22                                  18.18.1.47.25    18.18.2.1.5           18.18.2.1.13                   18.18.2.1.18                          18.18.2.1.22                                  18.18.2.1.25    18.18.2.2.5           18.18.2.2.13                   18.18.2.2.18                          18.18.2.2.22                                  18.18.2.2.25    18.18.2.5.5           18.18.2.5.13                   18.18.2.5.18                          18.18.2.5.22                                  18.18.2.5.25    18.18.2.7.5           18.18.2.7.13                   18.18.2.7.18                          18.18.2.7.22                                  18.18.2.7.25    18.18.2.46.5           18.18.2.46.13                   18.18.2.46.18                          18.18.2.46.22                                  18.18.2.46.25    18.18.2.47.5           18.18.2.47.13                   18.18.2.47.18                          18.18.2.47.22                                  18.18.2.47.25    18.18.6.1.5           18.18.6.1.13                   18.18.6.1.18                          18.18.6.1.22                                  18.18.6.1.25    18.18.6.2.5           18.18.6.2.13                   18.18.6.2.18                          18.18.6.2.22                                  18.18.6.2.25    18.18.6.5.5           18.18.6.5.13                   18.18.6.5.18                          18.18.6.5.22                                  18.18.6.5.25    18.18.6.7.5           18.18.6.7.13                   18.18.6.7.18                          18.18.6.7.22                                  18.18.6.7.25    18.18.6.46.5           18.18.6.46.13                   18.18.6.46.18                          18.18.6.46.22                                  18.18.6.46.25    18.18.6.47.5           18.18.6.47.13                   18.18.6.47.18                          18.18.6.47.22                                  18.18.6.47.25    18.18.7.1.5           18.18.7.1.13                   18.18.7.1.18                          18.18.7.1.22                                  18.18.7.1.25    18.18.7.2.5           18.18.7.2.13                   18.18.7.2.18                          18.18.7.2.22                                  18.18.7.2.25    18.18.7.5.5           18.18.7.5.13                   18.18.7.5.18                          18.18.7.5.22                                  18.18.7.5.25    18.18.7.7.5           18.18.7.7.13                   18.18.7.7.18                          18.18.7.7.22                                  18.18.7.7.25    18.18.7.46.5           18.18.7.46.13                   18.18.7.46.18                          18.18.7.46.22                                  18.18.7.46.25    18.18.7.47.5           18.18.7.47.13                   18.18.7.47.18                          18.18.7.47.22                                  18.18.7.47.25    18.18.8.1.5           18.18.8.1.13                   18.18.8.1.18                          18.18.8.1.22                                  18.18.8.1.25    18.18.8.2.5           18.18.8.2.13                   18.18.8.2.18                          18.18.8.2.22                                  18.18.8.2.25    18.18.8.5.5           18.18.8.5.13                   18.18.8.5.18                          18.18.8.5.22                                  18.18.8.5.25    18.18.8.7.5           18.18.8.7.13                   18.18.8.7.18                          18.18.8.7.22                                  18.18.8.7.25    18.18.8.46.5           18.18.8.46.13                   18.18.8.46.18                          18.18.8.46.22                                  18.18.8.46.25    18.18.8.47.5           18.18.8.47.13                   18.18.8.47.18                          18.18.8.47.22                                  18.18.8.47.25    18.18.9.1.5           18.18.9.1.13                   18.18.9.1.18                          18.18.9.1.22                                  18.18.9.1.25    18.18.9.2.5           18.18.9.2.13                   18.18.9.2.18                          18.18.9.2.22                                  18.18.9.2.25    18.18.9.5.5           18.18.9.5.13                   18.18.9.5.18                          18.18.9.5.22                                  18.18.9.5.25    18.18.9.7.5           18.18.9.7.13                   18.18.9.7.18                          18.18.9.7.22                                  18.18.9.7.25    18.18.9.46.5           18.18.9.46.13                   18.18.9.46.18                          18.18.9.46.22                                  18.18.9.46.25    18.18.9.47.5           18.18.9.47.13                   18.18.9.47.18                          18.18.9.47.22                                  18.18.9.47.25    18.18.10.1.5           18.18.10.1.13                   18.18.10.1.18                          18.18.10.1.22                                  18.18.10.1.25    18.18.10.2.5           18.18.10.2.13                   18.18.10.2.18                          18.18.10.2.22                                  18.18.10.2.25    18.18.10.5.5           18.18.10.5.13                   18.18.10.5.18                          18.18.10.5.22                                  18.18.10.5.25    18.18.10.7.5           18.18.10.7.13                   18.18.10.7.18                          18.18.10.7.22                                  18.18.10.7.25    18.18.10.46.5           18.18.10.46.13                   18.18.10.46.18                          18.18.10.46.22                                  18.18.10.46.25    18.18.10.47.5           18.18.10.47.13                   18.18.10.47.18                          18.18.10.47.22                                  18.18.18.47.25    18.19.1.1.5           18.19.1.1.13                   18.19.1.1.18                          18.19.1.1.22                                  18.19.1.1.25    18.19.1.2.5           18.19.1.2.13                   18.19.1.2.18                          18.19.1.2.22                                  18.19.1.2.25    18.19.1.5.5           18.19.1.5.13                   18.19.1.5.18                          18.19.1.5.22                                  18.19.1.5.25    18.19.1.7.5           18.19.1.7.13                   18.19.1.7.18                          18.19.1.7.22                                  18.19.1.7.25    18.19.1.46.5           18.19.1.46.13                   18.19.1.46.18                          18.19.1.46.22                                  18.19.1.46.25    18.19.1.47.5           18.19.1.47.13                   18.19.1.47.18                          18.19.1.47.22                                  18.19.1.47.25    18.19.2.1.5           18.19.2.1.13                   18.19.2.1.18                          18.19.2.1.22                                  18.19.2.1.25    18.19.2.2.5           18.19.2.2.13                   18.19.2.2.18                          18.19.2.2.22                                  18.19.2.2.25    18.19.2.5.5           18.19.2.5.13                   18.19.2.5.18                          18.19.2.5.22                                  18.19.2.5.25    18.19.2.7.5           18.19.2.7.13                   18.19.2.7.18                          18.19.2.7.22                                  18.19.2.7.25    18.19.2.46.5           18.19.2.46.13                   18.19.2.46.18                          18.19.2.46.22                                  18.19.2.46.25    18.19.2.47.5           18.19.2.47.13                   18.19.2.47.18                          18.19.2.47.22                                  18.19.2.47.25    18.19.6.1.5           18.19.6.1.13                   18.19.6.1.18                          18.19.6.1.22                                  18.19.6.1.25    18.19.6.2.5           18.19.6.2.13                   18.19.6.2.18                          18.19.6.2.22                                  18.19.6.2.25    18.19.6.5.5           18.19.6.5.13                   18.19.6.5.18                          18.19.6.5.22                                  18.19.6.5.25    18.19.6.7.5           18.19.6.7.13                   18.19.6.7.18                          18.19.6.7.22                                  18.19.6.7.25    18.19.6.46.5           18.19.6.46.13                   18.19.6.46.18                          18.19.6.46.22                                  18.19.6.46.25    18.19.6.47.5           18.19.6.47.13                   18.19.6.47.18                          18.19.6.47.22                                  18.19.6.47.25    18.19.7.1.5           18.19.7.1.13                   18.19.7.1.18                          18.19.7.1.22                                  18.19.7.1.25    18.19.7.2.5           18.19.7.2.13                   18.19.7.2.18                          18.19.7.2.22                                  18.19.7.2.25    18.19.7.5.5           18.19.7.5.13                   18.19.7.5.18                          18.19.7.5.22                                  18.19.7.5.25    18.19.7.7.5           18.19.7.7.13                   18.19.7.7.18                          18.19.7.7.22                                  18.19.7.7.25    18.19.7.46.5           18.19.7.46.13                   18.19.7.46.18                          18.19.7.46.22                                  18.19.7.46.25    18.19.7.47.5           18.19.7.47.13                   18.19.7.47.18                          18.19.7.47.22                                  18.19.7.47.25    18.19.8.1.5           18.19.8.1.13                   18.19.8.1.18                          18.19.8.1.22                                  18.19.8.1.25    18.19.8.2.5           18.19.8.2.13                   18.19.8.2.18                          18.19.8.2.22                                  18.19.8.2.25    18.19.8.5.5           18.19.8.5.13                   18.19.8.5.18                          18.19.8.5.22                                  18.19.8.5.25    18.19.8.7.5           18.19.8.7.13                   18.19.8.7.18                          18.19.8.7.22                                  18.19.8.7.25    18.19.8.46.5           18.19.8.46.13                   18.19.8.46.18                          18.19.8.46.22                                  18.19.8.46.25    18.19.8.47.5           18.19.8.47.13                   18.19.8.47.18                          18.19.8.47.22                                  18.19.8.47.25    18.19.9.1.5           18.19.9.1.13                   18.19.9.1.18                          18.19.9.1.22                                  18.19.9.1.25    18.19.9.2.5           18.19.9.2.13                   18.19.9.2.18                          18.19.9.2.22                                  18.19.9.2.25    18.19.9.5.5           18.19.9.5.13                   18.19.9.5.18                          18.19.9.5.22                                  18.19.9.5.25    18.19.9.7.5           18.19.9.7.13                   18.19.9.7.18                          18.19.9.7.22                                  18.19.9.7.25    18.19.9.46.5           18.19.9.46.13                   18.19.9.46.18                          18.19.9.46.22                                  18.19.9.46.25    18.19.9.47.5           18.19.9.47.13                   18.19.9.47.18                          18.19.9.47.22                                  18.19.9.47.25    18.19.10.1.5           18.19.10.1.13                   18.19.10.1.18                          18.19.10.1.22                                  18.19.10.1.25    18.19.10.2.5           18.19.10.2.13                   18.19.10.2.18                          18.19.10.2.22                                  18.19.10.2.25    18.19.10.5.5           18.19.10.5.13                   18.19.10.5.18                          18.19.10.5.22                                  18.19.10.5.25    18.19.10.7.5           18.19.10.7.13                   18.19.10.7.18                          18.19.10.7.22                                  18.19.10.7.25    18.19.10.46.5           18.19.10.46.13                   18.19.10.46.18                          18.19.10.46.22                                  18.19.10.46.25    18.19.10.47.5           18.19.10.47.13                   18.19.10.47.18                          18.19.10.47.22                                  18.19.10.47.25    18.20.1.1.5           18.20.1.1.13                   18.20.1.1.18                          18.20.1.1.22                                  18.20.1.1.25    18.20.1.2.5           18.20.1.2.13                   18.20.1.2.18                          18.20.1.2.22                                  18.20.1.2.25    18.20.1.5.5           18.20.1.5.13                   18.20.1.5.18                          18.20.1.5.22                                  18.20.1.5.25    18.20.1.7.5           18.20.1.7.13                   18.20.1.7.18                          18.20.1.7.22                                  18.20.1.7.25    18.20.1.46.5           18.20.1.46.13                   18.20.1.46.18                          18.20.1.46.22                                  18.20.1.46.25    18.20.1.47.5           18.20.1.47.13                   18.20.1.47.18                          18.20.1.47.22                                  18.20.1.47.25    18.20.2.1.5           18.20.2.1.13                   18.20.2.1.18                          18.20.2.1.22                                  18.20.2.1.25    18.20.2.2.5           18.20.2.2.13                   18.20.2.2.18                          18.20.2.2.22                                  18.20.2.2.25    18.20.2.5.5           18.20.2.5.13                   18.20.2.5.18                          18.20.2.5.22                                  18.20.2.5.25    18.20.2.7.5           18.20.2.7.13                   18.20.2.7.18                          18.20.2.7.22                                  18.20.2.7.25    18.20.2.46.5           18.20.2.46.13                   18.20.2.46.18                          18.20.2.46.22                                  18.20.2.46.25    18.20.2.47.5           18.20.2.47.13                   18.20.2.47.18                          18.20.2.47.22                                  18.20.2.47.25    18.20.6.1.5           18.20.6.1.13                   18.20.6.1.18                          18.20.6.1.22                                  18.20.6.1.25    18.20.6.2.5           18.20.6.2.13                   18.20.6.2.18                          18.20.6.2.22                                  18.20.6.2.25    18.20.6.5.5           18.20.6.5.13                   18.20.6.5.18                          18.20.6.5.22                                  18.20.6.5.25    18.20.6.7.5           18.20.6.7.13                   18.20.6.7.18                          18.20.6.7.22                                  18.20.6.7.25    18.20.6.46.5           18.20.6.46.13                   18.20.6.46.18                          18.20.6.46.22                                  18.20.6.46.25    18.20.6.47.5           18.20.6.47.13                   18.20.6.47.18                          18.20.6.47.22                                  18.20.6.47.25    18.20.7.1.5           18.20.7.1.13                   18.20.7.1.18                          18.20.7.1.22                                  18.20.7.1.25    18.20.7.2.5           18.20.7.2.13                   18.20.7.2.18                          18.20.7.2.22                                  18.20.7.2.25    18.20.7.5.5           18.20.7.5.13                   18.20.7.5.18                          18.20.7.5.22                                  18.20.7.5.25    18.20.7.7.5           18.20.7.7.13                   18.20.7.7.18                          18.20.7.7.22                                  18.20.7.7.25    18.20.7.46.5           18.20.7.46.13                   18.20.7.46.18                          18.20.7.46.22                                  18.20.7.46.25    18.20.7.47.5           18.20.7.47.13                   18.20.7.47.18                          18.20.7.47.22                                  18.20.7.47.25    18.20.8.1.5           18.20.8.1.13                   18.20.8.1.18                          18.20.8.1.22                                  18.20.8.1.25    18.20.8.2.5           18.20.8.2.13                   18.20.8.2.18                          18.20.8.2.22                                  18.20.8.2.25    18.20.8.5.5           18.20.8.5.13                   18.20.8.5.18                          18.20.8.5.22                                  18.20.8.5.25    18.20.8.7.5           18.20.8.7.13                   18.20.8.7.18                          18.20.8.7.22                                  18.20.8.7.25    18.20.8.46.5           18.20.8.46.13                   18.20.8.46.18                          18.20.8.46.22                                  18.20.8.46.25    18.20.8.47.5           18.20.8.47.13                   18.20.8.47.18                          18.20.8.47.22                                  18.20.8.47.25    18.20.9.1.5           18.20.9.1.13                   18.20.9.1.18                          18.20.9.1.22                                  18.20.9.1.25    18.20.9.2.5           18.20.9.2.13                   18.20.9.2.18                          18.20.9.2.22                                  18.20.9.2.25    18.20.9.5.5           18.20.9.5.13                   18.20.9.5.18                          18.20.9.5.22                                  18.20.9.5.25    18.20.9.7.5           18.20.9.7.13                   18.20.9.7.18                          18.20.9.7.22                                  18.20.9.7.25    18.20.9.46.5           18.20.9.46.13                   18.20.9.46.18                          18.20.9.46.22                                  18.20.9.46.25    18.20.9.47.5           18.20.9.47.13                   18.20.9.47.18                          18.20.9.47.22                                  18.20.9.47.25    18.20.10.1.5           18.20.10.1.13                   18.20.10.1.18                          18.20.10.1.22                                  18.20.10.1.25    18.20.10.2.5           18.20.10.2.13                   18.20.10.2.18                          18.20.10.2.22                                  18.20.10.2.25    18.20.10.5.5           18.20.10.5.13                   18.20.10.5.18                          18.20.10.5.22                                  18.20.10.5.25    18.20.10.7.5           18.20.10.7.13                   18.20.10.7.18                          18.20.10.7.22                                  18.20.10.7.25    18.20.10.46.5           18.20.10.46.13                   18.20.10.46.18                          18.20.10.46.22                                  18.20.10.46.25    18.20.10.47.5           18.20.10.47.13                   18.20.10.47.18                          18.20.10.47.22                                  18.20.10.47.25    18.21.1.1.5           18.21.1.1.13                   18.21.1.1.18                          18.21.1.1.22                                  18.21.1.1.25    18.21.1.2.5           18.21.1.2.13                   18.21.1.2.18                          18.21.1.2.22                                  18.21.1.2.25    18.21.1.5.5           18.21.1.5.13                   18.21.1.5.18                          18.21.1.5.22                                  18.21.1.5.25    18.21.1.7.5           18.21.1.7.13                   18.21.1.7.18                          18.21.1.7.22                                  18.21.1.7.25    18.21.1.46.5           18.21.1.46.13                   18.21.1.46.18                          18.21.1.46.22                                  18.21.1.46.25    18.21.1.47.5           18.21.1.47.13                   18.21.1.46.18                          18.21.1.46.22                                  18.21.1.46.25    18.21.2.1.5           18.21.2.1.13                   18.21.2.1.18                          18.21.2.1.22                                  18.21.2.1.25    18.21.2.2.5           18.21.2.2.13                   18.21.2.2.18                          18.21.2.2.22                                  18.21.2.2.25    18.21.2.5.5           18.21.2.5.13                   18.21.2.5.18                          18.21.2.5.22                                  18.21.2.5.25    18.21.2.7.5           18.21.2.7.13                   18.21.2.7.18                          18.21.2.7.22                                  18.21.2.7.25    18.21.2.46.5           18.21.2.46.13                   18.21.2.46.18                          18.21.2.46.22                                  18.21.2.46.25    18.21.2.47.5           18.21.2.47.13                   18.21.2.47.18                          18.21.2.47.22                                  18.21.2.47.25    18.21.6.1.5           18.21.6.1.13                   18.21.6.1.18                          18.21.6.1.22                                  18.21.6.1.25    18.21.6.2.5           18.21.6.2.13                   18.21.6.2.18                          18.21.6.2.22                                  18.21.6.2.25    18.21.6.5.5           18.21.6.5.13                   18.21.6.5.18                          18.21.6.5.22                                  18.21.6.5.25    18.21.6.7.5           18.21.6.7.13                   18.21.6.7.18                          18.21.6.7.22                                  18.21.6.7.25    18.21.6.46.5           18.21.6.46.13                   18.21.6.46.18                          18.21.6.46.22                                  18.21.6.46.25    18.21.6.47.5           18.21.6.47.13                   18.21.6.47.18                          18.21.6.47.22                                  18.21.6.47.25    18.21.7.1.5           18.21.7.1.13                   18.21.7.1.18                          18.21.7.1.22                                  18.21.7.1.25    18.21.7.2.5           18.21.7.2.13                   18.21.7.2.18                          18.21.7.2.22                                  18.21.7.2.25    18.21.7.5.5           18.21.7.5.13                   18.21.7.5.18                          18.21.7.5.22                                  18.21.7.5.25    18.21.7.7.5           18.21.7.7.13                   18.21.7.7.18                          18.21.7.7.22                                  18.21.7.7.25    18.21.7.46.5           18.21.7.46.13                   18.21.7.46.18                          18.21.7.46.22                                  18.21.7.46.25    18.21.7.47.5           18.21.7.47.13                   18.21.7.47.18                          18.21.7.47.22                                  18.21.7.47.25    18.21.8.1.5           18.21.8.1.13                   18.21.8.1.18                          18.21.8.1.22                                  18.21.8.1.25    18.21.8.2.5           18.21.8.2.13                   18.21.8.2.18                          18.21.8.2.22                                  18.21.8.2.25    18.21.8.5.5           18.21.8.5.13                   18.21.8.5.18                          18.21.8.5.22                                  18.21.8.5.25    18.21.8.7.5           18.21.8.7.13                   18.21.8.7.18                          18.21.8.7.22                                  18.21.8.7.25    18.21.8.46.5           18.21.8.46.13                   18.21.8.46.18                          18.21.8.46.22                                  18.21.8.46.25    18.21.8.47.5           18.21.8.47.13                   18.21.8.47.18                          18.21.8.47.22                                  18.21.8.47.25    18.21.9.1.5           18.21.9.1.13                   18.21.9.1.18                          18.21.9.1.22                                  18.21.9.1.25    18.21.9.2.5           18.21.9.2.13                   18.21.9.2.18                          18.21.9.2.22                                  18.21.9.2.25    18.21.9.5.5           18.21.9.5.13                   18.21.9.5.18                          18.21.9.5.22                                  18.21.9.5.25    18.21.9.7.5           18.21.9.7.13                   18.21.9.7.18                          18.21.9.7.22                                  18.21.9.7.25    18.21.9.46.5           18.21.9.46.13                   18.21.9.46.18                          18.21.9.46.22                                  18.21.9.46.25    18.21.9.47.5           18.21.9.47.13                   18.21.9.46.18                          18.21.9.46.22                                  18.21.9.46.25    18.21.10.1.5           18.21.10.1.13                   18.21.10.1.18                          18.21.10.1.22                                  18.21.10.1.25    18.21.10.2.5           18.21.10.2.13                   18.21.10.2.18                          18.21.10.2.22                                  18.21.10.2.25    18.21.10.5.5           18.21.10.5.13                   18.21.10.5.18                          18.21.10.5.22                                  18.21.10.5.25    18.21.10.7.5           18.21.10.7.13                   18.21.10.7.18                          18.21.10.7.22                                  18.21.10.7.25    18.21.10.46.5           18.21.10.46.13                   18.21.10.46.18                          18.21.10.46.22                                  18.21.10.46.25    18.21.10.47.5           18.21.10.47.13                   18.21.10.47.18                          18.21.10.47.22                                  18.21.10.47.25    18.22.1.1.5           18.22.1.1.13                   18.22.1.1.18                          18.22.1.1.22                                  18.22.1.1.25    18.22.1.2.5           18.22.1.2.13                   18.22.1.2.18                          18.22.1.2.22                                  18.22.1.2.25    18.22.1.5.5           18.22.1.5.13                   18.22.1.5.18                          18.22.1.5.22                                  18.22.1.5.25    18.22.1.7.5           18.22.1.7.13                   18.22.1.7.18                          18.22.1.7.22                                  18.22.1.7.25    18.22.1.46.5           18.22.1.46.13                   18.22.1.46.18                          18.22.1.46.22                                  18.22.1.46.25    18.22.1.47.5           18.22.1.47.13                   18.22.1.47.18                          18.22.1.47.22                                  18.22.1.47.25    18.22.2.1.5           18.22.2.1.13                   18.22.2.1.18                          18.22.2.1.22                                  18.22.2.1.25    18.22.2.2.5           18.22.2.2.13                   18.22.2.2.18                          18.22.2.2.22                                  18.22.2.2.25    18.22.2.5.5           18.22.2.5.13                   18.22.2.5.18                          18.22.2.5.22                                  18.22.2.5.25    18.22.2.7.5           18.22.2.7.13                   18.22.2.7.18                          18.22.2.7.22                                  18.22.2.7.25    18.22.2.46.5           18.22.2.46.13                   18.22.2.46.18                          18.22.2.46.22                                  18.22.2.46.25    18.22.2.47.5           18.22.2.47.13                   18.22.2.47.18                          18.22.2.47.22                                  18.22.2.47.25    18.22.6.1.5           18.22.6.1.13                   18.22.6.1.18                          18.22.6.1.22                                  18.22.6.1.25    18.22.6.2.5           18.22.6.2.13                   18.22.6.2.18                          18.22.6.2.22                                  18.22.6.2.25    18.22.6.5.5           18.22.6.5.13                   18.22.6.5.18                          18.22.6.5.22                                  18.22.6.5.25    18.22.6.7.5           18.22.6.7.13                   18.22.6.7.18                          18.22.6.7.22                                  18.22.6.7.25    18.22.6.46.5           18.22.6.46.13                   18.22.6.46.18                          18.22.6.46.22                                  18.22.6.46.25    18.22.6.47.5           18.22.6.47.13                   18.22.6.47.18                          18.22.6.47.22                                  18.22.6.47.25    18.22.7.1.5           18.22.7.1.13                   18.22.7.1.18                          18.22.7.1.22                                  18.22.7.1.25    18.22.7.2.5           18.22.7.2.13                   18.22.7.2.18                          18.22.7.2.22                                  18.22.7.2.25    18.22.7.5.5           18.22.7.5.13                   18.22.7.5.18                          18.22.7.5.22                                  18.22.7.5.25    18.22.7.7.5           18.22.7.7.13                   18.22.7.7.18                          18.22.7.7.22                                  18.22.7.7.25    18.22.7.46.5           18.22.7.46.13                   18.22.7.46.18                          18.22.7.46.22                                  18.22.7.46.25    18.22.7.47.5           18.22.7.47.13                   18.22.7.47.18                          18.22.7.47.22                                  18.22.7.47.25    18.22.8.1.5           18.22.8.1.13                   18.22.8.1.18                          18.22.8.1.22                                  18.22.8.1.25    18.22.8.2.5           18.22.8.2.13                   18.22.8.2.18                          18.22.8.2.22                                  18.22.8.2.25    18.22.8.5.5           18.22.8.5.13                   18.22.8.5.18                          18.22.8.5.22                                  18.22.8.5.25    18.22.8.7.5           18.22.8.7.13                   18.22.8.7.18                          18.22.8.7.22                                  18.22.8.7.25    18.22.8.46.5           18.22.8.46.13                   18.22.8.46.18                          18.22.8.46.22                                  18.22.8.46.25    18.22.8.47.5           18.22.8.47.13                   18.22.8.47.18                          18.22.8.47.22                                  18.22.8.47.25    18.22.9.1.5           18.22.9.1.13                   18.22.9.1.18                          18.22.9.1.22                                  18.22.9.1.25    18.22.9.2.5           18.22.9.2.13                   18.22.9.2.18                          18.22.9.2.22                                  18.22.9.2.25    18.22.9.5.5           18.22.9.5.13                   18.22.9.5.18                          18.22.9.5.22                                  18.22.9.5.25    18.22.9.7.5           18.22.9.7.13                   18.22.9.7.18                          18.22.9.7.22                                  18.22.9.7.25    18.22.9.46.5           18.22.9.46.13                   18.22.9.46.18                          18.22.9.46.22                                  18.22.9.46.25    18.22.9.47.5           18.22.9.47.13                   18.22.9.47.18                          18.22.9.47.22                                  18.22.9.47.25    18.22.10.1.5           18.22.10.1.13                   18.22.10.1.18                          18.22.10.1.22                                  18.22.10.1.25    18.22.10.2.5           18.22.10.2.13                   18.22.10.2.18                          18.22.10.2.22                                  18.22.10.2.25    18.22.10.5.5           18.22.10.5.13                   18.22.10.5.18                          18.22.10.5.22                                  18.22.10.5.25    18.22.10.7.5           18.22.10.7.13                   18.22.10.7.18                          18.22.10.7.22                                  18.22.10.7.25    18.22.10.46.5           18.22.10.46.13                   18.22.10.46.18                          18.22.10.46.22                                  18.22.10.46.25    18.22.10.47.5           18.22.10.47.13                   18.22.10.47.18                          18.22.10.47.22                                  18.22.10.47.25    18.33.1.1.5           18.33.1.1.13                   18.33.1.1.18                          18.33.1.1.22                                  18.33.1.1.25    18.33.1.2.5           18.33.1.2.13                   18.33.1.2.18                          18.33.1.2.22                                  18.33.1.2.25    18.33.1.5.5           18.33.1.5.13                   18.33.1.5.18                          18.33.1.5.22                                  18.33.1.5.25    18.33.1.7.5           18.33.1.7.13                   18.33.1.7.18                          18.33.1.7.22                                  18.33.1.7.25    18.33.1.46.5           18.33.1.46.13                   18.33.1.46.18                          18.33.1.46.22                                  18.33.1.46.25    18.33.1.47.5           18.33.1.47.13                   18.33.1.47.18                          18.33.1.47.22                                  18.33.1.47.25    18.33.2.1.5           18.33.2.1.13                   18.33.2.1.18                          18.33.2.1.22                                  18.33.2.1.25    18.33.2.2.5           18.33.2.2.13                   18.33.2.2.18                          18.33.2.2.22                                  18.33.2.2.25    18.33.2.5.5           18.33.2.5.13                   18.33.2.5.18                          18.33.2.5.22                                  18.33.2.5.25    18.33.2.7.5           18.33.2.7.13                   18.33.2.7.18                          18.33.2.7.22                                  18.33.2.7.25    18.33.2.46.5           18.33.2.46.13                   18.33.2.46.18                          18.33.2.46.22                                  18.33.2.46.25    18.33.2.47.5           18.33.2.47.13                   18.33.2.47.18                          18.33.2.47.22                                  18.33.2.47.25    18.33.6.1.5           18.33.6.1.13                   18.33.6.1.18                          18.33.6.1.22                                  18.33.6.1.25    18.33.6.2.5           18.33.6.2.13                   18.33.6.2.18                          18.33.6.2.22                                  18.33.6.2.25    18.33.6.5.5           18.33.6.5.13                   18.33.6.5.18                          18.33.6.5.22                                  18.33.6.5.25    18.33.6.7.5           18.33.6.7.13                   18.33.6.7.18                          18.33.6.7.22                                  18.33.6.7.25    18.33.6.46.1           18.33.6.46.13                   18.33.6.46.18                          18.33.6.46.22                                  18.33.6.46.25    18.33.6.47.1           18.33.6.47.13                   18.33.6.47.18                          18.33.6.47.22                                  18.33.6.47.25    18.33.7.1.5           18.33.7.1.13                   18.33.7.1.18                          18.33.7.1.22                                  18.33.7.1.25    18.33.7.2.5           18.33.7.2.13                   18.33.7.2.18                          18.33.7.2.22                                  18.33.7.2.25    18.33.7.5.5           18.33.7.5.13                   18.33.7.5.18                          18.33.7.5.22                                  18.33.7.5.25    18.33.7.7.5           18.33.7.7.13                   18.33.7.7.18                          18.33.7.7.22                                  18.33.7.7.25    18.33.7.46.5           18.33.7.46.13                   18.33.7.46.18                          18.33.7.46.22                                  18.33.7.46.25    18.33.7.47.5           18.33.7.47.13                   18.33.7.47.18                          18.33.7.47.22                                  18.33.7.47.25    18.33.8.1.5           18.33.8.1.13                   18.33.8.1.18                          18.33.8.1.22                                  18.33.8.1.25    18.33.8.2.5           18.33.8.2.13                   18.33.8.2.18                          18.33.8.2.22                                  18.33.8.2.25    18.33.8.5.5           18.33.8.5.13                   18.33.8.5.18                          18.33.8.5.22                                  18.33.8.5.25    18.33.8.7.5           18.33.8.7.13                   18.33.8.7.18                          18.33.8.7.22                                  18.33.8.7.25    18.33.8.46.5           18.33.8.46.13                   18.33.8.46.18                          18.33.8.46.22                                  18.33.8.46.25    18.33.8.47.5           18.33.8.47.13                   18.33.8.47.18                          18.33.8.47.22                                  18.33.8.47.25    18.33.9.1.5           18.33.9.1.13                   18.33.9.1.18                          18.33.9.1.22                                  18.33.9.1.25    18.33.9.2.5           18.33.9.2.13                   18.33.9.2.18                          18.33.9.2.22                                  18.33.9.2.25    18.33.9.5.5           18.33.9.5.13                   18.33.9.5.18                          18.33.9.5.22                                  18.33.9.5.25    18.33.9.7.5           18.33.9.7.13                   18.33.9.7.18                          18.33.9.7.22                                  18.33.9.7.25    18.33.9.46.5           18.33.9.46.13                   18.33.9.46.18                          18.33.9.46.22                                  18.33.9.46.25    18.33.9.47.5           18.33.9.47.13                   18.33.9.47.18                          18.33.9.47.22                                  18.33.9.47.25    18.33.10.1.5           18.33.10.1.13                   18.33.10.1.18                          18.33.10.1.22                                  18.33.10.1.25    18.33.10.2.5           18.33.10.2.13                   18.33.10.2.18                          18.33.10.2.22                                  18.33.10.2.25    18.33.10.5.5           18.33.10.5.13                   18.33.10.5.18                          18.33.10.5.22                                  18.33.10.5.25    18.33.10.7.5           18.33.10.7.13                   18.33.10.7.18                          18.33.10.7.22                                  18.33.10.7.25    18.33.10.46.5           18.33.10.46.13                   18.33.10.46.18                          18.33.10.46.22                                  18.33.10.46.25    18.33.10.47.5           18.33.10.47.13                   18.33.10.47.18                          18.33.10.47.22                                  18.33.10.47.25    18.34.1.1.5           18.34.1.1.13                   18.34.1.1.18                          18.34.1.1.22                                  18.34.1.1.25    18.34.1.2.5           18.34.1.2.13                   18.34.1.2.18                          18.34.1.2.22                                  18.34.1.2.25    18.34.1.5.5           18.34.1.5.13                   18.34.1.5.18                          18.34.1.5.22                                  18.34.1.5.25    18.34.1.7.5           18.34.1.7.13                   18.34.1.7.18                          18.34.1.7.22                                  18.34.1.7.25    18.34.1.46.5           18.34.1.46.13                   18.34.1.46.18                          18.34.1.46.22                                  18.34.1.46.25    18.34.1.47.5           18.34.1.47.13                   18.34.1.47.18                          18.34.1.47.22                                  18.34.1.47.25    18.34.2.1.5           18.34.2.1.13                   18.34.2.1.18                          18.34.2.1.22                                  18.34.2.1.25    18.34.2.2.5           18.34.2.2.13                   18.34.2.2.18                          18.34.2.2.22                                  18.34.2.2.25    18.34.2.5.5           18.34.2.5.13                   18.34.2.5.18                          18.34.2.5.22                                  18.34.2.5.25    18.34.2.7.5           18.34.2.7.13                   18.34.2.7.18                          18.34.2.7.22                                  18.34.2.7.25    18.34.2.46.5           18.34.2.46.13                   18.34.2.46.18                          18.34.2.46.22                                  18.34.2.46.25    18.34.2.47.5           18.34.2.47.13                   18.34.2.47.18                          18.34.2.47.22                                  18.34.2.47.25    18.34.6.1.5           18.34.6.1.13                   18.34.6.1.18                          18.34.6.1.22                                  18.34.6.1.25    18.34.6.2.5           18.34.6.2.13                   18.34.6.2.18                          18.34.6.2.22                                  18.34.6.2.25    18.34.6.5.5           18.34.6.5.13                   18.34.6.5.18                          18.34.6.5.22                                  18.34.6.5.25    18.34.6.7.5           18.34.6.7.13                   18.34.6.7.18                          18.34.6.7.22                                  18.34.6.7.25    18.34.6.46.5           18.34.6.46.13                   18.34.6.46.18                          18.34.6.46.22                                  18.34.6.46.25    18.34.6.47.5           18.34.6.47.13                   18.34.6.47.18                          18.34.6.47.22                                  18.34.6.47.25    18.34.7.1.5           18.34.7.1.13                   18.34.7.1.18                          18.34.7.1.22                                  18.34.7.1.25    18.34.7.2.5           18.34.7.2.13                   18.34.7.2.18                          18.34.7.2.22                                  18.34.7.2.25    18.34.7.5.5           18.34.7.5.13                   18.34.7.5.18                          18.34.7.5.22                                  18.34.7.5.25    18.34.7.7.5           18.34.7.7.13                   18.34.7.7.18                          18.34.7.7.22                                  18.34.7.7.25    18.34.7.46.5           18.34.7.46.13                   18.34.7.46.18                          18.34.7.46.22                                  18.34.7.46.25    18.34.7.47.5           18.34.7.47.13                   18.34.7.47.18                          18.34.7.47.22                                  18.34.7.47.25    18.34.8.1.5           18.34.8.1.13                   18.34.8.1.18                          18.34.8.1.22                                  18.34.8.1.25    18.34.8.2.5           18.34.8.2.13                   18.34.8.2.18                          18.34.8.2.22                                  18.34.8.2.25    18.34.8.5.5           18.34.8.5.13                   18.34.8.5.18                          18.34.8.5.22                                  18.34.8.5.25    18.34.8.7.5           18.34.8.7.13                   18.34.8.7.18                          18.34.8.7.22                                  18.34.8.7.25    18.34.8.46.5           18.34.8.46.13                   18.34.8.46.18                          18.34.8.46.22                                  18.34.8.46.25    18.34.8.47.5           18.34.8.47.13                   18.34.8.47.18                          18.34.8.47.22                                  18.34.8.47.25    18.34.9.1.5           18.34.9.1.13                   18.34.9.1.18                          18.34.9.1.22                                  18.34.9.1.25    18.34.9.2.5           18.34.9.2.13                   18.34.9.2.18                          18.34.9.2.22                                  18.34.9.2.25    18.34.9.5.5           18.34.9.5.13                   18.34.9.5.18                          18.34.9.5.22                                  18.34.9.5.25    18.34.9.7.5           18.34.9.7.13                   18.34.9.7.18                          18.34.9.7.22                                  18.34.9.7.25    18.34.9.46.5           18.34.9.46.13                   18.34.9.46.18                          18.34.9.46.22                                  18.34.9.46.25    18.34.9.47.5           18.34.9.47.13                   18.34.9.47.18                          18.34.9.47.22                                  18.34.9.47.25    18.34.10.1.5           18.34.10.1.13                   18.34.10.1.18                          18.34.10.1.22                                  18.34.10.1.25    18.34.10.2.5           18.34.10.2.13                   18.34.10.2.18                          18.34.10.2.22                                  18.34.10.2.25    18.34.10.5.5           18.34.10.5.13                   18.34.10.5.18                          18.34.10.5.22                                  18.34.10.5.25    18.34.10.7.5           18.34.10.7.13                   18.34.10.7.18                          18.34.10.7.22                                  18.34.10.7.25    18.34.10.46.5           18.34.10.46.13                   18.34.10.46.18                          18.34.10.46.22                                  18.34.10.46.25    18.34.10.47.5           18.34.10.47.13                   18.34.10.47.18                          18.34.10.47.22                                  18.34.10.47.25    18.37.1.1.5           18.37.1.1.13                   18.37.1.1.18                          18.37.1.1.22                                  18.37.1.1.25    18.37.1.2.5           18.37.1.2.13                   18.37.1.2.18                          18.37.1.2.22                                  18.37.1.2.25    18.37.1.5.5           18.37.1.5.13                   18.37.1.5.18                          18.37.1.5.22                                  18.37.1.5.25    18.37.1.7.5           18.37.1.7.13                   18.37.1.7.18                          18.37.1.7.22                                  18.37.1.7.25    18.37.1.46.5           18.37.1.46.13                   18.37.1.46.18                          18.37.1.46.22                                  18.37.1.46.25    18.37.1.47.5           18.37.1.47.13                   18.37.1.47.18                          18.37.1.47.22                                  18.37.1.47.25    18.37.2.1.5           18.37.2.1.13                   18.37.2.1.18                          18.37.2.1.22                                  18.37.2.1.25    18.37.2.2.5           18.37.2.2.13                   18.37.2.2.18                          18.37.2.2.22                                  18.37.2.2.25    18.37.2.5.5           18.37.2.5.13                   18.37.2.5.18                          18.37.2.5.22                                  18.37.2.5.25    18.37.2.7.5           18.37.2.7.13                   18.37.2.7.18                          18.37.2.7.22                                  18.37.2.7.25    18.37.2.46.5           18.37.2.46.13                   18.37.2.46.18                          18.37.2.46.22                                  18.37.2.46.25    18.37.2.47.5           18.37.2.47.13                   18.37.2.47.18                          18.37.2.47.22                                  18.37.2.47.25    18.37.6.1.5           18.37.6.1.13                   18.37.6.1.18                          18.37.6.1.22                                  18.37.6.1.25    18.37.6.2.5           18.37.6.2.13                   18.37.6.2.18                          18.37.6.2.22                                  18.37.6.2.25    18.37.6.5.5           18.37.6.5.13                   18.37.6.5.18                          18.37.6.5.22                                  18.37.6.5.25    18.37.6.7.5           18.37.6.7.13                   18.37.6.7.18                          18.37.6.7.22                                  18.37.6.7.25    18.37.6.46.5           18.37.6.46.13                   18.37.6.46.18                          18.37.6.46.22                                  18.37.6.46.25    18.37.6.47.5           18.37.6.47.13                   18.37.6.47.18                          18.37.6.47.22                                  18.37.6.47.25    18.37.7.1.5           18.37.7.1.13                   18.37.7.1.18                          18.37.7.1.22                                  18.37.7.1.25    18.37.7.2.5           18.37.7.2.13                   18.37.7.2.18                          18.37.7.2.22                                  18.37.7.2.25    18.37.7.5.5           18.37.7.5.13                   18.37.7.5.18                          18.37.7.5.22                                  18.37.7.5.25    18.37.7.7.5           18.37.7.7.13                   18.37.7.7.18                          18.37.7.7.22                                  18.37.7.7.25    18.37.7.46.5           18.37.7.46.13                   18.37.7.46.18                          18.37.7.46.22                                  18.37.7.46.25    18.37.7.47.5           18.37.7.47.13                   18.37.7.47.18                          18.37.7.47.22                                  18.37.7.47.25    18.37.8.1.5           18.37.8.1.13                   18.37.8.1.18                          18.37.8.1.22                                  18.37.8.1.25    18.37.8.2.5           18.37.8.2.13                   18.37.8.2.18                          18.37.8.2.22                                  18.37.8.2.25    18.37.8.5.5           18.37.8.5.13                   18.37.8.5.18                          18.37.8.5.22                                  18.37.8.5.25    18.37.8.7.5           18.37.8.7.13                   18.37.8.7.18                          18.37.8.7.22                                  18.37.8.7.25    18.37.8.46.5           18.37.8.46.13                   18.37.8.46.18                          18.37.8.46.22                                  18.37.8.46.25    18.37.8.47.5           18.37.8.47.13                   18.37.8.47.18                          18.37.8.47.22                                  18.37.8.47.25    18.37.9.1.5           18.37.9.1.13                   18.37.9.1.18                          18.37.9.1.22                                  18.37.9.1.25    18.37.9.2.5           18.37.9.2.13                   18.37.9.2.18                          18.37.9.2.22                                  18.37.9.2.25    18.37.9.5.5           18.37.9.5.13                   18.37.9.5.18                          18.37.9.5.22                                  18.37.9.5.25    18.37.9.7.5           18.37.9.7.13                   18.37.9.7.18                          18.37.9.7.22                                  18.37.9.7.25    18.37.9.46.5           18.37.9.46.13                   18.37.9.46.18                          18.37.9.46.22                                  18.37.9.46.25    18.37.9.47.5           18.37.9.47.13                   18.37.9.47.18                          18.37.9.47.22                                  18.37.9.47.25    18.37.10.1.5           18.37.10.1.13                   18.37.10.1.18                          18.37.10.1.22                                  18.37.10.1.25    18.37.10.2.5           18.37.10.2.13                   18.37.10.2.18                          18.37.10.2.22                                  18.37.10.2.25    18.37.10.5.5           18.37.10.5.13                   18.37.10.5.18                          18.37.10.5.22                                  18.37.10.5.25    18.37.10.7.5           18.37.10.7.13                   18.37.10.7.18                          18.37.10.7.22                                  18.37.10.7.25    18.37.10.46.5           18.37.10.46.13                   18.37.10.46.18                          18.37.10.46.22                                  18.37.10.46.25    18.37.10.47.5           18.37.10.47.13                   18.37.10.47.18                          18.37.10.47.22                                  18.37.10.47.25    19.17.1.1.5           19.17.1.1.13                   19.17.1.1.18                          19.17.1.1.22                                  19.17.1.1.25    19.17.1.2.5           19.17.1.2.13                   19.17.1.2.18                          19.17.1.2.22                                  19.17.1.2.25    19.17.1.5.5           19.17.1.5.13                   19.17.1.5.18                          19.17.1.5.22                                  19.17.1.5.25    19.17.1.7.5           19.17.1.7.13                   19.17.1.7.18                          19.17.1.7.22                                  19.17.1.7.25    19.17.1.46.5           19.17.1.46.13                   19.17.1.46.18                          19.17.1.46.22                                  19.17.1.46.25    19.17.1.47.5           19.17.1.47.13                   19.17.1.47.18                          19.17.1.47.22                                  19.17.1.47.25    19.17.2.1.5           19.17.2.1.13                   19.17.2.1.18                          19.17.2.1.22                                  19.17.2.1.25    19.17.2.2.5           19.17.2.2.13                   19.17.2.2.18                          19.17.2.2.22                                  19.17.2.2.25    19.17.2.5.5           19.17.2.5.13                   19.17.2.5.18                          19.17.2.5.22                                  19.17.2.5.25    19.17.2.7.5           19.17.2.7.13                   19.17.2.7.18                          19.17.2.7.22                                  19.17.2.7.25    19.17.2.46.5           19.17.2.46.13                   19.17.2.46.18                          19.17.2.46.22                                  19.17.2.46.25    19.17.2.47.5           19.17.2.47.13                   19.17.2.47.18                          19.17.2.47.22                                  19.17.2.47.25    19.17.6.1.5           19.17.6.1.13                   19.17.6.1.18                          19.17.6.1.22                                  19.17.6.1.25    19.17.6.2.5           19.17.6.2.13                   19.17.6.2.18                          19.17.6.2.22                                  19.17.6.2.25    19.17.6.5.5           19.17.6.5.13                   19.17.6.5.18                          19.17.6.5.22                                  19.17.6.5.25    19.17.6.7.5           19.17.6.7.13                   19.17.6.7.18                          19.17.6.7.22                                  19.17.6.7.25    19.17.6.46.5           19.17.6.46.13                   19.17.6.46.18                          19.17.6.46.22                                  19.17.6.46.25    19.17.6.47.5           19.17.6.47.13                   19.17.6.47.18                          19.17.6.47.22                                  19.17.6.47.25    19.17.7.1.5           19.17.7.1.13                   19.17.7.1.18                          19.17.7.1.22                                  19.17.7.1.25    19.17.7.2.5           19.17.7.2.13                   19.17.7.2.18                          19.17.7.2.22                                  19.17.7.2.25    19.17.7.5.5           19.17.7.5.13                   19.17.7.5.18                          19.17.7.5.22                                  19.17.7.5.25    19.17.7.7.5           19.17.7.7.13                   19.17.7.7.18                          19.17.7.7.22                                  19.17.7.7.25    19.17.7.46.5           19.17.7.46.13                   19.17.7.46.18                          19.17.7.46.22                                  19.17.7.46.25    19.17.7.47.5           19.17.7.47.13                   19.17.7.47.18                          19.17.7.47.22                                  19.17.7.47.25    19.17.8.1.5           19.17.8.1.13                   19.17.8.1.18                          19.17.8.1.22                                  19.17.8.1.25    19.17.8.2.5           19.17.8.2.13                   19.17.8.2.18                          19.17.8.2.22                                  19.17.8.2.25    19.17.8.5.5           19.17.8.5.13                   19.17.8.5.18                          19.17.8.5.22                                  19.17.8.5.25    19.17.8.7.5           19.17.8.7.13                   19.17.8.7.18                          19.17.8.7.22                                  19.17.8.7.25    19.17.8.46.5           19.17.8.46.13                   19.17.8.46.18                          19.17.8.46.22                                  19.17.8.46.25    19.17.8.47.5           19.17.8.47.13                   19.17.8.47.18                          19.17.8.47.22                                  19.17.8.47.25    19.17.9.1.5           19.17.9.1.13                   19.17.9.1.18                          19.17.9.1.22                                  19.17.9.1.25    19.17.9.2.5           19.17.9.2.13                   19.17.9.2.18                          19.17.9.2.22                                  19.17.9.2.25    19.17.9.5.5           19.17.9.5.13                   19.17.9.5.18                          19.17.9.5.22                                  19.17.9.5.25    19.17.9.7.5           19.17.9.7.13                   19.17.9.7.18                          19.17.9.7.22                                  19.17.9.7.25    19.17.9.46.5           19.17.9.46.13                   19.17.9.46.18                          19.17.9.46.22                                  19.17.9.46.25    19.17.9.47.5           19.17.9.47.13                   19.17.9.47.18                          19.17.9.47.22                                  19.17.9.47.25    19.17.10.1.5           19.17.10.1.13                   19.17.10.1.18                          19.17.10.1.22                                  19.17.10.1.25    19.17.10.2.5           19.17.10.2.13                   19.17.10.2.18                          19.17.10.2.22                                  19.17.10.2.25    19.17.10.5.5           19.17.10.5.13                   19.17.10.5.18                          19.17.10.5.22                                  19.17.10.5.25    19.17.10.7.5           19.17.10.7.13                   19.17.10.7.18                          19.17.10.7.22                                  19.17.10.7.25    19.17.10.46.5           19.17.10.46.13                   19.17.10.46.18                          19.17.10.46.22                                  19.17.10.46.25    19.17.10.47.5           19.17.10.47.13                   19.17.10.47.18                          19.17.10.47.22                                  19.17.10.47.25    19.18.1.1.5           19.18.1.1.13                   19.18.1.1.18                          19.18.1.1.22                                  19.18.1.1.25    19.18.1.2.5           19.18.1.2.13                   19.18.1.2.18                          19.18.1.2.22                                  19.18.1.2.25    19.18.1.5.5           19.18.1.5.13                   19.18.1.5.18                          19.18.1.5.22                                  19.18.1.5.25    19.18.1.7.5           19.18.1.7.13                   19.18.1.7.18                          19.18.1.7.22                                  19.18.1.7.25    19.18.1.46.5           19.18.1.46.13                   19.18.1.46.18                          19.18.1.46.22                                  19.18.1.46.25    19.18.1.47.5           19.18.1.47.13                   19.18.1.47.18                          19.18.1.47.22                                  19.18.1.47.25    19.18.2.1.5           19.18.2.1.13                   19.18.2.1.18                          19.18.2.1.22                                  19.18.2.1.25    19.18.2.2.5           19.18.2.2.13                   19.18.2.2.18                          19.18.2.2.22                                  19.18.2.2.25    19.18.2.5.5           19.18.2.5.13                   19.18.2.5.18                          19.18.2.5.22                                  19.18.2.5.25    19.18.2.7.5           19.18.2.7.13                   19.18.2.7.18                          19.18.2.7.22                                  19.18.2.7.25    19.18.2.46.5           19.18.2.46.13                   19.18.2.46.18                          19.18.2.46.22                                  19.18.2.46.25    19.18.2.47.5           19.18.2.47.13                   19.18.2.47.18                          19.18.2.47.22                                  19.18.2.47.25    19.18.6.1.5           19.18.6.1.13                   19.18.6.1.18                          19.18.6.1.22                                  19.18.6.1.25    19.18.6.2.5           19.18.6.2.13                   19.18.6.2.18                          19.18.6.2.22                                  19.18.6.2.25    19.18.6.5.5           19.18.6.5.13                   19.18.6.5.18                          19.18.6.5.22                                  19.18.6.5.25    19.18.6.7.5           19.18.6.7.13                   19.18.6.7.18                          19.18.6.7.22                                  19.18.6.7.25    19.18.6.46.5           19.18.6.46.13                   19.18.6.46.18                          19.18.6.46.22                                  19.18.6.46.25    19.18.6.47.5           19.18.6.47.13                   19.18.6.47.18                          19.18.6.47.22                                  19.18.6.47.25    19.18.7.1.5           19.18.7.1.13                   19.18.7.1.18                          19.18.7.1.22                                  19.18.7.1.25    19.18.7.2.5           19.18.7.2.13                   19.18.7.2.18                          19.18.7.2.22                                  19.18.7.2.25    19.18.7.5.5           19.18.7.5.13                   19.18.7.5.18                          19.18.7.5.22                                  19.18.7.5.25    19.18.7.7.5           19.18.7.7.13                   19.18.7.7.18                          19.18.7.7.22                                  19.18.7.7.25    19.18.7.46.5           19.18.7.46.13                   19.18.7.46.18                          19.18.7.46.22                                  19.18.7.46.25    19.18.7.47.5           19.18.7.47.13                   19.18.7.47.18                          19.18.7.47.22                                  19.18.7.47.25    19.18.8.1.5           19.18.8.1.13                   19.18.8.1.18                          19.18.8.1.22                                  19.18.8.1.25    19.18.8.2.5           19.18.8.2.13                   19.18.8.2.18                          19.18.8.2.22                                  19.18.8.2.25    19.18.8.5.5           19.18.8.5.13                   19.18.8.5.18                          19.18.8.5.22                                  19.18.8.5.25    19.18.8.7.5           19.18.8.7.13                   19.18.8.7.18                          19.18.8.7.22                                  19.18.8.7.25    19.18.9.46.5           19.18.9.46.13                   19.18.9.46.18                          19.18.9.46.22                                  19.18.9.46.25    19.18.9.47.5           19.18.9.47.13                   19.18.9.47.18                          19.18.9.47.22                                  19.18.9.47.25    19.18.9.1.5           19.18.9.1.13                   19.18.9.1.18                          19.18.9.1.22                                  19.18.9.1.25    19.18.9.2.5           19.18.9.2.13                   19.18.9.2.18                          19.18.9.2.22                                  19.18.9.2.25    19.18.9.5.5           19.18.9.5.13                   19.18.9.5.18                          19.18.9.5.22                                  19.18.9.5.25    19.18.9.7.5           19.18.9.7.13                   19.18.9.7.18                          19.18.9.7.22                                  19.18.9.7.25    19.18.9.46.5           19.18.9.46.13                   19.18.9.46.18                          19.18.9.46.22                                  19.18.9.46.25    19.18.9.47.5           19.18.9.47.13                   19.18.9.47.18                          19.18.9.47.22                                  19.18.9.47.25    19.18.10.1.5           19.18.10.1.13                   19.18.10.1.18                          19.18.10.1.22                                  19.18.10.1.25    19.18.10.2.5           19.18.10.2.13                   19.18.10.2.18                          19.18.10.2.22                                  19.18.10.2.25    19.18.10.5.5           19.18.10.5.13                   19.18.10.5.18                          19.18.10.5.22                                  19.18.10.5.25    19.18.10.7.5           19.18.10.7.13                   19.18.10.7.18                          19.18.10.7.22                                  19.18.10.7.25    19.18.10.46.5           19.18.10.46.13                   19.18.10.46.18                          19.18.10.46.22                                  19.18.10.46.25    19.18.10.47.5           19.18.10.47.13                   19.18.10.47.18                          19.18.10.47.22                                  19.18.10.47.25    19.19.1.1.5           19.19.1.1.13                   19.19.1.1.18                          19.19.1.1.22                                  19.19.1.1.25    19.19.1.2.5           19.19.1.2.13                   19.19.1.2.18                          19.19.1.2.22                                  19.19.1.2.25    19.19.1.5.5           19.19.1.5.13                   19.19.1.5.18                          19.19.1.5.22                                  19.19.1.5.25    19.19.1.7.5           19.19.1.7.13                   19.19.1.7.18                          19.19.1.7.22                                  19.19.1.7.25    19.19.1.46.5           19.19.1.46.13                   19.19.1.46.18                          19.19.1.46.22                                  19.19.1.46.25    19.19.1.47.5           19.19.1.47.13                   19.19.1.47.18                          19.19.1.47.22                                  19.19.1.47.25    19.19.2.1.5           19.19.2.1.13                   19.19.2.1.18                          19.19.2.1.22                                  19.19.2.1.25    19.19.2.2.5           19.19.2.2.13                   19.19.2.2.18                          19.19.2.2.22                                  19.19.2.2.25    19.19.2.5.5           19.19.2.5.13                   19.19.2.5.18                          19.19.2.5.22                                  19.19.2.5.25    19.19.2.7.5           19.19.2.7.13                   19.19.2.7.18                          19.19.2.7.22                                  19.19.2.7.25    19.19.2.46.5           19.19.2.46.13                   19.19.2.46.18                          19.19.2.46.22                                  19.19.2.46.25    19.19.2.47.5           19.19.2.47.13                   19.19.2.47.18                          19.19.2.47.22                                  19.19.2.47.25    19.19.6.1.5           19.19.6.1.13                   19.19.6.1.18                          19.19.6.1.22                                  19.19.6.1.25    19.19.6.2.5           19.19.6.2.13                   19.19.6.2.18                          19.19.6.2.22                                  19.19.6.2.25    19.19.6.5.5           19.19.6.5.13                   19.19.6.5.18                          19.19.6.5.22                                  19.19.6.5.25    19.19.6.7.5           19.19.6.7.13                   19.19.6.7.18                          19.19.6.7.22                                  19.19.6.7.25    19.19.6.46.5           19.19.6.46.13                   19.19.6.46.18                          19.19.6.46.22                                  19.19.6.46.25    19.19.6.47.5           19.19.6.47.13                   19.19.6.47.18                          19.19.6.47.22                                  19.19.6.47.25    19.19.7.1.5           19.19.7.1.13                   19.19.7.1.18                          19.19.7.1.22                                  19.19.7.1.25    19.19.7.2.5           19.19.7.2.13                   19.19.7.2.18                          19.19.7.2.22                                  19.19.7.2.25    19.19.7.5.5           19.19.7.5.13                   19.19.7.5.18                          19.19.7.5.22                                  19.19.7.5.25    19.19.7.7.5           19.19.7.7.13                   19.19.7.7.18                          19.19.7.7.22                                  19.19.7.7.25    19.19.7.46.5           19.19.7.46.13                   19.19.7.46.18                          19.19.7.46.22                                  19.19.7.46.25    19.19.7.47.5           19.19.7.47.13                   19.19.7.47.18                          19.19.7.47.22                                  19.19.7.47.25    19.19.8.1.5           19.19.8.1.13                   19.19.8.1.18                          19.19.8.1.22                                  19.19.8.1.25    19.19.8.2.5           19.19.8.2.13                   19.19.8.2.18                          19.19.8.2.22                                  19.19.8.2.25    19.19.8.5.5           19.19.8.5.13                   19.19.8.5.18                          19.19.8.5.22                                  19.19.8.5.25    19.19.8.7.5           19.19.8.7.13                   19.19.8.7.18                          19.19.8.7.22                                  19.19.8.7.25    19.19.8.46.5           19.19.8.46.13                   19.19.8.46.18                          19.19.8.46.22                                  19.19.8.46.25    19.19.8.47.5           19.19.8.47.13                   19.19.8.47.18                          19.19.8.47.22                                  19.19.8.47.25    19.19.9.1.5           19.19.9.1.13                   19.19.9.1.18                          19.19.9.1.22                                  19.19.9.1.25    19.19.9.2.5           19.19.9.2.13                   19.19.9.2.18                          19.19.9.2.22                                  19.19.9.2.25    19.19.9.5.5           19.19.9.5.13                   19.19.9.5.18                          19.19.9.5.22                                  19.19.9.5.25    19.19.9.7.5           19.19.9.7.13                   19.19.9.7.18                          19.19.9.7.22                                  19.19.9.7.25    19.19.9.46.5           19.19.9.46.13                   19.19.9.46.18                          19.19.9.46.22                                  19.19.9.46.25    19.19.9.47.5           19.19.9.47.13                   19.19.9.47.18                          19.19.9.47.22                                  19.19.9.47.25    19.19.10.1.5           19.19.10.1.13                   19.19.10.1.18                          19.19.10.1.22                                  19.19.10.1.25    19.19.10.2.5           19.19.10.2.13                   19.19.10.2.18                          19.19.10.2.22                                  19.19.10.2.25    19.19.10.5.5           19.19.10.5.13                   19.19.10.5.18                          19.19.10.5.22                                  19.19.10.5.25    19.19.10.7.5           19.19.10.7.13                   19.19.10.7.18                          19.19.10.7.22                                  19.19.10.7.25    19.19.10.46.5           19.19.10.46.13                   19.19.10.46.18                          19.19.10.46.22                                  19.19.10.46.25    19.19.10.47.5           19.19.10.47.13                   19.19.10.47.18                          19.19.10.47.22                                  19.19.10.47.25    19.20.1.1.5           19.20.1.1.13                   19.20.1.1.18                          19.20.1.1.22                                  19.20.1.1.25    19.20.1.2.5           19.20.1.2.13                   19.20.1.2.18                          19.20.1.2.22                                  19.20.1.2.25    19.20.1.5.5           19.20.1.5.13                   19.20.1.5.18                          19.20.1.5.22                                  19.20.1.5.25    19.20.1.7.5           19.20.1.7.13                   19.20.1.7.18                          19.20.1.7.22                                  19.20.1.7.25    19.20.1.46.5           19.20.1.46.13                   19.20.1.46.18                          19.20.1.46.22                                  19.20.1.46.25    19.20.1.47.5           19.20.1.47.13                   19.20.1.47.18                          19.20.1.47.22                                  19.20.1.47.25    19.20.2.1.5           19.20.2.1.13                   19.20.2.1.18                          19.20.2.1.22                                  19.20.2.1.25    19.20.2.2.5           19.20.2.2.13                   19.20.2.2.18                          19.20.2.2.22                                  19.20.2.2.25    19.20.2.5.5           19.20.2.5.13                   19.20.2.5.18                          19.20.2.5.22                                  19.20.2.5.25    19.20.2.7.5           19.20.2.7.13                   19.20.2.7.18                          19.20.2.7.22                                  19.20.2.7.25    19.20.2.46.5           19.20.2.46.13                   19.20.2.46.18                          19.20.2.46.22                                  19.20.2.46.25    19.20.2.47.5           19.20.2.47.13                   19.20.2.47.18                          19.20.2.47.22                                  19.20.2.47.25    19.20.6.1.5           19.20.6.1.13                   19.20.6.1.18                          19.20.6.1.22                                  19.20.6.1.25    19.20.6.2.5           19.20.6.2.13                   19.20.6.2.18                          19.20.6.2.22                                  19.20.6.2.25    19.20.6.5.5           19.20.6.5.13                   19.20.6.5.18                          19.20.6.5.22                                  19.20.6.5.25    19.20.6.7.5           19.20.6.7.13                   19.20.6.7.18                          19.20.6.7.22                                  19.20.6.7.25    19.20.6.46.5           19.20.6.46.13                   19.20.6.46.18                          19.20.6.46.22                                  19.20.6.46.25    19.20.6.47.5           19.20.6.47.13                   19.20.6.47.18                          19.20.6.47.22                                  19.20.6.47.25    19.20.7.1.5           19.20.7.1.13                   19.20.7.1.18                          19.20.7.1.22                                  19.20.7.1.25    19.20.7.2.5           19.20.7.2.13                   19.20.7.2.18                          19.20.7.2.22                                  19.20.7.2.25    19.20.7.5.5           19.20.7.5.13                   19.20.7.5.18                          19.20.7.5.22                                  19.20.7.5.25    19.20.7.7.5           19.20.7.7.13                   19.20.7.7.18                          19.20.7.7.22                                  19.20.7.7.25    19.20.7.46.5           19.20.7.46.13                   19.20.7.46.18                          19.20.7.46.22                                  19.20.7.46.25    19.20.7.47.5           19.20.7.47.13                   19.20.7.47.18                          19.20.7.47.22                                  19.20.7.47.25    19.20.8.1.5           19.20.8.1.13                   19.20.8.1.18                          19.20.8.1.22                                  19.20.8.1.25    19.20.8.2.5           19.20.8.2.13                   19.20.8.2.18                          19.20.8.2.22                                  19.20.8.2.25    19.20.8.5.5           19.20.8.5.13                   19.20.8.5.18                          19.20.8.5.22                                  19.20.8.5.25    19.20.8.7.5           19.20.8.7.13                   19.20.8.7.18                          19.20.8.7.22                                  19.20.8.7.25    19.20.8.46.5           19.20.8.46.13                   19.20.8.46.18                          19.20.8.46.22                                  19.20.8.46.25    19.20.8.47.5           19.20.8.47.13                   19.20.8.47.18                          19.20.8.47.22                                  19.20.8.47.25    19.20.9.1.5           19.20.9.1.13                   19.20.9.1.18                          19.20.9.1.22                                  19.20.9.1.25    19.20.9.2.5           19.20.9.2.13                   19.20.9.2.18                          19.20.9.2.22                                  19.20.9.2.25    19.20.9.5.5           19.20.9.5.13                   19.20.9.5.18                          19.20.9.5.22                                  19.20.9.5.25    19.20.9.7.5           19.20.9.7.13                   19.20.9.7.18                          19.20.9.7.22                                  19.20.9.7.25    19.20.9.46.5           19.20.9.46.13                   19.20.9.46.18                          19.20.9.46.22                                  19.20.9.46.25    19.20.9.47.5           19.20.9.47.13                   19.20.9.47.18                          19.20.9.47.22                                  19.20.9.47.25    19.20.10.1.5           19.20.10.1.13                   19.20.10.1.18                          19.20.10.1.22                                  19.20.10.1.25    19.20.10.2.5           19.20.10.2.13                   19.20.10.2.18                          19.20.10.2.22                                  19.20.10.2.25    19.20.10.5.5           19.20.10.5.13                   19.20.10.5.18                          19.20.10.5.22                                  19.20.10.5.25    19.20.10.7.5           19.20.10.7.13                   19.20.10.7.18                          19.20.10.7.22                                  19.20.10.7.25    19.20.10.46.5           19.20.10.46.13                   19.20.10.46.18                          19.20.10.46.22                                  19.20.10.46.25    19.20.10.47.5           19.20.10.47.13                   19.20.10.47.18                          19.20.10.47.22                                  19.20.10.47.25    19.21.1.1.5           19.21.1.1.13                   19.21.1.1.18                          19.21.1.1.22                                  19.21.1.1.25    19.21.1.2.5           19.21.1.2.13                   19.21.1.2.18                          19.21.1.2.22                                  19.21.1.2.25    19.21.1.5.5           19.21.1.5.13                   19.21.1.5.18                          19.21.1.5.22                                  19.21.1.5.25    19.21.1.7.5           19.21.1.7.13                   19.21.1.7.18                          19.21.1.7.22                                  19.21.1.7.25    19.21.1.46.5           19.21.1.46.13                   19.21.1.46.18                          19.21.1.46.22                                  19.21.1.46.25    19.21.1.47.5           19.21.1.47.13                   19.21.1.47.18                          19.21.1.47.22                                  19.21.1.47.25    19.21.2.1.5           19.21.2.1.13                   19.21.2.1.18                          19.21.2.1.22                                  19.21.2.1.25    19.21.2.2.5           19.21.2.2.13                   19.21.2.2.18                          19.21.2.2.22                                  19.21.2.2.25    19.21.2.5.5           19.21.2.5.13                   19.21.2.5.18                          19.21.2.5.22                                  19.21.2.5.25    19.21.2.7.5           19.21.2.7.13                   19.21.2.7.18                          19.21.2.7.22                                  19.21.2.7.25    19.21.2.46.5           19.21.2.46.13                   19.21.2.46.18                          19.21.2.46.22                                  19.21.2.46.25    19.21.2.47.5           19.21.2.47.13                   19.21.2.47.18                          19.21.2.47.22                                  19.21.2.47.25    19.21.6.1.5           19.21.6.1.13                   19.21.6.1.18                          19.21.6.1.22                                  19.21.6.1.25    19.21.6.2.5           19.21.6.2.13                   19.21.6.2.18                          19.21.6.2.22                                  19.21.6.2.25    19.21.6.5.5           19.21.6.5.13                   19.21.6.5.18                          19.21.6.5.22                                  19.21.6.5.25    19.21.6.7.5           19.21.6.7.13                   19.21.6.7.18                          19.21.6.7.22                                  19.21.6.7.25    19.21.6.46.5           19.21.6.46.13                   19.21.6.46.18                          19.21.6.46.22                                  19.21.6.46.25    19.21.6.47.5           19.21.6.47.13                   19.21.6.47.18                          19.21.6.47.22                                  19.21.6.47.25    19.21.7.1.5           19.21.7.1.13                   19.21.7.1.18                          19.21.7.1.22                                  19.21.7.1.25    19.21.7.2.5           19.21.7.2.13                   19.21.7.2.18                          19.21.7.2.22                                  19.21.7.2.25    19.21.7.5.5           19.21.7.5.13                   19.21.7.5.18                          19.21.7.5.22                                  19.21.7.5.25    19.21.7.7.5           19.21.7.7.13                   19.21.7.7.18                          19.21.7.7.22                                  19.21.7.7.25    19.21.7.46.5           19.21.7.46.13                   19.21.7.46.18                          19.21.7.46.22                                  19.21.7.46.25    19.21.7.47.5           19.21.7.47.13                   19.21.7.47.18                          19.21.7.47.22                                  19.21.7.47.25    19.21.8.1.5           19.21.8.1.13                   19.21.8.1.18                          19.21.8.1.22                                  19.21.8.1.25    19.21.8.2.5           19.21.8.2.13                   19.21.8.2.18                          19.21.8.2.22                                  19.21.8.2.25    19.21.8.5.5           19.21.8.5.13                   19.21.8.5.18                          19.21.8.5.22                                  19.21.8.5.25    19.21.8.7.5           19.21.8.7.13                   19.21.8.7.18                          19.21.8.7.22                                  19.21.8.7.25    19.21.8.46.5           19.21.8.46.13                   19.21.8.46.18                          19.21.8.46.22                                  19.21.8.46.25    19.21.8.47.5           19.21.8.47.13                   19.21.8.47.18                          19.21.8.47.22                                  19.21.8.47.25    19.21.9.1.5           19.21.9.1.13                   19.21.9.1.18                          19.21.9.1.22                                  19.21.9.1.25    19.21.9.2.5           19.21.9.2.13                   19.21.9.2.18                          19.21.9.2.22                                  19.21.9.2.25    19.21.9.5.5           19.21.9.5.13                   19.21.9.5.18                          19.21.9.5.22                                  19.21.9.5.25    19.21.9.7.5           19.21.9.7.13                   19.21.9.7.18                          19.21.9.7.22                                  19.21.9.7.25    19.21.9.46.5           19.21.9.46.13                   19.21.9.46.18                          19.21.9.46.22                                  19.21.9.46.25    19.21.9.47.5           19.21.9.47.13                   19.21.9.47.18                          19.21.9.47.22                                  19.21.9.47.25    19.21.10.1.5           19.21.10.1.13                   19.21.10.1.18                          19.21.10.1.22                                  19.21.10.1.25    19.21.10.2.5           19.21.10.2.13                   19.21.10.2.18                          19.21.10.2.22                                  19.21.10.2.25    19.21.10.5.5           19.21.10.5.13                   19.21.10.5.18                          19.21.10.5.22                                  19.21.10.5.25    19.21.10.7.5           19.21.10.7.13                   19.21.10.7.18                          19.21.10.7.22                                  19.21.10.7.25    19.21.10.46.5           19.21.10.46.13                   19.21.10.46.18                          19.21.10.46.22                                  19.21.10.46.25    19.21.10.47.5           19.21.10.47.13                   19.21.10.47.18                          19.21.10.47.22                                  19.21.10.47.25    19.22.1.1.5           19.22.1.1.13                   19.22.1.1.18                          19.22.1.1.22                                  19.22.1.1.25    19.22.1.2.5           19.22.1.2.13                   19.22.1.2.18                          19.22.1.2.22                                  19.22.1.2.25    19.22.1.5.5           19.22.1.5.13                   19.22.1.5.18                          19.22.1.5.22                                  19.22.1.5.25    19.22.1.7.5           19.22.1.7.13                   19.22.1.7.18                          19.22.1.7.22                                  19.22.1.7.25    19.22.1.46.5           19.22.1.46.13                   19.22.1.46.18                          19.22.1.46.22                                  19.22.1.46.25    19.22.1.47.5           19.22.1.47.13                   19.22.1.47.18                          19.22.1.47.22                                  19.22.1.47.25    19.22.2.1.5           19.22.2.1.13                   19.22.2.1.18                          19.22.2.1.22                                  19.22.2.1.25    19.22.2.2.5           19.22.2.2.13                   19.22.2.2.18                          19.22.2.2.22                                  19.22.2.2.25    19.22.2.5.5           19.22.2.5.13                   19.22.2.5.18                          19.22.2.5.22                                  19.22.2.5.25    19.22.2.7.5           19.22.2.7.13                   19.22.2.7.18                          19.22.2.7.22                                  19.22.2.7.25    19.22.2.46.5           19.22.2.46.13                   19.22.2.46.18                          19.22.2.46.22                                  19.22.2.46.25    19.22.2.47.5           19.22.2.47.13                   19.22.2.47.18                          19.22.2.47.22                                  19.22.2.47.25    19.22.6.1.5           19.22.6.1.13                   19.22.6.1.18                          19.22.6.1.22                                  19.22.6.1.25    19.22.6.2.5           19.22.6.2.13                   19.22.6.2.18                          19.22.6.2.22                                  19.22.6.2.25    19.22.6.5.5           19.22.6.5.13                   19.22.6.5.18                          19.22.6.5.22                                  19.22.6.5.25    19.22.6.7.5           19.22.6.7.13                   19.22.6.7.18                          19.22.6.7.22                                  19.22.6.7.25    19.22.6.46.5           19.22.6.46.13                   19.22.6.46.18                          19.22.6.46.22                                  19.22.6.46.25    19.22.6.47.5           19.22.6.47.13                   19.22.6.47.18                          19.22.6.47.22                                  19.22.6.47.25    19.22.7.1.5           19.22.7.1.13                   19.22.7.1.18                          19.22.7.1.22                                  19.22.7.1.25    19.22.7.2.5           19.22.7.2.13                   19.22.7.2.18                          19.22.7.2.22                                  19.22.7.2.25    19.22.7.5.5           19.22.7.5.13                   19.22.7.5.18                          19.22.7.5.22                                  19.22.7.5.25    19.22.7.7.5           19.22.7.7.13                   19.22.7.7.18                          19.22.7.7.22                                  19.22.7.7.25    19.22.7.46.5           19.22.7.46.13                   19.22.7.46.18                          19.22.7.46.22                                  19.22.7.46.25    19.22.7.47.5           19.22.7.47.13                   19.22.7.47.18                          19.22.7.47.22                                  19.22.7.47.25    19.22.8.1.5           19.22.8.1.13                   19.22.8.1.18                          19.22.8.1.22                                  19.22.8.1.25    19.22.8.2.5           19.22.8.2.13                   19.22.8.2.18                          19.22.8.2.22                                  19.22.8.2.25    19.22.8.5.5           19.22.8.5.13                   19.22.8.5.18                          19.22.8.5.22                                  19.22.8.5.25    19.22.8.7.5           19.22.8.7.13                   19.22.8.7.18                          19.22.8.7.22                                  19.22.8.7.25    19.22.8.46.5           19.22.8.46.13                   19.22.8.46.18                          19.22.8.46.22                                  19.22.8.46.25    19.22.8.47.5           19.22.8.47.13                   19.22.8.47.18                          19.22.8.47.22                                  19.22.8.47.25    19.22.9.1.5           19.22.9.1.13                   19.22.9.1.18                          19.22.9.1.22                                  19.22.9.1.25    19.22.9.2.5           19.22.9.2.13                   19.22.9.2.18                          19.22.9.2.22                                  19.22.9.2.25    19.22.9.5.5           19.22.9.5.13                   19.22.9.5.18                          19.22.9.5.22                                  19.22.9.5.25    19.22.9.7.5           19.22.9.7.13                   19.22.9.7.18                          19.22.9.7.22                                  19.22.9.7.25    19.22.9.46.5           19.22.9.46.13                   19.22.9.46.18                          19.22.9.46.22                                  19.22.9.46.25    19.22.9.47.5           19.22.9.47.13                   19.22.9.47.18                          19.22.9.47.22                                  19.22.9.47.25    19.22.10.1.5           19.22.10.1.13                   19.22.10.1.18                          19.22.10.1.22                                  19.22.10.1.25    19.22.10.2.5           19.22.10.2.13                   19.22.10.2.18                          19.22.10.2.22                                  19.22.10.2.25    19.22.10.5.5           19.22.10.5.13                   19.22.10.5.18                          19.22.10.5.22                                  19.22.10.5.25    19.22.10.7.5           19.22.10.7.13                   19.22.10.7.18                          19.22.10.7.22                                  19.22.10.7.25    19.22.10.46.5           19.22.10.46.13                   19.22.10.46.18                          19.22.10.46.22                                  19.22.10.46.25    19.22.10.47.5           19.22.10.47.13                   19.22.10.47.18                          19.22.10.47.22                                  19.22.10.47.25    19.33.1.1.5           19.33.1.1.13                   19.33.1.1.18                          19.33.1.1.22                                  19.33.1.1.25    19.33.1.2.5           19.33.1.2.13                   19.33.1.2.18                          19.33.1.2.22                                  19.33.1.2.25    19.33.1.5.5           19.33.1.5.13                   19.33.1.5.18                          19.33.1.5.22                                  19.33.1.5.25    19.33.1.7.5           19.33.1.7.13                   19.33.1.7.18                          19.33.1.7.22                                  19.33.1.7.25    19.33.1.46.5           19.33.1.46.13                   19.33.1.46.18                          19.33.1.46.22                                  19.33.1.46.25    19.33.1.47.5           19.33.1.47.13                   19.33.1.47.18                          19.33.1.47.22                                  19.33.1.47.25    19.33.2.1.5           19.33.2.1.13                   19.33.2.1.18                          19.33.2.1.22                                  19.33.2.1.25    19.33.2.2.5           19.33.2.2.13                   19.33.2.2.18                          19.33.2.2.22                                  19.33.2.2.25    19.33.2.5.5           19.33.2.5.13                   19.33.2.5.18                          19.33.2.5.22                                  19.33.2.5.25    19.33.2.7.5           19.33.2.7.13                   19.33.2.7.18                          19.33.2.7.22                                  19.33.2.7.25    19.33.2.46.5           19.33.2.46.13                   19.33.2.46.18                          19.33.2.46.22                                  19.33.2.46.25    19.33.2.47.5           19.33.2.47.13                   19.33.2.47.18                          19.33.2.47.22                                  19.33.2.47.25    19.33.6.1.5           19.33.6.1.13                   19.33.6.1.18                          19.33.6.1.22                                  19.33.6.1.25    19.33.6.2.5           19.33.6.2.13                   19.33.6.2.18                          19.33.6.2.22                                  19.33.6.2.25    19.33.6.5.5           19.33.6.5.13                   19.33.6.5.18                          19.33.6.5.22                                  19.33.6.5.25    19.33.6.7.5           19.33.6.7.13                   19.33.6.7.18                          19.33.6.7.22                                  19.33.6.7.25    19.33.6.46.5           19.33.6.46.13                   19.33.6.46.18                          19.33.6.46.22                                  19.33.6.46.25    19.33.6.47.5           19.33.6.47.13                   19.33.6.47.18                          19.33.6.47.22                                  19.33.6.47.25    19.33.7.1.5           19.33.7.1.13                   19.33.7.1.18                          19.33.7.1.22                                  19.33.7.1.25    19.33.7.2.5           19.33.7.2.13                   19.33.7.2.18                          19.33.7.2.22                                  19.33.7.2.25    19.33.7.5.5           19.33.7.5.13                   19.33.7.5.18                          19.33.7.5.22                                  19.33.7.5.25    19.33.7.7.5           19.33.7.7.13                   19.33.7.7.18                          19.33.7.7.22                                  19.33.7.7.25    19.33.7.46.5           19.33.7.46.13                   19.33.7.46.18                          19.33.7.46.22                                  19.33.7.46.25    19.33.7.47.5           19.33.7.47.13                   19.33.7.47.18                          19.33.7.47.22                                  19.33.7.47.25    19.33.8.1.5           19.33.8.1.13                   19.33.8.1.18                          19.33.8.1.22                                  19.33.8.1.25    19.33.8.2.5           19.33.8.2.13                   19.33.8.2.18                          19.33.8.2.22                                  19.33.8.2.25    19.33.8.5.5           19.33.8.5.13                   19.33.8.5.18                          19.33.8.5.22                                  19.33.8.5.25    19.33.8.7.5           19.33.8.7.13                   19.33.8.7.18                          19.33.8.7.22                                  19.33.8.7.25    19.33.8.46.5           19.33.8.46.13                   19.33.8.46.18                          19.33.8.46.22                                  19.33.8.46.25    19.33.8.47.5           19.33.8.47.13                   19.33.8.47.18                          19.33.8.47.22                                  19.33.8.47.25    19.33.9.1.5           19.33.9.1.13                   19.33.9.1.18                          19.33.9.1.22                                  19.33.9.1.25    19.33.9.2.5           19.33.9.2.13                   19.33.9.2.18                          19.33.9.2.22                                  19.33.9.2.25    19.33.9.5.5           19.33.9.5.13                   19.33.9.5.18                          19.33.9.5.22                                  19.33.9.5.25    19.33.9.7.5           19.33.9.7.13                   19.33.9.7.18                          19.33.9.7.22                                  19.33.9.7.25    19.33.9.46.5           19.33.9.46.13                   19.33.9.46.18                          19.33.9.46.22                                  19.33.9.46.25    19.33.9.47.5           19.33.9.47.13                   19.33.9.47.18                          19.33.9.47.22                                  19.33.9.47.25    19.33.10.1.5           19.33.10.1.13                   19.33.10.1.18                          19.33.10.1.22                                  19.33.10.1.25    19.33.10.2.5           19.33.10.2.13                   19.33.10.2.18                          19.33.10.2.22                                  19.33.10.2.25    19.33.10.5.5           19.33.10.5.13                   19.33.10.5.18                          19.33.10.5.22                                  19.33.10.5.25    19.33.10.7.5           19.33.10.7.13                   19.33.10.7.18                          19.33.10.7.22                                  19.33.10.7.25    19.33.10.46.5           19.33.10.46.13                   19.33.10.46.18                          19.33.10.46.22                                  19.33.10.46.25    19.33.10.47.5           19.33.10.47.13                   19.33.10.47.18                          19.33.10.47.22                                  19.33.10.47.25    19.34.1.1.5           19.34.1.1.13                   19.34.1.1.18                          19.34.1.1.22                                  19.34.1.1.25    19.34.1.2.5           19.34.1.2.13                   19.34.1.2.18                          19.34.1.2.22                                  19.34.1.2.25    19.34.1.5.5           19.34.1.5.13                   19.34.1.5.18                          19.34.1.5.22                                  19.34.1.5.25    19.34.1.7.5           19.34.1.7.13                   19.34.1.7.18                          19.34.1.7.22                                  19.34.1.7.25    19.34.1.46.5           19.34.1.46.13                   19.34.1.46.18                          19.34.1.46.22                                  46.25    19.34.1.47.5           19.34.1.47.13                   19.34.1.47.18                          19.34.1.47.22                                  47.25    19.34.2.1.5           19.34.2.1.13                   19.34.2.1.18                          19.34.2.1.22                                  19.34.2.1.25    19.34.2.2.5           19.34.2.2.13                   19.34.2.2.18                          19.34.2.2.22                                  19.34.1.2.25    19.34.2.5.5           19.34.2.5.13                   19.34.2.5.18                          19.34.2.5.22                                  19.34.1.5.25    19.34.2.7.5           19.34.2.7.13                   19.34.2.7.18                          19.34.2.7.22                                  19.34.1.7.25    19.34.2.46.5           19.34.2.46.13                   19.34.2.46.18                          19.34.2.46.22                                  19.34.2.46.25    19.34.2.47.5           19.34.2.47.13                   19.34.2.47.18                          19.34.2.47.22                                  19.34.2.47.25    19.34.6.1.5           19.34.6.1.13                   19.34.6.1.18                          19.34.6.1.22                                  19.34.6.1.25    19.34.6.2.5           19.34.6.2.13                   19.34.6.2.18                          19.34.6.2.22                                  19.34.6.2.25    19.34.6.5.5           19.34.6.5.13                   19.34.6.5.18                          19.34.6.5.22                                  19.34.6.5.25    19.34.6.7.5           19.34.6.7.13                   19.34.6.7.18                          19.34.6.7.22                                  19.34.6.7.25    19.34.6.46.5           19.34.6.46.13                   19.34.6.46.18                          19.34.6.46.22                                  19.34.6.46.25    19.34.6.47.5           19.34.6.47.13                   19.34.6.47.18                          19.34.6.47.22                                  19.34.6.47.25    19.34.7.1.5           19.34.7.1.13                   19.34.7.1.18                          19.34.7.1.22                                  19.34.7.1.25    19.34.7.2.5           19.34.7.2.13                   19.34.7.2.18                          19.34.7.2.22                                  19.34.7.2.25    19.34.7.5.5           19.34.7.5.13                   19.34.7.5.18                          19.34.7.5.22                                  19.34.7.5.25    19.34.7.7.5           19.34.7.7.13                   19.34.7.7.18                          19.34.7.7.22                                  19.34.7.7.25    19.34.7.46.5           19.34.7.46.13                   19.34.7.46.18                          19.34.7.46.22                                  19.34.7.46.25    19.34.7.47.5           19.34.7.47.13                   19.34.7.47.18                          19.34.7.47.22                                  19.34.7.47.25    19.34.8.1.5           19.34.8.1.13                   19.34.8.1.18                          19.34.8.1.22                                  19.34.8.1.25    19.34.8.2.5           19.34.8.2.13                   19.34.8.2.18                          19.34.8.2.22                                  19.34.8.2.25    19.34.8.5.5           19.34.8.5.13                   19.34.8.5.18                          19.34.8.5.22                                  19.34.8.5.25    19.34.8.7.5           19.34.8.7.13                   19.34.8.7.18                          19.34.8.7.22                                  19.34.8.7.25    19.34.8.46.5           19.34.8.46.13                   19.34.8.46.18                          19.34.8.46.22                                  19.34.8.46.25    19.34.8.47.5           19.34.8.47.13                   19.34.8.47.18                          19.34.8.47.22                                  19.34.8.47.25    19.34.9.1.5           19.34.9.1.13                   19.34.9.1.18                          19.34.9.1.22                                  19.34.9.1.25    19.34.9.2.5           19.34.9.2.13                   19.34.9.2.18                          19.34.9.2.22                                  19.34.9.2.25    19.34.9.5.5           19.34.9.5.13                   19.34.9.5.18                          19.34.9.5.22                                  19.34.9.5.25    19.34.9.7.5           19.34.9.7.13                   19.34.9.7.18                          19.34.9.7.22                                  19.34.9.7.25    19.34.9.46.5           19.34.9.46.13                   19.34.9.46.18                          19.34.9.46.22                                  19.34.9.46.25    19.34.9.47.5           19.34.9.47.13                   19.34.9.47.18                          19.34.9.47.22                                  19.34.9.47.25    19.34.10.1.5           19.34.10.1.13                   19.34.10.1.18                          19.34.10.1.22                                  19.34.10.1.25    19.34.10.2.5           19.34.10.2.13                   19.34.10.2.18                          19.34.10.2.22                                  19.34.10.2.25    19.34.10.5.5           19.34.10.5.13                   19.34.10.5.18                          19.34.10.5.22                                  19.34.10.5.25    19.34.10.7.5           19.34.10.7.13                   19.34.10.7.18                          19.34.10.7.22                                  19.34.10.7.25    19.34.10.46.5           19.34.10.46.13                   19.34.10.46.18                          19.34.10.46.22                                  19.34.10.46.25    19.34.10.47.5           19.34.10.47.13                   19.34.10.47.18                          19.34.10.47.22                                  19.34.10.47.25    19.37.1.1.5           19.37.1.1.13                   19.37.1.1.18                          19.37.1.1.22                                  19.37.1.1.25    19.37.1.2.5           19.37.1.2.13                   19.37.1.2.18                          19.37.1.2.22                                  19.37.1.2.25    19.37.1.5.5           19.37.1.5.13                   19.37.1.5.18                          19.37.1.5.22                                  19.37.1.5.25    19.37.1.7.5           19.37.1.7.13                   19.37.1.7.18                          19.37.1.7.22                                  19.37.1.7.25    19.37.1.46.5           19.37.1.46.13                   19.37.1.46.18                          19.37.1.46.22                                  19.37.1.46.25    19.37.1.47.5           19.37.1.47.13                   19.37.1.47.18                          19.37.1.47.22                                  19.37.1.47.25    19.37.2.1.5           19.37.2.1.13                   19.37.2.1.18                          19.37.2.1.22                                  19.37.2.1.25    19.37.2.2.5           19.37.2.2.13                   19.37.2.2.18                          19.37.2.2.22                                  19.37.2.2.25    19.37.2.5.5           19.37.2.5.13                   19.37.2.5.18                          19.37.2.5.22                                  19.37.2.5.25    19.37.2.7.5           19.37.2.7.13                   19.37.2.7.18                          19.37.2.7.22                                  19.37.2.7.25    19.37.2.46.5           19.37.2.46.13                   19.37.2.46.18                          19.37.2.46.22                                  19.37.2.46.25    19.37.2.47.5           19.37.2.47.13                   19.37.2.47.18                          19.37.2.47.22                                  19.37.2.47.25    19.37.6.1.5           19.37.6.1.13                   19.37.6.1.18                          19.37.6.1.22                                  19.37.6.1.25    19.37.6.2.5           19.37.6.2.13                   19.37.6.2.18                          19.37.6.2.22                                  19.37.6.2.25    19.37.6.5.5           19.37.6.5.13                   19.37.6.5.18                          19.37.6.5.22                                  19.37.6.5.25    19.37.6.7.5           19.37.6.7.13                   19.37.6.7.18                          19.37.6.7.22                                  19.37.6.7.25    19.37.6.46.5           19.37.6.46.13                   19.37.6.46.18                          19.37.6.46.22                                  19.37.6.46.25    19.37.6.47.5           19.37.6.47.13                   19.37.6.47.18                          19.37.6.47.22                                  19.37.6.47.25    19.37.7.1.5           19.37.7.1.13                   19.37.7.1.18                          19.37.7.1.22                                  19.37.7.1.25    19.37.7.2.5           19.37.7.2.13                   19.37.7.2.18                          19.37.7.2.22                                  19.37.7.2.25    19.37.7.5.5           19.37.7.5.13                   19.37.7.5.18                          19.37.7.5.22                                  19.37.7.5.25    19.37.7.7.5           19.37.7.7.13                   19.37.7.7.18                          19.37.7.7.22                                  19.37.7.7.25    19.37.7.46.5           19.37.7.46.13                   19.37.7.46.18                          19.37.7.46.22                                  19.37.7.46.25    19.37.7.47.5           19.37.7.47.13                   19.37.7.47.18                          19.37.7.47.22                                  19.37.7.47.25    19.37.8.1.5           19.37.8.1.13                   19.37.8.1.18                          19.37.8.1.22                                  19.37.8.1.25    19.37.8.2.5           19.37.8.2.13                   19.37.8.2.18                          19.37.8.2.22                                  19.37.8.2.25    19.37.8.5.5           19.37.8.5.13                   19.37.8.5.18                          19.37.8.5.22                                  19.37.8.5.25    19.37.8.7.5           19.37.8.7.13                   19.37.8.7.18                          19.37.8.7.22                                  19.37.8.7.25    19.37.8.46.5           19.37.8.46.13                   19.37.8.46.18                          19.37.8.46.22                                  19.37.8.46.25    19.37.8.47.5           19.37.8.47.13                   19.37.8.47.18                          19.37.8.47.22                                  19.37.8.47.25    19.37.9.1.5           19.37.9.1.13                   19.37.9.1.18                          19.37.9.1.22                                  19.37.9.1.25    19.37.9.2.5           19.37.9.2.13                   19.37.9.2.18                          19.37.9.2.22                                  19.37.9.2.25    19.37.9.5.5           19.37.9.5.13                   19.37.9.5.18                          19.37.9.5.22                                  19.37.9.5.25    19.37.9.7.5           19.37.9.7.13                   19.37.9.7.18                          19.37.9.7.22                                  19.37.9.7.25    19.37.9.46.5           19.37.9.46.13                   19.37.9.46.18                          19.37.9.46.22                                  19.37.9.46.25    19.37.9.47.5           19.37.9.47.13                   19.37.9.47.18                          19.37.9.47.22                                  19.37.9.47.25    19.37.10.1.5           19.37.10.1.13                   19.37.10.1.18                          19.37.10.1.22                                  19.37.10.1.25    19.37.10.2.5           19.37.10.2.13                   19.37.10.2.18                          19.37.10.2.22                                  19.37.10.2.25    19.37.10.5.5           19.37.10.5.13                   19.37.10.5.18                          19.37.10.5.22                                  19.37.10.5.25    19.37.10.7.5           19.37.10.7.13                   19.37.10.7.18                          19.37.10.7.22                                  19.37.10.7.25    19.37.10.46.5           19.37.10.46.13                   19.37.10.46.18                          19.37.10.46.22                                  19.37.10.46.25    19.37.10.47.5           19.37.10.47.13                   19.37.10.47.18                          19.37.10.47.22                                  19.37.10.47.25    20.17.1.1.5           20.17.1.1.13                   20.17.1.1.18                          20.17.1.1.22                                  20.17.1.1.25    20.17.1.2.5           20.17.1.2.13                   20.17.1.2.18                          20.17.1.2.22                                  20.17.1.2.25    20.17.1.5.5           20.17.1.5.13                   20.17.1.5.18                          20.17.1.5.22                                  20.17.1.5.25    20.17.1.7.5           20.17.1.7.13                   20.17.1.7.18                          20.17.1.7.22                                  20.17.1.7.25    20.17.1.46.5           20.17.1.46.13                   20.17.1.46.18                          20.17.1.46.22                                  20.17.1.46.25    20.17.1.47.5           20.17.1.47.13                   20.17.1.47.18                          20.17.1.47.22                                  20.17.1.47.25    20.17.2.1.5           20.17.2.1.13                   20.17.2.1.18                          20.17.2.1.22                                  20.17.2.1.25    20.17.2.2.5           20.17.2.2.13                   20.17.2.2.18                          20.17.2.2.22                                  20.17.2.2.25    20.17.2.5.5           20.17.2.5.13                   20.17.2.5.18                          20.17.2.5.22                                  20.17.2.5.25    20.17.2.7.5           20.17.2.7.13                   20.17.2.7.18                          20.17.2.7.22                                  20.17.2.7.25    20.17.2.46.5           20.17.2.46.13                   20.17.2.46.18                          20.17.2.46.22                                  20.17.2.46.25    20.17.2.47.5           20.17.2.47.13                   20.17.2.47.18                          20.17.2.47.22                                  20.17.2.47.25    20.17.6.1.5           20.17.6.1.13                   20.17.6.1.18                          20.17.6.1.22                                  20.17.6.1.25    20.17.6.2.5           20.17.6.2.13                   20.17.6.2.18                          20.17.6.2.22                                  20.17.6.2.25    20.17.6.5.5           20.17.6.5.13                   20.17.6.5.18                          20.17.6.5.22                                  20.17.6.5.25    20.17.6.7.5           20.17.6.7.13                   20.17.6.7.18                          20.17.6.7.22                                  20.17.6.7.25    20.17.6.46.5           20.17.6.46.13                   20.17.6.46.18                          20.17.6.46.22                                  20.17.6.46.25    20.17.6.47.5           20.17.6.47.13                   20.17.6.47.18                          20.17.6.47.22                                  20.17.6.47.25    20.17.7.1.5           20.17.7.1.13                   20.17.7.1.18                          20.17.7.1.22                                  20.17.7.1.25    20.17.7.2.5           20.17.7.2.13                   20.17.7.2.18                          20.17.7.2.22                                  20.17.7.2.25    20.17.7.5.5           20.17.7.5.13                   20.17.7.5.18                          20.17.7.5.22                                  20.17.7.5.25    20.17.7.7.5           20.17.7.7.13                   20.17.7.7.18                          20.17.7.7.22                                  20.17.7.7.25    20.17.7.46.5           20.17.7.46.13                   20.17.7.46.18                          20.17.7.46.22                                  20.17.7.46.25    20.17.7.47.5           20.17.7.47.13                   20.17.7.47.18                          20.17.7.47.22                                  20.17.7.47.25    20.17.8.1.5           20.17.8.1.13                   20.17.8.1.18                          20.17.8.1.22                                  20.17.8.1.25    20.17.8.2.5           20.17.8.2.13                   20.17.8.2.18                          20.17.8.2.22                                  20.17.8.2.25    20.17.8.5.5           20.17.8.5.13                   20.17.8.5.18                          20.17.8.5.22                                  20.17.8.5.25    20.17.8.7.5           20.17.8.7.13                   20.17.8.7.18                          20.17.8.7.22                                  20.17.8.7.25    20.17.8.46.5           20.17.8.46.13                   20.17.8.46.18                          20.17.8.46.22                                  20.17.8.46.25    20.17.8.47.5           20.17.8.47.13                   20.17.8.47.18                          20.17.8.47.22                                  20.17.8.47.25    20.17.9.1.5           20.17.9.1.13                   20.17.9.1.18                          20.17.9.1.22                                  20.17.9.1.25    20.17.9.2.5           20.17.9.2.13                   20.17.9.2.18                          20.17.9.2.22                                  20.17.9.2.25    20.17.9.5.5           20.17.9.5.13                   20.17.9.5.18                          20.17.9.5.22                                  20.17.9.5.25    20.17.9.7.5           20.17.9.7.13                   20.17.9.7.18                          20.17.9.7.22                                  20.17.9.7.25    20.17.9.46.5           20.17.9.46.13                   20.17.9.46.18                          20.17.9.46.22                                  20.17.9.46.25    20.17.9.47.5           20.17.9.47.13                   20.17.9.47.18                          20.17.9.47.22                                  20.17.9.47.25    20.17.10.1.5           20.17.10.1.13                   20.17.10.1.18                          20.17.10.1.22                                  20.17.10.1.25    20.17.10.2.5           20.17.10.2.13                   20.17.10.2.18                          20.17.10.2.22                                  20.17.10.2.25    20.17.10.5.5           20.17.10.5.13                   20.17.10.5.18                          20.17.10.5.22                                  20.17.10.5.25    20.17.10.7.5           20.17.10.7.13                   20.17.10.7.18                          20.17.10.7.22                                  20.17.10.7.25    20.17.10.46.5           20.17.10.46.13                   20.17.10.46.18                          20.17.10.46.22                                  20.17.10.46.25    20.17.10.47.5           20.17.10.47.13                   20.17.10.47.18                          20.17.10.47.22                                  20.17.10.47.25    20.18.1.1.5           20.18.1.1.13                   20.18.1.1.18                          20.18.1.1.22                                  20.18.1.1.25    20.18.1.2.5           20.18.1.2.13                   20.18.1.2.18                          20.18.1.2.22                                  20.18.1.2.25    20.18.1.5.5           20.18.1.5.13                   20.18.1.5.18                          20.18.1.5.22                                  20.18.1.5.25    20.18.1.7.5           20.18.1.7.13                   20.18.1.7.18                          20.18.1.7.22                                  20.18.1.7.25    20.18.1.46.5           20.18.1.46.13                   20.18.1.46.18                          20.18.1.46.22                                  20.18.1.46.25    20.18.1.47.5           20.18.1.47.13                   20.18.1.47.18                          20.18.1.47.22                                  20.18.1.47.25    20.18.2.1.5           20.18.1.1.13                   20.18.1.1.18                          20.18.1.1.22                                  20.18.1.1.25    20.18.2.2.5           20.18.1.2.13                   20.18.1.2.18                          20.18.1.2.22                                  20.18.1.2.25    20.18.2.5.5           20.18.1.5.13                   20.18.1.5.18                          20.18.1.5.22                                  20.18.1.5.25    20.18.2.7.5           20.18.1.7.13                   20.18.1.7.18                          20.18.1.7.22                                  20.18.1.7.25    20.18.2.46.5           20.18.1.46.13                   20.18.1.46.18                          20.18.1.46.22                                  20.18.1.46.25    20.18.2.47.5           20.18.1.47.13                   20.18.1.47.18                          20.18.1.47.22                                  20.18.1.47.25    20.18.6.1.5           20.18.6.1.13                   20.18.6.1.18                          20.18.6.1.22                                  20.18.6.1.25    20.18.6.2.5           20.18.6.2.13                   20.18.6.2.18                          20.18.6.2.22                                  20.18.6.2.25    20.18.6.5.5           20.18.6.5.13                   20.18.6.5.18                          20.18.6.5.22                                  20.18.6.5.25    20.18.6.7.5           20.18.6.7.13                   20.18.6.7.18                          20.18.6.7.22                                  20.18.6.7.25    20.18.6.46.5           20.18.6.46.13                   20.18.6.46.18                          20.18.6.46.22                                  20.18.6.46.25    20.18.6.47.5           20.18.6.47.13                   20.18.6.47.18                          20.18.6.47.22                                  20.18.6.47.25    20.18.7.1.5           20.18.7.1.13                   20.18.7.1.18                          20.18.7.1.22                                  20.18.7.1.25    20.18.7.2.5           20.18.7.2.13                   20.18.7.2.18                          20.18.7.2.22                                  20.18.7.2.25    20.18.7.5.5           20.18.7.5.13                   20.18.7.5.18                          20.18.7.5.22                                  20.18.7.5.25    20.18.7.7.5           20.18.7.7.13                   20.18.7.7.18                          20.18.7.7.22                                  20.18.7.7.25    20.18.7.46.5           20.18.7.46.13                   20.18.7.46.18                          20.18.7.46.22                                  20.18.7.46.25    20.18.7.47.5           20.18.7.47.13                   20.18.7.47.18                          20.18.7.47.22                                  20.18.7.47.25    20.18.8.1.5           20.18.8.1.13                   20.18.8.1.18                          20.18.8.1.22                                  20.18.8.1.25    20.18.8.2.5           20.18.8.2.13                   20.18.8.2.18                          20.18.8.2.22                                  20.18.8.2.25    20.18.8.5.5           20.18.8.5.13                   20.18.8.5.18                          20.18.8.5.22                                  5.25    20.18.8.7.5           20.18.8.7.13                   20.18.8.7.18                          20.18.8.7.22                                  20.18.8.7.25    20.18.8.46.5           20.18.8.46.13                   20.18.8.46.18                          20.18.8.46.22                                  20.18.8.46.25    20.18.8.47.5           20.18.8.47.13                   20.18.8.47.18                          20.18.8.47.22                                  20.18.8.47.25    20.18.9.1.5           20.18.9.1.13                   20.18.9.1.18                          20.18.9.1.22                                  20.18.9.1.25    20.18.9.2.5           20.18.9.2.13                   20.18.9.2.18                          20.18.9.2.22                                  20.18.9.2.25    20.18.9.5.5           20.18.9.5.13                   20.18.9.5.18                          20.18.9.5.22                                  20.18.9.5.25    20.18.9.7.5           20.18.9.7.13                   20.18.9.7.18                          20.18.9.7.22                                  20.18.9.7.25    20.18.9.46.5           20.18.9.46.13                   20.18.9.46.18                          20.18.9.46.22                                  20.18.9.46.25    20.18.9.47.5           20.18.9.47.13                   20.18.9.47.18                          20.18.9.47.22                                  20.18.9.47.25    20.18.10.1.5           20.18.10.1.13                   20.18.10.1.18                          20.18.10.1.22                                  20.18.10.1.25    20.18.10.2.5           20.18.10.2.13                   20.18.10.2.18                          20.18.10.2.22                                  20.18.10.2.25    20.18.10.5.5           20.18.10.5.13                   20.18.10.5.18                          20.18.10.5.22                                  20.18.10.5.25    20.18.10.7.5           20.18.10.7.13                   20.18.10.7.18                          20.18.10.7.22                                  20.18.10.7.25    20.18.10.46.5           20.18.10.46.13                   20.18.10.46.18                          20.18.10.46.22                                  20.18.10.46.25    20.18.10.47.5           20.18.10.47.13                   20.18.10.47.18                          20.18.10.47.22                                  20.18.10.47.25    20.19.1.1.5           20.19.1.1.13                   20.19.1.1.18                          20.19.1.1.22                                  20.19.1.1.25    20.19.1.2.5           20.19.1.2.13                   20.19.1.2.18                          20.19.1.2.22                                  20.19.1.2.25    20.19.1.5.5           20.19.1.5.13                   20.19.1.5.18                          20.19.1.5.22                                  20.19.1.5.25    20.19.1.7.5           20.19.1.7.13                   20.19.1.7.18                          20.19.1.7.22                                  20.19.1.7.25    20.19.1.46.5           20.19.1.46.13                   20.19.1.46.18                          20.19.1.46.22                                  20.19.1.46.25    20.19.1.47.5           20.19.1.47.13                   20.19.1.47.18                          20.19.1.47.22                                  20.19.1.47.25    20.19.2.1.5           20.19.2.1.13                   20.19.2.1.18                          20.19.2.1.22                                  20.19.2.1.25    20.19.2.2.5           20.19.2.2.13                   20.19.2.2.18                          20.19.2.2.22                                  20.19.2.2.25    20.19.2.5.5           20.19.2.5.13                   20.19.2.5.18                          20.19.2.5.22                                  20.19.2.5.25    20.19.2.7.5           20.19.2.7.13                   20.19.2.7.18                          20.19.2.7.22                                  20.19.2.7.25    20.19.2.46.5           20.19.2.46.13                   20.19.2.46.18                          20.19.2.46.22                                  20.19.2.46.25    20.19.2.47.5           20.19.2.47.13                   20.19.2.47.18                          20.19.2.47.22                                  20.19.2.47.25    20.19.6.1.5           20.19.6.1.13                   20.19.6.1.18                          20.19.6.1.22                                  20.19.6.1.25    20.19.6.2.5           20.19.6.2.13                   20.19.6.2.18                          20.19.6.2.22                                  20.19.6.2.25    20.19.6.5.5           20.19.6.5.13                   20.19.6.5.18                          20.19.6.5.22                                  20.19.6.5.25    20.19.6.7.5           20.19.6.7.13                   20.19.6.7.18                          20.19.6.7.22                                  20.19.6.7.25    20.19.6.46.5           20.19.6.46.13                   20.19.6.46.18                          20.19.6.46.22                                  20.19.6.46.25    20.19.6.47.5           20.19.6.47.13                   20.19.6.47.18                          20.19.6.47.22                                  20.19.6.47.25    20.19.7.1.5           20.19.7.1.13                   20.19.7.1.18                          20.19.7.1.22                                  20.19.7.1.25    20.19.7.2.5           20.19.7.2.13                   20.19.7.2.18                          20.19.7.2.22                                  20.19.7.2.25    20.19.7.5.5           20.19.7.5.13                   20.19.7.5.18                          20.19.7.5.22                                  20.19.7.5.25    20.19.7.7.5           20.19.7.7.13                   20.19.7.7.18                          20.19.7.7.22                                  20.19.7.7.25    20.19.7.46.5           20.19.7.46.13                   20.19.7.46.18                          20.19.7.46.22                                  20.19.7.46.25    20.19.7.47.5           20.19.7.47.13                   20.19.7.47.18                          20.19.7.47.22                                  20.19.7.47.25    20.19.8.1.5           20.19.8.1.13                   20.19.8.1.18                          20.19.8.1.22                                  20.19.8.1.25    20.19.8.2.5           20.19.8.2.13                   20.19.8.2.18                          20.19.8.2.22                                  20.19.8.2.25    20.19.8.5.5           20.19.8.5.13                   20.19.8.5.18                          20.19.8.5.22                                  20.19.8.5.25    20.19.8.7.5           20.19.8.7.13                   20.19.8.7.18                          20.19.8.7.22                                  20.19.8.7.25    20.19.8.46.5           20.19.8.46.13                   20.19.8.46.18                          20.19.8.46.22                                  20.19.8.46.25    20.19.8.47.5           20.19.8.47.13                   20.19.8.47.18                          20.19.8.47.22                                  20.19.8.47.25    20.19.9.1.5           20.19.9.1.13                   20.19.9.1.18                          20.19.9.1.22                                  20.19.9.1.25    20.19.9.2.5           20.19.9.2.13                   20.19.9.2.18                          20.19.9.2.22                                  20.19.9.2.25    20.19.9.5.5           20.19.9.5.13                   20.19.9.5.18                          20.19.9.5.22                                  20.19.9.5.25    20.19.9.7.5           20.19.9.7.13                   20.19.9.7.18                          20.19.9.7.22                                  20.19.9.7.25    20.19.9.46.5           20.19.9.46.13                   20.19.9.46.18                          20.19.9.46.22                                  20.19.9.46.25    20.19.9.47.5           20.19.9.47.13                   20.19.9.47.18                          20.19.9.47.22                                  20.19.9.47.25    20.19.10.1.5           20.19.10.1.13                   20.19.10.1.18                          20.19.10.1.22                                  20.19.10.1.25    20.19.10.2.5           20.19.10.2.13                   20.19.10.2.18                          20.19.10.2.22                                  20.19.10.2.25    20.19.10.5.5           20.19.10.5.13                   20.19.10.5.18                          20.19.10.5.22                                  20.19.10.5.25    20.19.10.7.5           20.19.10.7.13                   20.19.10.7.18                          20.19.10.7.22                                  20.19.10.7.25    20.19.10.46.5           20.19.10.46.13                   20.19.10.46.18                          20.19.10.46.22                                  20.19.10.46.25    20.19.10.47.5           20.19.10.47.13                   20.19.10.47.18                          20.19.10.47.22                                  20.19.10.47.25    20.20.1.1.5           20.20.1.1.13                   20.20.1.1.18                          20.20.1.1.22                                  20.20.1.1.25    20.20.1.2.5           20.20.1.2.13                   20.20.1.2.18                          20.20.1.2.22                                  20.20.1.2.25    20.20.1.5.5           20.20.1.5.13                   20.20.1.5.18                          20.20.1.5.22                                  20.20.1.5.25    20.20.1.7.5           20.20.1.7.13                   20.20.1.7.18                          20.20.1.7.22                                  20.20.1.7.25    20.20.1.46.5           20.20.1.46.13                   20.20.1.46.18                          20.20.1.46.22                                  20.20.1.46.25    20.20.1.47.5           20.20.1.47.13                   20.20.1.47.18                          20.20.1.47.22                                  20.20.1.47.25    20.20.2.1.5           20.20.2.1.13                   20.20.2.1.18                          20.20.2.1.22                                  20.20.2.1.25    20.20.2.2.5           20.20.2.2.13                   20.20.2.2.18                          20.20.2.2.22                                  20.20.2.2.25    20.20.2.5.5           20.20.2.5.13                   20.20.2.5.18                          20.20.2.5.22                                  20.20.2.5.25    20.20.2.7.5           20.20.2.7.13                   20.20.2.7.18                          20.20.2.7.22                                  20.20.2.7.25    20.20.2.46.5           20.20.2.46.13                   20.20.2.46.18                          20.20.2.46.22                                  20.20.2.46.25    20.20.2.47.5           20.20.2.47.13                   20.20.2.47.18                          20.20.2.47.22                                  20.20.2.47.25    20.20.6.1.5           20.20.6.1.13                   20.20.6.1.18                          20.20.6.1.22                                  20.20.6.1.25    20.20.6.2.5           20.20.6.2.13                   20.20.6.2.18                          20.20.6.2.22                                  20.20.6.2.25    20.20.6.5.5           20.20.6.5.13                   20.20.6.5.18                          20.20.6.5.22                                  20.20.6.5.25    20.20.6.7.5           20.20.6.7.13                   20.20.6.7.18                          20.20.6.7.22                                  20.20.6.7.25    20.20.6.46.5           20.20.6.46.13                   20.20.6.46.18                          20.20.6.46.22                                  20.20.6.46.25    20.20.6.47.5           20.20.6.47.13                   20.20.6.47.18                          20.20.6.47.22                                  20.20.6.47.25    20.20.7.1.5           20.20.7.1.13                   20.20.7.1.18                          20.20.7.1.22                                  20.20.7.1.25    20.20.7.2.5           20.20.7.2.13                   20.20.7.2.18                          20.20.7.2.22                                  20.20.7.2.25    20.20.7.5.5           20.20.7.5.13                   20.20.7.5.18                          20.20.7.5.22                                  20.20.7.5.25    20.20.7.7.5           20.20.7.7.13                   20.20.7.7.18                          20.20.7.7.22                                  20.20.7.7.25    20.20.7.46.5           20.20.7.46.13                   20.20.7.46.18                          20.20.7.46.22                                  20.20.7.46.25    20.20.7.47.5           20.20.7.47.13                   20.20.7.47.18                          20.20.7.47.22                                  20.20.7.47.25    20.20.8.1.5           20.20.8.1.13                   20.20.8.1.18                          20.20.8.1.22                                  20.20.8.1.25    20.20.8.2.5           20.20.8.2.13                   20.20.8.2.18                          20.20.8.2.22                                  20.20.8.2.25    20.20.8.5.5           20.20.8.5.13                   20.20.8.5.18                          20.20.8.5.22                                  20.20.8.5.25    20.20.8.7.5           20.20.8.7.13                   20.20.8.7.18                          20.20.8.7.22                                  20.20.8.7.25    20.20.8.46.5           20.20.8.46.13                   20.20.8.46.18                          20.20.8.46.22                                  20.20.8.46.25    20.20.8.47.5           20.20.8.47.13                   20.20.8.47.18                          20.20.8.47.22                                  20.20.8.47.25    20.20.9.1.5           20.20.9.1.13                   20.20.9.1.18                          20.20.9.1.22                                  20.20.9.1.25    20.20.9.2.5           20.20.9.2.13                   20.20.9.2.18                          20.20.9.2.22                                  20.20.9.2.25    20.20.9.5.5           20.20.9.5.13                   20.20.9.5.18                          20.20.9.5.22                                  20.20.9.5.25    20.20.9.7.5           20.20.9.7.13                   20.20.9.7.18                          20.20.9.7.22                                  20.20.9.7.25    20.20.9.46.5           20.20.9.46.13                   20.20.9.46.18                          20.20.9.46.22                                  20.20.9.46.25    20.20.9.47.5           20.20.9.47.13                   20.20.9.47.18                          20.20.9.47.22                                  20.20.9.47.25    20.20.10.1.5           20.20.10.1.13                   20.20.10.1.18                          20.20.10.1.22                                  20.20.10.1.25    20.20.10.2.5           20.20.10.2.13                   20.20.10.2.18                          20.20.10.2.22                                  20.20.10.2.25    20.20.10.5.5           20.20.10.5.13                   20.20.10.5.18                          20.20.10.5.22                                  20.20.10.5.25    20.20.10.7.5           20.20.10.7.13                   20.20.10.7.18                          20.20.10.7.22                                  20.20.10.7.25    20.20.10.46.5           20.20.10.46.13                   20.20.10.46.18                          20.20.10.46.22                                  20.20.10.46.25    20.20.10.47.5           20.20.10.47.13                   20.20.10.47.18                          20.20.10.47.22                                  20.20.10.47.25    20.21.1.1.5           20.21.1.1.13                   20.21.1.1.18                          20.21.1.1.22                                  20.21.1.1.25    20.21.1.2.5           20.21.1.2.13                   20.21.1.2.18                          20.21.1.2.22                                  20.21.1.2.25    20.21.1.5.5           20.21.1.5.13                   20.21.1.5.18                          20.21.1.5.22                                  20.21.1.5.25    20.21.1.7.5           20.21.1.7.13                   20.21.1.7.18                          20.21.1.7.22                                  20.21.1.7.25    20.21.1.46.5           20.21.1.46.13                   20.21.1.46.18                          20.21.1.46.22                                  20.21.1.46.25    20.21.1.47.5           20.21.1.47.13                   20.21.1.47.18                          20.21.1.47.22                                  20.21.1.47.25    20.21.2.1.5           20.21.2.1.13                   20.21.2.1.18                          20.21.2.1.22                                  20.21.2.1.25    20.21.2.2.5           20.21.2.2.13                   20.21.2.2.18                          20.21.2.2.22                                  20.21.2.2.25    20.21.2.5.5           20.21.2.5.13                   20.21.2.5.18                          20.21.2.5.22                                  20.21.2.5.25    20.21.2.7.5           20.21.2.7.13                   20.21.2.7.18                          20.21.2.7.22                                  20.21.2.7.25    20.21.2.46.5           20.21.2.46.13                   20.21.2.46.18                          20.21.2.46.22                                  20.21.2.46.25    20.21.2.47.5           20.21.2.47.13                   20.21.2.47.18                          20.21.2.47.22                                  20.21.2.47.25    20.21.6.1.5           20.21.6.1.13                   20.21.6.1.18                          20.21.6.1.22                                  20.21.6.1.25    20.21.6.2.5           20.21.6.2.13                   20.21.6.2.18                          20.21.6.2.22                                  20.21.6.2.25    20.21.6.5.5           20.21.6.5.13                   20.21.6.5.18                          20.21.6.5.22                                  20.21.6.5.25    20.21.6.7.5           20.21.6.7.13                   20.21.6.7.18                          20.21.6.7.22                                  20.21.6.7.25    20.21.6.46.5           20.21.6.46.13                   20.21.6.46.18                          20.21.6.46.22                                  20.21.6.46.25    20.21.6.47.5           20.21.6.47.13                   20.21.6.47.18                          20.21.6.47.22                                  20.21.6.47.25    20.21.7.1.5           20.21.7.1.13                   20.21.7.1.18                          20.21.7.1.22                                  20.21.7.1.25    20.21.7.2.5           20.21.7.2.13                   20.21.7.2.18                          20.21.7.2.22                                  20.21.7.2.25    20.21.7.5.5           20.21.7.5.13                   20.21.7.5.18                          20.21.7.5.22                                  20.21.7.5.25    20.21.7.7.5           20.21.7.7.13                   20.21.7.7.18                          20.21.7.7.22                                  20.21.7.7.25    20.21.7.46.5           20.21.7.46.13                   20.21.7.46.18                          20.21.7.46.22                                  20.21.7.46.25    20.21.7.47.5           20.21.7.47.13                   20.21.7.47.18                          20.21.7.47.22                                  20.21.7.47.25    20.21.8.1.5           20.21.8.1.13                   20.21.8.1.18                          20.21.8.1.22                                  20.21.8.1.25    20.21.8.2.5           20.21.8.2.13                   20.21.8.2.18                          20.21.8.2.22                                  20.21.8.2.25    20.21.8.5.5           20.21.8.5.13                   20.21.8.5.18                          20.21.8.5.22                                  20.21.8.5.25    20.21.8.7.5           20.21.8.7.13                   20.21.8.7.18                          20.21.8.7.22                                  20.21.8.7.25    20.21.8.46.5           20.21.8.46.13                   20.21.8.46.18                          20.21.8.46.22                                  20.21.8.46.25    20.21.8.47.5           20.21.8.47.13                   20.21.8.47.18                          20.21.8.47.22                                  20.21.8.47.25    20.21.9.1.5           20.21.9.1.13                   20.21.9.1.18                          20.21.9.1.22                                  20.21.9.1.25    20.21.9.2.5           20.21.9.2.13                   20.21.9.2.18                          20.21.9.2.22                                  20.21.9.2.25    20.21.9.5.5           20.21.9.5.13                   20.21.9.5.18                          20.21.9.5.22                                  20.21.9.5.25    20.21.9.7.5           20.21.9.7.13                   20.21.9.7.18                          20.21.9.7.22                                  20.21.9.7.25    20.21.9.46.5           20.21.9.46.13                   20.21.9.46.18                          20.21.9.46.22                                  20.21.9.46.25    20.21.9.47.5           20.21.9.47.13                   20.21.9.47.18                          20.21.9.47.22                                  20.21.9.47.25    20.21.10.1.5           20.21.10.1.13                   20.21.10.1.18                          20.21.10.1.22                                  20.21.10.1.25    20.21.10.2.5           20.21.10.2.13                   20.21.10.2.18                          20.21.10.2.22                                  20.21.10.2.25    20.21.10.5.5           20.21.10.5.13                   20.21.10.5.18                          20.21.10.5.22                                  20.21.10.5.25    20.21.10.7.5           20.21.10.7.13                   20.21.10.7.18                          20.21.10.7.22                                  20.21.10.7.25    20.21.10.46.5           20.21.10.46.13                   20.21.10.46.18                          20.21.10.46.22                                  20.21.10.46.25    20.21.10.47.5           20.21.10.47.13                   20.21.10.47.18                          20.21.10.47.22                                  20.21.10.47.25    20.22.1.1.5           20.22.1.1.13                   20.22.1.1.18                          20.22.1.1.22                                  20.22.1.1.25    20.22.1.2.5           20.22.1.2.13                   20.22.1.2.18                          20.22.1.2.22                                  20.22.1.2.25    20.22.1.5.5           20.22.1.5.13                   20.22.1.5.18                          20.22.1.5.22                                  20.22.1.5.25    20.22.1.7.5           20.22.1.7.13                   20.22.1.7.18                          20.22.1.7.22                                  20.22.1.7.25    20.22.1.46.5           20.22.1.46.13                   20.22.1.46.18                          20.22.1.46.22                                  20.22.1.46.25    20.22.1.47.5           20.22.1.47.13                   20.22.1.47.18                          20.22.1.47.22                                  20.22.1.47.25    20.22.2.1.5           20.22.2.1.13                   20.22.2.1.18                          20.22.2.1.22                                  20.22.2.1.25    20.22.2.2.5           20.22.2.2.13                   20.22.2.2.18                          20.22.2.2.22                                  20.22.2.2.25    20.22.2.5.5           20.22.2.5.13                   20.22.2.5.18                          20.22.2.5.22                                  20.22.2.5.25    20.22.2.7.5           20.22.2.7.13                   20.22.2.7.18                          20.22.2.7.22                                  20.22.2.7.25    20.22.2.46.5           20.22.2.46.13                   20.22.2.46.18                          20.22.2.46.22                                  20.22.2.46.25    20.22.2.47.5           20.22.2.47.13                   20.22.2.47.18                          20.22.2.47.22                                  20.22.2.47.25    20.22.6.1.5           20.22.6.1.13                   20.22.6.1.18                          20.22.6.1.22                                  20.22.6.1.25    20.22.6.2.5           20.22.6.2.13                   20.22.6.2.18                          20.22.6.2.22                                  20.22.6.2.25    20.22.6.5.5           20.22.6.5.13                   20.22.6.5.18                          20.22.6.5.22                                  20.22.6.5.25    20.22.6.7.5           20.22.6.7.13                   20.22.6.7.18                          20.22.6.7.22                                  20.22.6.7.25    20.22.6.46.5           20.22.6.46.13                   20.22.6.46.18                          20.22.6.46.22                                  20.22.6.46.25    20.22.6.47.5           20.22.6.47.13                   20.22.6.47.18                          20.22.6.47.22                                  20.22.6.47.25    20.22.7.1.5           20.22.7.1.13                   20.22.7.1.18                          20.22.7.1.22                                  20.22.7.1.25    20.22.7.2.5           20.22.7.2.13                   20.22.7.2.18                          20.22.7.2.22                                  20.22.7.2.25    20.22.7.5.5           20.22.7.5.13                   20.22.7.5.18                          20.22.7.5.22                                  20.22.7.5.25    20.22.7.7.5           20.22.7.7.13                   20.22.7.7.18                          20.22.7.7.22                                  20.22.7.7.25    20.22.7.46.5           20.22.7.46.13                   20.22.7.46.18                          20.22.7.46.22                                  20.22.7.46.25    20.22.7.47.5           20.22.7.47.13                   20.22.7.47.18                          20.22.7.47.22                                  20.22.7.47.25    20.22.8.1.5           20.22.8.1.13                   20.22.8.1.18                          20.22.8.1.22                                  20.22.8.1.25    20.22.8.2.5           20.22.8.2.13                   20.22.8.2.18                          20.22.8.2.22                                  20.22.8.2.25    20.22.8.5.5           20.22.8.5.13                   20.22.8.5.18                          20.22.8.5.22                                  20.22.8.5.25    20.22.8.7.5           20.22.8.7.13                   20.22.8.7.18                          20.22.8.7.22                                  20.22.8.7.25    20.22.8.46.5           20.22.8.46.13                   20.22.8.46.18                          20.22.8.46.22                                  20.22.8.46.25    20.22.8.47.5           20.22.8.47.13                   20.22.8.47.18                          20.22.8.47.22                                  20.22.8.47.25    20.22.9.1.5           20.22.9.1.13                   20.22.9.1.18                          20.22.9.1.22                                  20.22.9.1.25    20.22.9.2.5           20.22.9.2.13                   20.22.9.2.18                          20.22.9.2.22                                  20.22.9.2.25    20.22.9.5.5           20.22.9.5.13                   20.22.9.5.18                          20.22.9.5.22                                  20.22.9.5.25    20.22.9.7.5           20.22.9.7.13                   20.22.9.7.18                          20.22.9.7.22                                  20.22.9.7.25    20.22.9.46.5           20.22.9.46.13                   20.22.9.46.18                          20.22.9.46.22                                  20.22.9.46.25    20.22.9.47.5           20.22.9.47.13                   20.22.9.47.18                          20.22.9.47.22                                  20.22.9.47.25    20.22.10.1.5           20.22.10.1.13                   20.22.10.1.18                          20.22.10.1.22                                  20.22.10.1.25    20.22.10.2.5           20.22.10.2.13                   20.22.10.2.18                          20.22.10.2.22                                  20.22.10.2.25    20.22.10.5.5           20.22.10.5.13                   20.22.10.5.18                          20.22.10.5.22                                  20.22.10.5.25    20.22.10.7.5           20.22.10.7.13                   20.22.10.7.18                          20.22.10.7.22                                  20.22.10.7.25    20.22.10.46.5           20.22.10.46.13                   20.22.10.46.18                          20.22.10.46.22                                  20.22.10.46.25    20.22.10.47.5           20.22.10.47.13                   20.22.10.47.18                          20.22.10.47.22                                  20.22.10.47.25    20.33.1.1.5           20.33.1.1.13                   20.33.1.1.18                          20.33.1.1.22                                  20.33.1.1.25    20.33.1.2.5           20.33.1.2.13                   20.33.1.2.18                          20.33.1.2.22                                  20.33.1.2.25    20.33.1.5.5           20.33.1.5.13                   20.33.1.5.18                          20.33.1.5.22                                  20.33.1.5.25    20.33.1.7.5           20.33.1.7.13                   20.33.1.7.18                          20.33.1.7.22                                  20.33.1.7.25    20.33.1.46.5           20.33.1.46.13                   20.33.1.46.18                          20.33.1.46.22                                  20.33.1.46.25    20.33.1.47.5           20.33.1.47.13                   20.33.1.47.18                          20.33.1.47.22                                  20.33.1.47.25    20.33.2.1.5           20.33.2.1.13                   20.33.2.1.18                          20.33.2.1.22                                  20.33.2.1.25    20.33.2.2.5           20.33.2.2.13                   20.33.2.2.18                          20.33.2.2.22                                  20.33.2.2.25    20.33.2.5.5           20.33.2.5.13                   20.33.2.5.18                          20.33.2.5.22                                  20.33.2.5.25    20.33.2.7.5           20.33.2.7.13                   20.33.2.7.18                          20.33.2.7.22                                  20.33.2.7.25    20.33.2.46.5           20.33.2.46.13                   20.33.2.46.18                          20.33.2.46.22                                  20.33.2.46.25    20.33.2.47.5           20.33.2.47.13                   20.33.2.47.18                          20.33.2.47.22                                  20.33.2.47.25    20.33.6.1.5           20.33.6.1.13                   20.33.6.1.18                          20.33.6.1.22                                  20.33.6.1.25    20.33.6.2.5           20.33.6.2.13                   20.33.6.2.18                          20.33.6.2.22                                  20.33.6.2.25    20.33.6.5.5           20.33.6.5.13                   20.33.6.5.18                          20.33.6.5.22                                  20.33.6.5.25    20.33.6.7.5           20.33.6.7.13                   20.33.6.7.18                          20.33.6.7.22                                  20.33.6.7.25    20.33.6.46.5           20.33.6.46.13                   20.33.6.46.18                          20.33.6.46.22                                  20.33.6.46.25    20.33.6.47.5           20.33.6.47.13                   20.33.6.47.18                          20.33.6.47.22                                  20.33.6.47.25    20.33.7.1.5           20.33.7.1.13                   20.33.7.1.18                          20.33.7.1.22                                  20.33.7.1.25    20.33.7.2.5           20.33.7.2.13                   20.33.7.2.18                          20.33.7.2.22                                  20.33.7.2.25    20.33.7.5.5           20.33.7.5.13                   20.33.7.5.18                          20.33.7.5.22                                  20.33.7.5.25    20.33.7.7.5           20.33.7.7.13                   20.33.7.7.18                          20.33.7.7.22                                  20.33.7.7.25    20.33.7.46.5           20.33.7.46.13                   20.33.7.46.18                          20.33.7.46.22                                  20.33.7.46.25    20.33.7.47.5           20.33.7.47.13                   20.33.7.47.18                          20.33.7.47.22                                  20.33.7.47.25    20.33.8.1.5           20.33.8.1.13                   20.33.8.1.18                          20.33.8.1.22                                  20.33.8.1.25    20.33.8.2.5           20.33.8.2.13                   20.33.8.2.18                          20.33.8.2.22                                  20.33.8.2.25    20.33.8.5.5           20.33.8.5.13                   20.33.8.5.18                          20.33.8.5.22                                  20.33.8.5.25    20.33.8.7.5           20.33.8.7.13                   20.33.8.7.18                          20.33.8.7.22                                  20.33.8.7.25    20.33.8.46.5           20.33.8.46.13                   20.33.8.46.18                          20.33.8.46.22                                  20.33.8.46.25    20.33.8.47.5           20.33.8.47.13                   20.33.8.47.18                          20.33.8.47.22                                  20.33.8.47.25    20.33.9.1.5           20.33.9.1.13                   20.33.9.1.18                          20.33.9.1.22                                  20.33.9.1.25    20.33.9.2.5           20.33.9.2.13                   20.33.9.2.18                          20.33.9.2.22                                  20.33.9.2.25    20.33.9.5.5           20.33.9.5.13                   20.33.9.5.18                          20.33.9.5.22                                  20.33.9.5.25    20.33.9.7.5           20.33.9.7.13                   20.33.9.7.18                          20.33.9.7.22                                  20.33.9.7.25    20.33.9.46.5           20.33.9.46.13                   20.33.9.46.18                          20.33.9.46.22                                  20.33.9.46.25    20.33.9.47.5           20.33.9.47.13                   20.33.9.47.18                          20.33.9.47.22                                  20.33.9.47.25    20.33.10.1.5           20.33.10.1.13                   20.33.10.1.18                          20.33.10.1.22                                  20.33.10.1.25    20.33.10.2.5           20.33.10.2.13                   20.33.10.2.18                          20.33.10.2.22                                  20.33.10.2.25    20.33.10.5.5           20.33.10.5.13                   20.33.10.5.18                          20.33.10.5.22                                  20.33.10.5.25    20.33.10.7.5           20.33.10.7.13                   20.33.10.7.18                          20.33.10.7.22                                  20.33.10.7.25    20.33.10.46.5           20.33.10.46.13                   20.33.10.46.18                          20.33.10.46.22                                  20.33.10.46.25    20.33.10.47.5           20.33.10.47.13                   20.33.10.47.18                          20.33.10.47.22                                  20.33.10.47.25    20.34.1.1.5           20.34.1.1.13                   20.34.1.1.18                          20.34.1.1.22                                  20.34.1.1.25    20.34.1.2.5           20.34.1.2.13                   20.34.1.2.18                          20.34.1.2.22                                  20.34.1.2.25    20.34.1.5.5           20.34.1.5.13                   20.34.1.5.18                          20.34.1.5.22                                  20.34.1.5.25    20.34.1.7.5           20.34.1.7.13                   20.34.1.7.18                          20.34.1.7.22                                  20.34.1.7.25    20.34.1.46.5           20.34.1.46.13                   20.34.1.46.18                          20.34.1.46.22                                  20.34.1.46.25    20.34.1.47.5           20.34.1.47.13                   20.34.1.47.18                          20.34.1.47.22                                  20.34.1.47.25    20.34.2.1.5           20.34.2.1.13                   20.34.2.1.18                          20.34.2.1.22                                  20.34.2.1.25    20.34.2.2.5           20.34.2.2.13                   20.34.2.2.18                          20.34.2.2.22                                  20.34.2.2.25    20.34.2.5.5           20.34.2.5.13                   20.34.2.5.18                          20.34.2.5.22                                  20.34.2.5.25    20.34.2.7.5           20.34.2.7.13                   20.34.2.7.18                          20.34.2.7.22                                  20.34.2.7.25    20.34.2.46.5           20.34.2.46.13                   20.34.2.46.18                          20.34.2.46.22                                  20.34.2.46.25    20.34.2.47.5           20.34.2.47.13                   20.34.2.47.18                          20.34.2.47.22                                  20.34.2.47.25    20.34.6.1.5           20.34.6.1.13                   20.34.6.1.18                          20.34.6.1.22                                  20.34.6.1.25    20.34.6.2.5           20.34.6.2.13                   20.34.6.2.18                          20.34.6.2.22                                  20.34.6.2.25    20.34.6.5.5           20.34.6.5.13                   20.34.6.5.18                          20.34.6.5.22                                  20.34.6.5.25    20.34.6.7.5           20.34.6.7.13                   20.34.6.7.18                          20.34.6.7.22                                  20.34.6.7.25    20.34.6.46.5           20.34.6.46.13                   20.34.6.46.18                          20.34.6.46.22                                  20.34.6.46.25    20.34.6.47.5           20.34.6.47.13                   20.34.6.47.18                          20.34.6.47.22                                  20.34.6.47.25    20.34.7.1.5           20.34.7.1.13                   20.34.7.1.18                          20.34.7.1.22                                  20.34.7.1.25    20.34.7.2.5           20.34.7.2.13                   20.34.7.2.18                          20.34.7.2.22                                  20.34.7.2.25    20.34.7.5.5           20.34.7.5.13                   20.34.7.5.18                          20.34.7.5.22                                  20.34.7.5.25    20.34.7.7.5           20.34.7.7.13                   20.34.7.7.18                          20.34.7.7.22                                  20.34.7.7.25    20.34.7.46.5           20.34.7.46.13                   20.34.7.46.18                          20.34.7.46.22                                  20.34.7.46.25    20.34.7.47.5           20.34.7.47.13                   20.34.7.47.18                          20.34.7.47.22                                  20.34.7.47.25    20.34.8.1.5           20.34.8.1.13                   20.34.8.1.18                          20.34.8.1.22                                  20.34.8.1.25    20.34.8.2.5           20.34.8.2.13                   20.34.8.2.18                          20.34.8.2.22                                  20.34.8.2.25    20.34.8.5.5           20.34.8.5.13                   20.34.8.5.18                          20.34.8.5.22                                  20.34.8.5.25    20.34.8.7.5           20.34.8.7.13                   20.34.8.7.18                          20.34.8.7.22                                  20.34.8.7.25    20.34.8.46.5           20.34.8.46.13                   20.34.8.46.18                          20.34.8.46.22                                  20.34.8.46.25    20.34.8.47.5           20.34.8.47.13                   20.34.8.47.18                          20.34.8.47.22                                  20.34.8.47.25    20.34.9.1.5           20.34.9.1.13                   20.34.9.1.18                          20.34.9.1.22                                  20.34.9.1.25    20.34.9.2.5           20.34.9.2.13                   20.34.9.2.18                          20.34.9.2.22                                  20.34.9.2.25    20.34.9.5.5           20.34.9.5.13                   20.34.9.5.18                          20.34.9.5.22                                  20.34.9.5.25    20.34.9.7.5           20.34.9.7.13                   20.34.9.7.18                          20.34.9.7.22                                  20.34.9.7.25    20.34.9.46.5           20.34.9.46.13                   20.34.9.46.18                          20.34.9.46.22                                  20.34.9.46.25    20.34.9.47.5           20.34.9.47.13                   20.34.9.47.18                          20.34.9.47.22                                  20.34.9.47.25    20.34.10.1.5           20.34.10.1.13                   20.34.10.1.18                          20.34.10.1.22                                  20.34.10.1.25    20.34.10.2.5           20.34.10.2.13                   20.34.10.2.18                          20.34.10.2.22                                  20.34.10.2.25    20.34.10.5.5           20.34.10.5.13                   20.34.10.5.18                          20.34.10.5.22                                  20.34.10.5.25    20.34.10.7.5           20.34.10.7.13                   20.34.10.7.18                          20.34.10.7.22                                  20.34.10.7.25    20.34.10.46.5           20.34.10.46.13                   20.34.10.46.18                          20.34.10.46.22                                  20.34.10.46.25    20.34.10.47.5           20.34.10.47.13                   20.34.10.47.18                          20.34.10.47.22                                  20.34.10.47.25    20.37.1.1.5           20.37.1.1.13                   20.37.1.1.18                          20.37.1.1.22                                  20.37.1.1.25    20.37.1.2.5           20.37.1.2.13                   20.37.1.2.18                          20.37.1.2.22                                  20.37.1.2.25    20.37.1.5.5           20.37.1.5.13                   20.37.1.5.18                          20.37.1.5.22                                  20.37.1.5.25    20.37.1.7.5           20.37.1.7.13                   20.37.1.7.18                          20.37.1.7.22                                  20.37.1.7.25    20.37.1.46.5           20.37.1.46.13                   20.37.1.46.18                          20.37.1.46.22                                  20.37.1.46.25    20.37.1.47.5           20.37.1.47.13                   20.37.1.47.18                          20.37.1.47.22                                  20.37.1.47.25    20.37.2.1.5           20.37.2.1.13                   20.37.2.1.18                          20.37.2.1.22                                  20.37.2.1.25    20.37.2.2.5           20.37.2.2.13                   20.37.2.2.18                          20.37.2.2.22                                  20.37.2.2.25    20.37.2.5.5           20.37.2.5.13                   20.37.2.5.18                          20.37.2.5.22                                  20.37.2.5.25    20.37.2.7.5           20.37.2.7.13                   20.37.2.7.18                          20.37.2.7.22                                  20.37.2.7.25    20.37.2.46.5           20.37.2.46.13                   20.37.2.46.18                          20.37.2.46.22                                  20.37.2.46.25    20.37.2.47.5           20.37.2.47.13                   20.37.2.47.18                          20.37.2.47.22                                  20.37.2.47.25    20.37.6.1.5           20.37.6.1.13                   20.37.6.1.18                          20.37.6.1.22                                  20.37.6.1.25    20.37.6.2.5           20.37.6.2.13                   20.37.6.2.18                          20.37.6.2.22                                  20.37.6.2.25    20.37.6.5.5           20.37.6.5.13                   20.37.6.5.18                          20.37.6.5.22                                  20.37.6.5.25    20.37.6.7.5           20.37.6.7.13                   20.37.6.7.18                          20.37.6.7.22                                  20.37.6.7.25    20.37.6.46.5           20.37.6.46.13                   20.37.6.46.18                          20.37.6.46.22                                  20.37.6.46.25    20.37.6.47.5           20.37.6.47.13                   20.37.6.47.18                          20.37.6.47.22                                  20.37.6.47.25    20.37.7.1.5           20.37.7.1.13                   20.37.7.1.18                          20.37.7.1.22                                  20.37.7.1.25    20.37.7.2.5           20.37.7.2.13                   20.37.7.2.18                          20.37.7.2.22                                  20.37.7.2.25    20.37.7.5.5           20.37.7.5.13                   20.37.7.5.18                          20.37.7.5.22                                  20.37.7.5.25    20.37.7.7.5           20.37.7.7.13                   20.37.7.7.18                          20.37.7.7.22                                  20.37.7.7.25    20.37.7.46.5           20.37.7.46.13                   20.37.7.46.18                          20.37.7.46.22                                  20.37.7.46.25    20.37.7.47.5           20.37.7.47.13                   20.37.7.47.18                          20.37.7.47.22                                  20.37.7.47.25    20.37.8.1.5           20.37.8.1.13                   20.37.8.1.18                          20.37.8.1.22                                  20.37.8.1.25    20.37.8.2.5           20.37.8.2.13                   20.37.8.2.18                          20.37.8.2.22                                  20.37.8.2.25    20.37.8.5.5           20.37.8.5.13                   20.37.8.5.18                          20.37.8.5.22                                  20.37.8.5.25    20.37.8.7.5           20.37.8.7.13                   20.37.8.7.18                          20.37.8.7.22                                  20.37.8.7.25    20.37.8.46.5           20.37.8.46.13                   20.37.8.46.18                          20.37.8.46.22                                  20.37.8.46.25    20.37.8.47.5           20.37.8.47.13                   20.37.8.47.18                          20.37.8.47.22                                  20.37.8.47.25    20.37.9.1.5           20.37.9.1.13                   20.37.9.1.18                          20.37.9.1.22                                  20.37.9.1.25    20.37.9.2.5           20.37.9.2.13                   20.37.9.2.18                          20.37.9.2.22                                  20.37.9.2.25    20.37.9.5.5           20.37.9.5.13                   20.37.9.5.18                          20.37.9.5.22                                  20.37.9.5.25    20.37.9.7.5           20.37.9.7.13                   20.37.9.7.18                          20.37.9.7.22                                  20.37.9.7.25    20.37.9.46.5           20.37.9.46.13                   20.37.9.46.18                          20.37.9.46.22                                  20.37.9.46.25    20.37.9.47.5           20.37.9.47.13                   20.37.9.47.18                          20.37.9.47.22                                  20.37.9.47.25    20.37.10.1.5           20.37.10.1.13                   20.37.10.1.18                          20.37.10.1.22                                  20.37.10.1.25    20.37.10.2.5           20.37.10.2.13                   20.37.10.2.18                          20.37.10.2.22                                  20.37.10.2.25    20.37.10.5.5           20.37.10.5.13                   20.37.10.5.18                          20.37.10.5.22                                  20.37.10.5.25    20.37.10.7.5           20.37.10.7.13                   20.37.10.7.18                          20.37.10.7.22                                  20.37.10.7.25    20.37.10.46.5           20.37.10.46.13                   20.37.10.46.18                          20.37.10.46.22                                  20.37.10.46.25    20.37.10.47.5           20.37.10.47.13                   20.37.10.47.18                          20.37.10.47.22                                  20.37.10.47.25    21.17.1.1.5           21.17.1.1.13                   21.17.1.1.18                          21.17.1.1.22                                  21.17.1.1.25    21.17.1.2.5           21.17.1.2.13                   21.17.1.2.18                          21.17.1.2.22                                  21.17.1.2.25    21.17.1.5.5           21.17.1.5.13                   21.17.1.5.18                          21.17.1.5.22                                  21.17.1.5.25    21.17.1.7.5           21.17.1.7.13                   21.17.1.7.18                          21.17.1.7.22                                  21.17.1.7.25    21.17.1.46.5           21.17.1.46.13                   21.17.1.46.18                          21.17.1.46.22                                  21.17.1.46.25    21.17.1.47.5           21.17.1.47.13                   21.17.1.47.18                          21.17.1.47.22                                  21.17.1.47.25    21.17.2.1.5           21.17.2.1.13                   21.17.2.1.18                          21.17.2.1.22                                  21.17.2.1.25    21.17.2.2.5           21.17.2.2.13                   21.17.2.2.18                          21.17.2.2.22                                  21.17.2.2.25    21.17.2.5.5           21.17.2.5.13                   21.17.2.5.18                          21.17.2.5.22                                  21.17.2.5.25    21.17.2.7.5           21.17.2.7.13                   21.17.2.7.18                          21.17.2.7.22                                  21.17.2.7.25    21.17.2.46.5           21.17.2.46.13                   21.17.2.46.18                          21.17.2.46.22                                  21.17.2.46.25    21.17.2.47.5           21.17.2.47.13                   21.17.2.47.18                          21.17.2.47.22                                  21.17.2.47.25    21.17.6.1.5           21.17.6.1.13                   21.17.6.1.18                          21.17.6.1.22                                  21.17.6.1.25    21.17.6.2.5           21.17.6.2.13                   21.17.6.2.18                          21.17.6.2.22                                  21.17.6.2.25    21.17.6.5.5           21.17.6.5.13                   21.17.6.5.18                          21.17.6.5.22                                  21.17.6.5.25    21.17.6.7.5           21.17.6.7.13                   21.17.6.7.18                          21.17.6.7.22                                  21.17.6.7.25    21.17.6.46.5           21.17.6.46.13                   21.17.6.46.18                          21.17.6.46.22                                  21.17.6.46.25    21.17.6.47.5           21.17.6.47.13                   21.17.6.47.18                          21.17.6.47.22                                  21.17.6.47.25    21.17.7.1.5           21.17.7.1.13                   21.17.7.1.18                          21.17.7.1.22                                  21.17.7.1.25    21.17.7.2.5           21.17.7.2.13                   21.17.7.2.18                          21.17.7.2.22                                  21.17.7.2.25    21.17.7.5.5           21.17.7.5.13                   21.17.7.5.18                          21.17.7.5.22                                  21.17.7.5.25    21.17.7.7.5           21.17.7.7.13                   21.17.7.7.18                          21.17.7.7.22                                  21.17.7.7.25    21.17.7.46.5           21.17.7.46.13                   21.17.7.46.18                          21.17.7.46.22                                  21.17.7.46.25    21.17.7.47.5           21.17.7.47.13                   21.17.7.47.18                          21.17.7.47.22                                  21.17.7.47.25    21.17.8.1.5           21.17.8.1.13                   21.17.8.1.18                          21.17.8.1.22                                  21.17.8.1.25    21.17.8.2.5           21.17.8.2.13                   21.17.8.2.18                          21.17.8.2.22                                  21.17.8.2.25    21.17.8.5.5           21.17.8.5.13                   21.17.8.5.18                          21.17.8.5.22                                  21.17.8.5.25    21.17.8.7.5           21.17.8.7.13                   21.17.8.7.18                          21.17.8.7.22                                  21.17.8.7.25    21.17.8.46.5           21.17.8.46.13                   21.17.8.46.18                          21.17.8.46.22                                  21.17.8.46.25    21.17.8.47.5           21.17.8.47.13                   21.17.8.47.18                          21.17.8.47.22                                  21.17.8.47.25    21.17.9.1.5           21.17.9.1.13                   21.17.9.1.18                          21.17.9.1.22                                  21.17.9.1.25    21.17.9.2.5           21.17.9.2.13                   21.17.9.2.18                          21.17.9.2.22                                  21.17.9.2.25    21.17.9.5.5           21.17.9.5.13                   21.17.9.5.18                          21.17.9.5.22                                  21.17.9.5.25    21.17.9.7.5           21.17.9.7.13                   21.17.9.7.18                          21.17.9.7.22                                  21.17.9.7.25    21.17.9.46.5           21.17.9.46.13                   21.17.9.46.18                          21.17.9.46.22                                  21.17.9.46.25    21.17.9.47.5           21.17.9.47.13                   21.17.9.47.18                          21.17.9.47.22                                  21.17.9.47.25    21.17.10.1.5           21.17.10.1.13                   21.17.10.1.18                          21.17.10.1.22                                  21.17.10.1.25    21.17.10.2.5           21.17.10.2.13                   21.17.10.2.18                          21.17.10.2.22                                  21.17.10.2.25    21.17.10.5.5           21.17.10.5.13                   21.17.10.5.18                          21.17.10.5.22                                  21.17.10.5.25    21.17.10.7.5           21.17.10.7.13                   21.17.10.7.18                          21.17.10.7.22                                  21.17.10.7.25    21.17.10.46.5           21.17.10.46.13                   21.17.10.46.18                          21.17.10.46.22                                  21.17.10.46.25    21.17.10.47.5           21.17.10.47.13                   21.17.10.47.18                          21.17.10.47.22                                  21.17.10.47.25    21.18.1.1.5           21.18.1.1.13                   21.18.1.1.18                          21.18.1.1.22                                  21.18.1.1.25    21.18.1.2.5           21.18.1.2.13                   21.18.1.2.18                          21.18.1.2.22                                  21.18.1.2.25    21.18.1.5.5           21.18.1.5.13                   21.18.1.5.18                          21.18.1.5.22                                  21.18.1.5.25    21.18.1.7.5           21.18.1.7.13                   21.18.1.7.18                          21.18.1.7.22                                  21.18.1.7.25    21.18.1.46.5           21.18.1.46.13                   21.18.1.46.18                          21.18.1.46.22                                  21.18.1.46.25    21.18.1.47.5           21.18.1.47.13                   21.18.1.47.18                          21.18.1.47.22                                  21.18.1.47.25    21.18.2.1.5           21.18.2.1.13                   21.18.2.1.18                          21.18.2.1.22                                  21.18.2.1.25    21.18.2.2.5           21.18.2.2.13                   21.18.2.2.18                          21.18.2.2.22                                  21.18.2.2.25    21.18.2.5.5           21.18.2.5.13                   21.18.2.5.18                          21.18.2.5.22                                  21.18.2.5.25    21.18.2.7.5           21.18.2.7.13                   21.18.2.7.18                          21.18.2.7.22                                  21.18.2.7.25    21.18.2.46.5           21.18.2.46.13                   21.18.2.46.18                          21.18.2.46.22                                  21.18.2.46.25    21.18.2.47.5           21.18.2.47.13                   21.18.2.47.18                          21.18.2.47.22                                  21.18.2.47.25    21.18.6.1.5           21.18.6.1.13                   21.18.6.1.18                          21.18.6.1.22                                  21.18.6.1.25    21.18.6.2.5           21.18.6.2.13                   21.18.6.2.18                          21.18.6.2.22                                  21.18.6.2.25    21.18.6.5.5           21.18.6.5.13                   21.18.6.5.18                          21.18.6.5.22                                  21.18.6.5.25    21.18.6.7.5           21.18.6.7.13                   21.18.6.7.18                          21.18.6.7.22                                  21.18.6.7.25    21.18.6.46.5           21.18.6.46.13                   21.18.6.46.18                          21.18.6.46.22                                  21.18.6.46.25    21.18.6.47.5           21.18.6.47.13                   21.18.6.47.18                          21.18.6.47.22                                  21.18.6.47.25    21.18.7.1.5           21.18.7.1.13                   21.18.7.1.18                          21.18.7.1.22                                  21.18.7.1.25    21.18.7.2.5           21.18.7.2.13                   21.18.7.2.18                          21.18.7.2.22                                  21.18.7.2.25    21.18.7.5.5           21.18.7.5.13                   21.18.7.5.18                          21.18.7.5.22                                  21.18.7.5.25    21.18.7.7.5           21.18.7.7.13                   21.18.7.7.18                          21.18.7.7.22                                  21.18.7.7.25    21.18.7.46.5           21.18.7.46.13                   21.18.7.46.18                          21.18.7.46.22                                  21.18.7.46.25    21.18.7.47.5           21.18.7.47.13                   21.18.7.47.18                          21.18.7.47.22                                  21.18.7.47.25    21.18.8.1.5           21.18.8.1.13                   21.18.8.1.18                          21.18.8.1.22                                  21.18.8.1.25    21.18.8.2.5           21.18.8.2.13                   21.18.8.2.18                          21.18.8.2.22                                  21.18.8.2.25    21.18.8.5.5           21.18.8.5.13                   21.18.8.5.18                          21.18.8.5.22                                  21.18.8.5.25    21.18.8.7.5           21.18.8.7.13                   21.18.8.7.18                          21.18.8.7.22                                  21.18.8.7.25    21.18.8.46.5           21.18.8.46.13                   21.18.8.46.18                          21.18.8.46.22                                  21.18.8.46.25    21.18.8.47.5           21.18.8.47.13                   21.18.8.47.18                          21.18.8.47.22                                  21.18.8.47.25    21.18.9.1.5           21.18.9.1.13                   21.18.9.1.18                          21.18.9.1.22                                  21.18.9.1.25    21.18.9.2.5           21.18.9.2.13                   21.18.9.2.18                          21.18.9.2.22                                  21.18.9.2.25    21.18.9.5.5           21.18.9.5.13                   21.18.9.5.18                          21.18.9.5.22                                  21.18.9.5.25    21.18.9.7.5           21.18.9.7.13                   21.18.9.7.18                          21.18.9.7.22                                  21.18.9.7.25    21.18.9.46.5           21.18.9.46.13                   21.18.9.46.18                          21.18.9.46.22                                  21.18.9.46.25    21.18.9.47.5           21.18.9.47.13                   21.18.9.47.18                          21.18.9.47.22                                  21.18.9.47.25    21.18.10.1.5           21.18.10.1.13                   21.18.10.1.18                          21.18.10.1.22                                  21.18.10.1.25    21.18.10.2.5           21.18.10.2.13                   21.18.10.2.18                          21.18.10.2.22                                  21.18.10.2.25    21.18.10.5.5           21.18.10.5.13                   21.18.10.5.18                          21.18.10.5.22                                  21.18.10.5.25    21.18.10.7.5           21.18.10.7.13                   21.18.10.7.18                          21.18.10.7.22                                  21.18.10.7.25    21.18.10.46.5           21.18.10.46.13                   21.18.10.46.18                          21.18.10.46.22                                  21.18.10.46.25    21.18.10.47.5           21.18.10.47.13                   21.18.10.47.18                          21.18.10.47.22                                  21.18.10.47.25    21.19.1.1.5           21.19.1.1.13                   21.19.1.1.18                          21.19.1.1.22                                  21.19.1.1.25    21.19.1.2.5           21.19.1.2.13                   21.19.1.2.18                          21.19.1.2.22                                  21.19.1.2.25    21.19.1.5.5           21.19.1.5.13                   21.19.1.5.18                          21.19.1.5.22                                  21.19.1.5.25    21.19.1.7.5           21.19.1.7.13                   21.19.1.7.18                          21.19.1.7.22                                  21.19.1.7.25    21.19.1.46.5           21.19.1.46.13                   21.19.1.46.18                          21.19.1.46.22                                  21.19.1.46.25    21.19.1.47.5           21.19.1.47.13                   21.19.1.47.18                          21.19.1.47.22                                  21.19.1.47.25    21.19.2.1.5           21.19.2.1.13                   21.19.2.1.18                          21.19.2.1.22                                  21.19.2.1.25    21.19.2.2.5           21.19.2.2.13                   21.19.2.2.18                          21.19.2.2.22                                  21.19.2.2.25    21.19.2.5.5           21.19.2.5.13                   21.19.2.5.18                          21.19.2.5.22                                  21.19.2.5.25    21.19.2.7.5           21.19.2.7.13                   21.19.2.7.18                          21.19.2.7.22                                  21.19.2.7.25    21.19.2.46.5           21.19.2.46.13                   21.19.2.46.18                          21.19.2.46.22                                  21.19.2.46.25    21.19.2.47.5           21.19.2.47.13                   21.19.2.47.18                          21.19.2.47.22                                  21.19.2.47.25    21.19.6.1.5           21.19.6.1.13                   21.19.6.1.18                          21.19.6.1.22                                  21.19.6.1.25    21.19.6.2.5           21.19.6.2.13                   21.19.6.2.18                          21.19.6.2.22                                  21.19.6.2.25    21.19.6.5.5           21.19.6.5.13                   21.19.6.5.18                          21.19.6.5.22                                  21.19.6.5.25    21.19.6.7.5           21.19.6.7.13                   21.19.6.7.18                          21.19.6.7.22                                  21.19.6.7.25    21.19.6.46.5           21.19.6.46.13                   21.19.6.46.18                          21.19.6.46.22                                  21.19.6.46.25    21.19.6.47.5           21.19.6.47.13                   21.19.6.47.18                          21.19.6.47.22                                  21.19.6.47.25    21.19.7.1.5           21.19.7.1.13                   21.19.7.1.18                          21.19.7.1.22                                  21.19.7.1.25    21.19.7.2.5           21.19.7.2.13                   21.19.7.2.18                          21.19.7.2.22                                  21.19.7.2.25    21.19.7.5.5           21.19.7.5.13                   21.19.7.5.18                          21.19.7.5.22                                  21.19.7.5.25    21.19.7.7.5           21.19.7.7.13                   21.19.7.7.18                          21.19.7.7.22                                  21.19.7.7.25    21.19.7.46.5           21.19.7.46.13                   21.19.7.46.18                          21.19.7.46.22                                  21.19.7.46.25    21.19.7.47.5           21.19.7.47.13                   21.19.7.47.18                          21.19.7.47.22                                  21.19.7.47.25    21.19.8.1.5           21.19.8.1.13                   21.19.8.1.18                          21.19.8.1.22                                  21.19.8.1.25    21.19.8.2.5           21.19.8.2.13                   21.19.8.2.18                          21.19.8.2.22                                  21.19.8.2.25    21.19.8.5.5           21.19.8.5.13                   21.19.8.5.18                          21.19.8.5.22                                  21.19.8.5.25    21.19.8.7.5           21.19.8.7.13                   21.19.8.7.18                          21.19.8.7.22                                  21.19.8.7.25    21.19.8.46.5           21.19.8.46.13                   21.19.8.46.18                          21.19.8.46.22                                  21.19.8.46.25    21.19.8.47.5           21.19.8.47.13                   21.19.8.47.18                          21.19.8.47.22                                  21.19.8.47.25    21.19.9.1.5           21.19.9.1.13                   21.19.9.1.18                          21.19.9.1.22                                  21.19.9.1.25    21.19.9.2.5           21.19.9.2.13                   21.19.9.2.18                          21.19.9.2.22                                  21.19.9.2.25    21.19.9.5.5           21.19.9.5.13                   21.19.9.5.18                          21.19.9.5.22                                  21.19.9.5.25    21.19.9.7.5           21.19.9.7.13                   21.19.9.7.18                          21.19.9.7.22                                  21.19.9.7.25    21.19.9.46.5           21.19.9.46.13                   21.19.9.46.18                          21.19.9.46.22                                  21.19.9.46.25    21.19.9.47.5           21.19.9.47.13                   21.19.9.47.18                          21.19.9.47.22                                  21.19.9.47.25    21.19.10.1.5           21.19.10.1.13                   21.19.10.1.18                          21.19.10.1.22                                  21.19.10.1.25    21.19.10.2.5           21.19.10.2.13                   21.19.10.2.18                          21.19.10.2.22                                  21.19.10.2.25    21.19.10.5.5           21.19.10.5.13                   21.19.10.5.18                          21.19.10.5.22                                  21.19.10.5.25    21.19.10.7.5           21.19.10.7.13                   21.19.10.7.18                          21.19.10.7.22                                  21.19.10.7.25    21.19.10.46.5           21.19.10.46.13                   21.19.10.46.18                          21.19.10.46.22                                  21.19.10.46.25    21.19.10.47.5           21.19.10.47.13                   21.19.10.47.18                          21.19.10.47.22                                  21.19.10.47.25    21.20.1.1.5           21.20.1.1.13                   21.20.1.1.18                          21.20.1.1.22                                  21.20.1.1.25    21.20.1.2.5           21.20.1.2.13                   21.20.1.2.18                          21.20.1.2.22                                  21.20.1.2.25    21.20.1.5.5           21.20.1.5.13                   21.20.1.5.18                          21.20.1.5.22                                  21.20.1.5.25    21.20.1.7.5           21.20.1.7.13                   21.20.1.7.18                          21.20.1.7.22                                  21.20.1.7.25    21.20.1.46.5           21.20.1.46.13                   21.20.1.46.18                          21.20.1.46.22                                  21.20.1.46.25    21.20.1.47.5           21.20.1.47.13                   21.20.1.47.18                          21.20.1.47.22                                  21.20.1.47.25    21.20.2.1.5           21.20.2.1.13                   21.20.2.1.18                          21.20.2.1.22                                  21.20.2.1.25    21.20.2.2.5           21.20.2.2.13                   21.20.2.2.18                          21.20.2.2.22                                  21.20.2.2.25    21.20.2.5.5           21.20.2.5.13                   21.20.2.5.18                          21.20.2.5.22                                  21.20.2.5.25    21.20.2.7.5           21.20.2.7.13                   21.20.2.7.18                          21.20.2.7.22                                  21.20.2.7.25    21.20.2.46.5           21.20.2.46.13                   21.20.2.46.18                          21.20.2.46.22                                  21.20.2.46.25    21.20.2.47.5           21.20.2.47.13                   21.20.2.47.18                          21.20.2.47.22                                  21.20.2.47.25    21.20.6.1.5           21.20.6.1.13                   21.20.6.1.18                          21.20.6.1.22                                  21.20.6.1.25    21.20.6.2.5           21.20.6.2.13                   21.20.6.2.18                          21.20.6.2.22                                  21.20.6.2.25    21.20.6.5.5           21.20.6.5.13                   21.20.6.5.18                          21.20.6.5.22                                  21.20.6.5.25    21.20.6.7.5           21.20.6.7.13                   21.20.6.7.18                          21.20.6.7.22                                  21.20.6.7.25    21.20.6.46.5           21.20.6.46.13                   21.20.6.46.18                          21.20.6.46.22                                  21.20.6.46.25    21.20.6.47.5           21.20.6.47.13                   21.20.6.47.18                          21.20.6.47.22                                  21.20.6.47.25    21.20.7.1.5           21.20.7.1.13                   21.20.7.1.18                          21.20.7.1.22                                  21.20.7.1.25    21.20.7.2.5           21.20.7.2.13                   21.20.7.2.18                          21.20.7.2.22                                  21.20.7.2.25    21.20.7.5.5           21.20.7.5.13                   21.20.7.5.18                          21.20.7.5.22                                  21.20.7.5.25    21.20.7.7.5           21.20.7.7.13                   21.20.7.7.18                          21.20.7.7.22                                  21.20.7.7.25    21.20.7.46.5           21.20.7.46.13                   21.20.7.46.18                          21.20.7.46.22                                  21.20.7.46.25    21.20.7.47.5           21.20.7.47.13                   21.20.7.47.18                          21.20.7.47.22                                  21.20.7.47.25    21.20.8.1.5           21.20.8.1.13                   21.20.8.1.18                          21.20.8.1.22                                  21.20.8.1.25    21.20.8.2.5           21.20.8.2.13                   21.20.8.2.18                          21.20.8.2.22                                  21.20.8.2.25    21.20.8.5.5           21.20.8.5.13                   21.20.8.5.18                          21.20.8.5.22                                  21.20.8.5.25    21.20.8.7.5           21.20.8.7.13                   21.20.8.7.18                          21.20.8.7.22                                  21.20.8.7.25    21.20.8.46.5           21.20.8.46.13                   21.20.8.46.18                          21.20.8.46.22                                  21.20.8.46.25    21.20.8.47.5           21.20.8.47.13                   21.20.8.47.18                          21.20.8.47.22                                  21.20.8.47.25    21.20.9.1.5           21.20.9.1.13                   21.20.9.1.18                          21.20.9.1.22                                  21.20.9.1.25    21.20.9.2.5           21.20.9.2.13                   21.20.9.2.18                          21.20.9.2.22                                  21.20.9.2.25    21.20.9.5.5           21.20.9.5.13                   21.20.9.5.18                          21.20.9.5.22                                  21.20.9.5.25    21.20.9.7.5           21.20.9.7.13                   21.20.9.7.18                          21.20.9.7.22                                  21.20.9.7.25    21.20.9.46.5           21.20.9.46.13                   21.20.9.46.18                          21.20.9.46.22                                  21.20.9.46.25    21.20.9.47.5           21.20.9.47.13                   21.20.9.47.18                          21.20.9.47.22                                  21.20.9.47.25    21.20.10.1.5           21.20.10.1.13                   21.20.10.1.18                          21.20.10.1.22                                  21.20.10.1.25    21.20.10.2.5           21.20.10.2.13                   21.20.10.2.18                          21.20.10.2.22                                  21.20.10.2.25    21.20.10.5.5           21.20.10.5.13                   21.20.10.5.18                          21.20.10.5.22                                  21.20.10.5.25    21.20.10.7.5           21.20.10.7.13                   21.20.10.7.18                          21.20.10.7.22                                  21.20.10.7.25    21.20.10.46.5           21.20.10.46.13                   21.20.10.46.18                          21.20.10.46.22                                  21.20.10.46.25    21.20.10.47.5           21.20.10.47.13                   21.20.10.47.18                          21.20.10.47.22                                  21.20.10.47.25    21.21.1.1.5           21.21.1.1.13                   21.21.1.1.18                          21.21.1.1.22                                  21.21.1.1.25    21.21.1.2.5           21.21.1.2.13                   21.21.1.2.18                          21.21.1.2.22                                  21.21.1.2.25    21.21.1.5.5           21.21.1.5.13                   21.21.1.5.18                          21.21.1.5.22                                  21.21.1.5.25    21.21.1.7.5           21.21.1.7.13                   21.21.1.7.18                          21.21.1.7.22                                  21.21.1.7.25    21.21.1.46.5           21.21.1.46.13                   21.21.1.46.18                          21.21.1.46.22                                  21.21.1.46.25    21.21.1.47.5           21.21.1.47.13                   21.21.1.47.18                          21.21.1.47.22                                  21.21.1.47.25    21.21.2.1.5           21.21.2.1.13                   21.21.2.1.18                          21.21.2.1.22                                  21.21.2.1.25    21.21.2.2.5           21.21.2.2.13                   21.21.2.2.18                          21.21.2.2.22                                  21.21.2.2.25    21.21.2.5.5           21.21.2.5.13                   21.21.2.5.18                          21.21.2.5.22                                  21.21.2.5.25    21.21.2.7.5           21.21.2.7.13                   21.21.2.7.18                          21.21.2.7.22                                  21.21.2.7.25    21.21.2.46.5           21.21.2.46.13                   21.21.2.46.18                          21.21.2.46.22                                  21.21.2.46.25    21.21.2.47.5           21.21.2.47.13                   21.21.2.47.18                          21.21.2.47.22                                  21.21.2.47.25    21.21.6.1.5           21.21.6.1.13                   21.21.6.1.18                          21.21.6.1.22                                  21.21.6.1.25    21.21.6.2.5           21.21.6.2.13                   21.21.6.2.18                          21.21.6.2.22                                  21.21.6.2.25    21.21.6.5.5           21.21.6.5.13                   21.21.6.5.18                          21.21.6.5.22                                  21.21.6.5.25    21.21.6.7.5           21.21.6.7.13                   21.21.6.7.18                          21.21.6.7.22                                  21.21.6.7.25    21.21.6.46.5           21.21.6.46.13                   21.21.6.46.18                          21.21.6.46.22                                  21.21.6.46.25    21.21.6.47.5           21.21.6.47.13                   21.21.6.47.18                          21.21.6.47.22                                  21.21.6.47.25    21.21.7.1.5           21.21.7.1.13                   21.21.7.1.18                          21.21.7.1.22                                  21.21.7.1.25    21.21.7.2.5           21.21.7.2.13                   21.21.7.2.18                          21.21.7.2.22                                  21.21.7.2.25    21.21.7.5.5           21.21.7.5.13                   21.21.7.5.18                          21.21.7.5.22                                  21.21.7.5.25    21.21.7.7.5           21.21.7.7.13                   21.21.7.7.18                          21.21.7.7.22                                  21.21.7.7.25    21.21.7.46.5           21.21.7.46.13                   21.21.7.46.18                          21.21.7.46.22                                  21.21.7.46.25    21.21.7.47.5           21.21.7.47.13                   21.21.7.47.18                          21.21.7.47.22                                  21.21.7.47.25    21.21.8.1.5           21.21.8.1.13                   21.21.8.1.18                          21.21.8.1.22                                  21.21.8.1.25    21.21.8.2.5           21.21.8.2.13                   21.21.8.2.18                          21.21.8.2.22                                  21.21.8.2.25    21.21.8.5.5           21.21.8.5.13                   21.21.8.5.18                          21.21.8.5.22                                  21.21.8.5.25    21.21.8.7.5           21.21.8.7.13                   21.21.8.7.18                          21.21.8.7.22                                  21.21.8.7.25    21.21.8.46.5           21.21.8.46.13                   21.21.8.46.18                          21.21.8.46.22                                  21.21.8.46.25    21.21.8.47.5           21.21.8.47.13                   21.21.8.47.18                          21.21.8.47.22                                  21.21.8.47.25    21.21.9.1.5           21.21.9.1.13                   21.21.9.1.18                          21.21.9.1.22                                  21.21.9.1.25    21.21.9.2.5           21.21.9.2.13                   21.21.9.2.18                          21.21.9.2.22                                  21.21.9.2.25    21.21.9.5.5           21.21.9.5.13                   21.21.9.5.18                          21.21.9.5.22                                  21.21.9.5.25    21.21.9.7.5           21.21.9.7.13                   21.21.9.7.18                          21.21.9.7.22                                  21.21.9.7.25    21.21.9.46.5           21.21.9.46.13                   21.21.9.46.18                          21.21.9.46.22                                  21.21.9.46.25    21.21.9.47.5           21.21.9.47.13                   21.21.9.47.18                          21.21.9.47.22                                  21.21.9.47.25    21.21.10.1.5           21.21.10.1.13                   21.21.10.1.18                          21.21.10.1.22                                  21.21.10.1.25    21.21.10.2.5           21.21.10.2.13                   21.21.10.2.18                          21.21.10.2.22                                  21.21.10.2.25    21.21.10.5.5           21.21.10.5.13                   21.21.10.5.18                          21.21.10.5.22                                  21.21.10.5.25    21.21.10.7.5           21.21.10.7.13                   21.21.10.7.18                          21.21.10.7.22                                  21.21.10.7.25    21.21.10.46.5           21.21.10.46.13                   21.21.10.46.18                          21.21.10.46.22                                  21.21.10.46.25    21.21.10.47.5           21.21.10.47.13                   21.21.10.47.18                          21.21.10.47.22                                  21.21.10.47.25    21.22.1.1.5           21.22.1.1.13                   21.22.1.1.18                          21.22.1.1.22                                  21.22.1.1.25    21.22.1.2.5           21.22.1.2.13                   21.22.1.2.18                          21.22.1.2.22                                  21.22.1.2.25    21.22.1.5.5           21.22.1.5.13                   21.22.1.5.18                          21.22.1.5.22                                  21.22.1.5.25    21.22.1.7.5           21.22.1.7.13                   21.22.1.7.18                          21.22.1.7.22                                  21.22.1.7.25    21.22.1.46.5           21.22.1.46.13                   21.22.1.46.18                          21.22.1.46.22                                  21.22.1.46.25    21.22.1.47.5           21.22.1.47.13                   21.22.1.47.18                          21.22.1.47.22                                  21.22.1.47.25    21.22.2.1.5           21.22.2.1.13                   21.22.2.1.18                          21.22.2.1.22                                  21.22.2.1.25    21.22.2.2.5           21.22.2.2.13                   21.22.2.2.18                          21.22.2.2.22                                  21.22.2.2.25    21.22.2.5.5           21.22.2.5.13                   21.22.2.5.18                          21.22.2.5.22                                  21.22.2.5.25    21.22.2.7.5           21.22.2.7.13                   21.22.2.7.18                          21.22.2.7.22                                  21.22.2.7.25    21.22.2.46.5           21.22.2.46.13                   21.22.2.46.18                          21.22.2.46.22                                  21.22.2.46.25    21.22.2.47.5           21.22.2.47.13                   21.22.2.47.18                          21.22.2.47.22                                  21.22.2.47.25    21.22.6.1.5           21.22.6.1.13                   21.22.6.1.18                          21.22.6.1.22                                  21.22.6.1.25    21.22.6.2.5           21.22.6.2.13                   21.22.6.2.18                          21.22.6.2.22                                  21.22.6.2.25    21.22.6.5.5           21.22.6.5.13                   21.22.6.5.18                          21.22.6.5.22                                  21.22.6.5.25    21.22.6.7.5           21.22.6.7.13                   21.22.6.7.18                          21.22.6.7.22                                  21.22.6.7.25    21.22.6.46.5           21.22.6.46.13                   21.22.6.46.18                          21.22.6.46.22                                  21.22.6.46.25    21.22.6.47.5           21.22.6.47.13                   21.22.6.47.18                          21.22.6.47.22                                  21.22.6.47.25    21.22.7.1.5           21.22.7.1.13                   21.22.7.1.18                          21.22.7.1.22                                  21.22.7.1.25    21.22.7.2.5           21.22.7.2.13                   21.22.7.2.18                          21.22.7.2.22                                  21.22.7.2.25    21.22.7.5.5           21.22.7.5.13                   21.22.7.5.18                          21.22.7.5.22                                  21.22.7.5.25    21.22.7.7.5           21.22.7.7.13                   21.22.7.7.18                          21.22.7.7.22                                  21.22.7.7.25    21.22.7.46.5           21.22.7.46.13                   21.22.7.46.18                          21.22.7.46.22                                  21.22.7.46.25    21.22.7.47.5           21.22.7.47.13                   21.22.7.47.18                          21.22.7.47.22                                  21.22.7.47.25    21.22.8.1.5           21.22.8.1.13                   21.22.8.1.18                          21.22.8.1.22                                  21.22.8.1.25    21.22.8.2.5           21.22.8.2.13                   21.22.8.2.18                          21.22.8.2.22                                  21.22.8.2.25    21.22.8.5.5           21.22.8.5.13                   21.22.8.5.18                          21.22.8.5.22                                  21.22.8.5.25    21.22.8.7.5           21.22.8.7.13                   21.22.8.7.18                          21.22.8.7.22                                  21.22.8.7.25    21.22.8.46.5           21.22.8.46.13                   21.22.8.46.18                          21.22.8.46.22                                  21.22.8.46.25    21.22.8.47.5           21.22.8.47.13                   21.22.8.47.18                          21.22.8.47.22                                  21.22.8.47.25    21.22.9.1.5           21.22.9.1.13                   21.22.9.1.18                          21.22.9.1.22                                  21.22.9.1.25    21.22.9.2.5           21.22.9.2.13                   21.22.9.2.18                          21.22.9.2.22                                  21.22.9.2.25    21.22.9.5.5           21.22.9.5.13                   21.22.9.5.18                          21.22.9.5.22                                  21.22.9.5.25    21.22.9.7.5           21.22.9.7.13                   21.22.9.7.18                          21.22.9.7.22                                  21.22.9.7.25    21.22.9.46.5           21.22.9.46.13                   21.22.9.46.18                          21.22.9.46.22                                  21.22.9.46.25    21.22.9.47.5           21.22.9.47.13                   21.22.9.47.18                          21.22.9.47.22                                  21.22.9.47.25    21.22.10.1.5           21.22.10.1.13                   21.22.10.1.18                          21.22.10.1.22                                  21.22.10.1.25    21.22.10.2.5           21.22.10.2.13                   21.22.10.2.18                          21.22.10.2.22                                  21.22.10.2.25    21.22.10.5.5           21.22.10.5.13                   21.22.10.5.18                          21.22.10.5.22                                  21.22.10.5.25    21.22.10.7.5           21.22.10.7.13                   21.22.10.7.18                          21.22.10.7.22                                  21.22.10.7.25    21.22.10.46.5           21.22.10.46.13                   21.22.10.46.18                          21.22.10.46.22                                  21.22.10.46.25    21.22.10.47.5           21.22.10.47.13                   21.22.10.47.18                          21.22.10.47.22                                  21.22.10.47.25    21.33.1.1.5           21.33.1.1.13                   21.33.1.1.18                          21.33.1.1.22                                  21.33.1.1.25    21.33.1.2.5           21.33.1.2.13                   21.33.1.2.18                          21.33.1.2.22                                  21.33.1.2.25    21.33.1.5.5           21.33.1.5.13                   21.33.1.5.18                          21.33.1.5.22                                  21.33.1.5.25    21.33.1.7.5           21.33.1.7.13                   21.33.1.7.18                          21.33.1.7.22                                  21.33.1.7.25    21.33.1.46.5           21.33.1.46.13                   21.33.1.46.18                          21.33.1.46.22                                  21.33.1.46.25    21.33.1.47.5           21.33.1.47.13                   21.33.1.47.18                          21.33.1.47.22                                  21.33.1.47.25    21.33.2.1.5           21.33.2.1.13                   21.33.2.1.18                          21.33.2.1.22                                  21.33.2.1.25    21.33.2.2.5           21.33.2.2.13                   21.33.2.2.18                          21.33.2.2.22                                  21.33.2.2.25    21.33.2.5.5           21.33.2.5.13                   21.33.2.5.18                          21.33.2.5.22                                  21.33.2.5.25    21.33.2.7.5           21.33.2.7.13                   21.33.2.7.18                          21.33.2.7.22                                  21.33.2.7.25    21.33.2.46.5           21.33.2.46.13                   21.33.2.46.18                          21.33.2.46.22                                  21.33.2.46.25    21.33.2.47.5           21.33.2.47.13                   21.33.2.47.18                          21.33.2.47.22                                  21.33.2.47.25    21.33.6.1.5           21.33.6.1.13                   21.33.6.1.18                          21.33.6.1.22                                  21.33.6.1.25    21.33.6.2.5           21.33.6.2.13                   21.33.6.2.18                          21.33.6.2.22                                  21.33.6.2.25    21.33.6.5.5           21.33.6.5.13                   21.33.6.5.18                          21.33.6.5.22                                  21.33.6.5.25    21.33.6.7.5           21.33.6.7.13                   21.33.6.7.18                          21.33.6.7.22                                  21.33.6.7.25    21.33.6.46.5           21.33.6.46.13                   21.33.6.46.18                          21.33.6.46.22                                  21.33.6.46.25    21.33.6.47.5           21.33.6.47.13                   21.33.6.47.18                          21.33.6.47.22                                  21.33.6.47.25    21.33.7.1.5           21.33.7.1.13                   21.33.7.1.18                          21.33.7.1.22                                  21.33.7.1.25    21.33.7.2.5           21.33.7.2.13                   21.33.7.2.18                          21.33.7.2.22                                  21.33.7.2.25    21.33.7.5.5           21.33.7.5.13                   21.33.7.5.18                          21.33.7.5.22                                  21.33.7.5.25    21.33.7.7.5           21.33.7.7.13                   21.33.7.7.18                          21.33.7.7.22                                  21.33.7.7.25    21.33.7.46.5           21.33.7.46.13                   21.33.7.46.18                          21.33.7.46.22                                  21.33.7.46.25    21.33.7.47.5           21.33.7.47.13                   21.33.7.47.18                          21.33.7.47.22                                  21.33.7.47.25    21.33.8.1.5           21.33.8.1.13                   21.33.8.1.18                          21.33.8.1.22                                  21.33.8.1.25    21.33.8.2.5           21.33.8.2.13                   21.33.8.2.18                          21.33.8.2.22                                  21.33.8.2.25    21.33.8.5.5           21.33.8.5.13                   21.33.8.5.18                          21.33.8.5.22                                  21.33.8.5.25    21.33.8.7.5           21.33.8.7.13                   21.33.8.7.18                          21.33.8.7.22                                  21.33.8.7.25    21.33.8.46.5           21.33.8.46.13                   21.33.8.46.18                          21.33.8.46.22                                  21.33.8.46.25    21.33.8.47.5           21.33.8.47.13                   21.33.8.47.18                          21.33.8.47.22                                  21.33.8.47.25    21.33.9.1.5           21.33.9.1.13                   21.33.9.1.18                          21.33.9.1.22                                  21.33.9.1.25    21.33.9.2.5           21.33.9.2.13                   2.18   21.33.9.2.22                                  21.33.9.2.25    21.33.9.5.5           21.33.9.5.13                   21.33.9.5.18                          21.33.9.5.22                                  21.33.9.5.25    21.33.9.7.5           21.33.9.7.13                   21.33.9.7.18                          21.33.9.7.22                                  21.33.9.7.25    21.33.9.46.5           21.33.9.46.13                   21.33.9.46.18                          21.33.9.46.22                                  21.33.9.46.25    21.33.9.47.5           21.33.9.47.13                   21.33.9.47.18                          21.33.9.47.22                                  21.33.9.47.25    21.33.10.1.5           21.33.10.1.13                   21.33.10.1.18                          21.33.10.1.22                                  21.33.10.1.25    21.33.10.2.5           21.33.10.2.13                   21.33.10.2.18                          21.33.10.2.22                                  21.33.10.2.25    21.33.10.5.5           21.33.10.5.13                   21.33.10.5.18                          21.33.10.5.22                                  21.33.10.5.25    21.33.10.7.5           21.33.10.7.13                   21.33.10.7.18                          21.33.10.7.22                                  21.33.10.7.25    21.33.10.46.5           21.33.10.46.13                   21.33.10.46.18                          21.33.10.46.22                                  21.33.10.46.25    21.33.10.47.5           21.33.10.47.13                   21.33.10.47.18                          21.33.10.47.22                                  21.33.10.47.25    21.34.1.1.5           21.34.1.1.13                   21.34.1.1.18                          21.34.1.1.22                                  21.34.1.1.25    21.34.1.2.5           21.34.1.2.13                   21.34.1.2.18                          21.34.1.2.22                                  21.34.1.2.25    21.34.1.5.5           21.34.1.5.13                   21.34.1.5.18                          21.34.1.5.22                                  21.34.1.5.25    21.34.1.7.5           21.34.1.7.13                   21.34.1.7.18                          21.34.1.7.22                                  21.34.1.7.25    21.34.1.46.5           21.34.1.46.13                   21.34.1.46.18                          21.34.1.46.22                                  21.34.1.46.25    21.34.1.47.5           21.34.1.47.13                   21.34.1.47.18                          21.34.1.47.22                                  21.34.1.47.25    21.34.2.1.5           21.34.2.1.13                   21.34.2.1.18                          21.34.2.1.22                                  21.34.2.1.25    21.34.2.2.5           21.34.2.2.13                   21.34.2.2.18                          21.34.2.2.22                                  21.34.2.2.25    21.34.2.5.5           21.34.2.5.13                   21.34.2.5.18                          21.34.2.5.22                                  21.34.2.5.25    21.34.2.7.5           21.34.2.7.13                   21.34.2.7.18                          21.34.2.7.22                                  21.34.2.7.25    21.34.2.46.5           21.34.2.46.13                   21.34.2.46.18                          21.34.2.46.22                                  21.34.2.46.25    21.34.2.47.5           21.34.2.47.13                   21.34.2.47.18                          21.34.2.47.22                                  21.34.2.47.25    21.34.6.1.5           21.34.6.1.13                   21.34.6.1.18                          21.34.6.1.22                                  21.34.6.1.25    21.34.6.2.5           21.34.6.2.13                   21.34.6.2.18                          21.34.6.2.22                                  21.34.6.2.25    21.34.6.5.5           21.34.6.5.13                   21.34.6.5.18                          21.34.6.5.22                                  21.34.6.5.25    21.34.6.7.5           21.34.6.7.13                   21.34.6.7.18                          21.34.6.7.22                                  21.34.6.7.25    21.34.6.46.5           21.34.6.46.13                   21.34.6.46.18                          21.34.6.46.22                                  21.34.6.46.25    21.34.6.47.5           21.34.6.47.13                   21.34.6.47.18                          21.34.6.47.22                                  21.34.6.47.25    21.34.7.1.5           21.34.7.1.13                   21.34.7.1.18                          21.34.7.1.22                                  21.34.7.1.25    21.34.7.2.5           21.34.7.2.13                   21.34.7.2.18                          21.34.7.2.22                                  21.34.7.2.25    21.34.7.5.5           21.34.7.5.13                   21.34.7.5.18                          21.34.7.5.22                                  21.34.7.5.25    21.34.7.7.5           21.34.7.7.13                   21.34.7.7.18                          21.34.7.7.22                                  21.34.7.7.25    21.34.7.46.5           21.34.7.46.13                   21.34.7.46.18                          21.34.7.46.22                                  21.34.7.46.25    21.34.7.47.5           21.34.7.47.13                   21.34.7.47.18                          21.34.7.47.22                                  21.34.7.47.25    21.34.8.1.5           21.34.8.1.13                   21.34.8.1.18                          21.34.8.1.22                                  21.34.8.1.25    21.34.8.2.5           21.34.8.2.13                   21.34.8.2.18                          21.34.8.2.22                                  21.34.8.2.25    21.34.8.5.5           21.34.8.5.13                   21.34.8.5.18                          21.34.8.5.22                                  21.34.8.5.25    21.34.8.7.5           21.34.8.7.13                   21.34.8.7.18                          21.34.8.7.22                                  21.34.8.7.25    21.34.8.46.5           21.34.8.46.13                   21.34.8.46.18                          21.34.8.46.22                                  21.34.8.46.25    21.34.8.47.5           21.34.8.47.13                   21.34.8.47.18                          21.34.8.47.22                                  21.34.8.47.25    21.34.9.1.5           21.34.9.1.13                   21.34.9.1.18                          21.34.9.1.22                                  21.34.9.1.25    21.34.9.2.5           21.34.9.2.13                   21.34.9.2.18                          21.34.9.2.22                                  21.34.9.2.25    21.34.9.5.5           21.34.9.5.13                   21.34.9.5.18                          21.34.9.5.22                                  21.34.9.5.25    21.34.9.7.5           21.34.9.7.13                   21.34.9.7.18                          21.34.9.7.22                                  21.34.9.7.25    21.34.9.46.5           21.34.9.46.13                   21.34.9.46.18                          21.34.9.46.22                                  21.34.9.46.25    21.34.9.47.5           21.34.9.47.13                   21.34.9.47.18                          21.34.9.47.22                                  21.34.9.47.25    21.34.10.1.5           21.34.10.1.13                   21.34.10.1.18                          21.34.10.1.22                                  21.34.10.1.25    21.34.10.2.5           21.34.10.2.13                   21.34.10.2.18                          21.34.10.2.22                                  21.34.10.2.25    21.34.10.5.5           21.34.10.5.13                   21.34.10.5.18                          21.34.10.5.22                                  21.34.10.5.25    21.34.10.7.5           21.34.10.7.13                   21.34.10.7.18                          21.34.10.7.22                                  21.34.10.7.25    21.34.10.46.5           21.34.10.46.13                   21.34.10.46.18                          21.34.10.46.22                                  21.34.10.46.25    21.34.10.47.5           21.34.10.47.13                   21.34.10.47.18                          21.34.10.47.22                                  21.34.10.47.25    21.37.1.1.5           21.37.1.1.13                   21.37.1.1.18                          21.37.1.1.22                                  21.37.1.1.25    21.37.1.2.5           21.37.1.2.13                   21.37.1.2.18                          21.37.1.2.22                                  21.37.1.2.25    21.37.1.5.5           21.37.1.5.13                   21.37.1.5.18                          21.37.1.5.22                                  21.37.1.5.25    21.37.1.7.5           21.37.1.7.13                   21.37.1.7.18                          21.37.1.7.22                                  21.37.1.7.25    21.37.1.46.5           21.37.1.46.13                   21.37.1.46.18                          21.37.1.46.22                                  21.37.1.46.25    21.37.1.47.5           21.37.1.47.13                   21.37.1.47.18                          21.37.1.47.22                                  21.37.1.47.25    21.37.2.1.5           21.37.2.1.13                   21.37.2.1.18                          21.37.2.1.22                                  21.37.2.1.25    21.37.2.2.5           21.37.2.2.13                   21.37.2.2.18                          21.37.2.2.22                                  21.37.2.2.25    21.37.2.5.5           21.37.2.5.13                   21.37.2.5.18                          21.37.2.5.22                                  21.37.2.5.25    21.37.2.7.5           21.37.2.7.13                   21.37.2.7.18                          21.37.2.7.22                                  21.37.2.7.25    21.37.2.46.5           21.37.2.46.13                   21.37.2.46.18                          21.37.2.46.22                                  21.37.2.46.25    21.37.2.47.5           21.37.2.47.13                   21.37.2.47.18                          21.37.2.47.22                                  21.37.2.47.25    21.37.6.1.5           21.37.6.1.13                   21.37.6.1.18                          21.37.6.1.22                                  21.37.6.1.25    21.37.6.2.5           21.37.6.2.13                   21.37.6.2.18                          21.37.6.2.22                                  21.37.6.2.25    21.37.6.5.5           21.37.6.5.13                   21.37.6.5.18                          21.37.6.5.22                                  21.37.6.5.25    21.37.6.7.5           21.37.6.7.13                   21.37.6.7.18                          21.37.6.7.22                                  21.37.6.7.25    21.37.6.46.5           21.37.6.46.13                   21.37.6.46.18                          21.37.6.46.22                                  21.37.6.46.25    21.37.6.47.5           21.37.6.47.13                   21.37.6.47.18                          21.37.6.47.22                                  21.37.6.47.25    21.37.7.1.5           21.37.7.1.13                   21.37.7.1.18                          21.37.7.1.22                                  21.37.7.1.25    21.37.7.2.5           21.37.7.2.13                   21.37.7.2.18                          21.37.7.2.22                                  21.37.7.2.25    21.37.7.5.5           21.37.7.5.13                   21.37.7.5.18                          21.37.7.5.22                                  21.37.7.5.25    21.37.7.7.5           21.37.7.7.13                   21.37.7.7.18                          21.37.7.7.22                                  21.37.7.7.25    21.37.7.46.5           21.37.7.46.13                   21.37.7.46.18                          21.37.7.46.22                                  21.37.7.46.25    21.37.7.47.5           21.37.7.47.13                   21.37.7.47.18                          21.37.7.47.22                                  21.37.7.47.25    21.37.8.1.5           21.37.8.1.13                   21.37.8.1.18                          21.37.8.1.22                                  21.37.8.1.25    21.37.8.2.5           21.37.8.2.13                   21.37.8.2.18                          21.37.8.2.22                                  21.37.8.2.25    21.37.8.5.5           21.37.8.5.13                   21.37.8.5.18                          21.37.8.5.22                                  21.37.8.5.25    21.37.8.7.5           21.37.8.7.13                   21.37.8.7.18                          21.37.8.7.22                                  21.37.8.7.25    21.37.8.46.5           21.37.8.46.13                   21.37.8.46.18                          21.37.8.46.22                                  21.37.8.46.25    21.37.8.47.5           21.37.8.47.13                   21.37.8.47.18                          21.37.8.47.22                                  21.37.8.47.25    21.37.9.1.5           21.37.9.1.13                   21.37.9.1.18                          21.37.9.1.22                                  21.37.9.1.25    21.37.9.2.5           21.37.9.2.13                   21.37.9.2.18                          21.37.9.2.22                                  21.37.9.2.25    21.37.9.5.5           21.37.9.5.13                   21.37.9.5.18                          21.37.9.5.22                                  21.37.9.5.25    21.37.9.7.5           21.37.9.7.13                   21.37.9.7.18                          21.37.9.7.22                                  21.37.9.7.25    21.37.9.46.5           21.37.9.46.13                   21.37.9.46.18                          21.37.9.46.22                                  21.37.9.46.25    21.37.9.47.5           21.37.9.47.13                   21.37.9.47.18                          21.37.9.47.22                                  21.37.9.47.25    21.37.10.1.5           21.37.10.1.13                   21.37.10.1.18                          21.37.10.1.22                                  21.37.10.1.25    21.37.10.2.5           21.37.10.2.13                   21.37.10.2.18                          21.37.10.2.22                                  21.37.10.2.25    21.37.10.5.5           21.37.10.5.13                   21.37.10.5.18                          21.37.10.5.22                                  21.37.10.5.25    21.37.10.7.5           21.37.10.7.13                   21.37.10.7.18                          21.37.10.7.22                                  21.37.10.7.25    21.37.10.46.5           21.37.10.46.13                   21.37.10.46.18                          21.37.10.46.22                                  21.37.10.46.25    21.37.10.47.5           21.37.10.47.13                   21.37.10.47.18                          21.37.10.47.22                                  21.37.10.47.25    22.17.1.1.5           22.17.1.1.13                   22.17.1.1.18                          22.17.1.1.22                                  22.17.1.1.25    22.17.1.2.5           22.17.1.2.13                   22.17.1.2.18                          22.17.1.2.22                                  22.17.1.2.25    22.17.1.5.5           22.17.1.5.13                   22.17.1.5.18                          22.17.1.5.22                                  22.17.1.5.25    22.17.1.7.5           22.17.1.7.13                   22.17.1.7.18                          22.17.1.7.22                                  22.17.1.7.25    22.17.1.46.5           22.17.1.46.13                   22.17.1.46.18                          22.17.1.46.22                                  22.17.1.46.25    22.17.1.47.5           22.17.1.47.13                   22.17.1.47.18                          22.17.1.47.22                                  22.17.1.47.25    22.17.2.1.5           22.17.2.1.13                   22.17.2.1.18                          22.17.2.1.22                                  22.17.2.1.25    22.17.2.2.5           22.17.2.2.13                   22.17.2.2.18                          22.17.2.2.22                                  22.17.2.2.25    22.17.2.5.5           22.17.2.5.13                   22.17.2.5.18                          22.17.2.5.22                                  22.17.2.5.25    22.17.2.7.5           22.17.2.7.13                   22.17.2.7.18                          22.17.2.7.22                                  22.17.2.7.25    22.17.2.46.5           22.17.2.46.13                   22.17.2.46.18                          22.17.2.46.22                                  22.17.2.46.25    22.17.2.47.5           22.17.2.47.13                   22.17.2.47.18                          22.17.2.47.22                                  22.17.2.47.25    22.17.6.1.5           22.17.6.1.13                   22.17.6.1.18                          22.17.6.1.22                                  22.17.6.1.25    22.17.6.2.5           22.17.6.2.13                   22.17.6.2.18                          22.17.6.2.22                                  22.17.6.2.25    22.17.6.5.5           22.17.6.5.13                   22.17.6.5.18                          22.17.6.5.22                                  22.17.6.5.25    22.17.6.7.5           22.17.6.7.13                   22.17.6.7.18                          22.17.6.7.22                                  22.17.6.7.25    22.17.6.46.5           22.17.6.46.13                   22.17.6.46.18                          22.17.6.46.22                                  22.17.6.46.25    22.17.6.47.5           22.17.6.47.13                   22.17.6.47.18                          22.17.6.47.22                                  22.17.6.47.25    22.17.7.1.5           22.17.7.1.13                   22.17.7.1.18                          22.17.7.1.22                                  22.17.7.1.25    22.17.7.2.5           22.17.7.2.13                   22.17.7.2.18                          22.17.7.2.22                                  22.17.7.2.25    22.17.7.5.5           22.17.7.5.13                   22.17.7.5.18                          22.17.7.5.22                                  22.17.7.5.25    22.17.7.7.5           22.17.7.7.13                   22.17.7.7.18                          22.17.7.7.22                                  22.17.7.7.25    22.17.7.46.5           22.17.7.46.13                   22.17.7.46.18                          22.17.7.46.22                                  22.17.7.46.25    22.17.7.47.5           22.17.7.47.13                   22.17.7.47.18                          22.17.7.47.22                                  22.17.7.47.25    22.17.8.1.5           22.17.8.1.13                   22.17.8.1.18                          22.17.8.1.22                                  22.17.8.1.25    22.17.8.2.5           22.17.8.2.13                   22.17.8.2.18                          22.17.8.2.22                                  22.17.8.2.25    22.17.8.5.5           22.17.8.5.13                   22.17.8.5.18                          22.17.8.5.22                                  22.17.8.5.25    22.17.8.7.5           22.17.8.7.13                   22.17.8.7.18                          22.17.8.7.22                                  22.17.8.7.25    22.17.8.46.5           22.17.8.46.13                   22.17.8.46.18                          22.17.8.46.22                                  22.17.8.46.25    22.17.8.47.5           22.17.8.47.13                   22.17.8.47.18                          22.17.8.47.22                                  22.17.8.47.25    22.17.9.1.5           22.17.9.1.13                   22.17.9.1.18                          22.17.9.1.22                                  22.17.9.1.25    22.17.9.2.5           22.17.9.2.13                   22.17.9.2.18                          22.17.9.2.22                                  22.17.9.2.25    22.17.9.5.5           22.17.9.5.13                   22.17.9.5.18                          22.17.9.5.22                                  22.17.9.5.25    22.17.9.7.5           22.17.9.7.13                   22.17.9.7.18                          22.17.9.7.22                                  22.17.9.7.25    22.17.9.46.5           22.17.9.46.13                   22.17.9.46.18                          22.17.9.46.22                                  22.17.9.46.25    22.17.9.47.5           22.17.9.47.13                   22.17.9.47.18                          22.17.9.47.22                                  22.17.9.47.25    22.17.10.1.5           22.17.10.1.13                   22.17.10.1.18                          22.17.10.1.22                                  22.17.10.1.25    22.17.10.2.5           22.17.10.2.13                   22.17.10.2.18                          22.17.10.2.22                                  22.17.10.2.25    22.17.10.5.5           22.17.10.5.13                   22.17.10.5.18                          22.17.10.5.22                                  22.17.10.5.25    22.17.10.7.5           22.17.10.7.13                   22.17.10.7.18                          22.17.10.7.22                                  22.17.10.7.25    22.17.10.46.5           22.17.10.46.13                   22.17.10.46.18                          22.17.10.46.22                                  22.17.10.46.25    22.17.10.47.5           22.17.10.47.13                   22.17.10.47.18                          22.17.10.47.22                                  22.17.10.47.25    22.18.1.1.5           22.18.1.1.13                   22.18.1.1.18                          22.18.1.1.22                                  22.18.1.1.25    22.18.1.2.5           22.18.1.2.13                   22.18.1.2.18                          22.18.1.2.22                                  22.18.1.2.25    22.18.1.5.5           22.18.1.5.13                   22.18.1.5.18                          22.18.1.5.22                                  22.18.1.5.25    22.18.1.7.5           22.18.1.7.13                   22.18.1.7.18                          22.18.1.7.22                                  22.18.1.7.25    22.18.1.46.5           22.18.1.46.13                   22.18.1.46.18                          22.18.1.46.22                                  22.18.1.46.25    22.18.1.47.5           22.18.1.47.13                   22.18.1.47.18                          22.18.1.47.22                                  22.18.1.47.25    22.18.2.1.5           22.18.2.1.13                   22.18.2.1.18                          22.18.2.1.22                                  22.18.2.1.25    22.18.2.2.5           22.18.2.2.13                   22.18.2.2.18                          22.18.2.2.22                                  22.18.2.2.25    22.18.2.5.5           22.18.2.5.13                   22.18.2.5.18                          22.18.2.5.22                                  22.18.2.5.25    22.18.2.7.5           22.18.2.7.13                   22.18.2.7.18                          22.18.2.7.22                                  22.18.2.7.25    22.18.2.46.5           22.18.2.46.13                   22.18.2.46.18                          22.18.2.46.22                                  22.18.2.46.25    22.18.2.47.5           22.18.2.47.13                   22.18.2.47.18                          22.18.2.47.22                                  22.18.2.47.25    22.18.6.1.5           22.18.6.1.13                   22.18.6.1.18                          22.18.6.1.22                                  22.18.6.1.25    22.18.6.2.5           22.18.6.2.13                   22.18.6.2.18                          22.18.6.2.22                                  22.18.6.2.25    22.18.6.5.5           22.18.6.5.13                   22.18.6.5.18                          22.18.6.5.22                                  22.18.6.5.25    22.18.6.7.5           22.18.6.7.13                   22.18.6.7.18                          22.18.6.7.22                                  22.18.6.7.25    22.18.6.46.5           22.18.6.46.13                   22.18.6.46.18                          22.18.6.46.22                                  22.18.6.46.25    22.18.6.47.5           22.18.6.47.13                   22.18.6.47.18                          22.18.6.47.22                                  22.18.6.47.25    22.18.7.1.5           22.18.7.1.13                   22.18.7.1.18                          22.18.7.1.22                                  22.18.7.1.25    22.18.7.2.5           22.18.7.2.13                   22.18.7.2.18                          22.18.7.2.22                                  22.18.7.2.25    22.18.7.5.5           22.18.7.5.13                   22.18.7.5.18                          22.18.7.5.22                                  22.18.7.5.25    22.18.7.7.5           22.18.7.7.13                   22.18.7.7.18                          22.18.7.7.22                                  22.18.7.7.25    22.18.7.46.5           22.18.7.46.13                   22.18.7.46.18                          22.18.7.46.22                                  22.18.7.46.25    22.18.7.47.5           22.18.7.47.13                   22.18.7.47.18                          22.18.7.47.22                                  22.18.7.47.25    22.18.8.1.5           22.18.8.1.13                   22.18.8.1.18                          22.18.8.1.22                                  22.18.8.1.25    22.18.8.2.5           22.18.8.2.13                   22.18.8.2.18                          22.18.8.2.22                                  22.18.8.2.25    22.18.8.5.5           22.18.8.5.13                   22.18.8.5.18                          22.18.8.5.22                                  22.18.8.5.25    22.18.8.7.5           22.18.8.7.13                   22.18.8.7.18                          22.18.8.7.22                                  22.18.8.7.25    22.18.8.46.5           22.18.8.46.13                   22.18.8.46.18                          22.18.8.46.22                                  22.18.8.46.25    22.18.8.47.5           22.18.8.47.13                   22.18.8.47.18                          22.18.8.47.22                                  22.18.8.47.25    22.18.9.1.5           22.18.9.1.13                   22.18.9.1.18                          22.18.9.1.22                                  22.18.9.1.25    22.18.9.2.5           22.18.9.2.13                   22.18.9.2.18                          22.18.9.2.22                                  22.18.9.2.25    22.18.9.5.5           22.18.9.5.13                   22.18.9.5.18                          22.18.9.5.22                                  22.18.9.5.25    22.18.9.7.5           22.18.9.7.13                   22.18.9.7.18                          22.18.9.7.22                                  22.18.9.7.25    22.18.9.46.5           22.18.9.46.13                   22.18.9.46.18                          22.18.9.46.22                                  22.18.9.46.25    22.18.9.47.5           22.18.9.47.13                   22.18.9.47.18                          22.18.9.47.22                                  22.18.9.47.25    22.18.10.1.5           22.18.10.1.13                   22.18.10.1.18                          22.18.10.1.22                                  22.18.10.1.25    22.18.10.2.5           22.18.10.2.13                   22.18.10.2.18                          22.18.10.2.22                                  22.18.10.2.25    22.18.10.5.5           22.18.10.5.13                   22.18.10.5.18                          22.18.10.5.22                                  22.18.10.5.25    22.18.10.7.5           22.18.10.7.13                   22.18.10.7.18                          22.18.10.7.22                                  22.18.10.7.25    22.18.10.46.5           22.18.10.46.13                   22.18.10.46.18                          22.18.10.46.22                                  22.18.10.46.25    22.18.10.47.5           22.18.10.47.13                   22.18.10.47.18                          22.18.10.47.22                                  22.18.10.47.25    22.19.1.1.5           22.19.1.1.13                   22.19.1.1.18                          22.19.1.1.22                                  22.19.1.1.25    22.19.1.2.5           22.19.1.2.13                   22.19.1.2.18                          22.19.1.2.22                                  22.19.1.2.25    22.19.1.5.5           22.19.1.5.13                   22.19.1.5.18                          22.19.1.5.22                                  22.19.1.5.25    22.19.1.7.5           22.19.1.7.13                   22.19.1.7.18                          22.19.1.7.22                                  22.19.1.7.25    22.19.1.46.5           22.19.1.46.13                   22.19.1.46.18                          22.19.1.46.22                                  22.19.1.46.25    22.19.1.47.5           22.19.1.47.13                   22.19.1.47.18                          22.19.1.47.22                                  22.19.1.47.25    22.19.2.1.5           22.19.2.1.13                   22.19.2.1.18                          22.19.2.1.22                                  22.19.2.1.25    22.19.2.2.5           22.19.2.2.13                   22.19.2.2.18                          22.19.2.2.22                                  22.19.2.2.25    22.19.2.5.5           22.19.2.5.13                   22.19.2.5.18                          22.19.2.5.22                                  22.19.2.5.25    22.19.2.7.5           22.19.2.7.13                   22.19.2.7.18                          22.19.2.7.22                                  22.19.2.7.25    22.19.2.46.5           22.19.2.46.13                   22.19.2.46.18                          22.19.2.46.22                                  22.19.2.46.25    22.19.2.47.5           22.19.2.47.13                   22.19.2.47.18                          22.19.2.47.22                                  22.19.2.47.25    22.19.6.1.5           22.19.6.1.13                   22.19.6.1.18                          22.19.6.1.22                                  22.19.6.1.25    22.19.6.2.5           22.19.6.2.13                   22.19.6.2.18                          22.19.6.2.22                                  22.19.6.2.25    22.19.6.5.5           22.19.6.5.13                   22.19.6.5.18                          22.19.6.5.22                                  22.19.6.5.25    22.19.6.7.5           22.19.6.7.13                   22.19.6.7.18                          22.19.6.7.22                                  22.19.6.7.25    22.19.6.46.5           22.19.6.46.13                   22.19.6.46.18                          22.19.6.46.22                                  22.19.6.46.25    22.19.6.47.5           22.19.6.47.13                   22.19.6.47.18                          22.19.6.47.22                                  22.19.6.47.25    22.19.7.1.5           22.19.7.1.13                   22.19.7.1.18                          22.19.7.1.22                                  22.19.7.1.25    22.19.7.2.5           22.19.7.2.13                   22.19.7.2.18                          22.19.7.2.22                                  22.19.7.2.25    22.19.7.5.5           22.19.7.5.13                   22.19.7.5.18                          22.19.7.5.22                                  22.19.7.5.25    22.19.7.7.5           22.19.7.7.13                   22.19.7.7.18                          22.19.7.7.22                                  22.19.7.7.25    22.19.7.46.5           22.19.7.46.13                   22.19.7.46.18                          22.19.7.46.22                                  22.19.7.46.25    22.19.7.47.5           22.19.7.47.13                   22.19.7.47.18                          22.19.7.47.22                                  22.19.7.47.25    22.19.8.1.5           22.19.8.1.13                   22.19.8.1.18                          22.19.8.1.22                                  22.19.8.1.25    22.19.8.2.5           22.19.8.2.13                   22.19.8.2.18                          22.19.8.2.22                                  22.19.8.2.25    22.19.8.5.5           22.19.8.5.13                   22.19.8.5.18                          22.19.8.5.22                                  22.19.8.5.25    22.19.8.7.5           22.19.8.7.13                   22.19.8.7.18                          22.19.8.7.22                                  22.19.8.7.25    22.19.8.46.5           22.19.8.46.13                   22.19.8.46.18                          22.19.8.46.22                                  22.19.8.46.25    22.19.8.47.5           22.19.8.47.13                   22.19.8.47.18                          22.19.8.47.22                                  22.19.8.47.25    22.19.9.1.5           22.19.9.1.13                   22.19.9.1.18                          22.19.9.1.22                                  22.19.9.1.25    22.19.9.2.5           22.19.9.2.13                   22.19.9.2.18                          22.19.9.2.22                                  22.19.9.2.25    22.19.9.5.5           22.19.9.5.13                   22.19.9.5.18                          22.19.9.5.22                                  22.19.9.5.25    22.19.9.7.5           22.19.9.7.13                   22.19.9.7.18                          22.19.9.7.22                                  22.19.9.7.25    22.19.9.46.5           22.19.9.46.13                   22.19.9.46.18                          22.19.9.46.22                                  22.19.9.46.25    22.19.9.47.5           22.19.9.47.13                   22.19.9.47.18                          22.19.9.47.22                                  22.19.9.47.25    22.19.10.1.5           22.19.10.1.13                   22.19.10.1.18                          22.19.10.1.22                                  22.19.10.1.25    22.19.10.2.5           22.19.10.2.13                   22.19.10.2.18                          22.19.10.2.22                                  22.19.10.2.25    22.19.10.5.5           22.19.10.5.13                   22.19.10.5.18                          22.19.10.5.22                                  22.19.10.5.25    22.19.10.7.5           22.19.10.7.13                   22.19.10.7.18                          22.19.10.7.22                                  22.19.10.7.25    22.19.10.46.5           22.19.10.46.13                   22.19.10.46.18                          22.19.10.46.22                                  22.19.10.46.25    22.19.10.47.5           22.19.10.47.13                   22.19.10.47.18                          22.19.10.47.22                                  22.19.10.47.25    22.20.1.1.5           22.20.1.1.13                   22.20.1.1.18                          22.20.1.1.22                                  22.20.1.1.25    22.20.1.2.5           22.20.1.2.13                   22.20.1.2.18                          22.20.1.2.22                                  22.20.1.2.25    22.20.1.5.5           22.20.1.5.13                   22.20.1.5.18                          22.20.1.5.22                                  22.20.1.5.25    22.20.1.7.5           22.20.1.7.13                   22.20.1.7.18                          22.20.1.7.22                                  22.20.1.7.25    22.20.1.46.5           22.20.1.46.13                   22.20.1.46.18                          22.20.1.46.22                                  22.20.1.46.25    22.20.1.47.5           22.20.1.47.13                   22.20.1.47.18                          22.20.1.47.22                                  22.20.1.47.25    22.20.2.1.5           22.20.2.1.13                   22.20.2.1.18                          22.20.2.1.22                                  22.20.2.1.25    22.20.2.2.5           22.20.2.2.13                   22.20.2.2.18                          22.20.2.2.22                                  22.20.2.2.25    22.20.2.5.5           22.20.2.5.13                   22.20.2.5.18                          22.20.2.5.22                                  22.20.2.5.25    22.20.2.7.5           22.20.2.7.13                   22.20.2.7.18                          22.20.2.7.22                                  22.20.2.7.25    22.20.2.46.5           22.20.2.46.13                   22.20.2.46.18                          22.20.2.46.22                                  22.20.2.46.25    22.20.2.47.5           22.20.2.47.13                   22.20.2.47.18                          22.20.2.47.22                                  22.20.2.47.25    22.20.6.1.5           22.20.6.1.13                   22.20.6.1.18                          22.20.6.1.22                                  22.20.6.1.25    22.20.6.2.5           22.20.6.2.13                   22.20.6.2.18                          22.20.6.2.22                                  22.20.6.2.25    22.20.6.5.5           22.20.6.5.13                   22.20.6.5.18                          22.20.6.5.22                                  22.20.6.5.25    22.20.6.7.5           22.20.6.7.13                   22.20.6.7.18                          22.20.6.7.22                                  22.20.6.7.25    22.20.6.46.5           22.20.6.46.13                   22.20.6.46.18                          22.20.6.46.22                                  22.20.6.46.25    22.20.6.47.5           22.20.6.47.13                   22.20.6.47.18                          22.20.6.47.22                                  22.20.6.47.25    22.20.7.1.5           22.20.7.1.13                   22.20.7.1.18                          22.20.7.1.22                                  22.20.7.1.25    22.20.7.2.5           22.20.7.2.13                   22.20.7.2.18                          22.20.7.2.22                                  22.20.7.2.25    22.20.7.5.5           22.20.7.5.13                   22.20.7.5.18                          22.20.7.5.22                                  22.20.7.5.25    22.20.7.7.5           22.20.7.7.13                   22.20.7.7.18                          22.20.7.7.22                                  22.20.7.7.25    22.20.7.46.5           22.20.7.46.13                   22.20.7.46.18                          22.20.7.46.22                                  22.20.7.46.25    22.20.7.47.5           22.20.7.47.13                   22.20.7.47.18                          22.20.7.47.22                                  22.20.7.47.25    22.20.8.1.5           22.20.8.1.13                   22.20.8.1.18                          22.20.8.1.22                                  22.20.8.1.25    22.20.8.2.5           22.20.8.2.13                   22.20.8.2.18                          22.20.8.2.22                                  22.20.8.2.25    22.20.8.5.5           22.20.8.5.13                   22.20.8.5.18                          22.20.8.5.22                                  22.20.8.5.25    22.20.8.7.5           22.20.8.7.13                   22.20.8.7.18                          22.20.8.7.22                                  22.20.8.7.25    22.20.8.46.5           22.20.8.46.13                   22.20.8.46.18                          22.20.8.46.22                                  22.20.8.46.25    22.20.8.47.5           22.20.8.47.13                   22.20.8.47.18                          22.20.8.47.22                                  22.20.8.47.25    22.20.9.1.5           22.20.9.1.13                   22.20.9.1.18                          22.20.9.1.22                                  22.20.9.1.25    22.20.9.2.5           22.20.9.2.13                   22.20.9.2.18                          22.20.9.2.22                                  22.20.9.2.25    22.20.9.5.5           22.20.9.5.13                   22.20.9.5.18                          22.20.9.5.22                                  22.20.9.5.25    22.20.9.7.5           22.20.9.7.13                   22.20.9.7.18                          22.20.9.7.22                                  22.20.9.7.25    22.20.9.46.5           22.20.9.46.13                   22.20.9.46.18                          22.20.9.46.22                                  22.20.9.46.25    22.20.9.47.5           22.20.9.47.13                   22.20.9.47.18                          22.20.9.47.22                                  22.20.9.47.25    22.20.10.1.5           22.20.10.1.13                   22.20.10.1.18                          22.20.10.1.22                                  22.20.10.1.25    22.20.10.2.5           22.20.10.2.13                   22.20.10.2.18                          22.20.10.2.22                                  22.20.10.2.25    22.20.10.5.5           22.20.10.5.13                   22.20.10.5.18                          22.20.10.5.22                                  22.20.10.5.25    22.20.10.7.5           22.20.10.7.13                   22.20.10.7.18                          22.20.10.7.22                                  22.20.10.7.25    22.20.10.46.5           22.20.10.46.13                   22.20.10.46.18                          22.20.10.46.22                                  22.20.10.46.25    22.20.10.47.5           22.20.10.47.13                   22.20.10.47.18                          22.20.10.47.22                                  22.20.10.47.25    22.21.1.1.5           22.21.1.1.13                   22.21.1.1.18                          22.21.1.1.22                                  22.21.1.1.25    22.21.1.2.5           22.21.1.2.13                   22.21.1.2.18                          22.21.1.2.22                                  22.21.1.2.25    22.21.1.5.5           22.21.1.5.13                   22.21.1.5.18                          22.21.1.5.22                                  22.21.1.5.25    22.21.1.7.5           22.21.1.7.13                   22.21.1.7.18                          22.21.1.7.22                                  22.21.1.7.25    22.21.1.46.5           22.21.1.46.13                   22.21.1.46.18                          22.21.1.46.22                                  22.21.1.46.25    22.21.1.47.5           22.21.1.47.13                   22.21.1.47.18                          22.21.1.47.22                                  22.21.1.47.25    22.21.2.1.5           22.21.2.1.13                   22.21.2.1.18                          22.21.2.1.22                                  22.21.2.1.25    22.21.2.2.5           22.21.2.2.13                   22.21.2.2.18                          22.21.2.2.22                                  22.21.2.2.25    22.21.2.5.5           22.21.2.5.13                   22.21.2.5.18                          22.21.2.5.22                                  22.21.2.5.25    22.21.2.7.5           22.21.2.7.13                   22.21.2.7.18                          22.21.2.7.22                                  22.21.2.7.25    22.21.2.46.5           22.21.2.46.13                   22.21.2.46.18                          22.21.2.46.22                                  22.21.2.46.25    22.21.2.47.5           22.21.2.47.13                   22.21.2.47.18                          22.21.2.47.22                                  22.21.2.47.25    22.21.6.1.5           22.21.6.1.13                   22.21.6.1.18                          22.21.6.1.22                                  22.21.6.1.25    22.21.6.2.5           22.21.6.2.13                   22.21.6.2.18                          22.21.6.2.22                                  22.21.6.2.25    22.21.6.5.5           22.21.6.5.13                   22.21.6.5.18                          22.21.6.5.22                                  22.21.6.5.25    22.21.6.7.5           22.21.6.7.13                   22.21.6.7.18                          22.21.6.7.22                                  22.21.6.7.25    22.21.6.46.5           22.21.6.46.13                   22.21.6.46.18                          22.21.6.46.22                                  22.21.6.46.25    22.21.6.47.5           22.21.6.47.13                   22.21.6.47.18                          22.21.6.47.22                                  22.21.6.47.25    22.21.7.1.5           22.21.7.1.13                   22.21.7.1.18                          22.21.7.1.22                                  22.21.7.1.25    22.21.7.2.5           22.21.7.2.13                   22.21.7.2.18                          22.21.7.2.22                                  22.21.7.2.25    22.21.7.5.5           22.21.7.5.13                   22.21.7.5.18                          22.21.7.5.22                                  22.21.7.5.25    22.21.7.7.5           22.21.7.7.13                   22.21.7.7.18                          22.21.7.7.22                                  22.21.7.7.25    22.21.7.46.5           22.21.7.46.13                   22.21.7.46.18                          22.21.7.46.22                                  22.21.7.46.25    22.21.7.47.5           22.21.7.47.13                   22.21.7.47.18                          22.21.7.47.22                                  22.21.7.47.25    22.21.8.1.5           22.21.8.1.13                   22.21.8.1.18                          22.21.8.1.22                                  22.21.8.1.25    22.21.8.2.5           22.21.8.2.13                   22.21.8.2.18                          22.21.8.2.22                                  22.21.8.2.25    22.21.8.5.5           22.21.8.5.13                   22.21.8.5.18                          22.21.8.5.22                                  22.21.8.5.25    22.21.8.7.5           22.21.8.7.13                   22.21.8.7.18                          22.21.8.7.22                                  22.21.8.7.25    22.21.8.46.5           22.21.8.46.13                   22.21.8.46.18                          22.21.8.46.22                                  22.21.8.46.25    22.21.8.47.5           22.21.8.47.13                   22.21.8.47.18                          22.21.8.47.22                                  22.21.8.47.25    22.21.9.1.5           22.21.9.1.13                   22.21.9.1.18                          22.21.9.1.22                                  22.21.9.1.25    22.21.9.2.5           22.21.9.2.13                   22.21.9.2.18                          22.21.9.2.22                                  22.21.9.2.25    22.21.9.5.5           22.21.9.5.13                   22.21.9.5.18                          22.21.9.5.22                                  22.21.9.5.25    22.21.9.7.5           22.21.9.7.13                   22.21.9.7.18                          22.21.9.7.22                                  22.21.9.7.25    22.21.9.46.5           22.21.9.46.13                   22.21.9.46.18                          22.21.9.46.22                                  22.21.9.46.25    22.21.9.47.5           22.21.9.47.13                   22.21.9.47.18                          22.21.9.47.22                                  22.21.9.47.25    22.21.10.1.5           22.21.10.1.13                   22.21.10.1.18                          22.21.10.1.22                                  22.21.10.1.25    22.21.10.2.5           22.21.10.2.13                   22.21.10.2.18                          22.21.10.2.22                                  22.21.10.2.25    22.21.10.5.5           22.21.10.5.13                   22.21.10.5.18                          22.21.10.5.22                                  22.21.10.5.25    22.21.10.7.5           22.21.10.7.13                   22.21.10.7.18                          22.21.10.7.22                                  22.21.10.7.25    22.21.10.46.5           22.21.10.46.13                   22.21.10.46.18                          22.21.10.46.22                                  22.21.10.46.25    22.21.10.47.5           22.21.10.47.13                   22.21.10.47.18                          22.21.10.47.22                                  22.21.10.47.25    22.22.1.1.5           22.22.1.1.13                   22.22.1.1.18                          22.22.1.1.22                                  22.22.1.1.25    22.22.1.2.5           22.22.1.2.13                   22.22.1.2.18                          22.22.1.2.22                                  22.22.1.2.25    22.22.1.5.5           22.22.1.5.13                   22.22.1.5.18                          22.22.1.5.22                                  22.22.1.5.25    22.22.1.7.5           22.22.1.7.13                   22.22.1.7.18                          22.22.1.7.22                                  22.22.1.7.25    22.22.1.46.5           22.22.1.46.13                   22.22.1.46.18                          22.22.1.46.22                                  22.22.1.46.25    22.22.1.47.5           22.22.1.47.13                   22.22.1.47.18                          22.22.1.47.22                                  22.22.1.47.25    22.22.2.1.5           22.22.2.1.13                   22.22.2.1.18                          22.22.2.1.22                                  22.22.2.1.25    22.22.2.2.5           22.22.2.2.13                   22.22.2.2.18                          22.22.2.2.22                                  22.22.2.2.25    22.22.2.5.5           22.22.2.5.13                   22.22.2.5.18                          22.22.2.5.22                                  22.22.2.5.25    22.22.2.7.5           22.22.2.7.13                   22.22.2.7.18                          22.22.2.7.22                                  22.22.2.7.25    22.22.2.46.5           22.22.2.46.13                   22.22.2.46.18                          22.22.2.46.22                                  22.22.2.46.25    22.22.2.47.5           22.22.2.47.13                   22.22.2.47.18                          22.22.2.47.22                                  22.22.2.47.25    22.22.6.1.5           22.22.6.1.13                   22.22.6.1.18                          22.22.6.1.22                                  22.22.6.1.25    22.22.6.2.5           22.22.6.2.13                   22.22.6.2.18                          22.22.6.2.22                                  22.22.6.2.25    22.22.6.5.5           22.22.6.5.13                   22.22.6.5.18                          22.22.6.5.22                                  22.22.6.5.25    22.22.6.7.5           22.22.6.7.13                   22.22.6.7.18                          22.22.6.7.22                                  22.22.6.7.25    22.22.6.46.5           22.22.6.46.13                   22.22.6.46.18                          22.22.6.46.22                                  22.22.6.46.25    22.22.6.47.5           22.22.6.47.13                   22.22.6.47.18                          22.22.6.47.22                                  22.22.6.47.25    22.22.7.1.5           22.22.7.1.13                   22.22.7.1.18                          22.22.7.1.22                                  22.22.7.1.25    22.22.7.2.5           22.22.7.2.13                   22.22.7.2.18                          22.22.7.2.22                                  22.22.7.2.25    22.22.7.5.5           22.22.7.5.13                   22.22.7.5.18                          22.22.7.5.22                                  22.22.7.5.25    22.22.7.7.5           22.22.7.7.13                   22.22.7.7.18                          22.22.7.7.22                                  22.22.7.7.25    22.22.7.46.5           22.22.7.46.13                   22.22.7.46.18                          22.22.7.46.22                                  22.22.7.46.25    22.22.7.47.5           22.22.7.47.13                   22.22.7.47.18                          22.22.7.47.22                                  22.22.7.47.25    22.22.8.1.5           22.22.8.1.13                   22.22.8.1.18                          22.22.8.1.22                                  22.22.8.1.25    22.22.8.2.5           22.22.8.2.13                   22.22.8.2.18                          22.22.8.2.22                                  22.22.8.2.25    22.22.8.5.5           22.22.8.5.13                   22.22.8.5.18                          22.22.8.5.22                                  22.22.8.5.25    22.22.8.7.5           22.22.8.7.13                   22.22.8.7.18                          22.22.8.7.22                                  22.22.8.7.25    22.22.8.46.5           22.22.8.46.13                   22.22.8.46.18                          22.22.8.46.22                                  22.22.8.46.25    22.22.8.47.5           22.22.8.47.13                   22.22.8.47.18                          22.22.8.47.22                                  22.22.8.47.25    22.22.9.1.5           22.22.9.1.13                   22.22.9.1.18                          22.22.9.1.22                                  22.22.9.1.25    22.22.9.2.5           22.22.9.2.13                   22.22.9.2.18                          22.22.9.2.22                                  22.22.9.2.25    22.22.9.5.5           22.22.9.5.13                   22.22.9.5.18                          22.22.9.5.22                                  22.22.9.5.25    22.22.9.7.5           22.22.9.7.13                   22.22.9.7.18                          22.22.9.7.22                                  22.22.9.7.25    22.22.9.46.5           22.22.9.46.13                   22.22.9.46.18                          22.22.9.46.22                                  22.22.9.46.25    22.22.9.47.5           22.22.9.47.13                   22.22.9.47.18                          22.22.9.47.22                                  22.22.9.47.25    22.22.10.1.5           22.22.10.1.13                   22.22.10.1.18                          22.22.10.1.22                                  22.22.10.1.25    22.22.10.2.5           22.22.10.2.13                   22.22.10.2.18                          22.22.10.2.22                                  22.22.10.2.25    22.22.10.5.5           22.22.10.5.13                   22.22.10.5.18                          22.22.10.5.22                                  22.22.10.5.25    22.22.10.7.5           22.22.10.7.13                   22.22.10.7.18                          22.22.10.7.22                                  22.22.10.7.25    22.22.10.46.5           22.22.10.46.13                   22.22.10.46.18                          22.22.10.46.22                                  22.22.10.46.25    22.22.10.47.5           22.22.10.47.13                   22.22.10.47.18                          22.22.10.47.22                                  22.22.10.47.25    22.33.1.1.5           22.33.1.1.13                   22.33.1.1.18                          22.33.1.1.22                                  22.33.1.1.25    22.33.1.2.5           22.33.1.2.13                   22.33.1.2.18                          22.33.1.2.22                                  22.33.1.2.25    22.33.1.5.5           22.33.1.5.13                   22.33.1.5.18                          22.33.1.5.22                                  22.33.1.5.25    22.33.1.7.5           22.33.1.7.13                   22.33.1.7.18                          22.33.1.7.22                                  22.33.1.7.25    22.33.1.46.5           22.33.1.46.13                   22.33.1.46.18                          22.33.1.46.22                                  22.33.1.46.25    22.33.1.47.5           22.33.1.47.13                   22.33.1.47.18                          22.33.1.47.22                                  22.33.1.47.25    22.33.2.1.5           22.33.2.1.13                   22.33.2.1.18                          22.33.2.1.22                                  22.33.2.1.25    22.33.2.2.5           22.33.2.2.13                   22.33.2.2.18                          22.33.2.2.22                                  22.33.2.2.25    22.33.2.5.5           22.33.2.5.13                   22.33.2.5.18                          22.33.2.5.22                                  22.33.2.5.25    22.33.2.7.5           22.33.2.7.13                   22.33.2.7.18                          22.33.2.7.22                                  22.33.2.7.25    22.33.2.46.5           22.33.2.46.13                   22.33.2.46.18                          22.33.2.46.22                                  22.33.2.46.25    22.33.2.47.5           22.33.2.47.13                   22.33.2.47.18                          22.33.2.47.22                                  22.33.2.47.25    22.33.6.1.5           22.33.6.1.13                   22.33.6.1.18                          22.33.6.1.22                                  22.33.6.1.25    22.33.6.2.5           22.33.6.2.13                   22.33.6.2.18                          22.33.6.2.22                                  22.33.6.2.25    22.33.6.5.5           22.33.6.5.13                   22.33.6.5.18                          22.33.6.5.22                                  22.33.6.5.25    22.33.6.7.5           22.33.6.7.13                   22.33.6.7.18                          22.33.6.7.22                                  22.33.6.7.25    22.33.6.46.5           22.33.6.46.13                   22.33.6.46.18                          22.33.6.46.22                                  22.33.6.46.25    22.33.6.47.5           22.33.6.47.13                   22.33.6.47.18                          22.33.6.47.22                                  22.33.6.47.25    22.33.7.1.5           22.33.7.1.13                   22.33.7.1.18                          22.33.7.1.22                                  22.33.7.1.25    22.33.7.2.5           22.33.7.2.13                   22.33.7.2.18                          22.33.7.2.22                                  22.33.7.2.25    22.33.7.5.5           22.33.7.5.13                   22.33.7.5.18                          22.33.7.5.22                                  22.33.7.5.25    22.33.7.7.5           22.33.7.7.13                   22.33.7.7.18                          22.33.7.7.22                                  22.33.7.7.25    22.33.7.46.5           22.33.7.46.13                   22.33.7.46.18                          22.33.7.46.22                                  22.33.7.46.25    22.33.7.47.5           22.33.7.47.13                   22.33.7.47.18                          22.33.7.47.22                                  22.33.7.47.25    22.33.8.1.5           22.33.8.1.13                   22.33.8.1.18                          22.33.8.1.22                                  22.33.8.1.25    22.33.8.2.5           22.33.8.2.13                   22.33.8.2.18                          22.33.8.2.22                                  22.33.8.2.25    22.33.8.5.5           22.33.8.5.13                   22.33.8.5.18                          22.33.8.5.22                                  22.33.8.5.25    22.33.8.7.5           22.33.8.7.13                   22.33.8.7.18                          22.33.8.7.22                                  22.33.8.7.25    22.33.8.46.5           22.33.8.46.13                   22.33.8.46.18                          22.33.8.46.22                                  22.33.8.46.25    22.33.8.47.5           22.33.8.47.13                   22.33.8.47.18                          22.33.8.47.22                                  22.33.8.47.25    22.33.9.1.5           22.33.9.1.13                   22.33.9.1.18                          22.33.9.1.22                                  22.33.9.1.25    22.33.9.2.5           22.33.9.2.13                   22.33.9.2.18                          22.33.9.2.22                                  22.33.9.2.25    22.33.9.5.5           22.33.9.5.13                   22.33.9.5.18                          22.33.9.5.22                                  22.33.9.5.25    22.33.9.7.5           22.33.9.7.13                   22.33.9.7.18                          22.33.9.7.22                                  22.33.9.7.25    22.33.9.46.5           22.33.9.46.13                   22.33.9.46.18                          22.33.9.46.22                                  22.33.9.46.25    22.33.9.47.5           22.33.9.47.13                   22.33.9.47.18                          22.33.9.47.22                                  22.33.9.47.25    22.33.10.1.5           22.33.10.1.13                   22.33.10.1.18                          22.33.10.1.22                                  22.33.10.1.25    22.33.10.2.5           22.33.10.2.13                   22.33.10.2.18                          22.33.10.2.22                                  22.33.10.2.25    22.33.10.5.5           22.33.10.5.13                   22.33.10.5.18                          22.33.10.5.22                                  22.33.10.5.25    22.33.10.7.5           22.33.10.7.13                   22.33.10.7.18                          22.33.10.7.22                                  22.33.10.7.25    22.33.10.46.5           22.33.10.46.13                   22.33.10.46.18                          22.33.10.46.22                                  22.33.10.46.25    22.33.10.47.5           22.33.10.47.13                   22.33.10.47.18                          22.33.10.47.22                                  22.33.10.47.25    22.34.1.1.5           22.34.1.1.13                   22.34.1.1.18                          22.34.1.1.22                                  22.34.1.1.25    22.34.1.2.5           22.34.1.2.13                   22.34.1.2.18                          22.34.1.2.22                                  22.34.1.2.25    22.34.1.5.5           22.34.1.5.13                   22.34.1.5.18                          22.34.1.5.22                                  22.34.1.5.25    22.34.1.7.5           22.34.1.7.13                   22.34.1.7.18                          22.34.1.7.22                                  22.34.1.7.25    22.34.1.46.5           22.34.1.46.13                   22.34.1.46.18                          22.34.1.46.22                                  22.34.1.46.25    22.34.1.47.5           22.34.1.47.13                   22.34.1.47.18                          22.34.1.47.22                                  22.34.1.47.25    22.34.2.1.5           22.34.2.1.13                   22.34.2.1.18                          22.34.2.1.22                                  22.34.2.1.25    22.34.2.2.5           22.34.2.2.13                   22.34.2.2.18                          22.34.2.2.22                                  22.34.2.2.25    22.34.2.5.5           22.34.2.5.13                   22.34.2.5.18                          22.34.2.5.22                                  22.34.2.5.25    22.34.2.7.5           22.34.2.7.13                   22.34.2.7.18                          22.34.2.7.22                                  22.34.2.7.25    22.34.2.46.5           22.34.2.46.13                   22.34.2.46.18                          22.34.2.46.22                                  22.34.2.46.25    22.34.2.47.5           22.34.2.47.13                   22.34.2.47.18                          22.34.2.47.22                                  22.34.2.47.25    22.34.6.1.5           22.34.6.1.13                   22.34.6.1.18                          22.34.6.1.22                                  22.34.6.1.25    22.34.6.2.5           22.34.6.2.13                   22.34.6.2.18                          22.34.6.2.22                                  22.34.6.2.25    22.34.6.5.5           22.34.6.5.13                   22.34.6.5.18                          22.34.6.5.22                                  22.34.6.5.25    22.34.6.7.5           22.34.6.7.13                   22.34.6.7.18                          22.34.6.7.22                                  22.34.6.7.25    22.34.6.46.5           22.34.6.46.13                   22.34.6.46.18                          22.34.6.46.22                                  22.34.6.46.25    22.34.6.47.5           22.34.6.47.13                   22.34.6.47.18                          22.34.6.47.22                                  22.34.6.47.25    22.34.7.1.5           22.34.7.1.13                   22.34.7.1.18                          22.34.7.1.22                                  22.34.7.1.25    22.34.7.2.5           22.34.7.2.13                   22.34.7.2.18                          22.34.7.2.22                                  22.34.7.2.25    22.34.7.5.5           22.34.7.5.13                   22.34.7.5.18                          22.34.7.5.22                                  22.34.7.5.25    22.34.7.7.5           22.34.7.7.13                   22.34.7.7.18                          22.34.7.7.22                                  22.34.7.7.25    22.34.7.46.5           22.34.7.46.13                   22.34.7.46.18                          22.34.7.46.22                                  22.34.7.46.25    22.34.7.47.5           22.34.7.47.13                   22.34.7.47.18                          22.34.7.47.22                                  22.34.7.47.25    22.34.8.1.5           22.34.8.1.13                   22.34.8.1.18                          22.34.8.1.22                                  22.34.8.1.25    22.34.8.2.5           22.34.8.2.13                   22.34.8.2.18                          22.34.8.2.22                                  22.34.8.2.25    22.34.8.5.5           22.34.8.5.13                   22.34.8.5.18                          22.34.8.5.22                                  22.34.8.5.25    22.34.8.7.5           22.34.8.7.13                   22.34.8.7.18                          22.34.8.7.22                                  22.34.8.7.25    22.34.8.46.5           22.34.8.46.13                   22.34.8.46.18                          22.34.8.46.22                                  22.34.8.46.25    22.34.8.47.5           22.34.8.47.13                   22.34.8.47.18                          22.34.8.47.22                                  22.34.8.47.25    22.34.9.1.5           22.34.9.1.13                   22.34.9.1.18                          22.34.9.1.22                                  22.34.9.1.25    22.34.9.2.5           22.34.9.2.13                   22.34.9.2.18                          22.34.9.2.22                                  22.34.9.2.25    22.34.9.5.5           22.34.9.5.13                   22.34.9.5.18                          22.34.9.5.22                                  22.34.9.5.25    22.34.9.7.5           22.34.9.7.13                   22.34.9.7.18                          22.34.9.7.22                                  22.34.9.7.25    22.34.9.46.5           22.34.9.46.13                   22.34.9.46.18                          22.34.9.46.22                                  22.34.9.46.25    22.34.9.47.5           22.34.9.47.13                   22.34.9.47.18                          22.34.9.47.22                                  22.34.9.47.25    22.34.10.1.5           22.34.10.1.13                   22.34.10.1.18                          22.34.10.1.22                                  22.34.10.1.25    22.34.10.2.5           22.34.10.2.13                   22.34.10.2.18                          22.34.10.2.22                                  22.34.10.2.25    22.34.10.5.5           22.34.10.5.13                   22.34.10.5.18                          22.34.10.5.22                                  22.34.10.5.25    22.34.10.7.5           22.34.10.7.13                   22.34.10.7.18                          22.34.10.7.22                                  22.34.10.7.25    22.34.10.46.5           22.34.10.46.13                   22.34.10.46.18                          22.34.10.46.22                                  22.34.10.46.25    22.34.10.47.5           22.34.10.47.13                   22.34.10.47.18                          22.34.10.47.22                                  22.34.10.47.25    22.37.1.1.5           22.37.1.1.13                   22.37.1.1.18                          22.37.1.1.22                                  22.37.1.1.25    22.37.1.2.5           22.37.1.2.13                   22.37.1.2.18                          22.37.1.2.22                                  22.37.1.2.25    22.37.1.5.5           22.37.1.5.13                   22.37.1.5.18                          22.37.1.5.22                                  22.37.1.5.25    22.37.1.7.5           22.37.1.7.13                   22.37.1.7.18                          22.37.1.7.22                                  22.37.1.7.25    22.37.1.46.5           22.37.1.46.13                   22.37.1.46.18                          22.37.1.46.22                                  22.37.1.46.25    22.37.1.47.5           22.37.1.47.13                   22.37.1.47.18                          22.37.1.47.22                                  22.37.1.47.25    22.37.2.1.5           22.37.2.1.13                   22.37.2.1.18                          22.37.2.1.22                                  22.37.2.1.25    22.37.2.2.5           22.37.2.2.13                   22.37.2.2.18                          22.37.2.2.22                                  22.37.2.2.25    22.37.2.5.5           22.37.2.5.13                   22.37.2.5.18                          22.37.2.5.22                                  22.37.2.5.25    22.37.2.7.5           22.37.2.7.13                   22.37.2.7.18                          22.37.2.7.22                                  22.37.2.7.25    22.37.2.46.5           22.37.2.46.13                   22.37.2.46.18                          22.37.2.46.22                                  22.37.2.46.25    22.37.2.47.5           22.37.2.47.13                   22.37.2.47.18                          22.37.2.47.22                                  22.37.2.47.25    22.37.6.1.5           22.37.6.1.13                   22.37.6.1.18                          22.37.6.1.22                                  22.37.6.1.25    22.37.6.2.5           22.37.6.2.13                   22.37.6.2.18                          22.37.6.2.22                                  22.37.6.2.25    22.37.6.5.5           22.37.6.5.13                   22.37.6.5.18                          22.37.6.5.22                                  22.37.6.5.25    22.37.6.7.5           22.37.6.7.13                   22.37.6.7.18                          22.37.6.7.22                                  22.37.6.7.25    22.37.6.46.5           22.37.6.46.13                   22.37.6.46.18                          22.37.6.46.22                                  22.37.6.46.25    22.37.6.47.5           22.37.6.47.13                   22.37.6.47.18                          22.37.6.47.22                                  22.37.6.47.25    22.37.7.1.5           22.37.7.1.13                   22.37.7.1.18                          22.37.7.1.22                                  22.37.7.1.25    22.37.7.2.5           22.37.7.2.13                   22.37.7.2.18                          22.37.7.2.22                                  22.37.7.2.25    22.37.7.5.5           22.37.7.5.13                   22.37.7.5.18                          22.37.7.5.22                                  22.37.7.5.25    22.37.7.7.5           22.37.7.7.13                   22.37.7.7.18                          22.37.7.7.22                                  22.37.7.7.25    22.37.7.46.5           22.37.7.46.13                   22.37.7.46.18                          22.37.7.46.22                                  22.37.7.46.25    22.37.7.47.5           22.37.7.47.13                   22.37.7.47.18                          22.37.7.47.22                                  22.37.7.47.25    22.37.8.1.5           22.37.8.1.13                   22.37.8.1.18                          22.37.8.1.22                                  22.37.8.1.25    22.37.8.2.5           22.37.8.2.13                   22.37.8.2.18                          22.37.8.2.22                                  22.37.8.2.25    22.37.8.5.5           22.37.8.5.13                   22.37.8.5.18                          22.37.8.5.22                                  22.37.8.5.25    22.37.8.7.5           22.37.8.7.13                   22.37.8.7.18                          22.37.8.7.22                                  22.37.8.7.25    22.37.8.46.5           22.37.8.46.13                   22.37.8.46.18                          22.37.8.46.22                                  22.37.8.46.25    22.37.8.47.5           22.37.8.47.13                   22.37.8.47.18                          22.37.8.47.22                                  22.37.8.47.25    22.37.9.1.5           22.37.9.1.13                   22.37.9.1.18                          22.37.9.1.22                                  22.37.9.1.25    22.37.9.2.5           22.37.9.2.13                   22.37.9.2.18                          22.37.9.2.22                                  22.37.9.2.25    22.37.9.5.5           22.37.9.5.13                   22.37.9.5.18                          22.37.9.5.22                                  22.37.9.5.25    22.37.9.7.5           22.37.9.7.13                   22.37.9.7.18                          22.37.9.7.22                                  22.37.9.7.25    22.37.9.46.5           22.37.9.46.13                   22.37.9.46.18                          22.37.9.46.22                                  22.37.9.46.25    22.37.9.47.5           22.37.9.47.13                   22.37.9.47.18                          22.37.9.47.22                                  22.37.9.47.25    22.37.10.1.5           22.37.10.1.13                   22.37.10.1.18                          22.37.10.1.22                                  22.37.10.1.25    22.37.10.2.5           22.37.10.2.13                   22.37.10.2.18                          22.37.10.2.22                                  22.37.10.2.25    22.37.10.5.5           22.37.10.5.13                   22.37.10.5.18                          22.37.10.5.22                                  22.37.10.5.25    22.37.10.7.5           22.37.10.7.13                   22.37.10.7.18                          22.37.10.7.22                                  22.37.10.7.25    22.37.10.46.5           22.37.10.46.13                   22.37.10.46.18                          22.37.10.46.22                                  22.37.10.46.25    22.37.10.47.5           22.37.10.47.13                   22.37.10.47.18                          22.37.10.47.22                                  22.37.10.47.25    __________________________________________________________________________

Screens for Neuraminidase Inhibitors

Compositions of the invention are screened for inhibitory activityagainst neuraminidase by any of the conventional techniques forevaluating enzyme activity. Within the context of the invention,typically compositions are first screened for inhibition ofneuraminidase in vitro and compositions showing inhibitory activity arethen screened for activity in vivo. Compositions having in vitro Ki(inhibitory constants) of less then about 5×10⁻⁶ M, typically less thanabout 5×10⁻⁷ M and preferably less than about 5×10⁻⁸ M are excellentcandidates for in vivo screening.

Useful in vitro screens have been described in detail and will not beelaborated here. However, Itzstein, M. von et al.; Nature 1993,363(6428), 418-423, in particular page 420, column 2, full paragraph 3,to page 421, column 2, first partial paragraph, describes a suitable invitro assay of Potier, M.; et al.; Analyt. Biochem. 1979, 94 287-296, asmodified by Chong, A. K. J.; et al.; Biochem. biophys. Acta 1991, 1077,65-71; and Colman, P. M.; et al.; International Publication No. WO92/06691 (Int. App. No. PCT/AU90/00501, publication date Apr. 30, 1992)page 34, line 13, to page 35, line 16, describes another useful in vitroscreen.

In vivo screens have also been described in detail, see Itzstein, M. vonet al.; op. cit., in particular page 421, column 2, first fullparagraph, to page 423, column 2, first partial paragraph, and Colman,P. M.; et al.; op. cit. page 36, lines 1-38, describe suitable in vivoscreens.

Pharmaceutical Formulations

Another aspect of the invention relates to compositions comprising oneor more pharmaceutically-acceptable carriers. One or more compounds ofthe invention (herein referred to as the active ingredients) areadministered by any route appropriate to the condition to be treated.Suitable routes include oral, rectal, nasal, topical (including buccaland sublingual), vaginal and parenteral (including subcutaneous,intramuscular, intravenous, intradermal, intrathecal and epidural), andthe like. It will be appreciated that the preferred route may vary withfor example the condition of the recipient.

While it is possible for the active ingredients to be administered aloneit may be preferable to present them as pharmaceutical formulations. Theformulations, both for veterinary and for human use, of the inventioncomprise at least one active ingredient, as above defined, together withone or more acceptable carriers therefor and optionally othertherapeutic ingredients. The carrier(s) must be "acceptable" in thesense of being compatible with the other ingredients of the formulationand physiologically innocuous to the recipient thereof.

The formulations include those suitable for oral, rectal, nasal, topical(including buccal and sublingual), vaginal or parenteral (includingsubcutaneous, intramuscular, intravenous, intradermal, intrathecal andepidural) administration. The formulations may conveniently be presentedin unit dosage form and may be prepared by any of the methods well knownin the art of pharmacy. Techniques and formulations generally are foundin Remington's Pharmaceutical Sciences (Mack Publishing Co., Easton,Pa.). Such methods include the step of bringing into association theactive ingredient with the carrier which constitutes one or moreaccessory ingredients. In general the formulations are prepared byuniformly and intimately bringing into association the active ingredientwith liquid carriers or finely divided solid carriers or both, and then,if necessary, shaping the product.

Formulations of the invention suitable for oral administration areprepared as discrete units such as capsules, cachets or tablets eachcontaining a predetermined amount of the active ingredient; as a powderor granules; as solution or a suspension in an aqueous liquid or anon-aqueous liquid; or as an oil-in-water liquid emulsion or awater-in-oil liquid emulsion. The active ingredient may also bepresented as a bolus, electuary or paste.

A tablet is made by compression or molding, optionally with one or moreaccessory ingredients. Compressed tablets may be prepared by compressingin a suitable machine the active ingredient in a free-flowing form suchas a powder or granules, optionally mixed with a binder, lubricant,inert diluent, preservative, surface active or dispersing agent. Moldedtablets may be made by molding in a suitable machine a mixture of thepowdered active ingredient moistened with an inert liquid diluent. Thetablets may optionally are coated or scored and optionally areformulated so as to provide slow or controlled release of the activeingredient therefrom.

For infections of the eye or other external tissues e.g. mouth and skin,the formulations are preferably applied as a topical ointment or creamcontaining the active ingredient(s) in an amount of, for example, 0.075to 20% w/w (including active ingredient(s) in a range between 0.1% and20% in increments of 0.1% w/w such as 0.6% w/w, 0.7% w/w, etc.),preferably 0.2 to 15% w/w and most preferably 0.5 to 10% w/w. Whenformulated in an ointment, the active ingredients may be employed witheither a paraffinic or a water-miscible ointment base. Alternatively,the active ingredients may be formulated in a cream with an oil-in-watercream base.

If desired, the aqueous phase of the cream base may include, forexample, at least 30% w/w of a polyhydric alcohol, i.e. an alcoholhaving two or more hydroxyl groups such as propylene glycol, butane1,3-diol, mannitol, sorbitol, glycerol and polyethylene glycol(including PEG 400) and mixtures thereof. The topical formulations maydesirably include a compound which enhances absorption or penetration ofthe active ingredient through the skin or other affected areas. Examplesof such dermal penetration enhancers include dimethyl sulphoxide andrelated analogs.

The oily phase of the emulsions of this invention may be constitutedfrom known ingredients in a known manner. While the phase may comprisemerely an emulsifier (otherwise known as an emulgent), it desirablycomprises a mixture of at least one emulsifier with a fat or an oil orwith both a fat and an oil. Preferably, a hydrophilic emulsifier isincluded together with a lipophilic emulsifier which acts as astabilizer. It is also preferred to include both an oil and a fat.Together, the emulsifier(s) with or without stabilizer(s) make up theso-called emulsifying wax, and the wax together with the oil and fatmake up the so-called emulsifying ointment base which forms the oilydispersed phase of the cream formulations.

Emulgents and emulsion stabilizers suitable for use in the formulationof the invention include Tween® 60, Span® 80, cetostearyl alcohol,benzyl alcohol, myristyl alcohol, glyceryl mono-stearate and sodiumlauryl sulfate.

The choice of suitable oils or fats for the formulation is based onachieving the desired cosmetic properties, since the solubility of theactive compound in most oils likely to be used in pharmaceuticalemulsion formulations is very low. Thus the cream should preferably be anon-greasy, non-staining and washable product with suitable consistencyto avoid leakage from tubes or other containers. Straight or branchedchain, mono- or dibasic alkyl esters such as di-isoadipate, isocetylstearate, propylene glycol diester of coconut fatty acids, isopropylmyristate, decyl oleate, isopropyl palmitate, butyl stearate,2-ethylhexyl palmitate or a blend of branched chain esters known asCrodamol CAP may be used, the last three being preferred esters. Thesemay be used alone or in combination depending on the propertiesrequired. Alternatively, high melting point lipids such as white softparaffin and/or liquid paraffin or other mineral oils are used.

Formulations suitable for topical administration to the eye also includeeye drops wherein the active ingredient is dissolved or suspended in asuitable carrier, especially an aqueous solvent for the activeingredient. The active ingredient is preferably present in suchformulations in a concentration of 0.5 to 20%, advantageously 0.5 to 10%particularly about 1.5% w/w.

Formulations suitable for topical administration in the mouth includelozenges comprising the active ingredient in a flavored basis, usuallysucrose and acacia or tragacanth; pastilles comprising the activeingredient in an inert basis such as gelatin and glycerin, or sucroseand acacia; and mouthwashes comprising the active ingredient in asuitable liquid carrier.

Formulations for rectal administration may be presented as a suppositorywith a suitable base comprising for example cocoa butter or asalicylate.

Formulations suitable for nasal administration wherein the carrier is asolid include a coarse powder having a particle size for example in therange 20 to 500 microns (including particle sizes in a range between 20and 500 microns in increments of 5 microns such as 30 microns, 35microns, etc.), which is administered by rapid inhalation through thenasal passage from a container of the powder held close up to the nose.Suitable formulations wherein the carrier is a liquid, foradministration as for example a nasal spray or as nasal drops, includeaqueous or oily solutions of the active ingredient. Formulationssuitable for aerosol administration may be prepared according toconventional methods and may be delivered with other therapeutic agents.

Formulations suitable for inhalation therapy are prepared as aerosols orpowders having a particle size small enough to dose the alveoli. Suchpowders and aerosols are prepared by any of the methods common in theart. Ordinarily aerosols are aqueous aerosols.

Formulations suitable for vaginal administration may be presented aspessaries, tampons, creams, gels, pastes, foams or spray formulationscontaining in addition to the active ingredient such carriers as areknown in the art to be appropriate.

Formulations suitable for parenteral administration include aqueous andnon-aqueous sterile injection solutions which may contain anti-oxidants,buffers, bacteriostats and solutes which render the formulation isotonicwith the blood of the intended recipient; and aqueous and non-aqueoussterile suspensions which may include suspending agents and thickeningagents. The formulations may be presented in unit-dose or multi-dosecontainers, for example sealed ampoules and vials, and may be stored ina freeze-dried (lyophilized) condition requiring only the addition ofthe sterile liquid carrier, for example water for injections,immediately prior to use. Extemporaneous injection solutions andsuspensions may be prepared from sterile powders, granules and tabletsof the kind previously described. Preferred unit dosage formulations arethose containing a daily dose or unit daily sub-dose, as herein aboverecited, or an appropriate fraction thereof, of an active ingredient.

It should be understood that in addition to the ingredients particularlymentioned above the formulations of this invention may include otheragents conventional in the art having regard to the type of formulationin question, for example those suitable for oral administration mayinclude flavoring agents.

The invention further provides veterinary compositions comprising atleast one active ingredient as above defined together with a veterinarycarrier therefor.

Veterinary carriers are materials useful for the purpose ofadministering the composition and may be solid, liquid or gaseousmaterials which are otherwise inert or acceptable in the veterinary artand are compatible with the active ingredient. These veterinarycompositions may be administered orally, parenterally or by any otherdesired route.

Compounds of the invention are used to provide controlled releasepharmaceutical formulations containing as active ingredient one or morecompounds of the invention ("controlled release formulations") in whichthe release of the active ingredient are controlled and regulated toallow less frequency dosing or to improve the pharmacokinetic ortoxicity profile of a given active ingredient.

Effective dose of active ingredient depends on the nature of thecondition being treated, the method of treatment, pharmaceuticalformulation, and the like. It can be expected to be from about 0.001 toabout 30 mg/kg body weight per day. For example, for inhalation thedaily dose for an adult human of approximately 70 kg body weight willrange from 1 mg to 1000 mg, preferably between 5 mg and 500 mg, and maytake the form of single or multiple doses.

Active ingredients of the invention are also used in combination withother active ingredients. Such combinations are selected based on thecondition to be treated, cross-reactivities of ingredients andpharmaco-properties of the combination. For example, when treating viralinfections of the respiratory system, in particular influenza infection,the compositions of the invention are combined with mucolytic,expectorant, bronchial-dilators, antibiotics, antipyretics, oranalgesics. Ordinarily, antibiotics, antipyretics, and analgesics.

Methods of Inhibition of Neuraminidase

Another aspect of the invention relates to methods of inhibiting theactivity of neuraminidase comprising the step of treating a samplesuspected of containing neuraminidase with a composition of theinvention.

Within the context of the invention samples suspected of containingneuraminidase include natural or man-made materials such as livingorganisms; tissue or cell cultures; biological samples such asbiological material samples (blood, serum, urine, cerebrospinal fluid,tears, sputum, saliva, tissue samples, and the like); laboratorysamples; food, water, or air samples; bioproduct samples such asextracts of cells; and the like. Typically the sample will be suspectedof containing an organism which produces neuraminidase, frequently apathogenic organism such as a virus. Samples can be contained in anymedium including water and organic solvent\water mixtures. Frequentsamples are living organisms such as humans, and man made materials suchas bioproduct samples.

The treating step of the invention can involve adding the composition ofthe invention to the sample or it can involve adding a precursor of thecomposition to the sample. The addition step comprises any method ofadministration as described above.

If desired, the activity of neuraminidase after application of thecomposition can be observed by any method including direct and indirectmethods of detecting neuraminidase activity. Quantitative, qualitative,and semiquantitative methods of determining neuraminidase activity areall contemplated. Typically one of the screening methods described aboveare applied, however, any other method such as observation of thephysiological properties of a living organism are also applicable.

Organisms that contain neuraminidase include bacteria (Vibrio cholerae,Clostridium perfringens, Streptococcus pneumoniae, and Arthrobactersialophilus) and viruses (influenza virus, parainfluenza virus, mumpsvirus, Newcastle disease virus, fowl plague virus, and sendai virus).Inhibition of neuraminidase activity related to any of these organismsis within the objects of this invention. The virology of influenzaviruses is described in "Fundamental Virology" (Raven Press, New York,1986), Chapter 24.

Metabolites of the Compounds of the Invention

Also falling within the scope of this invention are the in vivometabolic products of the compounds described herein, to the extent suchproducts are novel and unobvious over the prior art. Such products mayresult for example from the oxidation, reduction, hydrolysis, amidation,esterification and the like of the administered compound, primarily dueto enzymatic processes. Accordingly, the invention includes novel andunobvious compounds produced by a process comprising contacting acompound of this invention with a mammal for a period of time sufficientto yield a metabolic product thereof. Such products typically areidentified by preparing a radiolabeled (e.g. C¹⁴ or H³) compound of theinvention, administering it parenterally in a detectable dose (e.g.greater than about 0.5 mg/kg) to an animal such as rat, mouse, guineapig, monkey, or to man, allowing sufficient time for metabolism to occur(typically about 30 seconds to 30 hours) and isolating its conversionproducts from the urine, blood or other biological samples. Theseproducts are easily isolated since they are labeled (others are isolatedby the use of antibodies capable of binding epitopes surviving in themetabolite). The metabolite structures are determined in conventionalfashion, e.g. by MS or NMR analysis. In general, analysis of metabolitesis done in the same way as conventional drug metabolism studieswell-known to those skilled in the art. The conversion products, so longas they are not otherwise found in vivo , are useful in diagnosticassays for therapeutic dosing of the compounds of the invention even ifthey possess no neuraminidase inhibitory activity of their own.

Immunogens, Antibodies, and Assays

The compounds of this invention, or the biologically active substancesproduced from these compounds by hydrolysis or metabolism in vivo, areused as immunogens or components of immunogenic compositions to prepareantibodies capable of binding specifically to the compounds or theirmetabolic products which retain immunologically recognized epitopes(sites of antibody binding). The immunogenic compositions therefore areuseful as intermediates in the preparation of antibodies for use indiagnostic, quality control, or the like, methods or in assays for thecompounds or their novel metabolic products.

The hydrolysis products of interest include products of the hydrolysisof the protected acidic and basic groups discussed above. In preferredembodiments the acidic or basic amides comprising immunogenicpolypeptides such as albumin keyhole limpet hemocyamin and othersdescribed below generally are useful as immunogens. The metabolicproducts described above may retain a substantial degree ofimmunological cross reactivity with the compounds of the invention.Thus, the antibodies of this invention will be capable of binding to theunprotected compounds of the invention without binding to the protectedcompounds; alternatively the metabolic products, will be capable ofbinding to the protected compounds and/or the metabolitic productswithout binding to the protected compounds of the invention, or will becapable of binding specifically to any one or all three. The antibodiesdesirably will not substantially cross-react with naturally-occurringmaterials. Substantial cross-reactivity is reactivity under specificassay conditions for specific analytes sufficient to interfere with theassay results.

The immunogens of this invention contain the compound presenting thedesired epitope in association with an immunogenic substance. Within thecontext of the invention such association means covalent bonding to forman immunogenic conjugate (when applicable) or a mixture ofnon-covalently bonded materials, or a combination of the above.Immunogenic substances include adjuvants such as Freund's adjuvant,immunogenic proteins such as viral, bacterial, yeast, plant and animalpolypeptides, in particular keyhole limpet hemocyanin, serum albumin,bovine thyroglobulin or soybean trypsin inhibitor, and immunogenicpolysaccharides. Typically, the compound having the structure of thedesired epitope is covalently conjugated to an immunogenic polypeptideor polysaccharide by the use of a polyfunctional (ordinarilybifunctional) cross-linking agent. Methods for the manufacture of haptenimmunogens are conventional per se, and any of the methods usedheretofore for conjugating haptens to immunogenic polypeptides or thelike are suitably employed here as well, taking into account thefunctional groups on the precursors or hydrolytic products which areavailable for cross-linking and the likelihood of producing antibodiesspecific to the epitope in question as opposed to the immunogenicsubstance.

Typically the polypeptide is conjugated to a site on the compound of theinvention distant from the epitope to be recognized.

The conjugates are prepared in conventional fashion. For example, thecross-linking agents N-hydroxysuccinimide, succinic anhydride oralkN═C═Nalk are useful in preparing the conjugates of this invention.The conjugates comprise a compound of the invention attached by a bondor a linking group of 1-100, typically, 1-25, more typically 1-10 carbonatoms to the immunogenic substance. The conjugates are separated fromstarting materials and by products using chromatography or the like, andthen are sterile filtered and vialed for storage.

The compounds of this invention include cross-linking for examplethrough any one or more of the following groups: a hydroxyl group of X;a carboxyl group of Y; a carbon atom of E, A, B, A₁, or B₁ insubstitution of H; and an amine group of Z.

Animals are typically immunized against the immunogenic conjugates orderivatives by combining 1 mg or 1 μg of conjugate (for rabbits or mice,respectively) with 3 volumes of Freund's complete adjuvant and injectingthe solution intradermally at multiple sites. One month later theanimals are boosted with 1/5 to 1/10 the original amount of conjugate inFreund's complete adjuvant (or other suitable adjuvant) by subcutaneousinjection at multiple sites. 7 to 14 days later animals are bled and theserum is assayed for the desired antibody titer. Animals are boosteduntil the titer plateaus. Preferably, the animal is boosted with theconjugate in which the precursor or product is linked to a differentprotein, through a different cross-linking agent or both. Optionally,aggregating agents such as alum are used to enhance the immune response.

After immunization, monoclonal antibodies are prepared by recoveringimmune lymphoid cells (typically spleen cells or lymphocytes from lymphnode tissue) from immunized animals and immortalizing the cells inconventional fashion, e.g., by fusion with myeloma cells or byEpstein-Barr virus transformation and screening for clones expressingthe desired antibody. The hybridoma technique described originally beKohler and Milstein, Eur. J. Immunol. (1976) 6:511 has been widelyapplied to produce hybrid cell lines that secrete high levels ofmonoclonal antibodies against many specific antigens.

It is possible to fuse cells of one species with another. However, it ispreferably that the source of the immunized antibody producing cells andthe myeloma be from the same species.

The hybrid cell lines are maintained in culture in vitro. The cell linesof this invention are selected or maintained in ahypoxanthine-aminopterin thymidine (HAT) medium. However, theestablished hybridoma cell line can be maintained on a variety ofnutritionally adequate media. The secreted antibody is recovered fromculture by conventional methods such as precipitation, ion exchangechromatography, affinity chromatography, or the like. The antibodiesdescribed herein are also recovered from hybridoma cell cultures byconventional methods for purification of IgG or IgM as the case may bethat heretofore have been used to purify immunoglobulins from pooledplasma, e.g., ethanol or polyethylene glycol precipitation procedures.The purified antibodies are sterile filtered, and optionally areconjugated to a detectable marker such as an enzyme or spin label foruse in diagnostic assays of test samples.

The antibodies of this invention are obtained from any animal species,but ordinarily are from murine or rat. Once a monoclonal antibody havingthe desired specificity and affinity is obtained, other conventionalmodifications of the antibodies are within the scope of this invention.For example, the complementarity determining regions of an animalantibody, together with as much of the framework domain as is needed,are substituted into an antibody of another animal species or class toproduce a cross-class or cross-species chimeric antibody. Fragments orother amino acid sequence variants of monoclonal antibodies also areencompassed within the meaning of antibody as that term is used herein,for example, Fab, Fab' or (Fab')2 fragments, single chain antibodies, bior polyspecific antibodies, and the like.

The antibodies of this invention are from any suitable class or isotype,e.g. IgG, IgM, IgA, IgD or IgE. They may or may not participate incomplement binding or ADCC.

Typically, hybridomas which are capable of binding to the immunogen arescreened for the ability to bind to the hapten itself in typical testsamples (plasma, serum and the like) with the requisite degree ofaffinity. The desired affinity will depend upon the use intended for theantibody, but should be adequate to function in a conventionalcompetitive-type ELISA or radioimmunoassays, or in conventional EMITimmunoassays.

The antibodies of this invention are used in such assays together with alabeled form of the compounds of the invention. Alternatively, theantibody is labeled. Suitable labels are well-known and includeradioisotopes, enzymes, stable free radicals, fluorophors,chemiluminescent moieties and other detectable groups heretoforeemployed to prepare covalent conjugates for use in assays. Methods forlinking the labels to ligand amino groups, or amino acid side chains ortermini of polypeptides, are known and are suitable for use herein.Other suitable linking methods will be apparent to the ordinary artisan.

The antibodies and labeled ligands herein optionally are assembled intokits for use in therapeutic drug monitoring or evaluation, or forprocess quality control, and used in the conventional manner.

The invention also relates to methods of detecting neuraminidase in asample suspected of containing neuraminidase comprising the steps of:treating a sample suspected of containing neuraminidase with acomposition comprising a compound of the invention bound to a label; andobserving the effect of the sample on the activity of the label.

Compositions of the invention include inhibitors of neuraminidase. Assuch the compositions will bind to locations on the surface or in acavity of neuraminidase having a geometry unique to neuraminidase.Compositions binding neuraminidase may bind with varying degrees ofreversibility. Those compounds binding substantially irreversibly areideal candidates for use in this method of the invention. Once labeled,the substantially irreversibly binding compositions become probes forthe detection of neuraminidase.

The compounds of the invention are useful for maintaining the structuralintegrity of glycoproteins in recombinant cell culture. Similarly, thecompounds are useful for inhibiting the neuraminidase mediated orcatalyzed cleavage of glycoproteins in recombinant cell culture.

Other Uses of the Compounds of the Invention

The compounds of the invention are polyfunctional. As such theyrepresent a unique class of monomers for the synthesis of polymers. Byway of example and not limitation, the polymers could include polyamidesand polyesters. Polyamides and polyesters are materials of well knownutility and the present monomers provide access to polymers havingunique pendent functionalities. The compounds of this invention areuseful as monomers in homopolymers or comonomers with monomers which donot fall within the scope of the invention. Homopolymers of thecompounds of this invention will have utility as cation exchange agents(polyesters) in the preparation of molecular sieves (polymides),textiles, fibers, films, formed articles and the like.

The preparation of polymers from the compounds of the invention is byconventional techniques. The polyesters are prepared from the compoundshaving a carboxylic acid as the acidic group and an alcohol or otherleaving group. The polyamides are prepared from the compounds of theinvention comprising an amine.

The compounds of the invention are also a unique class of polyfunctionalsurfactants. Particularly when the acidic group and the group comprisinga basic hetero atom have a chain of 1 to 12 atoms, the compounds havethe properties of bi-functional surfactants. As such they have usefulsurfactant, surface coating, emulsion modifying, rheology modifying andsurface wetting properties.

As polyfunctional compounds with defined geometry and carryingsimultaneously polar and non-polar moieties, the compounds of theinvention are useful as a unique class of phase transfer agents. By wayof example and not limitation, the compounds of the invention are usefulin phase transfer catalysis and liquid/liquid ion extraction (LIX).

The compounds of the invention optionally contain asymmetric carbonatoms in groups X, Y, and Z. As such, they are a unique class of chiralauxiliaries for use in the synthesis or resolution of other opticallyactive materials. For example, a racemic mixture of carboxylic acids canbe resolved into its component enantiomers by: 1) forming a mixture ofdiastereomeric esters with a compound of the invention wherein X is anasymmetric hydroxyalkane group; 2) separating the diastereomers; and 3)hydrolyzing the ester structure. Racemic alcohols are separated by esterformation with an acid group of Y. Further, such a method can be used toresolve the compounds of the invention themselves if optically activeacids or alcohols are used instead of racemic starting materials.

Exemplary Methods of Making the Compounds of the Invention

The invention also relates to methods of making the compositions of theinvention. The compositions are prepared by any of the applicabletechniques of organic synthesis. Many such techniques are well known inthe art. However, many of the known techniques are elaborated in"Compendium of Organic Synthetic Methods" (John Wiley & Sons, New York),Vol. 1, Ian T. Harrison and Shuyen Harrison, 1971; Vol. 2, Ian T.Harrison and Shuyen Harrison, 1974; Vol. 3, Louis S. Hegedus and LeroyWade, 1977; Vol. 4, Leroy G. Wade, jr., 1980; Vol. 5, Leroy G. Wade,Jr., 1984; and Vol. 6, Michael B. Smith; as well as March, J., "AdvancedOrganic Chemistry, Third Edition", (John Wiley & Sons, New York, 1985).

A number of exemplary methods for the preparation of the compositions ofthe invention are provided below. These methods are intended toillustrate the nature of such preparations are not intended to limit thescope of applicable methods.

Generally, the reaction conditions such as temperature, reaction time,solvents, workup procedures, and the like, will be those common in theart for the particular reaction to be performed. The incorporatedreference material, together with material cited therein, containsdetailed descriptions of such conditions. Typically the temperatureswill be -100° C. to 200° C., solvents will be aprotic or protic, andreaction times will be 10 seconds to 10 days. Workup typically consistsof quenching any unreacted reagents followed by partition between awater/organic layer system (extraction) and separating the layercontaining the product.

Oxidation and reduction reactions are typically carried out attemperatures near room temperature (about 20° C.), although for metalhydride reductions frequently the temperature is reduced to 0° C. to-100° C., solvents are typically aprotic for reductions and may beeither protic or aprotic for oxidations. Reaction times are adjusted toachieve desired conversions.

Condensation reactions are typically carried out at temperatures nearroom temperature, although for non-equilibrating, kinetically controlledcondensations reduced temperatures (0° C. to -100° C.) are also common.Solvents can be either protic (common in equilibrating reactions) oraprotic (common in kinetically controlled reactions).

Standard synthetic techniques such as azeotropic removal of reactionby-products and use of anhydrous reaction conditions (e.g. inert gasenvironments) are common in the art and will be applied when applicable.

In the schemes P indicates a hydrolytically cleavable protecting group.Such groups have been described in the above cited work of Greene.Ordinarily such groups include silyl ethers, esters, amides and thelike. The selection of protecting group and the need to protect a groupsuch a hydroxyl, carboxyl, amidino, amino or the like will depend uponthe order and selection of synthetic reagents and processes,considerations that will be familiar to the ordinary artisan.

The first exemplary method is set forth in Scheme 1. In the methodhydroxymethylpyridine 15 is reacted with t-butyldimethylsilyl chloridein pyridine to form ether 16. Such steps are described in detail inGreene, T. W., "Protective Groups in Organic Synthesis" (John Wiley &sons, New York, 1981), pages 39-50, and in particular pages 44-46.

Compound 16 is then oxidized with m-chloroperoxybenzoic acid (m-CPBA) toform oxide 17. Such oxidations are described in Pedersen, C. L.; et al.;ACTA Chemica Scand., 1970, 24, 3435.

Oxide 17 is then condensed with D-glyceraldehyde acetonide as, forexample, by the method of Abramovitch, R. A.; et al.; J. Am. Chem. Soc.,1967, 89, 1537,. The acetonide is available in D-, L- and D,L- form andaccordingly the absolute stereochemistry of the condensation product atposition 2 of the propane triol side chain are controlled by selectionof D-, L- or D,L- material.

Compound 18 is then converted to compound 19 by reaction with PhCOCl andMe₃ SiCN. Such a reaction is described in Kobayashi, Y.; et al.; Chem.Pharm. Bull. (Japan), 1969,17, 510.

Compound 19 is then converted to primary alcohol 20 by treatment withBu₄ NF as described in the above cited work of Greene.

Alcohol 20 is converted to the N-alkylphthalimide 21 by reaction withphthalimide, Ph₃ P, and diethyl azodicarboxylate. This conversion isdescribed in the above cited work of March at page 378, Mitsunobu; etal.; J. Am. Chem. Soc. 1972, 94, 679, Grunewald; et al.; J. Org. Chem.1983, 48, 2321, and Mitsunobu, Synthesis 1981, 1-28.

Phthalimide 21 is then hydrolyzed to carboxylic acid 22. Such reactionsare generally described in Org. Synth. 1955, 3, 557.

Compound 22 is then converted to compound 23 by exchange with hydrazinedescribed in the above cited work of March at page 378 and in Ing; etal.; J. Chem. Soc. 1926, 2348.

A second exemplary method is shown in Scheme 2. Methyl acetoacetate 24is condensed with (-)-2,3--O--isopropylidene-D-erythronolactone (CA reg.no. 25581-41-3!) to form dione 25. Such a transformation is described byLarock, R. C. "Comprehensive Organic Transformations" (VCH, New York,1989), page 772. The lactone is available in D-, L- and D,L- form andaccordingly the absolute stereochemistry of the condensation productside chain are controlled by selection of D-, L- or D,L- material.

Compound 25 is then reacted with H₂ N(CCN)NH to form pyrimidine 26. Suchreactions are described in Katritzky, A. R. "Handbook of HeterocyclicChemistry" (Pergamon, New York, 1985).

Pyrimidine 26 is converted to acetate 27 by reaction with AcCl/Et₃ N andNaI/pyridine. Such a conversion is described in Morita, T.; et al.; J.Chem. Soc., Chem. Commun. 1978, 874.

Acetate 27 is converted to amine 28 by reaction with ClCO₂ Et and NaN₃.Such a reaction is described in Weinstock, J.; J. Org. Chem. 1961, 26,3511.

Amine 28 is then converted to compound 29 by hydrolysis. Such aconversion was shown in Scheme 1.

A third exemplary method is shown in Scheme 3. Trimethyl pyridine 30 isconverted to triol 31 by oxidation with KMnO₄ and reduction with LiAlH₄.Such a reaction is described in Singer, A. W.; et al.; Org. Synth. 1955,III, 740.

The triol is diprotected to form alcohol 32 using t-butyldimethylsilylchloride and imidazole as described in the above cited work of Greene.Separation of the distribution of mono-, di- and tri- protectedmaterials is accomplished in a conventional manner, typically bychromatography using silica or alumina.

MnO₂ oxidation of alcohol 32 produces aldehyde 33. Such an oxidation isdescribed in Pratt, E. F.; et al.; J. Org. Chem. 1961, 26, 2973.

Triol 35 is prepared by reaction of aldehyde 33 with vinylmagnesiumbromide and reaction of the allylic alcohol 34 with OsO₄ /t-BuOOH. Adescription of the oxidation process is found in Akashi, K.; et al.; J.Org. Chem. 1978,43,2063.

Formation of the triacetate 36 and deprotection of the silyl ethers toform diol 37 is described in the above cited work of Greene.

Diol 37 is converted to the mono-N-alkylphthalimide 38 by reaction withphthalimide, Ph₃ P, and diethyl azodicarboxylate as described above inScheme 1. Should separation of mono- and/or di- phthalimides berequired, it is performed in the usual manner, typically by silica oralumina chromatography.

Oxidation of the alcohol 38 to the carboxylic acid 39 is accomplished bytraditional techniques, as for example the well known Jones reactionusing CrO₃ \H₂ SO₄ \acetone or CrO₃ \HOAc\H₂ O.

Deprotection of acid 39 to form amine 40 is performed using H₂ NNH₂, asdescribed above in Scheme 1.

A fourth exemplary method is shown in Scheme 4. Halide 41 is condensedwith D-glyceraldehyde acetonide as, for example, by the method ofKnight, D. W.; et al. Tet. Lett. 1980, 21, 5051. As described above theacetonide is available in D-, L- and D,L- form so that the side chainstereochemistry can be selected.

The resulting acetonide 42 is protected to form compound 43. Suchreactions are discussed above in Scheme 1.

Compound 43 is then converted to carboxylic acid 44 by reaction withstrong base (e.g. LDA/THF) and CO₂. Such a reaction is described inDavies, G. M.; et al.; Tet. Lett. 1972, 33, 3507.

Carboxylic acid 44 is converted to nitrile 45 by reaction withKCN/Pd(PPh₃)₄. Such a reaction is described in Yamamura, K.; et al.;Tet. Lett. 1977,50,4429.

Nitrile 45 is then converted to compound 46 by removal of the silylgroup as describe in the above cited work of Greene, and hydrogenated ina manner similar to that of Cordes, E. H.; et al.; Chem. Rev. 1974, 74,5 and 581, and Rylander, "Catalytic Hydrogenation over Platinum Metals"(Academic Press, New York, 1967), pages 203-226.

A fifth exemplary method is shown in Scheme 5. As described above inScheme 1, Halide 41 is converted to carboxylic acid 47 which in turn isconverted to acetonide 48. Compound 48 is then converted to nitrile 49which in turn is converted to compound 50. Each of these steps wasdescribed above in Scheme 1.

A sixth exemplary method is shown in Scheme 6. Aminoacetonitrile 51 iscondensed with (-)-2,3-O-isopropylidene-D-erythronolactone (CA reg. no.25581-41-3!) to form compound 52. Such a transformation was describedabove in Scheme 2.

Compound 52 is extended to form compound 53 by reaction with MeO₂ CCO₂Me/Et₃ N and AcCl/Et₃ N and then cyclized to form oxazole 54 by reactionwith ClCOCOCl/Et₃ N. Such a combination of transformations is describedin Maeda, I.; et al.; Bull. Chem. Soc. Jpn. 1969, 42, 1435.

Hydrolysis of compound 55 and hydrogenation of nitrile 56 leads tocompound 57. Such reactions were described in Schemes 4 and 5 above.

A seventh exemplary method is shown in Scheme 8. Commercially availablemethoxy acetic acid 58 and serine methyl ester 59 (Aldrich #19,455-7 and#22,313-1) is coupled using isobutyl chloroformate, 4-methyl morpholinein DMF to give amide 60. Such a conversion is described in TetrahedronLett. 1992, 33, 7835.

Alcohol 60 is converted to the vinyl bromide in four steps as describedin Tetrahedron Lett. 1992, 33, 7835.

Vinyl bromide 61 is converted into the 5-bromo oxazole 62 by treatmentwith CuBr₂ and DBU in CH₂ Cl₂ as described in Tetrahedron Lett. 1992,33, 7835.

Methyl ester 62 is reduced with diisobutylaluminum hydride to thecorresponding aldehyde and then converted to the primary amine byreductive amination using ammonia and NaBH₃ CN. Such a conversion isdescribed in Synthesis 1975, 135.

Amine 63 is protected with phthaloyl dichloride to give phthalimide 64as described in the above cited book of Greene.

Methyl ether 64 is cleaved with TMS iodide as described in J. Org. Chem.1977, 42 3761. Subsequent oxidation gives the carboxylic acid 65. Suchconversions are described in the above cited book of LaRock.

5-Bromo oxazole 65 is converted to the 5-lithio derivative withn-butyllithium. Such a conversion is described in Tetrahedron 1968, 24,3965. The anion is condensed with either D- or L- glyceraldehydeacetonide to give 66. D- or L- glyceraldehyde is obtained according tothe references cited earlier.

Removal of the amine protecting group of 66 according to the methodscited in Greene followed by subsequent hydrolysis of the acetonide withTsOH/MeOH gives the triol 67. Such a conversion is described inTetrahedron Lett. 1977, 3473.

An eighth exemplary method is shown in Scheme 8. 5-bromo oxazole 64 isconverted into the 5-lithio derivative as described in the aboveconversion of 65. Trapping with CO₂ gas gives the correspondingcarboxylic acid. Such a conversion is described in Tetrahedron Lett.1975, 3973. Cyclization of the amine and carboxylic acid gives thelactam 68. Such conversions are described in the cited book of LaRock,pg. 944.

Methyl ether 68 is cleaved as described above for 64 followed bysubsequent oxidation with PDC and addition of vinyl lithium gives theallylic alcohol 69.

Sharpless epoxidation of 69 followed by opening of the epoxide gives thetriol 70. Such conversions are described in J. Am. Chem. Soc. 1973, 95,6136 and Synthesis 1981, 280.

Cleavage of the lactam 70 gives the corresponding free amino carboxylicacid 71.

A ninth exemplary method is shown in Scheme 9. Compound 62 is reducedwith diisobutylaluminum hydride and the resultant alcohol protected witht-butyldiphenylsilyl chloride to give the silyl ether 72. Suchconversions are described in Synthesis 1975, 617 and Can J. Chem. 1977,5, 562.

Vinyl bromide 72 is converted in several steps to the primary amine 73by treatment with n-butyllithium and DMF. Such a conversion is describedin J. Org. Chem. 1991, 56, 449. Reductive amination, as describedpreviously in the transformation of 62 into 63 gives the amine 73.

Silyl ether 74 is treated with TBAF and then oxidized to thecorresponding carboxylic acid which is cyclized to give lactam 74. Suchconversions are described in the above cited book of LaRock, pg. 944.

Compound 74 is treated with TMS iodide and oxidized to the aldehyde 75with PCC. Such a conversion is described in Tetrahedron Lett. 1975,2647.

Compound 75 is converted into the triol 76 by the same method asdescribed for the conversion of 69 into 70.

Cleavage of lactam 76 gives the free amino carboxylic acid 77.

A tenth exemplary method is shown in Scheme 10. 1,3-Diketone 90 iscondensed with carbohydrate derived 91 in the presence of NH₃ to affordpyrimidine 92. Such general synthetic methods are described in"Comprehensive Heterocyclic Chemistry" Boulton, A. J.; McKillop, A.,eds. (Pergamon, New York, 1984), v. 3. p.106.

Monosaponification of 92 using standard conditions (NaOH or Ba(OH)₂/MeOH) followed by conversion of the resulting carboxylic acid to theamide (SOCl₂ then NH₃) provides amide 93.

Treatment of 93 under dehydrative conditions affords nitrile 94. Such aconversion is described by Yamamoto; Tetrahedron Lett. 1970,4843.

Compound 94 is then subjected to basic hydrolysis (Org. Synth. 1963, 4,608) with subsequent catalytic hydrogenation of the nitrilefunctionality, as described in Scheme 4, affording the correspondingfunctionalized pyrimidine 95.

An eleventh exemplary method is shown in Scheme 11. 2,6-Dimethylpyridine 96 is converted under oxidative conditions to the diacid, whichis then esterified to the diester 97. Such general manipulations aredescribed in "Pyridine and its Derivatives", Supplement, Abramovitch, R.A. ed. (John Wiley, New York, 1974). vol 1-5 and "ComprehensiveHeterocyclic Chemistry" Boulton, A. J.; McKillop, A., eds. (Pergamon,New York, 1984), v. 2.

Reduction of 97 with DIBAL gives aldehyde 98. Such a conversion isdescribed in Tetrahedron Lett. 1962, 619 and 1969, 1779.

Addition of vinyl magnesium bromide to aldehyde 98 followed by furtherfunctionalization of the double bond with either OsO₄ orepoxidation/basic hydrolysis then provides triol 99. Such a process hasbeen described in Scheme 3.

Treatment of 99 with an excess of benzoyl chloride and base, results inprotection of the hydroxyl groups and conversion of the pyridine to itspyridinium salt. Addition of cyanide to the pyridinium salt affordsnitrile 100. Such addition of nucleophiles to pyridinium salts has beendescribed in "Pyridine and its Derivatives" ed. Supplement, Abramovitch,R. A. ed. (John Wiley, New York, 1974). vol 1-5.

A twelfth exemplary method is shown in Scheme 12.1-Carboxy-2,6-dihydroxypyridine 102 was reacted with POBr₃ at 170° C. toproduce 1-carboxy-2,6-dibromopyridine 103 which was then converted tothe N-acytyl compound 104 by sequential reaction with SOCl₂, NH₃.H₂ O,BH₃.THF, and Ac₂ O/pyridine. Conversion to allylic alcohol 105 wasaccomplished using Pd(PPh₃)₄ in toluene at 100° C. Compound 105 wasreacted with CO/EtOH/Et₃ N using PdCl₂ (PPh₃)₂ as a catalyst at 100° C.and 120 psi to produce ester 106. Oxidation to the triol 107 wasaccomplished using OsO₄ /K₃ Fe(CN)₆ in t-BuOH/H₂ O. Hydrolysis usingNaOH/EtOH/H₂ O at 90° C. followed by acidification with HCl producedtriol 108. Conversion of 108 to 109 was accomplished in 10% KHCO₃.

A thirteenth exemplary method is shown in Scheme 13. Compound 105,prepared above, is reacted with HPO(OEt)₂ using Pd(PPh₃)₄ as a catalystat 90° C. by the method of Hirao, T.; Masunaga, T.; Yamada, N.; Bull.Chem. Soc. Japan, 1982, 55, 909, to produce allylic alcohol 110.Compound 110 is reacted with OsO₄ /K₃ Fe(CN)₆ in t-BuOH/H₂ O to preparetriol 111. Deprotection with TMSBr produces compound 112 which isconverted to disalt 113 by use of NaOH/MeOH/H₂ O. Guanidine 114 isprepared in 10% KHCO₃.

A fourteenth exemplary method is shown in Scheme 14. Amine salt 115 wasconverted to acetate 116 by use of AcCl in pyridine. Compound 116 wasreacted with allyl bromide (CH₂ CHCH₂ Br) at 55° C. in DMF/K₂ CO₃ toform allyl ether 117. Rearrangement to form phenol 118 was performed indiethylaniline at 200° C. Protection was accomplished with PhC(O)Cl inpyridine to form compound 119 which was oxidized with OsO₄ inN-methylmorphiline oxide to diol 120. Deprotection was performed withNaOH in H₂ O/EtOH to form free phenol 121 which was converted toguanidine 122 in 10% KHCO₃.

A fifteenth exemplary method is shown in Scheme 15. Phenol 123 isprotected by sequential treatment with MeOH/H₂ SO₄ and AcCl/pyridine toform phenol 124. Conversion to allyl ether 125 is accomplished bytreatment with allyl bromide in K₂ CO₃. Rearrangement in xylene at 190°C. produces phenol 126. Sequential treatment of compound 126 with MeI/K₂CO₃, OsO₄ /N-methylmorphiline oxide, and Ac₂ O/pyridine produces fullyprotected compound 127. Reaction with F₃ CC(O)!₂ O/NH₄ NO₃ producesprotected nitro phenol 128. Deprotection with Br₃ produces nitro phenol129. Hydrogenation to amine 130 is accomplished using H₂ /Pd-C.Hydrolysis with NaOH in H₂ O/MeOH produces diol 131 which is convertedto guanidine compound 132 by reaction with (BocNH)₂ C(S) followed by F₃CCO₂ H.

A sixteenth exemplary method is shown in Scheme 16. Phenol 126 (preparedabove) is reacted sequentially with C₆ H₅ N(SO₂ CF₃)₂ and Pd(OAc)₂ /PPh₃/Et₃ N/HCO₂ H to produce ester 133. Oxidation with OsO₄ /N-methylmorphiline oxide followed by Ac₂ O/pyridine produces protected diol 134.Reaction of compound 134 with (F₃ C(O))₂ O and NH₄ NO₃ produces compound135 which is hydrogenated using H₂ /Pd-C to form amine 136. Hydrolysiswith NaOH in H₂ O/MeOH forms diol 137, which is converted to guanidine138 by sequential reaction with (BocNH)₂ C(S) followed by F₃ CCO₂ H.

Basic hydrolysis of 100, under standard conditions, removes both esterand alcohol protecting groups. The carboxylic acid-triol intermediate isthen subjected to catalytic hydrogenation affording functionalizedpyridine 101. Such a reductive process was described in Scheme 4.

Modifications of each of the above schemes leads to various analogs ofthe specific exemplary materials produced above. The above citedcitations describing suitable methods of organic synthesis areapplicable to such modifications. By way of example, and not limitation,a number of specific modifications will be described. The specificmodifications are applicable to other compounds having similarfunctional groups including other specifically disclosed compounds. Ineach of these exemplary modifications, it may be appropriate to prepareprotected derivatives of the starting materials as described in theabove cited work of Greene. Generally, protection is not required,however, to optimize yields and reduce separation and purification stepsto a minimum, protection may be advantageous. In certain individualcases prior protection of starting materials may have a significanteffect on yield or purity.

The acidic substituent of the compounds prepared in Schemes 1 and 2, thebasic substituent of the compounds prepared in Schemes 4, 5, and 6, andeither substituent in the compound prepared in Scheme 3, are produced byway of a nitrile intermediate (compounds 21, 28, 45, 49, and 56). Any ofthese substituents can be produced in homologous form by conversion ofthe nitrile first to an aldehyde, homologation of the aldehyde by thedesired number of carbon atoms and conversion of the product to acarboxylic acid (or other acidic function) or amine (or other basichetero atom containing function). The conversion of the nitrite to thealdehyde is accomplished by reaction of the nitrile with (i-Bu)₂ AlH inbenzene. Such a conversion is described in J. Org. Chem. 1959, 607 627.The direct homologation of an aldehyde can be performed by wittigreaction with an appropriate reagent. The aldehyde is reacted with Ph₃P═CHSPh (or homologous reagent)/Me₂ SO and HgCl₂ /HgO/H₂ O to producethe homolog. Such a conversion is described in Tetr. Lett. 1969, 3665.

The carboxylic acid group of compounds 23, 29, 39, 46, 50, and 57 can behomologated by conversion of the corresponding ester to the aldehyde andapplying the above described method for aldehyde homologation. The esteris reacted with (i-Bu)₂ AlH/toluene/hexane/Et₂ O to produce thealdehyde. Such a conversion is described in Tetr. Lett. 1962, 619, and1969, 1779.

Compounds 18, 25-27, 32, 38, 49, 52, and 55 are all primary or secondarymono-ols. As such each can be homologated by oxidation to thecorresponding aldehyde or ketone by standard techniques. The carbonylcompound is then homologated by reaction with Ph₃ P═CHSPh (or homologousreagent)/Me₂ SO and HgCl₂ /HgO/H₂ O. Such a conversion is described inTetr. Lett. 1969, 3665. Once homologated the material can be reduced bystandard techniques to the homologated alcohol.

The sulfur analogs of the carboxylic acid compounds of the invention areprepared by any of the standard techniques. By way of example and notlimitation, the acids are reduced to the alcohols by standard methods.The alcohols are converted to halides or sulfonic acid esters bystandard methods and the resulting compounds are reacted with NaSH toproduce the sulfide product. Such reactions are described in Patai, "TheChemistry of the Thiol Group" (John Wiley, New York, 1974), pt. 2, andin particular pages 721-735.

In addition to the modification reactions described above, each of thesynthetic methods of the invention produce modified products whendifferent starting materials are employed. By why of example and notlimitation, methylated analogs of compounds 15, 24, 27, 30, and 41 areall available and can be readily substituted.

Acids and amines of the Y and Z groups are modified to form amides. Forexample, a carboxylic acid or amine group is reacted with an amino acidor polypeptide to form an amide. Alternatively, the carboxylic acidcomponent can be readily activated by any of the techniques common inpolypeptide synthesis to form an activated carboxylic acid and thenreacted with an amine. Amines are converted to form mono- and di-alkylamines by the standard methods of amine alkylation.

In each of the above exemplary schemes it may be advantageous toseparate reaction products from one another and/or from startingmaterials. The desired products of each step or series of steps isseparated and/or purified (hereinafter separated) to the desired degreeof homogeneity by the techniques common in the art. Typically suchseparations involve multiphase extraction, crystallization from asolvent or solvent mixture, distillation, sublimation, orchromatography. Chromatography can involve any number of methodsincluding, for example, size exclusion or ion exchange chromatography,high, medium, or low pressure liquid chromatography, small scale andpreparative thin or thick layer chromatography, as well as techniques ofsmall scale thin layer and flash chromatography.

Another class of separation methods involve treatment of a mixture witha reagent selected to bind to or render otherwise separable a desiredproduct, unreacted starting material, reaction by product, or the like.Such reagents include adsorbents or absorbents such as activated carbon,molecular sieves, ion exchange media, or the like. Alternatively, thereagents can be acids in the case of a basic material, bases in the caseof an acidic material, binding reagents such as antibodies, bindingproteins, selective chelators such as crown ethers, liquid/liquid ionextraction reagents (LIX), or the like.

Selection of appropriate methods of separation depends on the nature ofthe materials involved. For example, boiling point, and molecular weightin distillation and sublimation, presence or absence of polar functionalgroups in chromatography, stability of materials in acidic and basicmedia in multiphase extraction, and the like. One skilled in the artwill apply techniques most likely to achieve the desired separation.

To the extent any compound of this invention cannot be produced by oneof the foregoing schemes other methods will be apparent to the artisanreferring to conventional methods (see for instance Liotta et al."Compendium of Organic Synthesis Methods" (John Wiley & Sons, New York),Vol. 1, Ian T. Harrison and Shuyen Harrison, 1971; Vol. 2, Ian T.Harrison and Shuyen Harrison, 1974; Vol. 3, Louis S. Hegedus and LeroyWade, 1977; Vol. 4, Leroy G. Wade, Jr., 1980; Vol. 5, Leroy G. Wade,Jr., 1984; and Vol. 6, Michael B. Smith; March, J., "Advanced OrganicChemistry, Third Edition", (John Wiley & Sons, New York, 1985); as wellas "Comprehensive Organic Synthesis. Selectivity, Strategy & Efficiencyin Modern Organic Chemistry. In 9 Volumes", Barry M. Trost,Editor-in-Chief (Pergamon Press, New York, 1993 printing).

Each of the cited works above is incorporated by reference in itsentirety. Specifically cited sections or pages of the above cited worksare incorporated by reference with specificity. The invention has beendescribed in detail sufficient to allow one of ordinary skill in the artto make and use the subject matter of the following claims. It isobvious that certain modifications of the methods and compositions ofthe following claims can be made within the scope and spirit of theinvention. ##STR39##

EXAMPLES

General

The following Examples refer to Schemes 17, 18 and 19.

Example 1

Methyl ester 200: A suspension of commercially available3,4-diaminobenzoic acid (5 g, 32.9 mmol, Aldrich D1,260-0) in MeOH (150mL) was saturated with anhydrous HCl. The resulting solution was stirredat rt for 12 h, and the solids were filtered, washed with ether anddried to afford methyl ester 200 (5.76 g, 78%) as an off white powder: ¹H NMR d (300 MHz, DMSO-d₆) 3.76 (s, 3H), 6.86 (d, 1H, J=8.7), 7.65 (dd,1H, J=1.8, 8.7), 7.81 (d, 1H, J=1.8), 9.40 (br s, 6H).

Example 2

Amino bis-Boc-guanidine 201: To a solution of 200 (714 mg, 3 mmol),N,N'-bis-tert-butoxycarbonylthiourea (828 mg, 3 mmol, prepared accordingto literature procedure: Synthetic Commun.1993, 23, 1443.), and Et₃ N(1.63 mL, 12 mmol) in DMF (5 mL) was added HgCl₂ (814 mg, 3 mmol) andthe mixture was stirred at rt for 22 h. The reaction mixture was dilutedwith ethyl acetate, filtered through a pad of celite and evaporated.After partitioning the crude residue between ethyl acetate and water,the organic phase was washed with additional water, brine and was dried(Na₂ SO₄). The solvent was evaporated and the residue waschromatographed on silica gel (20/1-dichloromethane/ethyl acetate) toafford amino bis-Boc-guanidine 201 (700 mg, 57%) as a white foam: ¹ HNMR (300 MHz, CDCl₃) d 1.45 (s, 9H), 1.54 (s, 9H), 3.85 (s, 3H), 4.60(s, 2H), 6.75 (d, 1H, J=8.4), 7.75 (d, 1H), 7.86 (s, 1H), 9.9 (s, 1H),11.63 (br s, 1H).

Example 3

Acetamide 202: A solution of 201 (400 mg, 0.98 mmol) in acetic anhydride(2.5 mL) was heated at 60° C. for 15 min. Evaporation of the solventgave acetamide 202 in quantitative yield as a white solid: mp 165° C.(dec); ¹ H NMR (300 MHz, CDCl₃) 1.49 (s, 9H), 1.57 (s, 9H), 2.17 (s,3H), 3.90 (s, 3H), 7.83 (d, 1H, J=1.6), 7.95 (dd, 1H, J=1.6, 8.6), 8.13(d, 1H, J=8.6), 10.43 (br s, 2H), 11.52 (br s, 1H).

Example 4

Carboxylic acid 203: To a solution of 202 (150 mg, 0.33 mmol) in THF (1mL) was added LiOH.H₂ O (28 mg, 0.67 mmol) followed by the addition ofwater (1 mL). The solution was stirred at rt 16 h, additional LiOH.H₂ O(14 mg, 0.33 mmol) was added and the reaction was allowed to continuefor 10 h. After dilution with water and extraction with ether, theorganic phase was acidified with 5% citric acid and was extracted withchloroform (3×20 mL). The combined organic extracts were dried (MgSO₄)and evaporated to afford carboxylic acid 203 (100 mg, 69%) as a whitesolid: ¹ H NMR (300 MHz, DMSO-d₆, all signals are broad) d 1.42 (s,18H), 2.08 (s, 3H), 7.74 (s, 2H), 8.12 (s, 1H), 9.81 (2s, 2H), 11.50 (s,1H), 12.80 (s, 1H).

Example 5

N-acetyl guanidine 204: Carboxylic acid 203 (100 mg, 0.23 mmol) wastreated with trifluoroacetic acid (2 mL) at rt for 14 h. The solvent wasevaporated and the residue was dissolved in methanol, filtered andevaporated to near dryness. Addition of ether precipitated a white solidwhich was filtered and dried under high vacuum to afford guanidine 204(77 mg, 95%) as the trifluoroacetate salt: ¹ H NMR (300 MHz, DMSO-d₆) d2.12 (s, 3H), 7.50 (br s, 4H), 7.74 (d, 1H, J=1.2), 7.85 (dd, 1H, J=1.5,8.4), 7.90 (d, 1H, J=8.7), 9.04 (s, 1H), 9.91 (s, 1H).

Example 6

tert-Butyl ester 205: A suspension of commercially available3,4-diaminobenzoic acid (3.04 g, 20 mmol, Aldrich Cat. D1,260-0) indioxane (40 mL) was added N,N'-diisopropyl-O-tert-butylisourea (4 g, 20mmol, prepared by general literature method: Synthesis 1979, 561) andthe mixture was heated at 70° C. for 1 h at which time more isourea (4g, 20 mmol) was added. After 1.5 h the temperature was increased to 80°C. and isourea (2 g, 10 mmol) was added and the reaction was allowed toproceed at this temperature for 1.5 h. The mixture was cooled to rt andwas filtered, washing the filtercake with several portions of dioxane.Evaporation of the filtrate gave a residue which was dissolved in ethylacetate and washed with 1 M Na₂ CO₃ (2×100 mL), brine, and dried (Na₂SO₄). The solvent was evaporated and the residue was chromatographed onsilica gel (10% ethyl acetate/dichloromethane) to afford tert-butylester 205 (1.43 g, 34%) as a brown oil: ¹ H NMR (300 MHz, CDCl₃) d 1.56(s, 9H), 3.45 (br s, 4H), 6.65 (d, 1H, J=8.1), 7.36 (d, 1H, J=1.9), 7.42(dd, 1H, J=1.9, 8.1).

Example 7

Bis-Boc-guanidine 206: To a solution of 205 (340 mg, 1.6 mmol),N,N'-bis-tert-butoxycarbonylthiourea (442 mg, 1.6 mmol, preparedaccording to literature procedure: Synthetic Commun.1993, 23, 1443.),and Et₃ N (292 mL, 3.36 mmol) in DMF (4 mL) at 0° C. was added HgCl₂(478 mg, 1.76 mmol) and the mixture was allowed to warm to rt overnight,stirring a total of 20 h. The crude product was isolated in the samemanner as described in Example 201 and the was chromatographed on silicagel (5% ethyl acetate/dichloromethane) to afford bis-Boc-guanidine 206(229 mg, 31%) as a pale orange solid: ¹ H NMR (300 MHz, CDCl₃) d 1.49(s, 9H), 1.54 and 1.56 (2s, 18H), 4.48 (br s, 2H, NOE observed for C-4NH₂ and C-3 H), 6.73 (d, 1H, J=8.4), 7.68 (dd, 1H, J=1.6, 8.4), 7.86 (s,1H), 9.96 (s, 1H), 11.64 (s, 1H).

Example 8

Trifluoroacetamide 207: To a solution of 206 (70 mg, 0.16 mmol) indichloromethane (2 mL) at 0° C. was added pyridine (25 mL, 0.31 mmol)followed by the addition of trifluoroacetic anhydride (24 mL, 0.17mmol). After 15 min the reaction solution was diluted withdichloromethane and was washed with cold 5% citric acid. The organicphase was dried (MgSO₄), and evaporated to afford trifluoroacetamide 207(84 mg, 99%) as a pale yellow solid: ¹ H NMR (300 MHz, CDCl₃) 1.48 (s,9H), 1.57 and 1.59 (2s, 18H), 7.78 (d, 1H, J=1.6), 7.92 (dd, 1H, J=1.6,8.6), 7.99 (d, 1H, J=8.6), 10.56 (br s, 1H), 11.61 (s, 1H), 11.89 (s,1H).

Example 9

N-Trifluoroacetyl guanidine 208: A solution of trifluoroacetamide 207(84 mg, 0.15 mmol) in dichloromethane (1.5 mL) was treated withtrifluoroacetic acid (1.5 mL) and the solution was stirred at rt for 5h. The solution was evaporated and the residue was passed through a plugof C-18 reverse phase silica using water as eluent. Afterlyophilization, guanidine 208 (45 mg, 72%) was obtained as a whitesolid: ¹ H NMR (300 MHz, DMSO-d₆) d 7.55 (s, 4H), 7.6 (d, 1H, J=8.3),7.8 (s, 1H), 7.92 (d, 1H, J=8.3), 9.52 (s, 1H), 11.37 (s, 1H), 13.30 (brs, 1H).

Example 10

Iodo methyl ester 209: To a suspension of 5-iodo-4-amino-3-nitrobenzoicacid (7.58 g, 24.5 mmol, prepared according to literature method,Roczniki Chem. 1962, 36, 971. from commercially available4-amino-3-nitrobenzoic acid, Eastman Kodak Cat. 117-8474) in methanol(150 mL) was slowly added 98% H₂ SO₄ (1 mL) and the mixture was heatedto reflux for 12 h. The resulting solution was slowly cooled to 0° C.and the crystalline product was filtered and washed with cold methanolto afford methyl ester 209 (5.8 g, 73%) as orange needles: mp 142-144°C.; ¹ H NMR (300 MHz, CDCl₃) d 3.92 (s, 3H), 7.03 (br s, 2H), 8.55 (d,1H, J=1.8), 8.86 (d, 1H, J=1.8).

Example 11

Iodo acetamide 210: To a suspension of 209 (4 g, 12.4 mmol) in aceticanhydride (50 mL) at rt was added a catalytic amount of 98% H₂ SO₄.After 10 min the mixture was cooled to 0° C. and the solid was filtered,washed with cold acetic anhydride, and dried to afford iodo acetamide210 (4.13 g, 91%) as a pale yellow powder: mp 204-205° C.; ¹ H NMR (300MHz, CDCl₃) d 2.27 (s, 3H), 3.97 (s, 3H), 7.73 (s, 1H), 8.55 (d, 1H,J=1.5), 8.72 (d, 1H, J=1.5).

Example 12

Vinyl Arene 211: To a suspension 210 (944 mg, 2.6 mmol) in toluene (20mL) was added vinyltributyltin (950 mL, 3.25 mmol) and2,6-di-tert-butyl-4-methylphenol (˜1 mol %). The solution was purgedwith argon, tetrakis(triphenylphosphine)palladium (0) (60 mg, 0.05 mmol)was added, and the mixture was heated to reflux for 3 h. The solvent wasevaporated residue was dissolved in tetrahydrofuran (50 mL) and wasvigorously stirred with 10% aqueous KF (20 mL). After filtration of thebiphasic mixture through celite and evaporation of the tetrahydrofuran,the aqueous phase was extracted with dichloromethane. The organicextracts were dried (MgSO₄), evaporated, and the crude residue waschromatographed on silica gel (5% ethyl acetate/dichloromethane) to give600 mg of product containing residual tin impurities. Recrystallizationfrom ethyl acetate/hexane gave vinyl derivative 211 (489 mg, 71%) aspale yellow crystals: ¹ H NMR (300 MHz, CDCl₃) d 2.25 (s, 3H), 3.98 (s,3H), 5.52 (d, 1H, J=11.0), 5.91 (d, 1H, J=17.5), 6.68 (dd, 1H, J=11.0,17.5), 8.46 (d, J=1.9) overlapping 8.48 (s, total 2H), 8.53 (d, 1H,J=1.9).

Example 13

Ethyl bis-Boc-Guanidine 212: A solution of 211 (100 mg, 0.38 mmol) inmethanol was treated with 10% Pd-C (50 mg) and was shaken under 60 psiH₂ in a Paar apparatus. The catalyst was filtered (celite) and solventwas evaporated to afford a solid residue which was dissolved in DMF (2.5mL). To this solution was added bis-Boc-thiourea (113 mg, 0.42 mmol),and Et₃ N (111 mL, 0.80 mmol). The DMF solution was cooled to 0° C.,HgCl₂ (114 mg, 0.42 mmol) was added, and the mixture was stirred at 0°C. for 3 h then at rt for 20 h. The crude product was isolated in thesame manner as described for Example 201 and was chromatographed onsilica gel (1/1-ethyl acetate/hexane) to afford bis-Boc-guanidine 212(145 mg, 79%) as a colorless glass: ¹ H NMR (300 MHz, CDCl₃) d 1.25 (t,3H, J=7.6), 1.49 (s, 9H), 1.55 (s, 9H), 2.16 (s, 3H), 2.68 (q, 2H,J=7.6), 3.91 (s, 3H), 7.86 (d, 1H, J=1.5), 8.05 (d, 1H, J=1.5), 8.76 (s,1H), 10.46 (s, 1H), 11.54 (s, 1H).

Example 14

Ethyl guanidine 213: To a solution of 212 (136 mg, 0.28 mmol) inmethanol (2 mL) was added dilute KOH as needed, stirring at rt untilcomplete hydrolysis was detected by TLC (>20 h). The solution was cooledto 0° C. and was acidified with Amberlite IR120 ion exchange resin. Theresin was filtered and the solution was evaporated to afford 33 mg ofsolid residue which was directly treated with trifluoroacetic acid (5mL) at rt for 1.5 h then evaporated. The residue was dissolved in water(˜5 mL), passed through a plug of C-18 reverse phase silica andlyophilized to provide guanidine 213 (24 mg, 23%) as a white powder: ¹ HNMR (300 MHz, DMSO-d₆) d 1.11 (t, 3H, J=7.5), 2.10 (s, 3H), 2.56 (q, 2H,J=7.5), 7.46 (s, 4H), 7.65 (d, 1H, J=1.5), 7.79 (d, 1H, J=1.5), 8.69 (s,1H), 9.76 (s, 1H), 13.15 (br s, 1H).

Example 15

Enzyme Inhibition: Using the methods of screening in vitro activitydescribed above, the following activities were observed (+>75-100 μm,++20-75 μm, +++<20 μm):

    ______________________________________           Compound        IC.sub.50    ______________________________________           204             +++           208             ++           213             +    ______________________________________

What is claimed is:
 1. The composition of the formula: ##STR40##wherein: R₂ is H, or an alkyl group having 1 to 3 carbon atoms and 0 to2 hydroxyls;R₃ is H, or hydroxyl; R₄ is H, or forms a hydrolyzable esteror amide with --CO₂ --; R₅ are H, or are taken together to form ═NH; andR₆ comprises an amine, or a group having 1 to 12 carbon atoms and 1 to 3amine groups.
 2. The composition of claim 1 wherein R₂ is H, R₃ ishydroxyl, R₅ are H, and R₆ is amino alkyl.
 3. A method of inhibiting theactivity of neuraminidase comprising the step of treating a samplesuspected of containing neuraminidase with the composition of claim 1.4. The method of claim 3 wherein the neuraminidase is in vivo.